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* Tetsuo from ''Manga/{{Akira}}''. Originally a bike gang member, through a series of bizarre events he becomes an [[spoiler: ultra-powerful [[MindOverMatter telekinetic]] who [[BodyHorror morphs]] into [[EldritchAbomination a monstrosity worthy of the]] CthulhuMythos]].
* Ken from ''DigimonAdventure02'' started out as a lonely child who was always in the shadow of his older brother, however after his death a series of events lead to him becoming the evil Digimon Emperor.
** Oikawa started out the same way, having Iori's father as his only friend. But after Iori's dad was killed in line of duty, Oikawa promised himself he'd make their dream visiting the Digital World one day real no matter what, and with the help of [[spoiler:Myotismon]], he becomes a ruthless MagnificentBastard who almost brought both worlds to ruins in chasing his mad dream.
* [[{{Kekkaishi}} Kuroda]] was once an UnskilledButStrong samurai with a streak for killing. [[spoiler: He then makes a deal with the Ayakashi and becomes the series' most memorable villain Kaguro]].
* ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'' brings us Paptimus Scirocco, a minor official from Jupiter recruited by the Titans. Over the course of the series he slowly gathers followers and influence, culminating in him supplanting [[BigBadDuumvirate Jamitov and Bosque]] and seizing control of the Titans. And did we mention he slowly reveals himself to be an amazingly skilled pilot, genius mobile suit designer and extremely powerful Newtype?
* In ''Anime/MobileSuitGundamUnicorn,'' Buch Concern, the salvage firm Banagher Links works a part-time job at, is run by the business-oriented Ronah family. The only real notable thing about them at that point in the UC timeline is that they had taken (and bought) their last name from an impoverished line of European nobles. In less than 30 years, that same family would have enough manpower, resources and influence to forge their own realm almost overnight: Cosmo Babylonia from ''GundamF91''.
* ''Manga/InuYasha'''s Naraku. A bandit fails in his attempt to take over his band and ends up a crippled, burnt wreck of a man destined to live out the rest of his life in constant agony. But his PerverseSexualLust for [[{{Miko}} Kikyo]] grows so strong he makes a contract with demons and is transformed into the BigBad.
* [[MorallyAmbiguousDoctorate Dr.]] [[NamesToRunAwayFromReallyFast Hell]] from ''MazingerZ'' started like an unwanted son born in a pauper, ordinary family was -psychologically and physically- [[AbusiveParents abused by his mother]], berated by his teachers and bullied by his classmates. Thirty years later he was designing {{Doomsday Device}}s for UsefulNotes/AdolfHitler and experimenting with human beings in Auschwitz. Forty years later he was trying to TakeOverTheWorld and enslaving humankind with an army of HumongousMecha. [[spoiler:And in ''GreatMazinger'' he was handed over the command of the entire army of the Mykene Empire.]]
* Niki from ''Anime/{{Urotsukidouji}}'' is a [[YouSuck teenage loser]] with an [[DeusAngstMachina improbably shitty life]] who becomes a super-powerful demon-man after making a DealWithTheDevil of sorts.
* When [[spoiler:Roxanne of Love and Hate]] became a {{Claymore}}, she was assigned the position of Number 35 and steadily worked her way up the ranks. [[spoiler:When she died, she was Number 1.]]
* Lucy in ''Manga/ElfenLied'' was resigned to getting bullied by [[AllOfTheOtherReindeer the other children]] at the orphanage for being a [[YouGottaHaveBlueHair freak]] [[RedEyesTakeWarning of]] [[UnusualEars nature]]. Then she got [[PersonOfMassDestruction the power to turn a perfectly ordinary living room into a blender]].
* ''Manga/DeathNote:'' Disaffected high school student Light Yagami and incompetent, unpopular corporate drone [[spoiler: Kyosuke Higuchi]] each come across a [[ArtifactOfDoom simple notebook]] leading each to become notorious mass murderers and, in the case of one of them, [[AGodAmI GOD OF THE NEW WORLD]].
* [[UnluckyChildhoodFriend Hirose]] from ''AliveTheFinalEvolution''. Originally just TheHero's often ignored childhood friend, even ''after'' he [[TouchedByVorlons gains super powers]] and does a FaceHeelTurn he doesn't seem to be much more than the BigBad's mind controlled pawn. Then he gets his hands on [[MacGuffin The Heart of Akuro]], which frees him from the mind control and gives him ''godlike'' power, and he promptly decides to use it to ''[[OmnicidalManiac kill everyone on Earth]]''.
