* ''WesternAnimation/ActionMan'': Alex (choleric), Rikki (melancholic), Grinder (phlegmatic), and Fidget (sanguine).
* From ''WesternAnimation/AdventuresFromTheBookOfVirtues'', Plato (phlegmatic), Aristotle (melancholic), Socrates (choleric), Aurora (sanguine), and Zack and Annie (both leukine).
* In ''WesternAnimation/AdventuresOfTheGalaxyRangers'', The Series 5 Rangers are also a quaternity. The series actually has very few episodes where all four are heavily involved, mostly breaking the team up into groups of two or three.
* ''Franchise/AlvinAndTheChipmunks'': Alvin (choleric), Simon (melancholic), Theodore (sanguine), and Dave (phlegmatic).
* [[FanNickname Ozai's Angels]] ([[MyFriendsAndZoidberg and]] [[TheOneGuy Zuko]]) of ''WesternAnimation/AvatarTheLastAirbender'': [[TheChessmaster Azula]] (choleric), [[ByronicHero Zuko]] (melancholic, who pretends to be choleric), [[TheQuietOne Mai]] (phlegmatic), and [[{{Cloudcuckoolander}} Ty Lee]] (sanguine).
** The [[FanNickname Gaang]] themselves become one of these as well during the second season: Toph (choleric), Sokka (melancholic), Aang (sanguine), and Katara (phlegmatic).
** The Avatars before Aang also fit: Kyoshi (choleric), Yangchen (melancholic), Roku (phlegmatic), and Kuruk (sanguine).
** ''WesternAnimation/TheLegendOfKorra'' follows this perfectly: [[HotBlooded Korra]] (choleric), [[TallDarkAndHandsome Mako]] (melancholic), [[UptownGirl Asami]] (phlegmatic), [[TheCharmer Bolin]] (sanguine), and [[TheMentor Tenzin]] (leukine).
* ''[[WesternAnimation/BatmanTheAnimatedSeries The New Batman Adventures]]'': Though they rarely all worked together in the same episode, there was still a four-person "bat family." Robin (Tim Drake) is sanguine; Nightwing (Dick Grayson) is choleric; Batman is melancholic (as if it had to be said; he basically defines the temperament); and Batgirl is phlegmatic. Catwoman was the back-up choleric; in one episode, she and Nightwing even team up because of their similar personalities.
* And from ''WesternAnimation/BatmanBeyond'', we've got the Royal Flush Gang who also form a [[FiveManBand Five Man Band]] with the robotic Ace, who doesn't have a personality so they fit both categories: Authoritarian King (choleric), conflicted Ten (melancholic), Queen -- a proper lady who tries to keep the family united (phlegmatic), and fun-loving Jack (sanguine).
* ''WesternAnimation/BeastWars'': The four main Maximals: Optimus Primal (choleric), Rattrap (melancholic), Rhinox (phlegmatic), and Cheetor (sanguine).
* ''WesternAnimation/BeavisAndButthead'': Beavis (sanguine), Butt-Head (choleric), ''WesternAnimation/{{Daria}}'' (melancholic), and Stewart (phlegmatic).
* ''BlinkyBill'': Blinky Bill and Marcia Marsupial Mouse (choleric), Nutsy Koala (melancholic), Flap Platypus (phlegmatic), Splodge Kangaroo (sanguine), and Shifty Dingo (leukine).
* ''{{Bonkers}}'': Lucky Piquel (choleric), Fawn Deer (melancholic), Fallapart Rabbit (phlegmatic), and Bonkers (sanguine).
* ''CaptainPlanet'': Kwame (melancholic - earth), Wheeler (choleric - fire), Linka (sanguine - wind / air), Gi (phlegmatic - water), and Ma-ti (leukine).
* ''WesternAnimation/CodeLyoko'': [[BirdsOfAFeather Yumi and Ulrich]] (melancholic), Jeremie (phlegmatic), Odd (sanguine), and Aelita (leukine).
* ''WesternAnimation/CodenameKidsNextDoor'': Numbuh One - Nigel Uno (melancholic), Numbuh Two - Hoagie P. Gilligan Jr. (phlegmatic), Numbuh Three - Kuki Sanban (sanguine), Numbuh Four - Wallabee Beetles (choleric), and Numbuh Five - Abigail Lincoln (leukine).
