* After Karin offers to make Kenta lunch every day in exchange for helping her during the daylight hours, he decides to seal the deal with a handshake. Karin [[OhCrap stares in horror]] at their hands as the screen starts to pulse with a heartbeat; she knows full well [[{{Nosebleed}} what's about to happen.]]
* After finding out that Yuriya is a [[HalfHumanHybrid half vampire]], Kenta says that it probably wont be a problem for him and Karin. 5 seconds later they both realize the implications of what he just said.
* [[GratuitousEnglish OH MY]] [[BigOMG GOD!]] [[BigNo NNNNOOOOOOOOOOOOOOOOOOOO!!!]] [[https://www.youtube.com/watch?v=6dJ-C-1Hrw0 Never change, Winner.]]
* [[ChickMagnet Ren's]] reaction to Bridget's revelation [[spoiler: that she's pregnant with their kid]] at the end of the manga.
* Between Anju's constant OffscreenTeleportation and her cooking with [[LethalChef Carrera]], episode 14 of the anime was just hilarious.
-->'''Maki:''' How nice. [[ThreatBackfire Your little sister's actually worried about me walking home alone.]]
-->'''Karin:''' [[SureLetsGoWithThat Of course that's what she meant.]]
* [[VampireHunter Winner]]'s antics while doing his job. And getting arrested by the same cop multiple times for disturbing the peace.
* The entirety of the introduction with Elda Marker, including Ren running away in fear at the sight of her.
* Karin and Kenta's first kiss turns into this when they hold it for so long [[MoodWhiplash they forget to breathe]].
* Karin brings Ren a gift of ''lubricant'' during his stay at an all-boys school, thanks to a [[{{Yaoi}} manga]] she read on the subject. The fact that Karin can't be older than 12 at that point is funny in and of itself, but Ren's [[LaughingMad reaction]] is gold as well. Say what you will about the English dub, but Jerry Szombathy's utterly gobsmacked 'HWHA-?!?' is hilarious.
* Ren's smooth, suave image is blown out the window by [[OhCrap his reaction]] to his one true fear: his Grandmother.