* In the first issue of volume 2, the Runaways take on the Wrecking Crew. Thunderball prepares to attack Gert, who has so far done nothing but go to lean against a tree.
-->'''Gert''': I've got the power to make grown men lose control of their bowels.
-->'''Thunderball''': Seriously?
-->*Old Lace drops down out of the tree.*
-->'''Gert''': More or less.
** And her musings after about how she wished Old Lace had been her Bat Mizvah present, if only to have made her school days more tolerable.
* Issue 17 of Vol. 2 has Nico and Gert fighting and making up at the same time, leaving Victor confused as to what was happening.
* Issue 25 of Vol. 2 It... makes sense in context.
-->'''Nico''': I told you like ten times to stay out of my stuff.
-->'''Molly''': But we're heisting! Why couldn't you wear normal-person stockings anyway? I'm gonna have waffle-face.
* When Victor starts getting obvious about his thing with Lillie, which is shortly after he and Nico got together:
--> '''Molly:''' "Victor's been kind of a ho-bag lately."
** Later, when Nico announces that Lillie will be coming back to the present with them, Victor tries to apologize, but she shuts him down.
---> "You're a toaster and she's a ho."
* During the ''Teenage Wasteland'' arc, some convenience store robbers(who turn out to be [[OurVampiresAreDifferent something else entirely]]) confuse the gang with PowerPack, a much earlier group of kid superheroes.
* The opening scene in Vol. 1 where {{Comicbook/The Avengers}} start acting bizarrely out of character during a mission to stop the {{Comicbook/Incredible Hulk}} from destroying TheWhiteHouse. It turns out [[spoiler: that it's just Alex playing an MMORPG with his online friends]]. Actually scratch that, ''all'' of the opening scenes introducing the main characters and their families are quite humorous as well.
* "Why aren't you awesomed by me?!"
* In the second volume of ''Comicbook/{{Runaways}}'', Victor tries to do a FastballSpecial with Molly. Molly is the strongest member of the team. Guess who turns out to be Wolverine.
* Molly taking on Eli Roston. (Also a CrowningMomentOfAwesome.)
--> '''Molly''': You. Bad man. *MegatonPunch* Me. Bad ass!
* [[ItMakesSenseInContext HELP! I'M BEING KIDNAPPED BY AN EVIL BLACK MAN FROM THE 1980'S!"]]
** "Dude, you don't have to bring race into this."
* Chase talking to himself at the start of the "Dead End Kids" Arc
-->'''Chase:''' ''KKcht.'' Eagle One to German guys from ''Film/DieHard'', what is your position? ''KKRrzt.'' This is German Guys, we are splitting up a bazillion dollars in diamonds and primo weed while you freeze your ass off up there pretending you have a walkie talkie, over. ''KHHHT''.
* When the group spies on their parents and sees them in their supervillain get-up for the first time.
--> '''Alex:''' Do you know what this means?
--> '''Chase:''' Yeah, our parents are totally gay.
* After [[ItMakesSenseInContext fighting a giant serpent-monster that sprang up during a game of Truth or Dare]], Karolina (who by this point has come out as a lesbian) is asked if she ever has considered trying being with a guy. Karolina's pissed response is to point out how the incredibly phallic monster they just defeated made her even less inclined than usual to consider the idea, leaving the rest of the team scrambling for BrainBleach. [[spoiler:Or in Victor's case, outright erase the memory]].
** During that same game, the guys ask Nico who's the best kisser since she'd kissed all three of Chase, Alex & Victor. Nico instead responds that Karolina is the best kisser. [[GirlOnGirlIshot Chase & Victor are both okay with this]].
*** Klara, who just walked in, is appalled.
* Molly [[TheWorfEffect Worfing]] Wolverine, from near the front of a church, all the way through the heavy doors and across the street into a snowbank.
* The Runaways' first encounter with the Young X-Men is full of hilarity.
-->'''Nico''': Okay, see? This is why we should never leave the house.
-->'''Klara''': Lord save us... more demons!!
-->'''Victor''': Thaaaaat's not helping, Klara.
* Some funny innuendo in issue 4
-->'''Karolina''': Where am i going, anyway?
-->'''Nico''': The hospital! I've got a... a giant rod stuck inside my body!
-->'''Chase''': Heh.
* When Victor's powers suddenly emerge.
-->'''Victor''': Whoa...did you see how high I just jumped?\\
'''Nico''': Yeah. Did you see how high my stilettos are? [[PreAsskickingOneLiner Look closely]].\\
''*kicks Victor in the face*''
* Spider-man's appearance in volume 5
-->'''Victor''': Ho...Holy...
-->'''Gert''': You're...You're...
-->'''Spider-man''': Yes. I'm Batman.
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