* ''Manga/FullmetalAlchemist:'' Father, the BigBad and leader of the Homunculi, [[spoiler:began life as a small Xerxian alchemy experiment who could think and act like a human. Eventually, he tricked a slave(Van Hohenheim) into helping him absorb the souls of half the people of Xerxes, gaining humanoid form. Soon, he introduced Alchemy to the rest of the world and became the founder of the entire country of Armestris, kickstarting the manga's plot.]]
* In ''Manga/KatekyoHitmanReborn'', Irie Shouichi manages, through rampant misuse of TimeTravel, to accidentally make a nobody named Byakuran capable of communicating with [[AlternateUniverse alternate realities]], bent on [[TakeOverTheWorld taking over the worlds]]... ''[[MultiversalConqueror all of them]]''.
* In ''Manga/OnePiece'', both hero of the show Monkey D. Luffy and his EvilCounterpart Marshall D. Teach/Blackbeard have amassed great infamy in just under a year, from being some no-named rookie on the East Blue, the weakest sea in the world, to having a 400 Million beli bounty, and pegged as a future threat with no end in sight for Luffy, and from being a random GiantMook for Whitebeard's 2nd Division to killing a high-ranking commander and becoming one of the Shichibukai, the World Government's group of PsychoForHire pirates, by beating the man formerly in charge of him, and Luffy's NighInvulnerable brother for Blackbeard, also still growing too. The rest of the Eleven Supernovas, a group Luffy is sort-of part of with TheLancer Zoro, also counts as well. [[spoiler:Granted, this depends on your definition of 'nobody', as Luffy is 1) the grandson of a military hero, 2) the son of a dangerous rebel leader, and 3) the adoptive brother of the former Pirate King's son.]]
** Blackbeard, who [[spoiler:busted out the worst among the worst prisoners alive of [[TheAlcatraz Impel Down]] and stole Whitebeard's Quake Quake Fruit power, and declared war on the entire world and everyone in it.]]
*** And at the end of the 2-year TimeSkip, [[spoiler:we find out he's no longer part of the Shichibukai... because in that time he's become Whitebeard's replacement among the Yonkou, ''the'' mightiest pirates in the world, each of them powerful enough to make the Marines and the World Government crap their pants.]]
** Buggy the Clown is an interesting example. On his first appearance, he's the arc's BigBad. Shortly afterwards, he comes back to take revenge on Luffy, and the only thing that keeps him from succeeding is being struck by lightning. He doesn't appear again until a few hundred chapters later, when the SortingAlgorithmOfEvil has left him in the dust. But one thing leads to another, resulting in him amassing a powerful crew from [[TheAlcatraz Impel Down]] [[spoiler:and becoming a Shichibukai after the time-skip.]] Yeah, he's a nightmare in the eyes of the general public, but the Straw Hats and everyone beyond the fourth wall knows that he's just a [[FakeUltimateHero Fake Ultimate Villain]]…that is, unless he's [[TookALevelInBadass Taken a Level in Badass]] during the time skip, but that's yet to be seen.
** Another example is Eustass Kid, who managed to get his 470,000,000 Beli bounty by sheer quantity of criminal activities, rather than being regarded as a significant threat to the World Government.
* The Noah from ''DGrayMan''. All of them regular humans until [[InTheBlood their cursed lineage]] makes them spontaneously reincarnate into supernatural {{Omnicidal Maniac}}s.
** And then it turns out that [[spoiler:since the Noah's souls are those of the original survivors of the biblical Flood ([[MeaningfulName notice the name?]]), ''everyone on the planet shares their lineage'', meaning that absolutely anyone could potentially turn out to be their host]]. Can you smell the ParanoiaFuel?
* Jellal Fernandez in ''Manga/FairyTail'' started out as a slave working under the oppression of a ReligionOfEvil. Watching his best friend and love interest be brutally tortured and being even ''more'' brutally tortured himself, along with subtle {{brainwash|ed}}ing by a false god, turned him into an incredibly powerful mage whose powers come directly from celestial objects (such as meteors, among other things). He also managed to pull off a perfect EvilPlan, and it was only by devouring [[DeathRay Etherion]] that Natsu was able to summon the power to defeat him.
** [[spoiler:He is later healed by Wendy and becomes a good guy, although he is still one of the most powerful characters in the series.]]
