%%
%%
%% This list is alphabetized by game title (except for direct sequels). Please try to keep it that way.
%%
%%
* While the ''VisualNovel/AceAttorney'' series prefers using duos or trios, the investigation team from case 3-5 fits perfectly: [[WhipItGood Franziska]] (choleric), [[TheComicallySerious Edgeworth]] (melancholic), [[MustHaveCaffeine Godot]] (phlegmatic), and [[InspectorLestrade Gumshoe]] (sanguine).
* ''AngryBirds'': Black bird (choleric), white bird (melancholic), red bird (phlegmatic), and yellow bird (sanguine).
* The four spirits of the Book of Prophecy in ''VideoGame/AvalonCode'' can be identified as this: Rempo (choleric), Ur (melancholic), Neaki (phlegmatic), and Mieli (sanguine).
* In ''VideoGame/BlazeUnion'', the first five party members: Garlot (choleric), Jenon (melancholic), Medoute (phlegmatic), Siskier (sanguine), and Aegina (leukine). And after the party dynamics suffer an upheaval, things shake down like so: Gulcasa and Leon (choleric), Nessiah (melancholic), Baldus (phlegmatic), Emilia (sanguine), and Aegina is... still leukine.
* ''VideoGame/{{Borderlands}}'': Mordecai (melancholic), Lilith (phlegmatic), Roland (choleric), and Brick (sanguine).
** ''VideoGame/{{Borderlands 2}}'': Axton (sanguine with a bit of choleric), Maya (melancholic), Salvador (choleric), Zer0 (phlegmatic). With DLC, there's also Gaige and Krieg, who are Sanguine and Choleric respectively.
** Hyperion: Handsome Jack (choleric), Mr. Blake (melancholic), Professor Nakayama (sanguine), [[spoiler:Angel]] (phlegmatic).
* ''{{Catherine}}'', in terms of Vincent and his three bros that he hangs out with at the Stray Sheep. Orlando (choleric), Jonny (melancholic), Vincent (phlegmatic), and Toby (sanguine).
* ''{{VisualNovel/Dangan Ronpa}}'''s students:
** Sanguine: Asahina, Junko, Leon and Sayaka.
** Choleric: Ishimaru, Togami and Mondo.
** Melancholic: Kirigiri, Yamada, Fukawa and Sakura.
** Phlegmatic: Celes, Hagakure, Chihiro and Naegi.
** Leukine: Chihiro could also be considered this.
* ''{{VisualNovel/Super Dangan Ronpa 2}}'':
** Sanguine: Hanamura, Mioda, Souda and Saionji.
** Choleric: Kuzuryuu, Nidai, [[spoiler:Togami]] and Owari.
** Melancholic: Hinata, Koizumi, Pekoyama and Gundam.
** Phlegmatic: Komaeda, Nanami and Sonia.
** Leukine: Tsumiki.
* The LoveInterests in ''VideoGame/DragonAgeII'': Isabela (sanguine), Merrill (choleric), Anders (melancholic), Fenris (phlegmatic with a dash of melancholic).
* The four playable characters of ''{{Drakengard}}'', though at times they muddle about with their humors, tend to fall into distinct ones: Arioch (sanguine), Caim (choleric), Leonard (melancholic), and Seere (phlegmatic).
* [[TheChosenMany The Chosen Four]] of ''VideoGame/EarthBound'': Ness (choleric), Poo (melancholic), Jeff (phlegmatic), and Paula (sanguine).
* ''VisualNovel/FateStayNight'' has Rin/Archer (choleric), Shirou/Saber (melancholic), Sakura (phlegmatic), and Rider (leukine).
* ''VideoGame/FinalFantasyVI''
** Melancholics: Celes, Shadow, and Cyan
** Sanguines: Edgar, Relm, and Setzer
** Cholerics: Locke, Mog, Sabin, and Kefka (with a bit of sanguine).
** Phlegmatics: Terra, Leo, Gau, and Strago
* ''VideoGame/FinalFantasyIX'''s first party: Steiner (choleric), Vivi (melancholic), Garnet (phlegmatic), and Zidane (sanguine).