* ''WesternAnimation/DanVs'': Dan (choleric), Elyse Jr. (melancholic), Chris (phlegmatic), Mr. Mumbles (sanguine)
* ''WesternAnimation/DannyPhantom'''s four-member "Team Phantom" can exhibit these: Danny is choleric for good leadership skills, but highly emotional personality; Jazz (though not depressive) is melancholic for her kind-but-perfectionist persona; Sam is phlegmatic because she's a responsible [[DeadpanSnarker Stoic Goth]]; and Tucker is sanguine for he's fun loving.
* The Fashion Club from ''WesternAnimation/{{Daria}}'' : Quinn (melancholic), Sandi (choleric), Stacy (sanguine), and Tiffany (phlegmatic).
** Daria's family: Quinn (sanguine), Helen (choleric), Daria (melancholic), and Jake (phlegmatic).
** As far as Lawndale High School: Mr. [=DeMartino=] (choleric), Mr. O'Neill (phlegmatic), Kevin and Brittany (sanguine), and Mack and Jodie (melancholic)
** Finally, there's [[FakeBand Mystik Spiral]]: Trent Lane (phlegmatic), Jesse Moreno (melancholic), Max Tyler (choleric), and Nicholas Campbell (sanguine).
* ''WesternAnimation/DastardlyAndMuttleyInTheirFlyingMachines'': Dick Dastardly (choleric), Klunk (melancholic), and Zilly (phlegmatic), and Muttley (sanguine).
* ''WesternAnimation/EdEddNEddy'': Ed (sanguine/phlegmatic), Edd (melancholic), and Eddy (choleric).
** As for the kids: Sarah and Kevin (choleric), Rolf and Nazz (phlegmatic), Jonny (sanguine), Jimmy (melancholic), and Plank (leukine).
** And for the Kankers: Lee & Marie (sanguine/choleric) and May (sanguine/phlegmatic).
* ''WesternAnimation/FamilyGuy'':
** Neighbors: Peter (choleric), Joe (melancholic), Cleveland (phlegmatic), and Quagmire (sanguine).
** Family: Peter (choleric) Stewie (choleric/sanguine), Lois (phlegmatic), Meg (melancholic), Brian (melancholic/phlegmatic), and Chris (sanguine).
* ''WesternAnimation/{{Futurama}}'': Fry (phlegmatic), Leela (choleric), Bender (sanguine), and Farnsworth (melancholic).
** Other characters: Zoidberg (leukine), Hermes (choleric), Nibbler (melancholic), Amy (sanguine), and Scruffy (phlegmatic).
* ''WesternAnimation/GravityFalls'': Grunkle Stan (choleric), Mabel (sanguine), Dipper (melancholic), Soos and Wendy (phlegmatic).
* ''WesternAnimation/GreenLanternTheAnimatedSeries'': [[CowboyCop Hal Jordan]] (sanguine), [[DrillSergeantNasty Kilowog]] (choleric), [[SpaceshipGirl Aya]] (phlegmatic) and [[TheAtoner Razer]] (melancholic).
* ''WesternAnimation/{{Grojband}}'': Corey (sanguine), Laney (phlegmatic), Kin (melancholic), and Kon (choleric).
** Also, Trina (choleric), Mina (melancholic), Kate and Allie (sanguines), and Nick (phlegmatic).
* A good chunk of the classic ''Creator/HannaBarbera'' cartoons characters that are connected to the Yogi Bear universe fit this mold if you put them together (think of all of the main characters in ''WesternAnimation/YogisTreasureHunt'' minus Ranger Smith, Snooper and Blabbermouse, Auggie Doggie and Doggie Daddy with Baba Looey included). Yogi (sanguine), Quick Draw [=McGraw=] (choleric, albeit a more dim-witted and incompetent example), Snagglepuss (melancholic, although mostly in terms of mannerisms since he's much more upbeat and cheerful than most examples), Huckleberry Hound (phlegmatic), Boo Boo and Baba Looey (leukine), and Top Cat (sanguine/choleric).
