Being supervised by the creators of ''Anime/TengenToppaGurrenLagann'' and ''Anime/DeadLeaves'', and also being a [[GrossoutShow sickeningly]] [[RefugeInAudacity raunchy]] WidgetSeries that is like [[XMeetsY the love child of]] ''WesternAnimation/ThePowerpuffGirls'' and ''WesternAnimation/SouthPark'', ''Panty & Stocking with Garterbelt'' easily gets an A+ in the department of hilarity.
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* One of the most notable ones is when an [[AttackOfThe50FootWhatever EXCEPTIONALLY]] [[BalloonBelly large]] Stocking does her [[HilarityEnsues transformation sequence]], in Episode 4.
* From Episode 7: [[OhCrap "Oh, shit."]]
* The [[DoubleEntendre quite]] ''[[VisualPun literal]]'' [[GRatedSex screwing]] in "Trans-homers".
* "...of the Dead"
** "Fuck! Sonofabitch!" "You motherfucker!" "Oh yeah, you fatherfucker!"
*** "Oh yeah you so fuckin' crazy!"
* General Scottie. Also, "Men, we have reached the Bush! Urk!"
* The heroines forgetting their InTheNameOfTheMoon speech in "Trans-homers", instead opting for ''screaming''.
* "The Diet Syndrome". Just... "The Diet Syndrome".
** "Don't tell me you're on a... '''[[GratuitousEnglish DIETO]]'''?!" '''"[[http://www.youtube.com/watch?v=U4_6KIF4ZUs HHUUUUUUUUGGGGGHHHHH]]"'''
*** [[http://www.youtube.com/watch?v=qYwXvWDqOaE Panty playing peekaboo with Stocking's belt in the dub.]]
-->'''Panty:''' Uh oh~! Peekaboo! I saw it. There it is...there it is again. Hello! Still there. Fatty! Fatass! One more hip! Fattyfattyfattyfattyfatty...
-->'''Stocking:''' [[NoblewomansLaugh Ohhhhhhh]]-[[ActorAllusion hohoho]][[Manga/OuranHighSchoolHostClub hohoho~!]] Chuuuuuuuck, come heeeeeeere~! [takes Chuck to the elevator while ''twirling'' to beat the shit out of him] SPIT IT OUT RIGHT THERE OR I'LL GAG YOU WITH A TOOTHBRUSH AND EAT THE CHUNKS LEFT OVER FROM EVERY DONUT HOLE YOU'VE STOLEN FROM ME IN THE PAST 48 HOURS! [Chuck pukes] TRY AGAIN!
** Panty making good on her promise to laugh if Stocking got fat from all the cake she was eating.
* ''Every'' time [[TheChewToy Chuck]] gets the crap beaten out of him.
* Garterbelt [[spoiler: being killed by [[BigBad Corset]] (and later by [[EvilAllAlong Stoc]][[FaceHeelTurn king]]) in Episode 13, complete with the traditional model-exploding clip]]
-->[[spoiler: '''Garterbelt:''' [[BigOMG OHHH MY GOOOOOOOOOOD]] ]]
** ...only to [[spoiler: ''un-explode'' thanks to God, due to his mission being incomplete]].
---> [[spoiler: '''Garterbelt:''' GOOOOOOOD MYYY OOOOOOOH]]
* At Episode 13's climax, the girls [[spoiler:manage to put together some huge ultra weapon, do an extended TransformationSequence as Corset is {{Oh Crap}}ing in the background, and fire it... only to shoot a laser beam into Heaven. [[EpicFail They were holding it backwards]].]]
--> "[[OhCrap Oops."]]
** [[spoiler: The gun is shaped like a [[Anime/TengenToppaGurrenLagann Giga Drill]]. In other words... their drill just [[StealthPun pierced the heavens]].]]
* Brief's reaction to [[spoiler:Garterbelt coming back to life: he screams/gasps in a manner that sound more like a goofy laugh, which really sounds nothing like how he normally sounds]].
* The end of Episode 13. [[spoiler: Stocking ''kills Panty and Garterbelt'' (who unexplodes again), and walks away with Corset. Cue Garterbelt, Brief, Chuck and the Demon Sisters staring blankly for a good five seconds, with appropriately hilarious facial expressions.]]
** Which goes to show, Gainax might be the only studio to [[spoiler: troll their own characters.]]
* The [[spoiler: death of Sam]], simply because of how ridiculously over-the-top it is.
* From "1 Angry Ghost":
--> '''[[Creator/TomCruise Tom]] [[strike: Cruise]] [[NoCelebritiesWereHarmed Croos]]:''' [[GratuitousEnglish UNBERIVABOH]]!!!
** From the same episode, the monkey lawyer [[http://www.youtube.com/watch?v=V4Ye87P-EWw after he gets shocked and turns into]] a [[VisualNovel/PhoenixWrightAceAttorney Phoenix Wright]] {{Expy}}. [[https://www.youtube.com/watch?v=Es-UAZBD88o (Dub option)]]
* Panty beginning to do her transformation sequence, only to be interrupted for "making a mockery of this sacred courtroom". Panty simply asks [[DeadpanSnarker "If it's so sacred than why is there a strip pole?"]]
* The "Bitch Flash" part of the Sanitary Box special thing. [[http://www.youtube.com/watch?v=whU1oX3sOTk&t=7m32s Words cannot describe.]]
* In "...Of The Dead," when Panty and Stocking beat the hell out of a zombie cat with a pair of brightly colored dildos, while saying [[http://www.youtube.com/watch?v=8rrCvXrBQHo this little gem]].
* For all the flack it gets from purists/weeaboos, the dub version is actually pretty funny when you actually give it a chance. Creator/JamieMarchi and Creator/MonicaRial make both Panty and Stocking sound hilarious, and still fairly true to their original characterization.
* As good as the English dub is, there's one thing from the original Japanese it can never recreate: the GratuitousEnglish cursing with heavy accents. It adds a level of hilarity impossible to get otherwise. [[http://www.youtube.com/watch?v=taYpsqpPkdg Exhibit A]]
* Panty's reaction to [[EnsembleDarkhorse Scanty and Kneesocks']] TransformationSequence.
--> '''Panty''': [[HilariousInHindsight "Well fuck me in the keyhole."]]
* In Episode 2-B, "Sex and the Daten City", Panty and Stocking are searching for copies of Panty's porn flick to destroy them. Where are some of said copies? In the mouth of a camel in Egypt, in Antarctica and ''on a space station'' (the last for educational purposes).
** Hell, [[BigOMG the audience's reaction]] to Panty's pornographic tape is priceless. Cue the [[ScrewTheRulesIHaveMoney mass bribe]] to make them keep their mouth shut.
* The History of the Earth, according to Garterbelt. While the animated sequence is funny, Garterbelt being in for several famous paintings and photographs is the best part, especially because he was an African-American Ku Klux Klan member.