* ''VideoGame/FrontMission'': Carrion Crow and close allies:
** Choleric: [[TheSmartGuy R. Sakata]], [[AntiHero Keith]], and Maury/Molly
** Choleric and melancholic (rational): [[RulesLawyer Natalie]] and [[spoiler:[[CoolOldGuy Alder]]]]
** Melancholic: [[KnightTemplar Commander]] ([[ByronicHero Lloyd]]/[[HelloInsertNameHere custom name]]), [[spoiler:Bobby]], and [[spoiler:Dr. Brown]] (moral support only)
** Melancholic and sanguine (idealist): [[TheIdealist J.J., Paul]], and [[spoiler:Yeehin]]
** Sanguine: Yang (Meihua), [[GentlemanAndAScholar Frederick, and Hans]]
** Sanguine and choleric (artisan): [[BoisterousBruiser Gregorio]], [[spoiler:[[TheMcCoy Porunga]]]], and [[spoiler:[[HotBlooded Gentz]]]]
** Phlegmatic/leukine: [[ManChild Peewie]], [[spoiler:[[TheStoic Ralph]]]], and [[spoiler:General Blakewood]] (moral support only).
* ''GearsOfWar'''s Delta Squad are like that: Marcus Fenix (choleric), Damon Baird (melancholic), Dominic Santiago (phlegmatic), and Augustus Cole (sanguine).
* ''GrandTheftAutoIV'': The four main characters fit: Brucie (choleric), Niko (melancholic), Little Jacob (phlegmatic), and Roman (sanguine).
* The female leads of the visual novel ''GSenjouNoMaou'' are a picture-perfect example: Haru (choleric), Mizuha (melancholic), Tsubaki (phlegmatic), and Kanon (sanguine).
* ''VideoGame/KidIcarusUprising'':
** Pit (phlegmatic/sanguine), Lady Palutena (phlegmatic), Magnus and Dark Pit (choleric/melancholic).
** The Forces of Nature: Viridi (choleric), Cragalanche (leukine), Arlon the Serene (melancholic/phlegmatic), and Lightning Flash Phosphora (sanguine/choleric).
** The Underworld Army: Medusa (choleric/melancholic); Twinbellows, Dark Lord Gaol, Hewdraw and Great Reaper (leukine), Pandora (phlegmatic), Thanatos (sanguine) and [[spoiler: Hades]] (sanguine/phlegmatic).
* The playable characters of ''VideoGame/KirbysReturnToDreamLand''. King Dedede (choleric), Meta Knight (melancholic), and Waddle Dee (phlegmatic), and Kirby (sanguine).
** In ''VideoGame/Kirby64TheCrystalShards'', we have Kirby (sanguine), Waddle Dee (phlegmatic), Ribbon (melancholic/phlegmatic), Adeleine (leukine), King Dedede (choleric), and the Fairy Queen (chloeric/phlegmatic).
* ''VideoGame/TomodachiLife'''s four personalities each fit in to these. Outgoing (sanguine), Confident (choleric), Independent/Reserved (melancholic), and Easygoing (phlegmatic).
* Both ''VideoGame/Left4Dead'' and ''VideoGame/Left4Dead2'' star a four-man (or, technically, three-man and [[TheSmurfettePrinciple one-woman]]) band. In the first: [[JerkWithAHeartOfGold Francis]] (choleric), [[CoolOldGuy Bill]] (melancholic), [[TheChick Zoey]] (phlegmatic), and [[NiceGuy Louis]] (sanguine). In the second, [[TeamDad Coach]], [[DeadpanSnarker Nick]], [[SassyBlackWoman Rochelle]], and [[CloudCuckoolander Ellis]] for the most part fill those roles respectively, though Ellis is the most clean-cut/consistent.
* The four forms, or, more precisely, [[SoulJar the people the transformation masks come from]] in ''MajorasMask'' look to fall into this decently as well. Darmani is/was choleric; the [[TheWoobie Woobie]]-like Deku Kid is/[[PosthumousCharacter was]] melancholic; Link, TheHero, gets to be phlegmatic; and Mikau is/was sanguine.
* Due to the author being interested with the subject, {{MARDEK}} RPG does this. The author believes everyone has a primary and a secondary temperament, though. Perhaps the clearest ingame example is Legion: [[spoiler:a construct created by an inventor. It was animated with dark magic, with the inventor saying the incantation - due to his stuttering, though, four souls entered the body instead of one - one for each temperament]].
