* At the end of the WarmUpBoss battle against Skelter Helter, Travis [[OffWithHisHead lops Skelter's head off]], the same way he killed his brother in the first game. Only this time, the head lands ''perfectly'' onto his torso. Travis and Sylvia (who just flew in mere seconds ago to confirm the kill) are stunned that he's still able to give a few more spiteful words before ripping his own head back off.
** "If you see your brother in hell, tell him he's ''still! A DOUCHE!''"
* "[[CallingYourOrgasms DOWNWARD FUCKING DOG!]]"
* Also, how the "NO MORE HEROES" sign breaks as you [[spoiler:do it with Sylvia]], it becomes "MORE ERO".
* Henry's super long phone message, in which he [[TheTapeKnewYouWouldSayThat has an argument with the present Travis]] about who is the older brother, and ending it with "Long message, eh?"
** "I took pictures of the kills. They'd make great wallpapers for your cell."
*** The pics are of Henry standing over mutilated remains flashing a goofy smile and a thumbs up.
* Travis reading Kimmy's letter, more the fact that he read past "my dream is to behead Travis the great" without drawing his weapon.
** Kimmy might have been the most hilarious boss ever. I personally spent a good twenty minutes running away from her just to watch her ridiculous run animation.
** Not to mention what happens [[GroinAttack when you lose a weapon clash to her.]]
** How about the throwaway line mention that there's an official ''student assassin'' competition league?
* During her save animation (a shower), Shinobu will mumble to herself, "What does {{Moe}} mean?" despite using it way more often than Travis.
* If you lose a weapon clash to Matt Helms, he'll knock Travis over and sit on him.
* One of [[spoiler:Pizza Batt Man's]] (less annoying) attacks is picking up Travis ("The fuck!?") and ''spinning him around on his finger like a wad of dough'' before throwing him into the ground.
* [[spoiler: Jasper's transformations]], as well as Travis and Henry's reaction to them.
-->'''Travis:''' [[spoiler: (after first transformation)]] You've gotta be shittin' me!
-->'''Henry:''' [[spoiler: (after the second)]] I can't be associated with that travesty. I mean, I've got standards, for fuck's sake!
* At the end of his duel with [[spoiler: Jasper]], Travis leaps off the side of the building to deliver the final blow, only to find he underestimated the distance and "swims" the rest of the way.
* "Everybody deals with grief differently, right? Some people fuck at funerals. I cut off heads."
* Henry's nightmare. Mimmy. That is all.
** "I KNOW YOU ARE TRYING TO TRICK ME!"
** "[[LampshadeHanging I bet you wanted to play as me more,]] [[MediumAwareness but this game's big enough as it is.]]"
* After fighting Chloe Walsh, the building starts to explode. Sylvia comes by in a UAA helicopter and tells Travis "hurry, you have to jump!" Travis leaps as the building explodes behind him, almost grabs Sylvia by the hand... and then Sylvia pulls her hand back, making Travis fall into the ocean.
-->'''Sylvia:''' I just remembered we are out of seats! Just swim back, okay?
* Henry waking up on Travis masturbating to Bizarre Jelly 5, and inviting him to watch.
* The fight with Charlie MacDonald. He's a football jock who invited Travis to his college field, has an army of identical cheerleaders and makes football-related puns. The fight against him? [[spoiler: A giant robot battle, of course!]]
-->'''Sylvia:''' [[spoiler: I'm sorry, but we will have to confiscate your robot.]]
-->'''Travis:''' [[spoiler: Like hell you will!]]
* [[https://www.youtube.com/watch?v=HYpk5SwBn54 This.]]
* Some of the side-mission guys (They're all identical) say some good stuff.
-->'''Buggin' Out Guy:''' ''(Before)'' Women love exterminators, much more than actors and pro athletes.
-->'''Buggin' Out Guy:''' ''(After)'' I was lying about the woman thing.

-->'''Pipes Guy:''' You sir are a GOD among plumbers! I'm putting your ass on speed-dial!

-->'''Scorpions Guy:''' ''(After failing)'' I hate you with all of my hate.