* The first ending theme. [[https://www.youtube.com/watch?v=6OCk4YVxDTM Just watch it.]] (Lyrics in description)
* Pantheon loses his shield fighting Caitlyn. He complains about it to Katarina and Kennen.
-->'''Pantheon''': [My shield] got shot by a girl!
-->'''Kat''': What kind of girl?
-->''*Katarina and [[ItMakesSenseInContext Kennen]] both look down at their [[ACupAngst chests disdainfully]]*''
-->'''Kat''' and '''Kennen''': WE WILL GET HER FOR YOU!
* Tryndamere & co. repeatedly and ineffectively charges at Sona, but when [[TilMurderDoUsPart Ashe]] shows up he immediately [[ScrewThisImOuttaHere flees in terror]] with the other two hot on his heels. And Ashe still manages to shoot an Enchanted Crystal Arrow to Xin Zhao's ass.
* Tryndamere (to Garen): Like a true champion, you must SPIN TO WIN!
* Garen constantly hiding in bushes. Even when Ashe uses Hawkshot on them and shoots him full of arrows.
* Tryndamere dodging Ashe's enchanted crystal arrow just in time for it to hit Katarina in the face.
* Master Yi found a ([[BilingualBonus Chinese]]) character tier list that puts all the heroes in the "[[EpicFail tragedy among men]]" category.
* Ahri laments that nobody loves her except for her beauty... then Wukong comes along. She tries to seduce him out of habit.
-->'''Wukong''': Not only are you not pretty, you're not even in my league! *shows picture of female monkey*
* Gangplank is made of this:
** Gangplank kicks Annie. Ahri's response is a FacePalm and "Oh god, you pissed off Annie..."
--->'''Gangplank''': This is the Institute of War, where even a little girl can kick your ass!
** Leona blinding minions in a flash:
--->'''Gangplank''': Then I can rest assured. ''*BoomHeadshot*''
** Gangplank deciding to extend the monkey king's staff to gigantic size... [[EpicFail on his ship... in the middle of the ocean.]]
** This moment from Season 2's climax:
--->'''Ahri''': Do you think I'm beautiful?
--->'''Gangplank''': Of course not! You're not an orange!
* Ezreal repeatedly declaring that he will save the world in Season 2, but being utterly ineffective when it comes to actual fighting. [[spoiler:In the epilogue, he still claims to have saved the world.]]
* Season 3: Xin Zhao's ''very'' direct proposal (second one at least) for Lux:
-->''"Lux, sweetie-- You wanna f**k with me, huh?"'' *slap*
* English dub exclusive: They turned Jax into Creator/MrT. It has to be seen to be believed.
* The trailer of the English Dub Season 2: Seeing that the EliteMook just look like a mass-produced mini Mordekaiser, cue a mass [[MemeticMutation Mordekaiser es #1, HUEHUEHUEHUEHUEHUEHUEHUE]]