* ''Videogame/MassEffect2'' has the starting four. Shepard (choleric), Miranda (melancholic), Jacob (phlegmatic), and Joker (sanguine).
* ''Videogame/MassEffect1'' and ''Videogame/MassEffect3'' squads are often comprised this way: Shepard and Javik(choleric), Garrus and Liara (melancholic) and Tali and EDI (phlegmatic). Likewise, James and Ashley (sanguine) and Kaiden (neutral phlegmatic).
* ''Videogame/MegaManClassic'' series: Forte/Bass (choleric/sanguine), Proto Man/Blues (melancholic/choleric), Mega/Rock Man (melancholic/sanguine), and Duo (phlegmatic/leukine).
* ''Videogame/MegaManBattleNetwork'': Dex and his Navi [=GutsMan.EXE=] (choleric), Chaud and Glyde.EXE (melancholic), Mayl and [=MegaMan.EXE=] (phlegmatic), Yai and her Navi Roll.EXE (sanguine), and Lan (leukine).
* ''Videogame/MegaManX'' Maverick Hunters: The fast-action AntiHero Zero (choleric), the conscientious defender X (melancholic), the calm and fatherly Signas (leukine/phlegmatic), and the flamboyant Axl (sanguine).
** The villains: Vile is choleric ([[{{HairTriggerTemper}} and dang!!]]); [[spoiler:Lumine]] is melancholic; Dynamo is sanguine; and Sigma is leukine.
** ''Videogame/MegaManX2's'' X-Hunters, plus Vile as the solo X-Hunter in his own right: Vile (choleric/melancholic), Agile (melancholic/sanguine), Violen (sanguine/choleric), and Serges (phlegmatic/leukine).
** Capcom never made clear whether classic Mega/Rock Man is the same Mega Man as X. If they are the same, Mega Man underwent a '''''major''''' temperament change. [[note]]Some may argue that the melancholic side to him simply got brought to clearer [[JustForPun light]] as Mega Man got infused with human feelings.[[/note]]
* ''{{Mega Man Zero}}'': The [[AFatherToHisMen motherly-toward-the-team]] Ciel (phlegmatic/melancholic) and Zero (choleric as usual).
** Among the Four Guardians: The encouraging but TriggerHappy Fefnir (sanguine/choleric), the loyal, confrontational Phantom (choleric/melancholic), the calm-but-playful Leviathan (phlegmatic/leukine), and the reliable and civil Harpuia (melancholic/sanguine).
*** [[spoiler:A duplicate was made of X]], but not quite the same temperament, and a lot less mature.
** Evil trio of Zero 3: With what little personality he's shown to have, Omega seems to be sanguine (opposite [[spoiler:Copy-X]]); [[BigBad Weil]] seems to be leukine/phlegmatic.
* ''VideoGame/{{Metroid}} [[VideoGame/MetroidPrime Prime 3: Corruption]]'': Samus (leukine/phlegmatic), Rundas (choleric), Ghor (melancholic), and Gandrayda (sanguine).
** In Temperament, Gandrayda alone fits her respective weapon element (electric -- sanguine).
* The Sons Of Big Boss in ''MetalGearSolid'': Liquid Snake (choleric), Decoy Octopus aka DARPA chief/Vulcan Raven (melancholic), Sniper Wolf (melancholic/phlegmatic), Revolver Ocelot (phlegmatic/sanguine), Psycho Mantis (sanguine/choleric).
* The Dead Cell Unit in ''MetalGearSolid2'' applies: Solidus Snake (choleric), Fortune (melancholic), Vamp (phlegmatic), Fatman (sanguine).
* The Cobra Unit in ''MetalGearSolid3'' applies: The Pain/The Fury (choleric), The Boss/The Sorrow (melancholic), The End (phlegmatic), The Fear (sanguine).
* The Beauty and the Beast unit in ''MetalGearSolid4'' applies: Raging Raven (choleric), Crying Wolf (melancholic), Screaming Mantis (phlegmatic), and Laughing Octopus (sanguine).
* ''NaziZombies'': Tank (choleric), Takeo (melancholic), Nikolai (phlegmatic), and Richtofen (sanguine).
* ''VideoGame/{{NieR}}'' features has something of this as well. Nier (choleric), Emil (melancholic), Grimoire Weiss (phlegmatic), and Kaine (sanguine).