* Tongpu aka Mad Pierrot from ''Anime/CowboyBebop'' was originally an average man who had volunteered for an experiment to become the ultimate super human, the resulting experiments drove him completely insane and he became a bulletproof, psychotic SerialKiller with the mind of a child.
* The D-Reaper from ''Anime/DigimonTamers''. It began as an extremely simple computer program, designed to delete any other program that grew beyond its purpose. Then the Digital World came into being, and the Reaper decided that not only did the Digimon qualify, ''so did we''. It also had an increase in power over its lifespan, going from ridiculously simple computer program to nigh-unstoppable, city-devouring EldritchAbomination.
** Impmon also went from a [[BoisterousWeakling not particularly powerful]] {{jerkass}} to the very powerful [[OmnicidalManiac Beelzebumon]], going so far as to [[spoiler:kill Leomon]] before his later [[spoiler:HeelFaceTurn]].
* Suitengu, the BigBad of ''SpeedGrapher'' started out as a nice (possibly SpoiledSweet) Japanese teenager who loved his little sister. Then, {{Evil Debt Collector}}s [[DrivenToSuicide drove]] [[ParentalAbandonment his parents]] [[DrivenToSuicide to suicide]], and he and his sister were taken as slaves- she was sold into prostitution and he was made into a ChildSoldier immediately after some rich guy paid to rape him. After surviving a bunch of battles, he was badly injured, and some scientists decide to do a bit of PlayingWithSyringes and make him into a PersonOfMassDestruction (he also gets a BloodbathVillainOrigin when he slaughters the soldiers who tried to cover up the experiment by killing him). After returning to Japan, within a period of about a decade, he goes from "some guy" to knowing (and knowing the dirt on) the most powerful people in Japanese society.
* ''Manga/{{Naruto}}''
** Kabuto Yakushi starts out as an experienced Genin [[spoiler:who's actually a high-level spy for [[BigBad Orochimaru]]]], but he eventually surpasses his already legendary leader in power and ends up [[spoiler:co-leading an evil army of resurrected legendary ninja and Venus Flytrap monsters created from the DNA of one of the most powerful ninja ever.]]
** [[spoiler:BigBad Tobi]], who turns out to be none other than [[spoiler: Obito Uchiha]]. That's right folks, the same kid that [[spoiler: spent his childhood [[EpicFail failing at everything]], [[AllLoveIsUnrequited pining for Rin]], [[TheRival feeling jealous of Kakashi]], and pretty much being the [[IdiotHero Naruto]] of his day]], is now the guy who [[spoiler: indirectly killed Naruto's parents (one of which was his own ''sensei'') by taking control of Kurama and unleashing him on Konoha, took part in the Uchiha massacre, corrupted Nagato and later Sasuke, co-led the aforementioned evil army against the five great powers of the ''Naruto'' universe and is now working to unleash the universe's resident Satan (albeit depowered somewhat), to say nothing of a whole laundry list of additional heinous acts he committed between his "death" and the current story.]]
** [[spoiler: Pain]] was once a normal kid, not even a shinobi as well as a StreetUrchin orphan, who [[spoiler: with Jiraiya's teachings, became the leader of the most powerful evil organization, killed the original leader of the Hidden Rain, along with his entire network of people who knew him and became a PhysicalGod who destroyed the Leaf village effortlessly.]]
** Gaara's somewhat of a lesser example. As a child, Gaara made many attempts to connect to the people of Sunagakure, all of whom feared him because of his connection with Shukaku. Then his uncle, the only person shown to have ever loved and cared for him at all attempted to murder him [[spoiler:under the orders of Gaara's father, the Fourth Kazekage.]] All of that was enough to turn Gaara into a sociopath by the age of ''six'', and a serial killer by the age of '''''twelve'''''. Naruto's intervention was what would finally set him straight and help reverse some of the damage.
* ChirinNoSuzu has Chirin, who starts out as a cute little lamb, grow up and become a ram who just looks demonic.
* The seemingly cute and harmless Misaki actually became an EldritchAbomination threat to the multiverse in ''TenchiMuyo''. The author had foreshadowed this but everyone had assumed he was joking until it actually happened.
* ''HunterXHunter'' has the Chimera Ants, initially a species of small insects that take on traits of the animals they eat; other than that, they're garden variety bugs. There even first mentioned by a character as a dining delicacy. That's until a rare six foot tall specimen starts eating literally eating everything from animals to Nen users, creating an army of animal hybrids capable of fighting and overpowering the elite officials of the Hunter Organization. And her heir offspring eventually gets so strong, that he's the closest thing to a PhysicalGod before [[spoiler: a virus kill him off in order to prevent him from destroying humanity]].
