* The Light Warriors of ''Webcomic/EightBitTheater'': Red Mage is sanguine (emphasis on arrogant and self-indulgent); Thief is choleric (emphasis on narrow-minded and obsessive); Fighter is phlegmatic (emphasis on lazy and reactionary); and Black Mage is melancholic (emphasis on [[LonersAreFreaks independence]] and [[KillEmAll perfection]]).
* ''Webcomic/AxeCop'': Axe Cop (choleric), Flute Cop (phlegmatic), Sockarang (sanguine), and Uni-Man (melancholic).
* There are a lot of characters in the WebAnimation series ''[[WebAnimation/TheBearShow The Bear Show]]'', so they have their own Temperaments: Mario, John Cena and Peter Griffin (sanguine and choleric), Randy Orton, Stewie Griffin, Sheriff Woody, Link and Alberto Del Rio (choleric), Luigi, Daddy Bear, CM Punk and Star (sanguine), Triple H and Pikachu (melancholic), Kirby (phlegmatic), and Toad (eclectic).
* ''WebAnimation/TheBigLezShow'': Lez i0 (choleric), Sassy (phlegmatic), Norton (sanguine), and Clarence (melancholic).
* The four main characters of the WebAnimation series ''WebAnimation/BrokenSaints'' fit fairly well: Oran (choleric), Kamimura (melancholic), Raimi (phlegmatic), and Shandala (sanguine).
** Albeit, Shandala doesn't quite fit any of them, but her bright, cheerful, and compassionate nature recommend her most to sanguine.
* ''Literature/TheChroniclesOfTaras'' gives us (In ''Red Dementia'', the first installment): [[AlphaBitch Lyla "Ghost" Marten]] (choleric), [[AntiHero Taras Jacobs]] (melancholic), [[TheLancer Sandra "Jumpy" Janssens]] (phlegmatic), and [[TheHeart Tawna "Cutter" Jones]] (sanguine).
* An entire episode of the webseries ''WebSite/{{Cracked}} WebVideo/AfterHours'' is devoted to discussing how many famous groups of four adhere to this schema, even describing several groups already listed on this page (though it's worth noting that they have misattributed the sanguine qualities to choleric characters, and vice versa). As they are also a quartet, they even describe themselves (indirectly, through analogy to the Franchise/TeenageMutantNinjaTurtles).
** ''By their definition'': Michael (sanguine), Dan (phlegmatic), Soren (melancholic), and Katie (choleric).
* ''Webcomic/CryHavoc'' features Skoll as sanguine, Karcharoth as choleric, Hati as melancholic, and Fenrir as phlegmatic. These characteristics seem to drive them apart more than unite them, as is normal.
* ''Webcomic/CtrlAltDel'': Ethan (sanguine), Lucas (melancholic), Lilah (choleric), and Zeke (phlegmatic).
* Looking at the the questing team in ''Webcomic/{{Digger}}'', The Shadowchild (sanguine), Grim Eyes (choleric), Murai (melancholic), and Digger (phlegmatic).
* The main fighters from ''WebVideo/DragonBallZAbridged'' each fit one or one combination: Goku (sanguine + choleric), Vegeta (choleric), Tien (choleric + melancholic), Piccolo (melancholic), Gohan (melancholic + phlegmatic), Krillin (phlegmatic), Trunks (phlegmatic + sanguine), Chiaotzu (sanguine), and Yamcha (eclectic).
* The eponymous doctors of ''Webcomic/TheDragonDoctors'': Sarin (sanguine), Goro (choleric), Mori (melancholic), Kili (phlegmatic), and Aki (eclectic). Fittingly, they were also compared by the artist to Air, Fire, Earth, and Water, respectively, matching the Four Temperments' elemental affiliations.
* ''Webcomic/TheDreamer'': Alexander (choleric), Beatrice (sanguine), Nathan (melancholic), and Alan (phlegmatic).
* ''Webcomic/ElectricWonderland'': Trawn (choleric), NJ (melancholic), Shroomy (phlegmatic), Aerynn (sanguine).