* Judging by their programmed natures, the ''PacMan'' ghosts:
** Choleric and melancholic (rational): Pinky (chases and ambushes)
** Melancholic and sanguine (idealist): Inky (cautious)
** Sanguine and choleric (artisan): Blinky (cocky, always chases)
** Leukine/phlegmatic: Clyde (indifferent and random)
* Intentionally invoked in ''Videogame/PlanescapeTorment''. [[spoiler:In the end game, you meet up with three copies of yourself, who are the good incarnation (melancholic), crazy incarnation (sanguine) and pragmatic incarnation (choleric). The character of the protagonist depends on how you've been playing him, but he does start out as phlegmatic]].
* The various Gym Leaders from the {{Pokemon}} games:
** Kanto: Lt. Surge and Blaine (choleric), Sabrina and Janine (melancholic), Brock and Erika (phlegmatic), and Misty and Blue (sanguine).
** Johto: Chuck and Clair (choleric), Morty and Pryce (melancholic), Falkner and Jasmine (phlegmatic), and Bugsy and Whitney (sanguine).
** Hoenn: Flannery and Winona (choleric), and Norman and Juan (melancholic), Roxanne and Lisa/Tate (phlegmatic), and Brawly and Watson (sanguine).
** Sinnoh: Crasher Wake and Byron (choleric), Fantina and Volkner (melancholic), Roark and Maylene (phlegmatic), and Gardenia and Candice (sanguine).
** Unova: Chili, Clay, Lenora,and Roxie (choleric); Cress, Drayden and Marlon (melancholic), Cheren, Cilan and Elesa (phlegmatic); and Iris and Skyla (sanguine).
** Kalos: Korrina and Wulfric (choleric), Grant and Olympia (melancholic), Ramos and Clemont (phlegmatic) and Viola and Valerie (sanguine).
* Similarly, the Elite Four:
** Kanto: Lance (choleric), Agatha (melancholic), Bruno (phlegmatic), and Lorelei (sanguine).
** Johto: Karen (choleric), Koga (melancholic), Bruno (phlegmatic), and Will (sanguine).
** Hoenn: Sidney (choleric), Drake (melancholic), Glacia (phlegmatic), and Phoebe (sanguine).
** Sinnoh: Flint (choleric), and Lucien (melancholic), Bertha (phlegmatic), and Aaron (sanguine).
** Unova: Marshal (choleric), Caitlin (melancholic), Grimsley (phlegmatic), and Shauntal (sanguine).
** Kalos: Wikstrom (choleric), Siebold (melancholic), Drasna (phlegmatic) and Malva (sanguine).
** As well as the various Pokemon League Champions: Blue & Lance (choleric), Cynthia & Red (melancholic), Steven & Wallace (phlegmatic), and Alder, Iris & Diantha (sanguine).
*** Kalos Battle Maison: Dana (choleric), Morgan (melancholic), Evelyn (phlegmatic), Nita (sanguine).
* ''VideoGame/PokerNightAtTheInventory'' uses this to balance the table dynamic: [[VideoGame/SamAndMaxFreelancePolice Max]] (sanguine), [[WebAnimation/HomestarRunner Strong Bad]] (choleric), [[VideoGame/TeamFortress2 Heavy]] (melancholic), and [[Webcomic/PennyArcade Tycho]] (phlegmatic).
** ''VideoGame/PokerNight2'': [[WesternAnimation/TheVentureBrothers Brock Samson]] (choleric-melancholic), [[VideoGame/{{Borderlands}} Claptrap]] (sanguine), [[Franchise/EvilDead Ash Williams]] (sanguine-choleric), VideoGame/{{Sam|AndMaxFreelancePolice}} (melancholic-phlegmatic)
* ''VideoGame/{{Psychonauts}}'': Whispering Rock Psychic Summer Camp staff - Milla Vodello (sanguine), Morceau Oleander (choleric), Sasha Nein (melancholic), Ford Cruller (phlegmatic)
* The crew in ''VideoGame/SaintsRow2'' match up with this ''perfectly'':
** Sanguine and choleric: Johnny Gat - he's happy when he's killing people or going to kill people.
** Choleric and melancholic: The Boss, ''very much'' so, regardless of the voice you use - tends to explode when questioned or fucked with.
