* For starters, Edna's many, many responses when using items with, well, just about everything and everyone in the asylum, whether it's required for a puzzle or not. Harvey, Comic Book, and Police Badge are just the tip of the iceberg.
* When she encounters an inmate in a bee suit she asks him why. He gives off a variety of complex reasons. Until Edna says...
--> '''Edna''': Admit it, you lost a wager.
--> '''Beeman''': I lost a wager.
* When Edna tastes the [[GargleBlaster Stinkydrink]] she starts sputter causing Harvey to worry, until she finally responds:
--> '''Edna''': The natives have surrounded the fort, Colonel.
** [[LethalChef Trying to mix earwax and the aforementioned Stinkydrink]] causes Edna to whimper in fear, apparently that idea is a MoralEventHorizon.
* After finally getting the Master Key and accessing the backyard, Edna can look into a couple of trash cans right outside the door. [[spoiler:Both are filled completely with nothing but Master Keys.]]