* Two callbacks to [[VideoGame/MetalGearSolid MGS1]]:
** First, [[spoiler:when re-infiltrating Shadow Moses Island, Otacon calls Snake to tell him to put in Disc 2, before realizing they were on a [=BluRay=] disc, which is dual-layered. Snake tolerates it for all of 3 seconds before telling Otacon to get a grip.]]
** And during the final act, [[spoiler:after defeating Screaming Mantis, the ghost of Psycho Mantis shows up to pull his old tricks. But after finding out the system doesn't have a memory card and (if you aren't using the Dual Shock 3) the controller doesn't vibrate, he freaks out and is banished by The Sorrow. Also, the flashbacks that normally call back to images of past games are of a [=PS1=].]]
** [[spoiler: His gleeful response to causing the [=DS3=] controller to vibrate is even funnier.]]
** A third callback and funny moment is when you call Campbell for help when dealing with Screaming Beauty. Campbell tells Snake to attack the bust, but as Snake puts it, "There's no bust!"
* Metal Gear Solid 4: Snake's Quest for a Good Smoke:
** The mission briefing where Sunny just walks up, snatches the cigarette out of Snake's hand, and yells "This is a no smoking flight!". His Psyche meter drains a quarter, like "I just got my ass handed to me by a little girl. I am not a man."
*** From that same mission briefing, Sunny [[FunnyBackgroundEvent snatching the cigarette out of Snake's mouth]], and Snake taking it back.
** At the end of the Act 5 mission briefing, Snake raises his hand and wiggles his fingers like an eager student. It's hilarious. And then when Mei Ling calls on him, he asks, "Anybody got a smoke?" Meryl groans, and his Psyche Meter drains.
* Otacon's responses for killing the resistance members in Act 3:
-->''(First kill)'': Snake, what are you doing?! We need them to lead us to Big Mama's hideout!\\
''(Second kill)'': Snake, do not kill them! Their our only means of finding Big Mama!\\
''(Third kill)'': Knock it off Snake! Are you trying to abort this mission?!\\
''(Fourth kill)'': JUSTWHATDIDYOU ''SNAKE!''
* Sneaking up on a soldier and holding them up at gunpoint, patting them down, followed by [[GroinAttack a very special knockout move.]] Their high pitched squeal of pain just makes it better.
** Even funnier when done on a woman.
* Although the Camera is on the Nomad each act briefing for you to retrieve in a playthrough, getting it in Act 4 has a small album of photos of Sunny and [[spoiler: Naomi]] included. .. including [[http://i286.photobucket.com/albums/ll95/DarkPhoenix-/failth0.png a picture of Sunny learning how to flip eggs the hard way.]]
* All of Akiba's scenes before he took a level in badass.
** His introduction, where he [[ToiletHumor gets caught relieving himself]] (or attempting to) [[http://www.youtube.com/watch?v=lR7LNAsK91k inside a barrel]], has to be seen to be believed. As Snake's behind a wall from an enemy {{Mook}}, the Mook walks by the barrel and then the most ''hilarious'' farts, gurgles and groans echo out of it. The Mook uncovers poor Johnny with his pants down in a crouch, and Johnny can only look embarrassed as he lets one rip a final time before legging it as he tugs his pants up. The Mook pursues him, but he doesn't shoot him possibly out of sheer bewilderment. Snake [[{{Squick}} later decides to use the barrel as a hiding spot.]]
** Nah, he's still hilarious even after he takes off his mask. Case in point, he incompetently launches himself onto Arsenal Gear, a huge contrast to the otherwise serious mood of the scene.
** Also, him trying to grab not only Mei Ling's ass, but Meryl's too.
* Vamp muttering [[HealingFactor "I'll be taking a nap."]] and falling over after getting shot in the head.
* There's a Codec conversation with Roy and Rose about how Rose is a LethalChef. She also states that she likes American military rations, after Roy had said how an international meet he went to found America has the crappiest tasting rations in the world.
-->'''Roy:''' ''(dryly)'' America for the win.
** Also during that conversation;
--->'''Roy:''' I want you to hear this too.\\
'''Rosemary:''' I've heard this a hundred times--\\
'''Roy:''' You'll survive.
* In what is otherwise a fairly serious scene full of carnage, Ocelot is doing [[http://31.media.tumblr.com/tumblr_mamy9hxML71rb8fpgo1_500.gif this]].
