* ''{{Fans}}'' adjusted the '''F'''ederal '''B'''ureau of '''I'''nvestigation into the '''F'''antasmagorical '''I'''nvestigation '''B'''ureau, or [[TheMenInBlack FIB]].
* The secret anti-alien organization in ''Webcomic/ItsWalky'' is called SEMME... which ''does'' stand for something, but the author has yet to reveal what. It's pronounced like "semi", creating useful pun fuel. In one strip, part of the E on their building is blown off, prompting Walky to start calling the organization "SEMMF".
** I'd think there'd be more pun fuel if it were pronounced [[{{Seme}} how it looks]].
* On ''TheWotch'', one character guessed that the first two letters of the [[StrawFeminist radical feminist]] group D.O.L.L.Y. stood for "'''D'''aughters '''o'''f", but [[TheUnreveal the rest was never determined]] and the [[spoiler: leader was defeated just before she could reveal its full meaning - and [[TakenForGranite turned into a dolly as punishment]] ]].
* In a 1990s Penn State in-joke (because [=PepsiCo=] seemed to have a great deal of influence at the college), ''TheInexplicableAdventuresOfBob'' once had a [[{{Kaiju}} giant monster]] called the '''P'''eople-'''E'''ating '''P'''oly-'''S'''orbate '''I'''nsectoid.
* ''TheKAMics'' had the Semi-Mystical Otherworldy Gates or S.M.O.G. Nothing deep about the name though, the author took the acronym from a running gag he was part of on one of [[http://nitcentral.philfarrand.com/discus/messages/17579/14907.html?1024222400 Nitcentral's humor threads]].
* Mr. Mighty in ''EverydayHeroes'' is a member of The '''S'''ociety of '''A'''mazing, '''V'''aliant, and '''E'''xtrememly '''U'''nselfish '''S'''uperheroes ... S.A.V.E.U.S.
** According to the cast page, Mr. Mighty has previously worked for the '''T'''eam '''H'''oping to '''U'''phold '''D'''ecency ('''THUD'''), the '''W'''hite '''H'''ouse '''A'''dvanced '''P'''ersonnel '''P'''rotective '''O'''ffice ('''WHAPPO'''), the '''A'''merican-'''M'''exican '''I'''nternational '''G'''roup '''O'''f '''S'''uperheroes ('''AMIGOS'''), and the '''G'''roup '''O'''f '''O'''fficial '''D'''o-'''G'''ooders '''U'''nited '''I'''n '''S'''uppressing '''E'''vil ('''GOOD GUISE.''').
* This episode of ''[[http://www.wcihigh.com/?p=259 WCI High]]'' spoofs [[{{Shazam}} Captain Marvel]] when Blossom Pearl invokes her "magic word".
* Spoofed in [[http://antiheroescomic.com/comic/187 this spoilerific]] entry for "anti-HEROES", a comic which seriosuly ripped off the art style of Webcomic/TheOrderOfTheStick.
* ''Webcomic/SluggyFreelance'' had the ''''N'''otification of '''U'''nified '''K'''indness' '''E'''nvelopes as the ultimate weapon within the Dimension of Peace.
** Also, from [[http://www.sluggy.com/comics/archives/daily/110215 this strip]], we get '''R'''ecording '''E'''ditable '''C'''ontent '''A'''pplication '''P'''eripheral.
** And [[http://www.sluggy.com/comics/archives/daily/090908 before that]] we get 4U City's '''M'''aternal '''O'''bedience '''M'''aintenance '''M'''edicating '''Y'''-Frames and the '''C'''hem-Lab '''R'''eview and '''A'''ssignment of '''P'''ersonnel Riff teaches.
* [[http://blag.xkcd.com/2009/09/02/urinal-protocol-vulnerability/ xkcd]] kicks it up a notch with the International Choice of Urinal Protocol. [[FridgeBrilliance Think about that for a second.]]
** A straighter example is [[http://xkcd.com/917/ this strip]], where Douglas Hofstadter's autobiography reads, "'''I''''m '''S'''o '''M'''eta, '''E'''ven '''T'''his '''''A'''cronym''".
* PennyArcade gives us '''G'''amers '''A'''gainst '''E'''xercise, a theoretical support group founded by Gabe who support traditional, controller-based gaming. Especially funny on a shirt.
* ''The Perpetual Aquarium'' had the fish take the Comprehesive Assessment and Report of Progress, or CARP. This was lampshaded when one of the fish comments that basing a year's progress isn't CARP, it's C----, and, when interrupted, comments that he likes anagrams.
* The FasterThanLightTravel drive in the ''Webcomic/{{Freefall}}'' universe is called the '''D'''angerous '''A'''nd '''V'''ery '''E'''xpensive drive.
** The name was suggested by a reader after the writer decided he had to call it something so he might as well call it DAVE.
* The Trustworthy Room test from ''Webcomic/TowerOfGod'' requires to gather rooms and teammates, though with a high risk of losing ones room. So Ja Wangnan and Nia decide to do it the gentlemanly way: Operation S.I.R., '''S'''tay '''I'''n the '''R'''oom.
* ''IrregularWebcomic'' has the '''S'''ecret '''A'''ction '''Squa'''dron '''T'''eam of '''C'''ryptid '''H'''unters.