* Going by the negative traits (because really, they have no others,) the cast of ''ExterminatusNow'' fits pretty nicely: East (sanguine), Lothar (choleric), Virus (melancholic), and Rogue (phlegmatic).
* The QuirkyMinibossSquad in ''Webcomic/TheFourth''. Slice (sanguine), Ecta (choleric), Davis (melancholic), and Floyd (phlegmatic).
* ''WebVideo/GameGrumps''/''WebVideo/SteamTrain'': Jon/Danny (sanguine), Arin (choleric), Ross/Suzy (phlegmatic), and Barry (melancholic).
* The Help Service from ''Webcomic/{{Hellp}}'': № 1 is choleric (competitive and overbearing leader), № 4 is phlegmatic (quiet, patient, and gentle), Marcus is sanguine (outgoing and oversexed drama queen), and Domino is melancholic (cynical and cold).
* ''WebAnimation/HomestarRunner'''s House of Strong: Strong Bad (choleric), Strong Mad (sanguine), Strong Sad (melancholic), The Cheat (phlegmatic).
* ''Webcomic/{{Homestuck}}'': John (phlegmatic), Rose (melancholic), Dave (choleric), and Jade (sanguine).
** And among the Midnight Crew: Spades Slick (choleric), Clubs Deuce (sanguine), Diamonds Droog (melancholic), and Hearts Boxcars (phlegmatic).
** Among the trolls: Nepeta, Terezi and Feferi (sanguine); Karkat, Vriska and Eridan (choleric); Aradia, Kanaya and Equius (melancholic); and Tavros, Sollux and Gamzee (phlegmatic).
** In the Alpha kids: Jane (phlegmatic), Jake (choleric), Roxy (sanguine), and Dirk (melancholic).
* ''Webcomic/TheInexplicableAdventuresOfBob:'' Bob (phlegmatic), Jean (melacholic), Molly (sanguine), and Voluptua (choleric). Albeit, Jean certainly has the hair-trigger ''temper'' of a choleric.
* ''Webcomic/KeychainOfCreation'': Misho (melancholic), Marena (choleric), Ten Winds (phlegmatic), and Secret (eclectic).
* In ''WebVideo/TheLizzieBennetDiaries'':
** Lizzie (sanguine), Lydia (choleric), Charlotte (melancholic), and Jane (phlegmatic).
** In Netherfield: Bing Lee (phlegmatic), Caroline (choleric), Darcy (eclectic), and Darcy's sister Gigi (sanguine).
* ''[[Webcomic/M9Girls M9 Girls!]]'': Any (melancholic), Pato (phlegmatic), Clau (sanguine), and Karla (choleric).
* ''Webcomic/{{Monsterkind}}'': Roy (sanguine), Molly (choleric), Kip (melancholic), and Wallace (phlegmatic).
* The four main guys of ''Mega64'' typically fall into the following; Rocco (sanguine), Derrick (phlegmatic), Shawn (melancholic), and Garrett (choleric).
** The rest of the crew could be seen as Eric (sanguine), Bryan (eclectic), and Kevin (extremely phlegmatic).
* ''WebAnimation/TheMostPopularGirlsInSchool'': The Cheerleaders (including Trisha 2) and/or Deandra. Mackenzie is Melancholic, Brittnay is Choleric, Trisha is Phlegmatic, and Deandra/Trisha 2 is Sanguine.
** In the Third Grade, Brittnay is still Choleric, Rachel is Sanguine, Shay is Melancholic, and Mackenzie is Phlegmatic.
** The van Burens: Mikayla (Sanguine), Cameron (Choleric), Shay (still Melancholic), and Jayna (Phlegmatic).
* ''Webcomic/{{Narbonic}}'': Helen (sanguine), Mell (choleric), Dave (phlegmatic), and Artie (melancholic).
