* With sincere desperation, on the verge of tears, Kitty realizes [[https://www.youtube.com/watch?v=_SbgEYBG-Y8 not everyone is as invested]] in the six year olds' dance troupe as she.
* "He told me to [[ExpospeakGag forcibly insert the lifeline exercise card]] [[AssShove into my anus!]]"
** The ReactionShot directly following this line. Mr. Darko unsuccessfully hides a snort of laughter, Rose just stares, and in the very back, Donnie is smirking.
* 'You can go suck a fuck!' 'Oh, please tell me, Elizabeth, how exactly does one suck a fuck?' Made even better by the fact that Elizabeth looks angry for a split second, then [[ActuallyPrettyFunny bursts into laughter.]]
** From the same scene, [[CorruptionOfAMinor "What's a fuckass?"]].
** Most of Elizabeth and Donnie's scenes, really, once you consider that they're played by [[RealLifeRelative real-life siblings]] Jake and Maggie Gyllenhaal, and that VitriolicBestBuds dynamic might not be faked.
* When not a {{Tearjerker}}, the hypnotherapy sessions are this. Dr. Thurman's increasing frustration [[AllMenArePerverts trying to get Donnie talk about something that isn't sex]] is funny. Her freaked-out expression after waking him up to stop him ''masturbating on her couch'', as if she was worried it wouldn't work, is ''priceless''.
--->'''Dr. Thurman:''' What do you think about during school?
--->'''Donnie:''' ''Series/MarriedWithChildren''.
--->'''Dr. Thurman:''' You think about your family?
--->'''Donnie:''' ''[laughing]'' [[ItMakesSenseInContext No, I don't think about fucking my family.]]
* [[http://www.youtube.com/watch?v=qACNqaEkHmE The Smurfs conversation]].
* "That's some good shit, huh?" [[DeadpanSnarker "It's a fucking cigarette."]]
* Drew Barrymore's AtomicFBomb after getting fired.
* The StylisticSuck of Jim Cunningham's "Cunning Visions" video is pretty funny to start with, but made even funnier on the [=DVD=] deleted scenes section where you can watch it with commentary by the in-universe producer and director, who are convinced they've created a masterpiece... and end up squabbling over who ate whose donut.