* Blade is transporting Karen [[spoiler: after she had been bitten by Quinn]], and as he is leaving, he is shot repeatedly by two hospital security guards, leading to this quip:
-->'''Blade''': Motherfucker, are you out of your damn mind?!
* One of Whistler's lines:
-->'''Whistler''': I'm too old for this! Somebody get me a goddamn wheelchair!
* In the climax as Blade prepare to fight Frost. Quinn, one of Frost's dragons and who has at the beginning got his arm slice off, shows up
--> '''Quinn''': I got two arms now Blade and I don't know which one to kill you with! (He charges...and is unceremoniously bisected into dust.)
* Frost admires Blade's sword and wants to demo it, so he orders Quinn to hold out his arm. Quinn is scared shitless, [[RunningGag as he has already lost limbs to Blade's sword]], as he dutifully does so and pleads with Frost not to do it. Frost holds the sword to Quinn's arm...then puts it away and deadpans, "Just kidding."
-->'''Quinn (laughing with relief)''': HE WAS JUST FUCKING WITH ME!
* When Blade [[HalfTheManHeUsedToBe slices Frost]], the baddie's newfound powers reattaches his torso back to his body before it hits the ground and makes him good as new, [[OhCrap eliciting Blade to silently mouth "What the fuck?"]]
!!''[[Anime/MarvelAnime Marvel Anime: Blade]]''
* Wolverine thinks Blade and Makoto are an item and teases them, which they vehemently deny.
-->'''Wolverine:''' I'm just saying, you might want to figure this relationship out.
-->'''Blade:''' Don't make me stab you!