[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/despicable_me_2_large.jpg]]
[[caption-width-right:350: [[Franchise/{{Pokemon}} Agent Wilde used Lipstick Taser! It's super effective! Ex-villain Gru fainted!]]]]
* The very first scene in which we see Gru. Wearing a grim expression on his face, he's assembling a gun. He points it, pulls the trigger... and out comes a balloon shaped like a unicorn. Then the viewpoint pulls back and we see that he's preparing Agnes' birthday party.
* "It is I, Gru...zinklebelle, the most magical fairy princess of all."
* "I'm sorry, I did not see you there."
** "Or there."
* "You know, you really should [[CallingYourAttacks announce your weapons]] ''after'' you fire them, Mr. Gru. For example... ''(shocks Gru)'' Lipstick taser!" This moment even provides the current page image.
* Need we forget [[https://youtu.be/m4VlD-JP0ug this scene later on in the movie]].
* Gru's [[https://www.youtube.com/watch?v=RF8R7NVogJE trip to the AVL]].
** The minions making fun of Silas' name.
-->'''Silas:''' I am the league's director, Silas Ramsbottom.\\
'''Minion 1:''' [[HehHehYouSaidX Hmf! Bottom.]]\\
'''Both Minions''': Hahahahahahahaha!!!\\
'''Silas:''' ''(sneers disapprovingly)'' Hilarious...
** Gru's parting insult to Ramsbottom on their first meeting.
--> '''Gru:''' Here's the tip. Instead of tasing people and kidnapping them, [[SuddenlyShouting MAYBE YOU SHOULD JUST GIVE THEM A CALL!]] Good day, [[MaliciousMisnaming Mr. Sheepsbutt]].\\
'''Ramsbottom:''' Ramsbottom.\\
'''Gru:''' Oh, yeah, like ''that's'' any better!\\
''(Minions burst into laughter)''
* Agnes telling Gru what makes him a boy... [[BaitAndSwitchComment his bald head]].
-->'''Agnes:''' It's really smooth... sometimes I stare at it, and imagine a little chick popping out. Peep, peep, peep.
* When Jillian comes to Gru's door to set him up with a date with her friend Shannon, and Gru ''really'' doesn't want to go...Problem is, he's letting ''[[CloudCuckoolander Agnes]]'' [[https://www.youtube.com/watch?v=yIi3uYKEwfk make excuses for him.]]
-->'''Gru:''' ''*makes 'zip it' movement*''\\
'''Agnes:''' He's...putting on lipstick!\\
'''Gru:''' ''*quickly swings his arms around, trying to convey 'stop'*''\\
'''Agnes:''' He's swatting out flies!\\
'''Gru:''' ''*slices hand beneath chin*''\\
'''Agnes:''' He's chopping his head off!\\
'''Gru:''' ''*covers his head and groans loudly*''\\
'''Agnes:''' He's...[[ToiletHumor pooping?]]
* [[https://www.youtube.com/watch?v=iG4BQBcZZwc Lucy meeting Gru in a bakery.]] ''All'' of it.
** Lucy unleashing a flurry of martial-arts moves... on falling cupcakes. "Wasn't expecting that... or ''was'' I?" She then boasts her moves are "a mix of jujitsu, Krav Maga, Aztec warfare, and ''krumpin'''" complete with visual demonstrations of each.
** "No! No ''yaaaaay!''"
** Dave the Minion [[ImagineSpot imagining]] a FallingInLoveMontage with Lucy, which includes him pouring her a glass of champagne and then [[CutASliceTakeTheRest chugging the rest of the bottle himself]], and the two setting off fireworks by pulling out matching rocket launchers.
** [[https://www.youtube.com/watch?v=EEY1XEjnWGc Here's an extended version with Dave.]]
* Gru [[DisguisedInDrag as a fairy princess]].
-->'''Little Girl:''' How come you're so fat?\\
'''Gru:''' ''(In a bad falsetto)'' Because my house is made of candy, and sometimes I ''eat'' instead of facing my problems. ''(hits the girl on the head with his wand with each word)''
** [[ItMakesSenseInContext It makes]] ''[[ItMakesSenseInContext glorious]]'' [[ItMakesSenseInContext sense in context]]. Gru had originally hired a woman to come in dressed as a fairy princess, only for the woman to bail. Gru doesn't take it well.
