* The way that the word "these" is pronounced in the phrase, "Let's get to bashing butts as well as DEEZ nuts!" is a pretty popular gag.
* The bard that launches into a hammy rant about how much he misses Imperial soaps and...MOIST TOWELETTES. [[FanDisservice He provides a demonstration as well.]]
* You have to admire this particular exchange for its multifaceted humor and nested punchlines.
-->'''A:''' [[YourMom May your mother's tongue be rough in my throat! May her dry vag loosen upon my lips.]]
-->'''B:''' [[SubvertedTrope Brother]], I'm not sure she would like that. Mother is far too proud a woman for that.
-->'''A:''' I suppose you're right.
-->'''B:''' Why don't you try sis?
-->'''A:''' [[HypocriticalHumor Brother, that's disgusting! That's our sister!]] And you know she tastes like aunt Agna.
* Upon hearing there is a [[RougeAnglesOfSatin sechs]] tape of Liara and Ashley, Shepard does the most impressive [[DoubleTake double take]] ever by spinning his head 360 degrees!
* The actual Mark Meer [[http://www.youtube.com/watch?v=ZYT66ALUUss speaking one of the lines]].