* In the ''Webcomic/JetDream'' RemixComic, the T-Girls represent {{NATO}}'s '''J'''oint '''E'''lite '''T'''eam, '''D'''ivision of '''R'''aiding-'''E'''xpert '''A'''eronautical '''M'''aidens ('''J.E.T. D.R.E.A.M.''', or usually just "Jet Dream.") Their "little sister" team is '''J'''unior '''E'''chelon, '''T'''een '''T'''-Girls, '''E'''lle-Boys, and '''E'''sprit-Girls ('''N'''atural!), or '''J.E.T. T.E.E.N.''' Both organizations must deal with the sinister schemes of '''Z'''oned '''E'''xtortion and '''R'''emoval, '''O'''ccidental ('''Z.E.R.O.''').
* ''{{Erfworld}}'' has Lord Stanley the Tool's elite hobgobwin knights, the '''K'''nights '''I'''n '''S'''tanley's '''S'''ervice. [[DontExplainTheJoke They are, of course, a reference to the band KISS;]] their "war paint" is the makeup KISS wears onstage, and their name is a reference to the old moral panic-driven legend that KISS stood for "Knights In Satan's Service" (which it didn't).
* The GIGAHERTZ, or '''G'''izmonic '''I'''nstitute '''G'''raphical '''A'''utomated '''H'''yper-'''E'''nhancement of '''R'''eality through '''T'''eleportation and, uh... '''Z'''oom, from TheWayOfTheMetagamer.
** Responded to with the '''C'''layton '''F'''orrester '''V'''olumetrically '''D'''isplayed '''E'''ntertainment and '''W'''orld-'''T'''aking '''O'''ver '''D'''evice, or, uh... CFVDEWTOD (khfhvhdootodd?) for short.
* ''PennyArcade'' played with it:
--> '''General''': We call it the '''K'''inetic '''I'''ngestion '''R'''egulator '''B'''io-'''Y'''organism.
-->'''[[VideoGame/{{Kirby}} Meta Knight]]''': Yorganism?
--> '''General''': [[ShoehornedFirstLetter Y is kind of a tricky letter.]]
** They're also the TropeNamer for the GreaterInternetFuckwadTheory.
* ''Webcomic/{{PHD}}'' [[http://www.phdcomics.com/comics.php?f=1100 explained how to create those]].
* ''Webcomic/{{Homestuck}}'' has Nepeta's planet, the '''L'''and '''O'''f '''L'''ittle '''C'''ubes '''A'''nd '''T'''ea. ('''[[ShoutOut LOL]][[{{Lolcats}} CAT]]''')
* The ''CrossoverWars'' had their DRACO (Dimensional Reality Arcane Crossover Organizer)
* ''Webcomic/ElGoonishShive'' being a Word Salad Title, it's no wonder that [[http://community.910cmx.com/index.php?showtopic=9749&st=20&p=392573&#entry392573 according to some fans]],
--> "EGS" really stands for "'''E'''xtremely '''G'''ratuitous '''S'''hapeshifting"
* SarahZero has the '''P'''rivacy '''I'''nvestigation '''S'''chadenfreude '''S'''ecret '''S'''ervice
* FreakingAwfulPuns has scared away some potential readers with its acronym.
* Played with in ''SkinHorse'':
--> '''Violet''': And you're U.N.I.T.Y.\\
'''Unity''': Yep!\\
'''Violet''': The '''U'''pgradeable '''N'''ecrotic '''I'''ndependent... what?\\
'''Unity''': We don't talk about my acronym.\\
'''Violet''': Sorry, did I touch a nerve?\\
'''Unity''': Well, you know. People died and stuff.\\
'''Violet''': People died... because of your acronym.\\
'''Unity''': [[NoodleIncident The committee meetings, man! It was law of the jungle!]]
** In a later arc, we meet G.O.D.O.T., an AI whose primary function is a military-grade backronym generator. It turns out [[spoiler: G.O.D.O.T. went mad trying to work out what U.N.I.T.Y. could stand for, which is presumably the point at which people died.]]
* From [[http://www.wastedtalent.ca/ Wasted Talent]], Jam's suggestion for an [[http://www.wastedtalent.ca/comic/and-acronym-here-and-acronym-there agriculture program.]]
* BOOBS ('''B'''asic '''O'''rganizational and '''O'''perational '''B'''a'''S'''eband) of [[http://ask-boobs.tumblr.com Ask Boobs]], a Tumblr-based Tron webcomic. The origins of her name are explained in [[http://ask-boobs.tumblr.com/post/17520242497/as-for-the-other-question-for-the-code-of-me this comic]]. She's, er...appropriately named.
* DorkTower has a TakeThat to Creator/MichaelBay, advertising that people should use the hashtag [[http://www.dorktower.com/2012/03/28/tmntwtf-dork-tower-28-03-12 #TAINT]] (Teenage Alien Imposter Ninja Turtles) for his TMNT movie.
* In [[http://www.captainsnes.com/2012/04/13/770-bunch-of-dhopes/ this]] CaptainSNES comic, we discover that [[VideoGame/ChronoTrigger Dalton]] is recruiting [[GoldfishPoopGang villains]] from different video worlds. His name for the team? The '''D'''altonian '''H'''yper-'''O'''ceanic '''P'''iratical '''E'''xtortion '''S'''quad.
* ''Webcomic/ThePackrat'' has the '''M'''emorymoog '''A'''coustic '''D'''eath Ray, a DeathRay [[ExactlyWhatItSaysOnTheTin powered by a Memorymoog polyphonic synthesizer]].

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