* The four main kids on ''WesternAnimation/HeyArnold'': Arnold (phlegmatic), Helga (choleric), Gerald (sanguine), and Phoebe (melancholic).
* ''WesternAnimation/InvaderZim'': Zim (choleric), Dib (melancholic), Gaz (phlegmatic), and Gir (sanguine).
* ''WesternAnimation/JackieChanAdventures'':
** The Dark Hand Enforcers ([[HeelFaceTurn after Tohru left]]): Hak Foo (choleric), Chow (melancholic), Ratso (phlegmatic), and Finn (sanguine).
** The heroes once Tohru joined them: Uncle (choleric), Jackie (melancholic), Tohru (phlegmatic), and Jade (sanguine).
* ''[[Disney/TheJungleBook Jungle Cubs]]'': Shere Khan (choleric), Bagheera (melancholic), Baloo (phlegmatic), and Louis (sanguine).
* The seven founding members of the ''WesternAnimation/JusticeLeague'' seem to fit this pretty well for the most part: Superman (leukine), Batman and Green Lantern (melancholic), Wonder Woman and Hawkgirl (choleric), Flash (sanguine), and Martian Manhunter (phlegmatic).
* ''WesternAnimation/{{Kaijudo}}: Rise of the Duel Masters'' has three groups:
** The main trio: Ray (choleric/sanguine), Gabe (melancholic), and Allie (sanguine).
** The Duel Masters: Nigel (choleric), Nadia (melancholic), Chavez (phlegmatic), Kimora (sanguine), and Jaha (leukine).
** The Choten's side: Alakshmi (choleric), Suguru/[[spoiler: Ken Okamoto]] (melancholic), The Choten (phlegmatic), Fingers (sanguine), and Heller (leukine).
* The four members of "Team Possible" in ''WesternAnimation/KimPossible'': Kim (choleric), Ron (phlegmatic), Rufus (sanguine), and Wade (melancholic).
* ''WesternAnimation/KingOfTheHill'': Hank Hill (melancholic), Dale Gribble (choleric), Boomhauer (phlegmatic), and Bill Dauterive (sanguine).
** The Hill family also qualifies: Hank (melancholic), Peggy (choleric), Bobby (phlegmatic), and Luanne (sanguine).
* LittlestPetShop: Zoe and Pepper (choleric), Russell and Sunil (melancholic), Penny and Blythe (phlegmatic), Minka and Vinnie (sanguine).
* ''WesternAnimation/MenInBlack'': Jay (sanguine), Kay (melancholic), Elle (phlegmatic), and Zed (choleric).
* {{Metalocalypse}}: Dethklok: Nathan (melancholic), Pickles (choleric), Skwisgaar (phlegmatic), Murderface (sanguine) and Toki (leukine).
* ''WesternAnimation/MrBogus'': In one of the rare cases that Bogus and his cousin Brattus get paired up with their enemies, Ratty and Mole, it goes like this: Bogus (melancholic), Brattus (sanguine) Ratty (choleric), and Mole (phlegmatic).
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'':
** Choleric: Applejack (extroverted, confident, and stubborn) and Rainbow Dash (ambitious and prone to aggression).
** Melancholic: Twilight Sparkle (introverted, organized, and has high expectations) and Rarity (work-focused and obsessed with detail).
** Phlegmatic: Fluttershy (introverted, compassionate, and docile).
** Sanguine: Pinkie Pie (fun-loving, loud, and driven to seek others' attention).
** Leukine: Spike (the most well-balanced of the seven).
** Princess Luna (melancholic), Princess Celestia (phlegmatic), and Princess Cadance (sanguine).
*** Works for the four main villains, too: Queen Chrysalis (choleric), Nightmare Moon (melancholic), King Sombra (phlegmatic), and Discord (''definitely'' sanguine).
* ''[[OscarsOasis Oscar's Oasis]]'': On the rare ocassions Oscar teams up with the trio: Popy (choleric), Buck (melancholic), Oscar (phlegmatic), and Harchi (sanguine).
