* The RunningGag that, before the plot starts rolling, every day preceding the plot is marked by the day of the week [[PlayedForHorror in bloody letters]].
* The conversation Millie has with a random druggie after waking up as the Butcher:
-->'''Druggie:''' ...You got any jelly beans?\\
'''Millie:''' ''(confused)'' I'm sorry, do I have jelly beans?\\
'''Druggie:''' You know... ice cubes, crunch-a-munch, some drugs, man!\\
'''Millie:''' Oh my God... no, I don't have any drugs, I'm not a drug person. Can- may I ask you a question?\\
'''Druggie:''' Yeah?\\
'''Millie:''' Yeah, just... you know, I'm just curious... what do I look like? Like when you're seeing me? Right now? Do I look like a- um... y'know, do I look like a ''girl''?\\
'''Druggie:''' A ''girl''?!\\
'''Millie:''' Yeah. Y'know, like 5'5", very petite, blonde?\\
'''Druggie:''' ''(laughs)'' You're fuckin' lying, man! You've got drugs, you're high right now!\\
'''Millie:''' Oh no, no. I don't have the drugs--\\
'''Druggie:''' C'mon, man! Gimme some of that good stuff. I wanna feel like a teenage girl. I wanna feel like a girl!\\
''(Millie panics and runs off)''\\
'''Druggie:''' Come back! I'LL SUCK YOUR DICK! ''All of it!''
* The ENTIRE chase sequence with Nyla and Josh running from Millie in the Butcher's body. Highlights include:
** As Millie keeps trying to explain things, Josh tries to fight back... by throwing a tray of frozen tater tots at her. [[NoSell It goes about as well as you'd expect.]]
--->'''Millie:''' ''[[YouHaveGotToBeKiddingMe Really?]]''
** Right before that, probably the most iconic line of the movie:
--->'''Josh:''' You're {{black|Dude Dies First}}, I'm {{gay|Guy Dies First}}, we are ''so'' dead!
** After all that, Millie does her mascot routine to prove her identity. Just the sight of Vince Vaughn shaking himself like a schoolgirl is hysterical.
* The at-first heartwarming moment of Millie (in the Butcher's body) opening up to her mother in a clothing store becomes hilarious once the mom eventually finds a connection with this considerate man and his soothing voice, asking about the possibility of them going out. Millie is understandably {{squick}}ed out.
* Millie's amusement once she has to pee in the Butcher's body ("This guy's bladder doesn't end!"). Along with her scaring off a boy who enters the bathroom.
* Both Millie and the Spanish teacher calling out Josh for being in said class, but not understanding the language.
* One of the jocks, Brett, pulls a move on The Butcher (in Millie's body) by groping his butt. His response is an excellent line to say to any sexual harasser:
-->'''The Butcher:''' ''(seductive whispering)'' Your touch makes this pussy drier than sandpaper, you fucking ''monkey''. I can't wait to kill you.\\
'''Brett:''' [[ComicallyMissingThePoint She fucking wants me.]]
* Booker kissing Millie... [[FanDisservice as the Butcher]].
-->'''Millie:''' Technically, you'd be kissing a mass murderer with yellow teeth.\\
'''Booker:''' [[SugarWiki/HeartwarmingMoments ...You're still Millie to me.]]\\
''(Both kiss, before Millie pushes his face away)''\\
'''Millie:''' ...Maybe we should wait for when my hand's not bigger than your whole face.