[[folder: Fridge Horror ]]
* Nothing really pertaining to do with the main story, but if you hit dying status with Barry Burton in the Mercenaries Reunion, you'll bear witness to the poor guy yelling "Don't let me die!" At first this seems nothing more than a dying plea, but if you're a hardcore Resident Evil fan then you will know Barry has a wife and two daughters so in essence he's begging you to save him from leaving his wife a widow and his daughters fatherless!
** If it makes you feel better, keep in mind that ''VideoGame/ResidentEvil5'' is set about 10 years after the Mansion Incident. Barry's daughters are more than likely college-aged by now.
* [[spoiler: Jill's]] position after being freed from their BrainwashedAndCrazy state since being held captive by Wesker for three years, and how [[spoiler: Jill]] hasn't been referenced much after the events of the Kijuju outbreak. For all we know [[spoiler: Jill]] had given up their position of the B.S.A.A and is likely undergoing serious counselling for committing terrorist acts, albeit beyond their control, which had ended up causing the deaths of many innocent people to advance Wesker's plan. And let's not forget that [[spoiler: Jill]] was also used as a guinea pig the entire time, which may eventually end up creating serious health problems in the long run.
[[folder: Fridge Brilliance ]]
* It seems that overdose of his own serum just made Wesker... ''drunk''. He doesn't lose his speed nor strength nor healing, but with each shot he staggers more when walking, he gets a headache, his vision blurs and his ears start ringing, and there's a drastic change in his behavior and speech. After the first dose of serum, he completely loses his usual cool, becomes loud, angrily raising his voice at Chris (rare for him), spits some God complex bullshit, and is easily beaten by Sheva. After the second... well, he does such things that he'd never do if sober, but would be prone to if drunk, such as shouting "comic book villain's ideas", completely forgetting that Chris & Co eat ''superstrong'' monsters for supper, while the ''superfast '''Wesker''''' has teased them for years, and the whole "Look, Chris, I just turned my arms into awful CombatTentacles ''permanently'' so we can fight like men, isn't it cool?" thing. And his final TakingYouWithMe, while he could reach a rock and pull himself from lava much easier.
** Don't forget, the whole point of the overdose was because it would disrupt his powers; although he kept them for a while, it makes sense that he'd go for the Uroboros because he's got no choice -- his SuperSpeed and SuperStrength are already fading away, or else he would have been ''even harder'' to defeat in the plane than he already was!
* Wesker's final form has been said to be a bit of a ClippedWingAngel; he's got exposed weak points, is no longer as fast, and can be defeated by repeated stabbing. Worth noting, however, is the fact the final battle takes place in a volcano; the earlier Uroboros you fought displayed an aversion to heat (the first being killed in a furnace and the second being particularly vulnerable to flamethrowers). He's in the absolute worst environment he could've been in to expose himself to Uroboros. Still, granting him an out on this ground doesn't excuse the fact that Sheva and Chris didn't immediately burst into flames, but still.
* I always thought that Jill's battle catsuit was purely for fanservice (and realistically that probably was the intention behind it), but the more I think about it, the more I think that it actually makes sense in-universe. Jill is second only to Chris and possibly Spencer as Wesker's greatest enemy, and as we all know, everything Wesker does he does UpToEleven. So with that in mind, it makes perfect sense that Wesker would seek ''absolute revenge'' upon her. Killing Jill wasn't enough - he wanted to ''hurt'' her and he wanted to ''hurt'' Chris more than mere death was capable of. After all, why has Wesker kept that STARS handgun of his after all these years? Is it because the gun is just that good, or is it to taunt Chris and Jill as to his betrayal and the friends that he has killed? By forcing her to wear this obviously ridiculous and impractical garment that shows off her boobs, is so tight that she might as well be wearing nothing at all, the blonde dye-job, and of course those ridiculous heels; Wesker is bragging to the world (and more importantly Chris) that he now not only owns Jill's mind, but her body too.
* The fact that infection makes its host revert to a more primal, antiquated state is actually consistent with ''4''. The village's people were Puritan-esque: burning and crucifying their victims, attacking with farming implements despite modern weapons being right there in their houses, obsessively obeying the church-bell's call even though doing so allowed their 'prey' to escape, etc. It's just that the village's inhabitants weren't African, so they reverted to different 'traditions' than the infected who were.