* ''ComicStrip/{{Dilbert}}'' spoofed this when the boss' secretary put "DOPE" on his business cards--unaware that he did in fact hold the title '''D'''irector '''O'''f '''P'''roduct '''E'''nhancements.
** The boss was also tricked into putting an "e-" in front of his previous title acronym, '''DIOT''', because all the cool things these days have them. (Forgot what it stands for.)
*** As I recall, his title at the time was '''D'''irector of '''I'''nformation, '''O'''perations, and '''T'''echnology.
** Interestingly enough, the new prefix is "i-".
** A variation: company e-mails are required to be the person's first initial and last name, causing complaints from an employee named Brenda Utthead.
** One of Dilbert's projects was named TTP, which stood for '''T'''he '''T'''TP '''P'''roject.
** The PointyHairedBoss came up with a rather bad one in [[http://thedilbertstore.com/comic_strips this]] strip.
* In ''GetFuzzy'', Satchel's dog group is called '''C'''anines '''A'''gainst '''T'''raffic. Bucky suggests that a better title would be '''D'''ogs '''O'''n '''R'''idiculous '''K'''rusades.
** Possibly the '''A'''tlantic '''R'''esearch of '''S'''upernatural '''E'''ntities Group.
** Also, '''M'''inks '''A'''gainst '''Y'''early '''B'''eing '''E'''viscerated - one of the minks wanted to change this not-so-assertive name to '''MACHO''', but as the other mink pointed out, "It doesn't stand for anything!"
** A more recent comic has '''I'''ntelligence '''D'''epartment '''I'''nstitute '''O'''f '''T'''he '''I'''nternational '''C'''athood.
* ''{{Eyebeam}}'' had the absurd megacorp '''TIC''' -- "Three Initial Corporation".
* One ''{{FoxTrot}}'' strip featured a dish called ''STEAK'' in the high school cafeteria. The name was an acronym for "'''S'''quid '''T'''entacles, '''E'''ggplant, '''A'''nd '''K'''etchup."
** In another, Jason offers Peter a PB&J. Turns out the "J" in this case stood for jalapenos.
* In the mid-1960s, Al Capp's comic strip "Li'l Abner" had '''S'''tudents '''W'''ildly '''I'''ndignant about '''N'''early '''E'''verything, or '''SWINE''', an unsubtle parody of student radical groups.
* ''TheFabulousFurryFreakBrothers'' once caught the attention of an ultra right-wing paramilitary group calling themselves the '''A'''mericans '''S'''ecretly '''S'''erving a '''H'''igher '''O'''rder of '''L'''aw '''E'''nforcement and '''S'''ubservience.
* ''CalvinAndHobbes'' played with this trope:
-->'''Calvin:''' Our top-secret club, G.R.O.S.S. -- Get Rid Of Slimy girlS!\\
'''Susie:''' Slimy girls?\\
'''Calvin:''' I know it's redundant, but otherwise it doesn't spell anything.
** In another strip when Calvin and Hobbes had a fight, Hobbes threatened to quit the club and start his own. When Calvin said his club wouldn't have a "cool acronym" for a name, Hobbes said he'd call it C.A.D. (For "Calvin's a Dope". This, of course, made Calivin change the name of ''his'' club to "Hobbbes is an ugly flea bag" and only made them fight more.)
* In the early 1990's, when the '''W'''orld '''L'''eague of '''A'''merican '''F'''ootball (later NFL Europe) was starting, the comic strip TankMcNamara showed a group of executives upset that people were calling the league, "What-A-Laugh". One suit suggested changing the name to '''A'''merican '''W'''orld '''F'''ootball '''L'''eague, until he realized that this was just as '''AWFL'''.
* DykesToWatchOutFor: A hidden one: it is not clear if the '''M'''arriage, '''O'''rder, and '''F'''amily '''O'''rganization actually uses its acronym.