-->'''Gru:''' You know, I hope you're able to sleep at night you crusher of little girls' dreams!
* The minions' rendition of the song "I Swear" by All-4-One and/or John Michael Montgomery at Gru and Lucy's wedding.
--> "[[MondegreenGag Under-weeeear!]]"
* When El Macho is dancing for his customers, he decides he needs a partner. He also decides that the woman walking by outside is as good a partner as any, and just reaches out and yanks her in.
* Whilst Gru and Co. are in El Macho's restaurant, he states that they should come along to his Cinco de Mayo party. While this in itself isn't funny, his comment to Gru most certainly is: "You are right [[BilingualBonus Cabeza de Huevo]], they must get to know each other better"! For any Spanish speakers, this is obvious, but for those who don't speak it, he called Gru an 'egg-head'.
* [[https://www.youtube.com/watch?v=-blu2QYxP70 Gru trying to ask Lucy out on a date for real]]. He psychs himself out so badly he ends up setting fire to the telephone with a ''flamethrower''.
** Made even TOTALLY funnier when a Minion (Stuart, apparently) is dressed as Lucy and says the following...
-->'''Stuart:''' Eeehhhh... No.
** One of Stuart's expressions when Gru was hesitating simply screams "Just call her already."
** And who could forget ''that'' scene when Gru burns the helpless telephone? He even says, "I hate you!" when he burns the phone!
** Who thought it a smart idea to give ''axes'' to the Minions?
** The Minion with the axes just keeps running forward swinging the axes around. He chops Gru's desk to bits and then tears through another wall to the outside. They're not on the first floor. You can hear the Minion scream as he falls.
** Before that, the Minion who ran in with the hose says something that sounds like "We've got this under control!" Yeah, you don't. Even funnier when he ends up in a WaterHoseRodeo and spraying water all over the office ''except'' on the fire.
** [[MemeticMutation "Bee-Do, Bee-Do, Bee-Do..."]]
** And Carl is the only Minion [[ThereWasADoor who enters through the door]].
** Stuart [[OnlySaneMan is the only one with the common sense to just use a fire extinguisher to put out the fire]], then promptly sprays Carl when he annoys him with his siren sounds.
* Margo's expression when she saw Antonio for the first time.
** Especially when she tries to chat with him.
--> '''Antonio:''' Cool glasses. \\
'''Margo:''' Uh... ''(chuckles nervously)''\\
'''Antonio:''' I’m Antonio.\\
'''Margo:''' I’m...Margo.\\
'''Antonio:''' I was just going to get a cookie. Care to join me?\\
'''Margo:''' ''(nervous)'' Uh,... sure. I’m... Margo.
* Just THIS:
--> '''Gru:''' Kyle, NO! Do not do your business in the petunias! ''(picks him up and drops him in the neighbor's yard)'' There. Those are Fred's. Go crazy.
--> ''(Kyle's pee incinerates Fred's flowers)''
--> '''Gru:''' ''(Wicked chuckle)'' Good boy....
* The minions holding auditions for their upcoming movie, but they're continuously blocked by a black wall.
** At the end of the audition, in the midst of trying to swat a moth, a minion begins to fall and another minion tries to catch him but falls with him. The last minion shrugs like, "Screw this," then jumps after them, screaming, "BAILAAAAAA!"
* Gru and the minions send Dr. Nefario off with a "21 fart gun salute." This leads to:
--> '''Dr. Nefario:''' I counted 22.
--> ''(He and Gru look at a minion, who laughs bashfully)''
** And also, the way Dr Nefario exits Gru's evil lair. His scooter is still very...slow.
--> '''Dr. Nefario:''' This may take a while.
* Margo decides to create an online dating profile for Gru.