* ''WesternAnimation/{{Phineas and Ferb}}''
** Fletcher family: Lawrence Fletcher (melancholic), Linda Flynn-Fletcher (sanguine), Candace Flynn-Fletcher (choleric),Phineas Flynn-Fletcher (sanguine) Ferb Fletcher- (phlegmatic)
** The Johnson family: Jack Johnson (melancholic), Hawkeye Johnson (sanguine), Jeremy Johnson (phlegmatic), Suzy Johnson (choleric)
** The kids: Baljett Tjinder (melancholic), Buford van Stomm (choleric), Isabella Garcia Shapiro (phlegmatic), Irving Du Bois (leukine)
** The teens: Stacy Hirano (sanguine), Jenny Brown and Vanessa Doofenshmirtz (melancholic), Coltrane and Monty Monogram(phlegmatic), Albert Du Bois (choleric)
** OWCA: Major Francis Monogram (choleric), Carl Karl and Perry the Platypus (leukine)
** Other: Dr. Heinz Doofenshmirtz (sanguine/choleric), Charlene Doofenshmirtz (melancholic)
* ''WesternAnimation/ThePowerpuffGirls'': Bubbles (sanguine), Buttercup (choleric), Blossom (melancholic), Professor Utonium (phlegmatic)
* ''WesternAnimation/{{Recess}}'':
** Melancholic: T.J. Detweiler (Team leader, determined, charismatic).
** Choleric: ([[DoNotCallMePaul Ashley]]) Spinelli (Hot-tempered, ambitious).
** Choleric/Melancholic: Vince [=LaSalle=] (Hard-working perfectionist who's also ambitious and determined).
** Phlegmatic: Gretchen Grundler (Smart, hard-working).
** Sanguine: Mikey Blumberg (Extroverted, optimistic).
** Leukine: Gus Griswald (Sweet, shy).
** For the three main faculty: Miss Finster (choleric), Principal Prickly (melancholic), and Miss Grotke (sanguine).
* ''WesternAnimation/RegularShow'': Benson (choleric), Skips and Pops (melancholic), Muscle Man and Rigby (sanguine), High Five Ghost and Mordecai(phlegmatic).
* ''WesternAnimation/RocketPower'': Otto (choleric), Reggie (melancholic), Twister (sanguine), and Sam/Squid (phlegmatic).
* ''RockosModernLife'': Ed Bighead (choleric), Filburt (melancholic), Rocko (phlegmatic), and Heffer (sanguine).
* The human characters of ''WesternAnimation/ScoobyDooMysteryIncorporated'' appropriately [[ColourCodedForYourConvenience match their own color schemes]]. Daphne (Red Hair) is sanguine, the most cheerful and optimistic of the group. Velma (Yellow Sweater) is choleric, exhibiting leadership when solving the mystery, and is rather pushy, and a rather violent {{Tsundere}} at her worst. Fred is melancholic as he is obsessive (when it comes to traps) and emotionally high strung (when Daphne is in danger). He wears... white, rather than black, kinda crashing his color coded bit. Shaggy (Green Shirt) is phlegmatic, the NonActionGuy who runs from anything spooky, and is only there to react to the situations. Scooby (Blue Collar) fits into leukine, as he is rather non-confrontational.
** The main villains, as well: Mayor Jones (Phlegmatic), Professor Pericles (Melancholic), Mr. E (Leukine), and Brad & Judy (sanguine).
* ''WesternAnimation/SouthPark:'' [[UnsympatheticComedyProtagonist C]][[BrilliantButLazy a]][[ManipulativeBastard rt]][[DangerouslyGenreSavvy man]] (choleric), [[InsufferableGenius Ky]][[TheHeart le]] (melancholic), [[OnlySaneMan St]][[DeadpanSnarker a]][[TheEveryman n]] (phlegmatic), [[TheHedonist Ke]][[ButtMonkey nny]] (sanguine), and [[ChildrenAreInnocent Bu]][[PollyAnna tt]][[GotVolunteered e]][[KiddieKid rs]] (leukine).
** The Marshes: Randy (sanguine), Sharon (melancholic), Stan (phlegmatic), and Shelly (choleric)
* The teachers from ''WesternAnimation/StickinAround'': Mr. Lederhosen (choleric), Principal Coffin (melancholic/phlegmatic), and Ms. Mobley (sanguine).
