* Ethan's CaptainObvious tone of voice when Peter asks him why his father's ashes are in a coffee can.
-->'''Ethan''': Because he's ''dead,'' Peter.
* "I puked on the wound!"
* The masturbating ''dog''.
* Everything about Peter’s encounter with the insolent TSA agent. When Peter calls him “inappropriate”, the agent is deeply offended as if that was the worst insult he’s ever received.
-->'''TSA Agent''': I been called a lot of things, but inappropriate? That’s some fucked up shit, yo.
* The epic ButtMonkey status that Peter has gained by the end of the film.
* Ethan panicking after [[spoiler: accidentally shooting Peter.]]
* Ethan rescuing Peter.
** During the rescue, the Mexican cops are yelling "Pull over!" in English and Ethan responds, in Spanish, that he doesn't speak English.
* Ethan threatening the handi-capable clerk with his ''hairbrush.''
* "You call me Peter, or Mr. Highman. I'll call you Mr. Chase... unless that was a fake [=ID=] too."
* The contact high and its results.
* Peter, who's been avoiding the possibility that his expectant wife is [[ChocolateBaby pregnant with the lovechild of his]] black friend, bursting into a delivery room he thinks she's in and the first thing he sees is... a newborn black baby. Cut to an understandably bewildered black ''family'' who quickly kick him out and a huge look of relief on Peter's face.
* Peter sucker-punching the obnoxious little son of the drug dealer. It's so wrong, but you will laugh so hard it hurts. And don't forget the fact that when the drug dealer returns, Peter and the boy act like nothing happened. Capped with Peter donning his sunglasses and pointing at the little boy as if to say, "Know your role, punk."
* After falling asleep at the wheel, Ethan send the rental car flying off a bridge, completing a barrel roll and almost completely destroying the vehicle, not to mention almost killing the two of them. After a brief moment in which Peter struggles to determine how injured he is and how lucky he is to be alive (during which he starts to cry), Ethan reaches over to the glovebox, pulls out the rental agreement, carefully reads it, and announces, "I have coverage."
** The scene can read entirely differently, if you hear Peter's sob as instead Robert Downey Jr. ''laughing'' immediately after Zach Galifianakis says "I have coverage". The situation is just ''so '''absurd''''' that even RDJ couldn't keep a straight face!
* The entirety of Peter's rant outside the hospital after Ethan almost gets them both killed in a car crash. Pick any line and I assure you it's gold.
** Special mention also goes to the scene afterwards where Peter's actual friend convinces him to calm down and make things right with Ethan.
-->'''Peter''': Alright, I've calmed down a little bit.
-->'''Ethan''': Are you ready to apologize?
-->'''Peter''': ''(enraged)'' What?! '''FUCK YOU!''' ''(turns to his friend)'' Let's go!
** Also, when Peter gives Ethan three warnings if he screws up again: He's going to flip out on Ethan the next time asks him a question, he's going to disembowel Ethan the next time he falls asleep, [[ArsonMurderAndJaywalking and Ethan shouldn't eat waffles if he's allergic to waffles]].
-->'''Peter''': If you're allergic to waffles, don't eat waffles.
-->'''Ethan''': [[NeverMyFault Then don't take me to a Waffle House!]]
-->'''Peter''': Shut up!
* And then there's the classic, "If you hand me that dog, I will ''rip it in half.''"