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* EVERY scene involving Creator/MelissaMcCarthy's Megan. Her sincere and somewhat deadpan deliveries help this. No wonder she was nominated for Best Supporting Actress.
** Her driving by Annie with nine puppies in the car and sporting a SlasherSmile.
** Her idea for Lillian's bridal shower: A female ''Film/FightClub'' where everyone surprises Lillian by not telling her the theme and then beating on her. Everyone's reaction just makes the scene all the sweeter.
** "THIS IS LIFE, ANNIE!"
** The sex tape with the Air Marshal that cuts into the DancePartyEnding during the credits.
** "I took two puppies. They're in my van."
** Her constant badgering of her seatmate on the plane, thinking he's an air marshal. Which is actually true, to her delight.
** "I'm glad you're not with him because I'm gonna climb him like a tree."
** "I can't protect you. I know where all the nukes are, and I know the codes. You would be amazed, a lot of shopping malls. Do NOT repeat that."
** "I own six houses and an eighteen-wheeler that I bought just because I wanted to."
** "I snuck a loaded handgun into Dougie's luggage. The TSA is gonna tear his ass up."
** Her very first speech to Annie, talking about how she fell off a cruise ship and communicated with a dolphin "I'm gonna say, telepathically?"
* The opening sex scene, including Ted's crazy laughter.
* Rita telling her children to "[[HypocriticalHumor Shut your filthy fucking mouths!]]"
* The entire extended insult scene between Annie and the rude teenager.
* Becca's drunken compliments to Rita: "You-you're more beautiful than Cinderella! You smell like pine needles and a face that looks like SUNSHINE!"
* Annie breaking every car law she can in order to get Nathan's attention.
** Nathan's deadpan response ignoring her: "Let's see what Marmaduke's up to."
* Lillian's dad:
-->I wish they'd just get married right now, just to save me a shitload of money. ''(Everyone laughs)''. I'm not joking. ''(Everyone laughs again)''. I'm not joking. ''(Everyone laughs one more time)''.
* The plane scene (along with others) is arguably an OverlyLongGag, but parts are excellent, such as a drunken Annie demanding that they keep the curtain between coach and first class open "because it's civil rights. This is the '90s."
* Pretty much any scene with Annie's roommates.
* You're really doin' it.... You're shittin' in the street...
** That entire scene where the bridesmaids succumb to food poisoning while in a very fancy dress shop is too hilarious to put into words.
* On first meeting Nathan, who's a police officer, Annie tries to prove to him that she wasn't driving drunk by... performing an odd yet nicely choreographed dance routine along the road's white line.
* "Lillian...*stares at Lillian*"
* Annie's (rather justified) tantrum at Lillian's bridal shower.
* [[DeadpanSnarker "I've seen better tennis playing in a tampon commercial."]]
* Helen screaming "Excuse me" through Officer Rhodes' closed car window.