* The very first villain to appear in ''Anime/TheBigO'', and one of the few to make a repeat appearance without being an outright BigBad, is Beck - a no-name low-level crook who wound up working as a go-between and muscle for a secret conspiracy between a MadScientist and a CorruptCorporateExecutive. That is, until he betrayed them both and stole the HumongousMecha they'd been developing in secret, and then proceeded to stomp through downtown in order to rob the Mint like an avaricious Godzilla. Between all the HumongousMecha and {{Kaiju}} that the titular robot has fought throughout the series, Beck's record remains the best, returning to challenge Roger four times - arguably five if you count [[spoiler:using his abilities to make the BigBad and TheDragon's [[HumongousMecha Bigs]] operational in time for the GrandFinale.]] And on top of that, he's responsible for releasing the most destructive weapon in the series when [[spoiler: he tells Dorothy how to activate Big O's [[WaveMotionGun Final Stage]] ]]. He's very hard to take seriously at ANY point, but really, you probably SHOULD...
** And in the manga, he manages to get his hands on a "Gigadeus", completely trashing the Big O and nearly winning in one of the [[MindScrew trippiest sequences]] in the series.
** A perhaps more conventional example is Schwarzvald - once upon a time, he was just an IntrepidReporter, driven to discover the truth about the City of Amnesia while working on his great manuscript in a tiny, run-down apartment. Then his search for the truth drove him to explore the [[DugTooDeep vast network of underground tunnels beneath the city]], and what he found made him GoMadFromTheRevelation. Next thing you know, he's reappeared covered in bandages, trying to teach people the 'meaning of fear', and generally acting like a combination of The Joker, Scarecrow, and a mummy. With a HumongousMecha. Which can fly.
* Griffith of ''{{Berserk}}'' began as nothing more than a simple commoner who had big dreams of becoming king. Over the years, he put together a band of thieves, which later became a mercenary army, and then became the highest-ranking general in Midland's army. He then suffered a tragic [[FallenHero fall from grace]] that left him disfigured and physically incapable of realizing his dream...until the Eclipse passed, where he became one of the five demon kings of the Godhand and one of the singlemost powerful individuals in the world.
* In ''ProjectARMS'', Alice was a sweet girl (albeit a genius, but no one outside of the Egrigori knew of her existence) who took care of the other experimental children and considered Keith White to be her dear "father". She gets shot while trying to see what the outside world is like, and ends up merging with an artificial alien life form, causing her to split into White Alice and [[BigBad Dark Alice]]. As Dark Alice, she first tries to [[spoiler: get the Jabberwock to destroy all of New York, ultimately aiming to get the city blown up by a nuclear bomb]]. When that doesn't work, she [[spoiler:possesses Katsumi, takes over her body, and tries ''again'' to destroy the world with her power. She only stops when Katsumi and Ryo offer her love, [[CrowningMomentOfHeartwarming which was all she ever actually wanted]].]]
* In ''AxisPowersHetalia'', Russia went from being a tiny, weak country under the control of the Mongols and constantly picked on by bigger nations, to being much larger and stronger. This would not be so bad, except that years of revolution and bloodshed mean have left him a PsychopathicManchild who terrifies pretty much all of the other nations he runs into. Exactly how bad he actually is is uncertain. He's shown snapping and firing on a crowd of protestors in the Bloody Sunday comic and it's implied that he whipped Lithuania when the Baltics were under his control, but he certain is not the [[FanNickname rapetruck]] he's portrayed as in a lot of {{fanon}}.
** From England's perspective, America could be seen as this. He went from a young child of a colony to declaring independence as a strong country to being a global superpower.
* [[spoiler: Shion, and, well, every character]] from ''HigurashiNoNakuKoroNi'' becomes this at one point or another. Special points go to [[spoiler: Shion]] becasue [[spoiler: she]] is introduced as a minor side-character rather than a main one. What makes this one so horrifying is that the first portrayal of [[spoiler: her]] is RADICALLY different from the portrayal of [[spoiler:her]] as pure evil in [[spoiler: Meagashi-hen]].