* ''WebVideo/{{NatOneProductions}}'': Their ''Denazra'' storyline features Captain Nassova Cyril (phlegmatic), XO Michio (sanguine), Dr. Varro (melancholic), and Officer Xa'net/[[spoiler: Chapslee]] (choleric).
* ''WebVideo/TheNostalgiaCritic'': Critic & Devil Boner (choleric), Santa Christ & Hyper Fangirl (sanguine), Satan (melancholic), Chester "A" Bum (phlegmatic).
* ''Webcomic/TheOrderOfTheStick'':
** Haley and Elan (sanguine), Belkar (choleric), V (melancholic), Roy (phlegmatic), and Durkon (eclectic).
** The bad guys form an ensemble as well: Xykon as choleric, Redcloak as melancholic, Tsukiko and Right Eye (Start of Darkness) fitting sanguine, and Monster in the Darkness as phlegmatic or eclectic.
* The main four characters in ''Webcomic/OurLittleAdventure'': Julie (sanguine), Angelika (choleric), Rocky (melancholic), and Lenny (phlegmatic).
* ''Webcomic/QuestionableContent'': Faye (choleric), Hannerlore (melancholic), Marten (phlegmatic), and Dora (sanguine).
* The Fatal Four of ''Podcast/RBRWeeklyWrestlingTalk'' can be thus described: William R. Washington (sanguine), Paul Griffin (choleric), Matt Galloway (melancholic), Felipe Diaz-Vera (phlegmatic).
* The two teams in ''Machinima/RedVsBlue'' fit, Red moreso than Blue.
** Red Team: Sarge (classic choleric), Grif and Lopez (classic phlegmatic), Simmons (melancholic), and Donut (sanguine).
** Blue Team: Church and Tex (choleric), Tucker (sanguine), Doc (melancholic), and Caboose (phlegmatic, despite being a complete [[TheDitz Ditz]]).
* ''LetsPlay/TheRunawayGuys'': LetsPlay/{{Chuggaaconroy}} (sanguine), LetsPlay/ProtonJon (melancholic), LetsPlay/NintendoCapriSun (phlegmatic), LetsPlay/MasaeAnela (choleric), and LetsPlay/{{Lucahjin}} (eclectic).
* ''Webcomic/{{Runners}}'': [[NiceGuy Bocce]] and [[AmnesiacsAreInnocent Sky]] are leukine, [[FunPersonified Cember]] is sanguine, [[TheCaptain Roka]] - melancholic, [[TriggerHappy Ril]] - choleric and [[GentleGiant Bennesaud]] - phlegmatic.
* ''Webcomic/RubysWorld'': Ruby (choleric), Alexis (sanguine), Jiro (melancholic), and Jens (phlegmatic). WordOfGod says this was planned from the start.
* The {{webcomic}} ''Webcomic/SacredPie'' features phlegmatic leader Roonas, choleric Sid, and a very sanguine Bob.
* ''Webcomic/SluggyFreelance'' fits this trope very well: Torg (sanguine), Riff (melancholic), Gwynn (choleric), and Zoë (phlegmatic).
* The core group of ''Literature/TalesOfMU'': Mack (melancholic), Amaranth (sanguine), Steff (choleric), and Two (phlegmatic). And Ian and Dee are both strong candidates for eclectic.
* ''Webcomic/VampiresDontBelongInFairytales'':
** Sanguine: [[AllLovingHero Tyr]][[TheHedonist ian]].
** Choleric: [[SupportingLeader Aur]][[OneOfTheBoys elia]].
** Phlegmatic: [[BadassPacifist Wi]][[WiseBeyondHisYears ll]].
%%** ??? Melancholic
* The arc villains of Arc 5 of ''Literature/{{Twig}}'' are four rogue human experiments who are code-named after the four temperaments, literally, along with each having enhanced senses.
* [[https://www.youtube.com/watch?v=QNSTNAbCzOg In this bizarre]] [[AllPeriodsArePMS period song]], we have an Elephant (Melancholic), a Lion (Sanguine), a Hedgehog (Choleric), and a Bear (Phlegmatic).
----