* The Thimble sketch. From beginning to end, it's a master class in OverlyLongGag.
** The joke's on the audience, who are clearly groaning by the third thimble knockdown because that thimble rack had to be reset after each time.
* David confesses that, while for years he's been playing a bald man on TV, he decides to finally come out as a bald man in real life. He then removes a bald cap to reveal his already bald head. [[DoesThisRemindYouOfAnything And he has to deal with his fellow cast mates not accepting him]].
* Anytime Bob yells. It's glorious.
* "I'm Fran and I'm a woman!"
* "Choo-Choo" the Hurky Jerky Dancer
* "Fuck yeah, man, [[{{Squick}} you should see all this]]"
* When Bob Odenkirk plays "a lady from the city" hired to write an anthem for a one-man country. Just him singing those lyrics.
* Mr Spencer? Killer Be Killed? Dingle? Prof. Murder? Pickles? Mr. Barnett?
** "I'm gonna fuck you like a bitch Dingle"
* "Mundees Mustmayostardayonnaise."
* [[DumbBlonde "I totally believe]] [[MakesJustAsMuchSenseInContext in dragons now!"]]
* The ending to "Oh, You Men" is one of the greatest [[BrickJoke Brick Jokes]] ever.
* Lots of the commentary tracks are this. Especially when you realize half of everything they say is bullshit.[[note]]They do reveal some facts, but make up a lot of stuff as jokes[[/note]] Also, several of the commentary tracks feature one of the actors in character (sometimes as a character from the show, sometimes exclusive to the track).
* "Horny Slut Hotline, this is Peppermint Speaking!"
-->'''(His boss, on the line)''': Hello? ''Petersen?'' Is that you?!
* David yelling "This is Bullshit" and FlippingTheBird at the camera. Cross doesn't actually think it's funny, but "mildly amusing."
** The whole "You're fired!" sketch in general, especially David's [[BigWhat Big "What the Fuck!?"]].
* The Drugachussettes skit, parodying Creator/SidAndMartyKrofftProductions.
-->'''Sam:''' Hello. I'm Sam Craffft, and this here's my brother, Criminey.
-->'''Criminey:''' You remember us!
-->'''Sam:''' Our menagerie of puppety oddballs were all over your sets when you were a kid.
-->'''Criminey:''' Yeah man, people are always askin' us, "Hey man, where'd you get all those crazy ideas from?" Well, this was the late 60s--
-->'''Sam:''' It was the early 70s.
-->'''Criminey:''' Yeah man, and y'know, we didn't have short attention spans like you kids today, man. I mean back then, we could just sit... and stare at a candle for like... ''three hours'', man... and our minds would be ''totally blown''! Eatin' an orange? That was like takin' a trip to a citrus mountain.
-->'''Sam:''' Riiiiiight.
* "Dalai Lama / Camp Monk Academy", an extended sketch about a normal guy who becomes the Dalai Lama and his stoner metalhead buddy, which abruptly turns into a bizarre satire of summer camp movies involving child murder, a freestyle rap-off, and [[Film/PrettyInPink Ducky]].
* This particular moment from the "Deprived Youth" sketch:
-->'''Sir Isaac Newton:''' My father touched my butthole: this made me thirst for ''knowledge''. ''*notices someone off screen*'' Hey!
* The [[https://www.youtube.com/watch?v=GjILPvearKs sketch]] the pair did for Comic Relief 1998, in which Bob is tricked into getting fully nude ''in front of the entire audience'' at Radio City Music Hall.
* "[[https://www.youtube.com/watch?v=GTJ3LIA5LmA On July 4th of this year,]] America will [[DetonationMoon blow up the Moon]]."