!As a Moments page, all spoilers are unmarked.

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* Killian says that taking down Gizmo in Junktown should be pretty funny, just to watch the FatBastard try to run away. Sure enough, Gizmo remains planted at his desk.
** On another note; if you didn't get rid of Gizmo in Junktown, the ending might actually make you belly-laugh. "He profits the most, and continues to increase the size of his casino, and the scope of his power, until he chokes to death while eating some iguana-on-a-stick."
* Upon meeting the Brotherhood of Steel for the first time at the Lost Hills.
-->'''Darrel''': The Brotherhood is a collective of men and women who have dedicated their lives to the preservation of technology.\\
'''Vault Dweller''': I've heard that you people sacrifice puppies.
* When you visit the Cathedral, an incredibly dark and creepy church, you're either infiltrating a crazy cult or trying to defeat the Master. This is why hitting on Laura feels a bit out of place.
-->'''Laura''': Hello, my brother/sister. May I be of service this glorious day?\\
'''Vault Dweller''': What kind of "services" do you offer?\\
'''Laura''': ([[https://vignette.wikia.nocookie.net/fallout/images/0/0e/FO01_NPC_Laura_B.png/revision/latest?cb=20101225090315 Angry Face]])
* When you bring up [[SinisterMinister Morpheus]] to the [[TheDragon Lieutenant]].
--> '''Lieutenant''': Morpheus. It's quite amusing. He think he's more than a pawn the Master chose to lead the [[ScamReligion Children of the Cathedral nonsense]]. Oh well, he too will be dipped in the virus and he'll probably die a horrible death. I hope.
* Before entering Mariposa, you could use the radio you looted from one of the mutants to convince them to leave their posts, no matter how bad your lies are.
--> '''Vault Dweller''': They don't suspect a thing.
* If your character is a female and you ask Tandi out after saving her from the Khans, she'll stutter and say she's into guys and quickly says she has work to do.
* One of the random encounters isn't with a creature at all: it's a footprint. A footprint about thirty-five feet long with a pancaked corpse in the middle. What makes it funny is that the corpse is carrying a ''cloaking device.'' [[FridgeLogic If only he hadn't been near-invisible when some mutant]] RentAZilla [[FridgeLogic happened along!]]
* Playing through the game with 3 INT or less, meaning you're so stupid that you can't even form coherent sentences. [[https://www.youtube.com/watch?v=i54tXdPUScE The Overseer trying to get you to take out the super mutants is especially hilarious.]]
** [[https://www.youtube.com/watch?v=IuBjeLiWhek The Overseer also has a difficult time convincing a low intelligence character to hand over the replacement water chip.]]
** If you try to talk to the Crimson Caravan in the Hub with low intelligence, they'll tell you that they don't hire drug addicts. You can choose to end the conversation with "I'm no drug add....I mean...Arg!"
** [[NightmareFuel As terrifying as the part where you confront]] [[BigBad the Master]] [[NightmareFuel is]], [[https://www.youtube.com/watch?v=jYttpuWClMM if you talk to him with low INT, your only dialogue option is "Ugh. Lee."]]
---> '''The Master''': I doubt even the FEV will help you. Why am I talking? It's unlikely you even understand...
** On the same note on interacting with the Master
--->'''The Master''': I don't have to prove anything to you! Prove.\\
'''Vault Dweller''': [[InvokedTrope Your ego demands you ]][[EvilGloating tell me.]] [[LampshadeHanging All villains have this strange urge to explain everything.]]
** At Necropolis, having low intelligence actually allows you to easily talk your way past Harry the supermutant. Well, "talk" is being generous. The exchange consists of both saying things like "What?" "Huh?" at each other a few times, and then the dialogue just ends without anyone turning hostile.
** Some quest givers and other [=NPC=]s will refuse to talk to an idiot like you or get offended because they think you're goofing off, not realizing how stupid you really are, such as [[DisproportionateRetribution Jain attacking the Vault Dweller just because she was called "mom"]].
--->'''Gizmo:''' Get your butt in here and sit down. We got some business to discuss.\\
'''Vault Dweller:''' Blehh.\\
'''Gizmo:''' [[GetOut Get outta here, ya' idiot!]]
* In the first half of the game, the Pip-Boy will have a helpful Post-It reminder stuck to it that says "Things to do!" before mentioning you have to find the water chip in X day. Just the fact that the existential threat to your Vault is written down on the same kind of paper where one would write "go get milk from the grocery store" is pure BlackComedy.
* Behind the scenes example: One of the [[https://fallout.fandom.com/wiki/Morpheus#Gallery concept sketches]] for [[SinisterMinister Morpheus]] has runes embroidered on the edge of his hood... runes of pre-War wisdom such as "Milk: it does a body good" and "[[Film/AChristmasStory be sure to drink your Ovaltine]]".
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