* Dio Brando of ''Manga/JoJosBizarreAdventure'' began life as an intelligent, but frustrated (and nigh psychotically [[AmbitionIsEvil ambitious]]) son of a petty thief in England, 1800s. From there, he quickly became a ''vampire'', a [[spoiler:HeroKiller]], attempted to raise a zombie army to take over the world, gained the psychic power to [[spoiler:[[TimeStandsStill freeze time]]]], and even after his death, continues to weigh heavily on the setting. It gets to the point that Dio mentored a FromNobodyToNightmare villain of his ''own'', [[spoiler:Father Enrico Pucci]], who through him, [[spoiler:''succeeded in rewriting the entire universe!'']]
* ''Manga/{{Bleach}}'': Done in the [[{{Anime}} Gotei 13]] [[{{Filler}} Invasion Arc]]. [[ArcVillain Ouka Yushima]] began as a very weak and pathetic shinigami who didn't have the strength to fight in battle or master his [[EmpathicWeapon zanpakutou]]. He therefore decided to split himself and his zanpakutou apart into two mod-soul beings that could master his powers. The one mod-soul was the apparent villain Kageroza Inaba and the second mod-soul was the apparent heroine Nozomi Kujou. Kageroza could manipulate space-time, bring the dead back to life and was so powerful he could defeat Ichigo and Yamamoto at the same time. Nozomi could absorb reiatsu, steal the powers of others, combine them with her own power and use it as super-powerful attack, and heal better than even Orihime, she was so powerful she could fight Kageroza even when Yamamoto himself could not. Where the mod-soul powers came from is never explained as none of them were abilities of the original zanpakutou, but when the two were recombined back into Yushima, he was able to combine all these powers to destroy the very existence of Soul Society itself. Being an IneffectualLoner, he was defeated by both ThePowerOfFriendship and ThePowerOfLove.
* In ''FistOfTheNorthStar'', the three Rasho, warlords of the Land of Asura, qualify, since only an Asura who has proven himself by killing hundreds of other warriors is worthy of having a name, let alone rising to the level of Rasho.
* Midora from ''Manga/{{Toriko}}'' was a nameless baby born for the sole purpose of being ''fed to livestock''. Now he's one of the most powerful beings on the planet who can literally eat everything around him.
* Pretty much any Puella Magi in any version of ''Anime/PuellaMagiMadokaMagica'' could qualify; most of them were ordinary girls upon making their [[DealWithTheDevil contract]], and many of those were so desperate they needed the wish. Upon making the contract, they become powerful magical warriors who tend to treat the rest of humanity as livestock. [[spoiler: When they [[TheCorruption become Witches]], they almost universally qualify; particularly the apocalyptically powerful Kreimhild Gretchen, born from someone who described herself as [[HeroicSelfDeprecation not having any real talents.]]]] Homura is a particular example; as we learn, before the series, she was a meek and flustered IllGirl who seemed fairly weak even after contracting. [[spoiler: By the end of TheMovie, she's a GodOfEvil.]]
* Seto Kaiba from the original ''Anime/YuGiOh'' was, along with his brother, a penniless orphan until he won a bet with billionaire Gozaburo Kaiba and was adopted by him. He then proceeded to take over [=KaibaCorp=] in a hostile takeover, remake it as a totally different company, and before his eighteenth birthday, become, along with Pegasus, one of the two biggest names in Duel Monsters. Of course the "nightmare" part comes in with how ruthless and cruel he could be early on, being almost as bad a corporate tycoon as his father (and in the manga version, trying to ''murder'' Yugi and his friends in the "Death-T" complex). He toned down a little later, but was still a man to be feared.
* Lots of examples in ''Anime/YuGiOh5Ds'':
** Jack Atlas was just "Satellite Scum" before Team Satisfaction folded, and Jeagar offered him a chance to escape. One act of theft and betrayal later, he was on his way to being the King of the Riding Duels, and one of the most intimidating opponents on the circuit. He mellowed a little after losing to Yusei (and ''a lot'' later on) but the past remains.
** Kiryu was a far darker nightmare. Also a nobody from Satellite, he was the reason Team Satisfaction folded, when he turned to violent attacks on security, leading to his arrest, death after mistreatment in prison, and rebirth as a Dark Signer.
** ''Every one'' of the android villains from the BadFuture of season two - Aporia, Paradox, Bruno, and Z-One himself - were nothing but four common soldiers in the ragtag army of civilians who were brave enough to try fight the horde of Meklords; they were simply the only ones lucky enough to survive. Unfortunately, their attempt to SetRightWhatOnceWentWrong turned them into {{Well Intentioned Extremist}}s who caused Zero Reverse and almost made it worse.
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