--> '''Margo:''' What celebrity do you most resemble?\\
'''Gru''' ''(oblivious to what she's up to):'' Uh...Creator/BruceWillis?\\
'''Margo''' ''(immediately):'' Uh - no.\\
'''Agnes:''' Humpty Dumpty!\\
'''Edith:''' Oh! Oh! [[Literature/TheHobbit Gollum!]]
* Agnes' excitement for the arrival of the fairy princess.
** As well as her absolute glee when 'she' shows up.
** Agnes (and her sisters) also not being fooled by Gru's PaperThinDisguise as the fairy princess also helps as well.
--> '''Agnes:''' ''(whispers in Gru's ear)'' I know it's really you, Gru. I'm just pretending for the other kids.
* Gru trying to find the serum in Eaglesan's shop, using a device Lucy has planted on him. He has to walk around the shop, get near everything he can, to find it...the problem is, it's on his lower-abdomen (specifically, his belt buckle) so when he tries to pick up a signal he's pelvic-thrusting at everything.
** The sound the device (or rather, Lucy) makes when it detects the serum: "MEE-MAW, MEE-MAW, MEE-MAW!"
* Basically anything to do with the minions. From the 'Brave Knights' scene to the 'Minion Island' scene to the 'Ice Cream Party' scene to the 'Hunter Posing with Dr. Nefario and El Macho' scene.
* The robotic way that Agnes recited her poem. Made even funnier by Gru's [[LampshadeHanging lampshade of it]]:
--> "Wow. That--was...something ''else''! I ''really'' liked the way you ''smiled'' at the end--? Let's try this ''one'' more time, but a ''teensy bit'' less...like--a ''zombie'', o-''kay''...?"
** Agnes wonders if she should even do the mother's day poem, since she doesn't have nor ever known her mother. Gru brings up an... ''interesting'' past example to convince her otherwise.
-->"You don't need [a mother] to do the show. You did the Veteran's Day paegant, and you've never been in combat."
* The Minion Golfing scene. Totally a throwaway gag, but hilarious. Kevin and Jerry put the girls to sleep, then Kevin says something to Jerry. Cut to Kevin dressed in a golf outfit, with Jerry laying on his back with a golf tee/ball in his mouth. Kevin takes a couple of practice swings at the ball, looks directly at the camera, and then lowers the club to the level of Jerry's head. He winds up... and is interrupted.
* Gru's attempt to do the dance-step password for El Macho's underground lair, only to keep tripping up and triggering booby traps.
* The chip-and-guacamole hat.
* Anything to do with El Macho's pet attack chicken.
-->'''Gru:''' I really hate that chicken. ''(The chicken activates the rocket with Gru and Lucy on it)''
* When Gru uses Lucy's lipstick taser to take down the mutated El Macho.
-->'''Gru:''' [[CallBack Lipstick taserrrr!]]
-->'''Lucy:''' Aw! He copied me.
** The fact that the PX-41 serum made whoever it was injected into or, in El Macho's case, drank it became basically invincible, yet El Macho was still weak to the lipstick taser.
* The conversation when Agnes sees Edith grabbing coins from a wishing fountain.
-->'''Agnes:''' Is that stealing?
-->'''Edith:''' [[LoopholeAbuse Not if my wish was that I would get a lot of free coins!]]
* A quick example: when the [=AVL=] is showing Gru the footage of the serum's testing, he sees the bunny mutate into a horrible monster. The Minions accompanying him look horrified, but if you look at Gru, [[AdmiringTheAbomination he has this big smile on his face like it's the coolest thing]] ''[[AdmiringTheAbomination ever]].''
** However, when the monster bunny begins to attack the scientists, Gru's face is priceless.
--->'''Gru:''' You don't usually see that in bunnies.
* Lucy's LoveEpiphany on the plane. After seeing Gru in both magazine ads and in her fellow passengers, she decides to just open the plane's window and jump out with a hang-glider. But before that she turns to the stewardess she was talking to and cheerfully shouts "Thank you, Gru-Stewardess!"
-->'''Stewardess:''' (confused) You're welcome!
** Special mention should go to the baby with Gru's head.
-->'''Baby Gru:''' I made a boom-boom.
* The cat being sent back down to earth. It was like "We have no use for cats here. Go forth and get adopted."