* ''WesternAnimation/StormHawks'': Aerrow (choleric), Stork (melancholic), Junko (phlegmatic), Finn (sanguine), and Piper (leukine).
** The Cyclonians, as well: Ravess (choleric), Master Cyclonis (melancholic), Dark Ace (phlegmatic), and Snipe (sanguine).
* ''WesternAnimation/TaleSpin'': Rebecca (choleric), Kit (melancholic), Wildcat (phlegmatic), Baloo (sanguine), and Molly (leukine).
** And as in the comics, the Doom Patrol with Mento replacing Niles Caulder as the choleric leader.
* To quote the ''WesternAnimation/{{Teenage Mutant Ninja Turtles|1987}}'' theme song: Leonardo leads (melancholic); Donatello does machines (phlegmatic); Raphael is cool, but rude (choleric); Michaelangelo is a party dude (sanguine).
* ''WesternAnimation/TeenTitans'': Robin (melancholic), Cyborg (choleric), Raven (phlegmatic), Beast Boy (sanguine) and Starfire (leukine).
* ''WesternAnimation/TheAmazingChanAndTheChanClan'', two examples.
** Four youngest children: Flip (choleric), Mimi (phlegmatic), Nancy (melancholic), and Scooter (sanguine).
** The middle four: Anne (choleric), Tom (melancholic), Suzie (phlegmatic), and Alan (sanguine).
* ''TheAmazingSpiez'': Lee (choleric), Marc (melancholic), Megan (phlegmatic), and Tony (sanguine). Megan and Marc sometimes switch roles.
* ''WesternAnimation/TheBackyardigans'': Pretty hard to qualify. Technically, all of them are sanguine, but Pablo is probably the most. As for the others: Tasha (choleric), Uniqua (melancholic, though not depressive, since we're talking about a little kids' show), and Tyrone (phlegmatic). Austin starts out as phlegmatic, then moving on to melancholic; these days, he's starting to become more leukine.
* ''TheBoondocks'': Robert (choleric), Huey (melancholic), Tom (phlegmatic), Riley (sanguine), and Jazmine (leukine).
* The five household appliances from ''TheBraveLittleToaster'': Lampy (choleric), Kirby (melancholic), Toaster (phlegmatic), Radio (sanguine), and Blanky (leukine).
* ''WesternAnimation/TheFlintstones'': Fred (choleric), Betty (melancholic), Wilma (phlegmatic), and Barney (sanguine).
* ''WesternAnimation/TheJetsons'': George (sanguine), Jane (melancholic), Elroy (phlegmatic), and Mr. Spacely (choleric).
* ''WesternAnimation/TheLandBeforeTime'' series: Littlefoot (leukine), Cera (choleric), Petrie (melancholic, though oddly na´ve and trustful), Ducky (sanguine), and Spike (phlegmatic).
* The kids in Ms. Frizzle's class on ''TheMagicSchoolBus'':
** The boys: Ralphie (sanguine), Carlos (choleric), Tim (melancholic), and Arnold (phlegmatic).
** The girls: Wanda (sanguine), Keesha (choleric), Dorothy Ann (melancholic), and Phoebe (phlegmatic).
* ''ThePenguinsOfMadagascar'': Skipper (melancholic), Kowalski (phlegmatic), Private (sanguine), and Rico (choleric).
* ''WesternAnimation/ThePerilsOfPenelopePitstop'': Penelope is melancholic; Clyde is choleric; Dum-Dum and Pockets are phlegmatic; and the Hooded Claw (Sylvester Sneekly) is sanguine. Of the other characters: Softy (melancholic), Yak-Yak (sanguine), Snoozy (phlegmatic), and Zippy (leukine).
* ''Disney/ThePrincessAndTheFrog'' must have read this trope before it was written. Tiana (choleric), Louis (melancholic), Ray (phlegmatic), and Naveen (sanguine).
