* Marian getting cold-clocked being the first scene of the game, and Billy's slightly exasperated "Marian! Aw, man; not this again."
** What really makes that scene is the freeze frame right on the moment of impact and the funky mission bumper music playing.
** Even funnier, If you decide to enable damage numbers, the gut punch that Marian gets at the beginning of almost every Double Dragon game is [[MegatonPunch 999 damage!]]
* Skullmageddon's [[WesternAnimation/HeManAndTheMastersOfTheUniverse1983 80's Skeletor]] voice.
--> '''Skullmageddon''': Damn I'm [[{{Pun}} humerous]]!
* Williams' lines.
--> "There's more where I came from!"\\
"I'll never die!" (As he's dying)\\
(Coming at you with a cartwheel kick) "Gymnastics!"
** Whenever you knock a Williams who is looking down a bottomless pit into said bottomless pit.
---> "[[TemptingFate I wonder what's down there...]]"
* In Bro-Op, you can revive the other player by standing near their downed body and mashing the button. The graphic they use for this? A pencil going into the spokes of a mixtape and frantically winding it back onto the spools.
* Skullmageddon's BadBoss tendencies, especially when you break his TV's.
-->"This is coming out of Williams' salary! ALL OF THEM!\\
"THAT'S A PLASMA SCREEN! That's expensive!"\\
"Williams, I'm docking your pay for this!"\\
"WILL YOU STOP destroying my things?!"
* While in Skullmageddon's rocket-dojo, Billy and Jimmy end up outside. How do they survive? By holding their breath of course! But not before making a [[BatmanCanBreatheInSpace one-liner about there being no air]] then sucking in air, WHILE THEY'RE IN SPACE.
* The title of the Mission 6 boss: The Expensive Experiment [[ExactlyWhatItSaysOnTheTin Giant Tank]]. Then you blow it up.
* Mission 7's intro:
-->"What is this? Some kind of lab?"\\
'''Mission 7: Some Kind of Lab''' *funky music*
* In the countryside, when you destroy the monuments, Billy shouts "Sacrilegious!" in the same excited way he'd shout "Awesome!"
* When you get close to the weak point of the Giant Tank, Skullmageddon asks [[LampshadeHanging why they even]] [[InventionalWisdom installed one]].
-->"IDIOTS! Don't let them near the glowing red weak point! (beat) Why does it even HAVE a weak point??? Couldn't you have put a cover on it??!?"
* After defeating the Tank, rather than the standard "Billy and Jimmy move forward to Skullmageddon's palace", the tank knocks down the Killacopter, causing it to crash into the tank. This creates a massive explosion that knocks Billy and Jimmy out. Skullmageddon, clearly a little confused, quickly tells his mooks to capture the brothers Lee.
* The [[BreakingTheFourthWall fourth wall-breaking]] ending credits song ("Dared to Dream") to ''Double Dragon Neon'', wherein Skullmageddon sings about being defeated by the Lee brothers. The funniest part comes at the 1-minute mark, when he sings "Here's a medal for your victory" and the [[Platform/{{Xbox 360}} Achievement Unlocked]]/[[Platform/{{PlayStation 3}} Trophy Unlocked]] dialogue pops up.
** He's got plenty of other moments as well:
*** Right after you press start for the first time in the 360 version, you get an achievement called Skullmageddon's Curse that's worth 1 GS, with the description "Nyah ha ha! Now finish what you have started!": a lot of people like to keep their GS divisible by 5 and the score can only be evened out by getting the achievement described above, which involves defeating him.
*** Right before you encounter him for the first time, you can find a hair pick from a barrel: if you throw it at him, it'll pin down his hat on his head, making it so that he can't use any attacks that involve removing it until he takes it off while complaining [[WeaksauceWeakness how he could be done in by such a mundane item]].
*** When trying to kill the Lee brothers with a helicopter, he's heard saying "''Of course'' helicopters can fly upside-down; don't be ridiculous. SHRED THEM!" and then proceeds to [[HelicopterBlender do just that.]]
*** If you pause the game while fighting him, he comments on it in a variety of ways:
---->"Oh fine, just pause the game!"\\
"I was just about to swing my sword!"\\
"I'm [[FlashOfPain flashing orange]] so quickly! Quick, just hit me a few more times!"\\
"When I'm about to swing my sword, just punch me and I'll stop! I'll save you a trip to the Internet!"
* Skullmageddon's summation of Billy and Jimmy's tirade to rescue Marian.
--> '''Skullmageddon''': Nyaaaaaaaa--YOU! You've taken my pride, you scrapped my Rocket-Dojo, laid waste to my laborotory, broke my televisions, and [[WhatMeasureIsAMook murdered countless Williamses]]! [[EvilIsPetty All I wanted was a date]]! This. Ends! NOW!
* The "Forbidden Moves" you can perform, which involve one bro crouching behind an enemy and the other pushing them over him.
* The Bros have some great lines.
-->(Knifing an enemy) "''Knife'' to meet you!"\\
(Hitting with a baseball bat) "Hole in one!"\\
(Hitting an enemy with a pistol) "I just hocked a ''luger''!"\\
"Better hold our breath. This is a hard vacuum!" (And they proceed to [[AchievementsInIgnorance do just that]])
* Mecha Biker also has some good lines.
-->(at the start of the battle) I feel ''crazy''!\\
(after killing the Bros) Hey, buddy, I do what I want!\\
(after having his bike destroyed) Being on-foot sucks!
* [[https://www.youtube.com/watch?v=njJAxeqTIUk Training Wheels]] is easily one of the funniest mixtapes.
-->"Dad took off my training wheels!\\
Boy oh boy, how great it feels!\\
In no time, I'm cruisin' around!\\
Immediately fell and [[AmusingInjuries smashed my teeth out!]]\\
[[CrossesTheLineTwice Fractured my jaw!]]"
** The mixtapes on the whole. Many of them are pitch-perfect parodies of '80s hits and bands, to the point of qualifying on that alone, but by far, the standout is "Weapons Up," a verbose, [[GoshDangItToHeck T-rated]] pastiche of [[Music/{{NWA}} "Fuck The Police"]] with Kaufman himself on vocals.
-->I dislike law enforcement with a vengeance!\\
They're just bullies with the worst of intentions!\\
Just the thought gets me and my friends so mad,\\
Gonna find a cop and kick him in the gonads!
* In ''VideoGame/CastlevaniaRondoOfBlood'', the Key occuped your subweapon slot until you found the correspondent lock and had very little range in spite of somehow hitting four times as hard as the whip. Attempting to Item Crash it still worked as a dodge but would result in Richter looking confused. ''Double Dragon Neon'' has its own Key as a ShoutOut to that, but this one really is worthless as a weapon: not only it does little damage but the Bros have a several seconds long ''uninterruptible'' animation where they push the key, attempt to unlock thin air and then gesture with spread arms in complete confusion.
* Per WordOfGod when the game was run at [[WebVideo/GamesDoneQuick SGDQ 2013]], "We played it completely straight up until that point," with "That point" being Skullmageddon's intro.

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