* The minions getting [[BadHumorTruck abducted by the ice cream truck]]. Especially the last minion who tried to run for it but was distracted by an ice-cream and then got taken too.
** Oh, and the funny way the minions were running past the young children towards the ice-cream truck.
** "GELATO!!!" Which is [[BilingualBonus Italian for ice cream]].
*** As they're being abducted like a vacuum sucking up sesame seeds, one of the taller minions urges the [[BrickJoke minion that got his head stuck inside a jelly jar]] to flee, and then he turns to the ice cream vacuum with his arms wide, [[HeroicSacrifice presenting himself as if saying "Take me instead!"]]
* Gru simply plowing into every other car in the lot at the Cinco de Mayo party.
* The ''entire'' date scene, including the part where they carry Shannon home.
-->'''Lucy:''' Wow. Looks like your date's out for the count. It's like she's been shot with a mild moose tranquilizer.
-->''(Shannon makes a moose-like sound and falls unconscious into her dinner plate again. Lucy then winks at Gru, but he doesn't understand.)''
-->'''Lucy:''' Yeah, I'm winking 'cause that's what actually happened.
* Blink-and-you'll-miss-it example. Gru and Lucy sneak into Eduardo's restaurant after closing hours to see if they can find the serum. They find ''something,'' but it turns out to be a jar of "secret salsa." Cut to Eduardo returning...and then cut back to Gru and Lucy, who apparently figured they might as well have a snack, because they're dunking chips in the salsa and eating it instead of continuing the mission.
* "HE'S SO FLUUUFFFYYYY!!!"[[note]]This quote is only in the junior novelization.[[/note]]
** "I'M SO HAAAPPPPPPYYYY!!!"
* The scene where Gru is rowing and one of the minions directs him through a megaphone.
** Which pops up again later, and is probably funnier because it's a Minion directing another Minion to pick up Gru and Lucy...and rowing right past them.
--->'''Gru:''' They'll be back.
* "Uh, hi everybody. I'd like to make some toast."
* The entire "never grow up" scene:
-->'''Gru:''' ''(Kisses Edith's forehead and playfully bops her nose)'' Good night, Edith. ''(Walks to Margo and kisses her forehead)'' Good night, Margooo-[[DoubleTake woah-woah-woah-woah]], hold the horses, who are you texting?
-->'''Margo:''' No one, just my friend Avery.
-->'''Gru:''' Avery... eh, Avery? Is that a girl's name or a boy's name?
-->'''Margo:''' Does it matter?
-->'''Gru:''' No, no, it doesn't matter, [[BoyfriendBlockingDad unless it's a boy!]]
-->'''Agnes:''' I know what makes you a boy.
-->'''Gru:''' Uh... you do?
-->'''Agnes:''' Your bald head.
-->'''Gru:''' Ah, yes.
-->'''Agnes:''' It's really smooth. Sometimes I stare at it, and imagine a little chick popping out. ''(Makes beak imitations with her hands)'' Peep peep peep.
-->'''Gru:''' Good night, Agnes. ''(Kisses her forehead)'' Never get older.
* The Minions ''attempting'' to sing "YMCA". The best part? You can find it on [=YouTube=] by searching for "the village minions" (without the quotes).
** What's also funny about this scene is that one of the minions appears to be dressed like Carmen Miranda.
* Gru trying to get [[BoyfriendBlockingDad Antonio thrown in jail for hitting on Margo]].
--> '''Gru:''' There's a devilish look in his eyes and ''I don't like it!!''
* "Are you single?"
** Following this, Agnes starts singing a song about how Gru & Lucy are going to get married (as Lucy is nearby) to which Gru comments "this is a song of lies!"
* [[https://www.youtube.com/watch?v=Z1g2fb0-q2A "Rawr, rawr." (Vroom, vroom)]]
* Eduardo's mountain top manor is quite ridiculous from an architectural standpoint. It's a sprawling complex designed for a much bigger site; a good chunk of the estate is suspended off of the flattened peak by wooden beams.