** Melancholic and phlegmatic: Pierce - humour involving him tends to make fun of his elaborate plans and high professional standards clashing with the extreme personalities of the rest of the group.
** Phlegmatic and sanguine: Shaundi '''by far''', what with being an archetypical laidback stoner.
** Carlos is a mild leukine.
* While in ''VideoGame/SaintsRowTheThird'', the group shift in some unusual ways:
** Shaundi shifts radically from leukine to choleric, running on pure anger from start to finish.
** Newcomer Oleg has some strong phlegmatic and leukine elements, but is mostly melancholic, becoming the key planner and thinker of the group.
** The Boss is left, oddly enough, as the phlegmatic one; unlike in ''Saints Row 2'', The Boss spends much more of the game haplessly reacting to the wild fortunes of fate thrown around him or her.
** Pierce has become significantly more sanguine, a happy-go-lucky gladhander.
* ''Franchise/SilentHill'''s first heroes: [[PluckyGirl Heather]] (choleric), [[ByronicHero James]] (melancholic), [[TheStoic Henry]] (phlegmatic), and [[PapaWolf Harry]] (sanguine).
* The main characters of ''Franchise/SlyCooper''
** [[GentlemanThief Sly Cooper]] (phlegmatic), [[GadgeteerGenius Bentley]] (melancholic), [[LargeHam THE MURRAY]] (sanguine), and [[InspectorJavert Carmelita Fox]] (choleric).
* ''Franchise/SonicTheHedgehog'' gives us many examples of this trope being used professionally:
** [[TheHero Sonic]]/[[BadBoss Dr Eggman/Robotnik]]/[[HotBlooded Vector]] are Choleric, all share a deep ambition that drives the story forward.
** [[TheSmartGuy Tails]]/[[ClassyCatBurglar Rouge]]/[[InstantAwesomejustaddNinja Espio]]/[[ShrinkingViolet Cream]] are Phlegmatic being both concerned about their friends and their jobs.
** [[TheBigGuy Knuckles]]/[[IWorkAlone Shadow]]/[[BadassPrincess Blaze]]/[[MindoverMatter Silver]] are Melancholic the most serious and brutally complex of characters.
** [[TheChick Amy]]/[[TooDumbtoLive Big]]/[[TheLoonie Charmy]] are Sanguine being the most optimistic and fun-loving of characters.
* ''VideoGame/StarWarsRepublicCommando'': The four Clone Commandos of Delta Squad are this. Delta-38, "Boss", is choleric, showing good leadership instincts. Delta-07, "Sev", is melancholic, being the ColdSniper of the group and showing great care to place each round for maximum effenciency. Delta-40, "Fixer", is phlegmatic, being, as Taun We put it, "A pure and uncomplicated soldier." Delta-62, "Scorch", is sanguine, showing much enjoyment in blowing the CIS forces apart.
* In ''VideoGame/StreetFighterII'', the four members of Shadaloo: Balrog (choleric), Sagat (melancholic), M. Bison (phlegmatic), and Vega (sanguine).
* ''SuikodenIII'' has three groups. The main characters: [[LadyOfWar Chris]] (choleric), [[NonActionGuy Thomas]] (melancholic), [[ShellShockedVeteran Geddoe]] (phlegmatic), and [[WarriorPrince Hugo]] (sanguine). Duke's group: [[UnknownRival Duke]] (choleric), [[ParentalSubstitute Nicholas]] (melancholic), [[EyePatchOfPower Gau]] (phlegmatic), and [[MsFanservice Elaine]] (sanguine). Luc's group: [[BigBad Luc]] (melancholic), [[DarkMagicalGirl Sara]] (phlegmatic), [[PsychoForHire Yuber]] (sanguine), and [[MagnificentBastard Albert]] (leukine).
* In the ''SuperMarioBros'' series and its ''WarioLand'' spinoff: Mario (melancholic/phlegmatic), Yoshi and Daisy (sanguine), Luigi (sanguine/choleric), Bowser (choleric), Wario (choleric/melancholic), Toad (melancholic), and Peach and Waluigi (leukine), also Rosalina (phlegmatic).
** The Koopalings and Bowser Jr.: Larry (choleric/phlegmatic), Roy (phlegmatic), Lemmy and Iggy (sanguine); Wendy and Bowser Jr. (choleric); Morton (leukine) and Ludwig (melancholic).