* ''WesternAnimation/TheSimpsons'':
** Homer (choleric), Marge (phlegmatic), Bart (sanguine), Lisa (melancholic), and Maggie (leukine).
** The regulars at Moe's Tavern: Homer (choleric), Barney (sanguine), Carl (melancholic), and Lenny (phlegmatic).
** The Bullies: Nelson (melancholic), Jimbo (choleric), Dolph (phlegmatic), and Kearney (sanguine).
* ''SpongebobSquarepants'': Spongebob (sanguine), Patrick (phlegmatic), Squidward (melancholic), and Mr. Krabs (choleric).
* ''WesternAnimation/TheVentureBrothers'': Brock Samson (choleric), Dean (phlegmatic), Dr. Venture (melancholic), and Hank (sanguine).
* The tender engines in ''ThomasTheTankEngine'': Gordon (choleric), Henry (melancholic), Edward (phlegmatic), and James (sanguine).
* ''WesternAnimation/ThunderCats2011'':
** Lion-O (melancholic), Pumyra (choleric), Panthro (starts out melancholic, gradually becomes more choleric), Cheetara (phlegmatic), Wilykit (phlegmatic/melancholic), Tygra (sanguine), and Wilykat (leukine).
** For the villains: Slithe (choleric), Vultaire (melancholic), Addicus (phlegmatic), Kaynar (sanguine), and Mumm-Ra (leukine).
** In the [[ThunderCats original series]], Tygra was the melancholic one while Panthro was choleric. Kit and Kat's temperaments were also reversed.
* ''WesternAnimation/TinyToonAdventures'': Babs (choleric), Buster (melancholic), Plucky (sanguine), and Hampton (phlegmatic).
* ''WesternAnimation/TitanMaximum'': Palmer (choleric), Sasha (sanguine), Jodi (phlegmatic), Willie (melancholic), and Leon (leukine).
** Originally, Palmer (choleric), Sasha (sanguine), Jodi (phlegmatic), Gibbs (melancholic), and Spud (leukine).
* The five main Autobots of ''WesternAnimation/TransformersAnimated'': Optimus Prime (choleric), Ratchet (melancholic), Prowl (phlegmatic), Bumblebee (sanguine), and Bulkhead (leukine).
* ''WesternAnimation/TransformersPrime'':
** Team Prime: Arcee and Ultra Magnus (choleric), Ratchet (melancholic), Bumblebee (phlegmatic), Bulkhead, Wheeljack and Smokescreen (sanguine), and Optimus (leukine).
** The Decepticons: Megatron and Starscream (choleric), Dreadwing and Predaking (melancholic), Soundwave (phlegmatic), Knock Out (sanguine), Breakdown and Shockwave (leukine).
* ''WesternAnimation/TransformersRescueBots'':
** The Rescue Bots are: Heatwave (melancholic), Chase (choleric), Boulder (sanguine), and Blades (phlegmatic).
* ''WesternAnimation/{{Trollz}}'': Ruby (Choleric), Amethyst/Onyx (Melancholic), Topaz (Sanguine), Sapphire (Phlegmatic).
* Most of the main characters of ''WesternAnimation/{{VeggieTales}}'' fit this mold; Bob the Tomato (choleric), Larry the Cucumber (sanguine), Junior Asparagus (leukine), Archibald Asparagus (melancholic), Jimmy Gourd (choleric/phlegmatic), and Jerry Gourd (phlegmatic).
* ''WanderOverYonder'': Wander (phlegmatic), Sylvia (sanguine), Lord Hater (choleric), Peepers (melancholic).
* The latter half of ''WesternAnimation/WheelieAndTheChopperBunch''; Chopper (choleric), Revs (melancholic), Hi-Riser (phlegmatic), and Scrambles (sanguine).
* ''Franchise/WinnieThePooh'': Pooh (phlegmatic), Tigger (sanguine), Rabbit (choleric), Eeyore (melancholic), and Piglet (leukine).
* ''WesternAnimation/XiaolinShowdown'': Raimundo (sanguine), Omi (melancholic), Clay (phlegmatic), Kimiko (choleric).
* ''WesternAnimation/YoungJustice'': Kid Flash (sanguine), Speedy (choleric), Robin (melancholic), and Aqualad (phlegmatic). After Speedy leaves, Superboy fills in for the choleric.
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