* After Margo gets dumped by Antonio, Gru sends a message to him... [[BoyfriendBlockingDad by turning him into a frozen statue.]]
** Especially the girl he was dancing with's reaction.
* Every dang time an evil minion goes:
--> ''({{Beat}}) ''BWLAAA!"
* When one of the captured minions gets "flushed" down the fake ocean, and finds himself strapped to a chair in a dark room. His response? [[UnusuallyUninterestingSight Shrug with a "Meh"]]--and eat his banana.
* Gru's attempt at cheering up Dr. Nefario regarding the jelly's awful taste:
-->'''Gru:''' [[LogicBomb Whoa... okay, just because everybody hates it doesn’t mean it’s not good.]]
** Also the previous scene when a minion was tasting the jelly, then realizing how awful it tastes, he screams and smashes the jar on to floor and all minions begin to run amok.
* The entire introduction flashback for El Macho is TestosteronePoisoning-ridden HILARITY, but especially clever is a subtle FunnyBackgroundEvent within it that involves a fellow taking a siesta...who doesn't even stir when El Macho ''punches out the door '''right near where the man is sleeping'''!!!''
* El Macho's reaction to Gru's feeble attempts to convince him (on his way out the door) that he's [[MostDefinitelyNotAVillain totally, 100% on board, honest,]] with this whole plan of El Macho's to TakeOverTheWorld. [[ScrewThisImOutOfHere Just got a few things to do first!]] [[BlatantLies Totally in!]]
-->'''El Macho:''' [[DeadpanSnarker You know what? I'm not so convinced that he is in.]]
* This exchange:
-->'''Margo:''' So I take it the date went well?
-->'''Gru:''' *gleefully* No, it was ''horrible!''
--> ''(Margo looks completely befuddled)''
* At the climax there's Gru's [[DoubleTake reaction]] when he notices that Nefario brought the girls with him.
-->'''Agnes:''' Hi!
-->'''Gru:''' You brought the ''girls?!''
-->'''Dr. Nefario:''' Yes! Oh... Was that wrong?
** Edith is put at the controls of one of the two [[GatlingGood jelly-shooting Vulcan cannons]]. She's a bit of an [[Series/TheAddamsFamily Addams type]]: her expression of joy clearly shows this is the most wonderful thing that she's ever been allowed to do.
* Tying into FunnyBackgroundEvent: El Macho's Evil Minion cannons are set to launch to major cities around the world, like Moscow and Paris...yet for some reason, there's one cannon that's labeled ''Hoboken''. As in Hoboken, New Jersey, which, while mildly important in the area, has ''no'' international clout.
* When El Macho is about to press the button that will launch the rocket Lucy is strapped to, one of the Minions snatches it while swinging on a rope and shouts, "Tallyho!", only to then immediately smash into a buttress.
* When Gru is on the rocket that Lucy is strapped to, he cut the bonds that are securing the explosives and the shark. This, in turn, causes the explosives and the shark to fall. We don't know what happens to the explosives, but the shark lands on the counter of a sushi bar. Everyone there promptly cheers.
* Eduardo showing off the Mexican flag on his hairy chest. Even better, Lucy looks almost ''hypnotized'' by it, while Gru, who is shielding his eyes, urges her to look away.
!!Mini Movies
* Puppy:
** Gru's face when he walks Kyle and passes Dave walking his UFO.
** When everyone is watching a movie and the UFO gets so scared by the [=UFOs=] being attacked that it blasts a gigantic hole on the TV screen and wall. Gru and the kids stare in shock, and the minions cheer. Cue GilliganCut to Gru kicking the UFO and Dave out.
* Training Wheels:
** When a trio of minions see Agnes fall off her bike and is about to cry, two of them angrily kick and stomp on the bike. Also counts as SugarWiki/{{Heartwarming|Moments}} because it shows that they did not like seeing Agnes getting hurt.
** When Agnes blows a kiss at the minions and they fight to receive that kiss.
* Panic in the Mailroom:
** The ENTIRE thing! But especially when Mike (the one who looks like Dave) starts randomly changing back and forth from his normal self to an Evil Minion, all while Ken is laughing and eating popcorn.
----