** While making machine gun noises from his mouth like a five-year-old, one might add.
* After the epic fight between Metal Gears RAY and REX, Liquid Ocelot jumps out of RAY and... runs away, [[http://www.youtube.com/watch?v=W0_QlA-0jw8 doing the most childish gestures and laughs]] as Snake limps after him.
* [[http://www.youtube.com/watch?v=BdSZHEH3uiw "Fox....DIE!"]] [[spoiler: "Think again!"]] Another hilarious callback to [[VideoGame/MetalGearSolid MGS1]].
* Should players last long enough against the human forms of the B&B Corps, the mission travels to a white void where not only can you get them to pose for your camera, but playing a particular J-Pop song on Snake's iPod causes them to begin dancing. Looking at the pause menu shows a security cam feed of Sunny doing the dance as well.
* "[[http://www.youtube.com/watch?v=s7E_TwUAdn4 You're... THE SHIT!]]" Elaboration: Call Otacon in the Canyon area where Snake fought Raven in an M1 Tank. Snake bluntly explains how he beat the Tank with a bunch of grenades leading to an awe-inspired Otacon to make the aforementioned statement.
** A comment on that YouTube link sums this page up nicely - "Solid Snake is the shit, Johnny Sasaki needs to shit, the Patriots are full of shit, and Ocelot is doing stuff justs for shits-n-giggles."
** In retrospect, Otacon might have studied ''too little'' considering what Big Boss did in ''Snake Eater'', ''Peace Walker'' AND ''Phantom Pain''. Or even about how Snake [[VideoGame/MetalGear1 beat a tank back in Outer Heaven by tricking it into driving over a bunch of mines.]]
* Just before you first encounter the Scarabs, right in the middle of a cutscene, holding down L1 lets you see a bunch of Scarabs pretending to be one guy in a trench coat and fedora. The sheer WTF factor of it is incredible. Best of all, they don't walk--they ''strut''.
* During the final battle [[spoiler: between Snake and Ocelot, if you allow Ocelot to choke hold Snake and do nothing, [[http://www.youtube.com/watch?v=15a2miaQwNQ Ocelot will kiss Snake on the cheek!]]]] Bonus points for the Achievement Trophy for unlocking this is ''You're pretty good''.
* Calling up Otacon in Act 1 while hiding in a trash bin gets a conversation where Snake discusses the insects crawling about him (On his face no less) with all the casual indifference of a guy talking about the weather ("I'd hide inside of a toilet if it would help me stay out of sight.") while Otacon is understandably grossed out and demands that Snake wash the smell off of him before coming back.
** Even funnier, it's implied that Snake is doing this ''specifically'' [[OddFriendship to mess with Otacon]]
* Early in Act 1, Snake can take advantage of his camo to disguise himself as a statue....grabbing another statue's genitals. Hide with the statue 3 times and Snake snaps the genitals off accidentally.
* While meant to indicate that Snake isn't at his best, his Psyche meter dropping by a quarter in cutscenes quickly becomes a RunningGag, and reaches its apex in the TheStinger when it falls as he's faced with the prospect of eating the eggs cooked by Sunny.
* HilariousInHindsight: In 2006, squirrelking (of FanFic/HalfLifeFullLifeConsequences fame) wrote a TrollFic called "[[https://www.fanfiction.net/s/2946083/1/Metal-Gear-Solid-Fight-of-Metal-Gears Fight of Metal Gears]]. Two years later, ''Metal Gear Solid 4'' comes out, which features a literal fight of Metal Gears.
* Just the fact that [[https://www.youtube.com/watch?v=4dbcsTEeBZs this]] is on Snake's [=iPod=], and you can [[SoundtrackDissonance listen to it while potentially in the middle of a massive firefight]].
* Among the in-game TV spots is a straight-laced nature documentary about [[EverythingsSquishierWithCephalopods octopi]] and their [[ChameleonCamouflage camouflage and mimicry capabilities]]. What sells it is the [[{{Crawl}} news ticker]] [[FreezeFrameBonus that floats around the screen]], with darkly funny headlines like "Voter turnout lower than expected in Mexico City biannual warlord elections" and "14 mauled by genetically modified 'aggressive cow' hybrid in Ulaanbataar Friday; [[SkewedPriorities city officials express disappointment in technology]], promise fewer glitches in Bovex 400 model scheduled for release this January".
** [[FridgeHorror If the ticker is any indication, even civilians well outside the war zones are endangered by the]] [[ForeverWar war economy]].
* During a massive firefight on [[spoiler:Outer Haven]], Akiba confesses [[spoiler:his love to Meryl but is rejected... because ''she'' wanted to do the proposing]].