!!! ''Astro Boy'' (2009 film)
* Astro's stunned reaction to the first time his rocket boots fire, including a hilarious expression and a wonderfully prompt (and pretty harsh) slap to his own face.
** And then as shock becomes delight he tries to zip off heroically - only to briefly ''forget how to power the jets'' and, on reactivating them, slam himself backwards into a building and then straight up through its stone facade.
* A soldier trying to use windshield wipers when Astro crashes into his ship. Astro's look of sheer annoyance is priceless.
* Trash Can the robot dog's [[spoiler:final attempt to "out" Toby as a robot, spelling out on the ground in huge letters "HE'S A ROBOT!" with an arrow pointing to Astro/Toby to Zane. Made funnier when Zane shrugs, "Almost makes me wish I could read!"]]
* When the RRF 'rescue' Astro.
--> '''Zane''': What just happened?
* "I'm voting for the other guy!"
* When Astro descovers his "accessories".
--> '''Astro''': What? I got ''machine guns?'' In my ''butt?!''
** And the first use of his [[ArmCannon]]s: "Hah! Cool!" ''*blam!*'' [goes flying backwards]
* When Astro saves one of the guy's after him, and then has to deal with the reinforcements.
--> '''Astro''': What is up with you guys?
--> '''Guard''': I love you man.
* Any scene involving the Robot Revelutionary Front.
* The President as the GiantMecha. Everything out of his mouth is pure hilarious GenreSavvy DeadpanSnarker.
!!! '''2003 series'''
* From the first episode, the Inspector asks Dr. O'Shay about the blackout caused by reviving Astro. His explanation? "I can't sleep with the lights on."
* Anytime someone bangs down Tenma's door. Made better by his sheer calmness about it.
--> '''Tenma''': ''(surrounded by police)'' So many visitors. And I didn't even make tea.
* Some of Tenma's creeper moments qualify as well.
--> '''Tenma''': ''(disturbing grin)'' Always a pleasure.
--> '''Astro''': You're creepy.
!!! '''Original Manga'''
* [[http://27.media.tumblr.com/tumblr_lpyd60voS11qinrdfo1_500.jpg This]] moment from the "Astro Reborn" arc.