* The five party members in ''VideoGame/SuperMarioRPG'': Mario (melancholic), Mallow (phlegmatic/leukine), Geno (leukine), Bowser (choleric) and Princess Toadstool (phlegmatic)
* The major ''PaperMario'' antagonists: Bowser (choleric), Sir Grodus (melancholic/choleric), [[spoiler: Shadow Queen]] (leukine/phlegmatic), Count Bleck (melancholic)
* Count Bleck's FiveBadBand in ''VideoGame/SuperPaperMario'': O'Chunks (choleric), Nastasia (melancholic), Mimi (phlegmatic, but with a good dose of AxCrazy), and Dimentio (sanguine).
* The major ''MarioAndLuigi'' antagonists: Cackletta, Princess Shroob, Bowser (choleric); Fawful (sanguine), Dark Star (melancholic), Antasma (phlegmatic), [[spoiler: Elder Princess Shroob]] (leukine)
* ''VideoGame/MarioAndLuigiDreamTeam'':
** Mario (melancholic), Luigi (sanguine/choleric), Starlow (sanguine), Prince Dreambert (leukine)
** Big Massif and his Hooraw disciples: Sorrow Fist (melancholic), Beef Cloud (phlegmatic), Heavy Zest (sanguine), Thunder Sass (choleric) and Big Massif himself (leukine).
* The ATX Team in ''VideoGame/SuperRobotWars''. At first the lineup is Sanger (choleric), Bullet (melancholic), Kyosuke (phlegmatic), and Excellen (sanguine). Later, Kusuha was drafted into the team as the leukine. Later on, Sanger leaves, and Kyosuke takes on the choleric mantle; and when Lamia enters, she takes on the phlegmatic mantle.
* ''VideoGame/SuperSmashBros Melee'':
** Choleric: Fox, Ness, Bowser, Captain Falcon
** Choleric and melancholic: Mewtwo, Roy
** Melancholic: Ganondorf
** Melancholic and sanguine: Mario, Marth
** Sanguine: Kirby, Yoshi, Jigglypuff
** Sanguine and choleric: Luigi, Donkey Kong, Pikachu, Falco
** Phlegmatic/leukine: Peach, Link, Samus, [[FlatCharacter Game and Watch]]
* ''VideoGame/SuperSmashBros Brawl'':
** Choleric: Fox, Ness, Bowser, King Dedede, Captain Falcon
** Choleric and melancholic: Wario, Wolf, Snake
** Melancholic: Ganondorf
** Melancholic and sanguine: Mario, Meta Knight, Marth
** Sanguine: Kirby, Yoshi, Jigglypuff
** Sanguine and choleric: Luigi, Donkey Kong, Pikachu, Falco, Ike
** Phlegmatic/leukine: Peach, Zelda/Sheik, Link, Diddy Kong, Samus, Pit, [[FlatCharacter Game and Watch]], R.O.B., Pokemon Trainer
* ''[[{{TCT RPG}} The Colour Tuesday]]'': Alex is the hotheaded driver of the story (choleric). Kyle is the determined and selfless (melancholic). Bella is a slightly airy {{Cloudcuckoolander}} (sanguine). Chadd, the last permanent cast member, is a born follower (phlegmatic).
* The ''VideoGame/TeamFortress2'' classes can be seen throughout the spectrum: Scout (choleric), Soldier (sanguine-choleric), Pyro (sanguine), Demoman (choleric-melancholic), Heavy (leukine, leaning choleric), Engineer (phlegmatic), Medic (phlegmatic-sanguine), Sniper (melancholic), Spy (melancholic-phlegmatic)
* The five playable characters in VideoGame/{{Touhou}} fit this better than a FiveManBand:
** Sanguine: Marisa is always boisterous and outgoing.
** Melancholy: Sakuya always seems to have [[UndyingLoyalty something on]] [[BodyguardCrush her mind]].
** Choleric: Sanae [[Memes/{{Touhou}} can't let herself be held back by common sense!]]
** Phlegmatic: Youmu, even at her angriest, always seems to [[ASpaceMarineIsYou stay frosty]].
** Leukine: Reimu falls somewhere in the middle. Exactly where [[DependingOnTheWriter Depends on the Writer]], but in {{Canon}} she's pretty solidly in the middle overall.
* The Group from ''VideoGame/TheLegendOfZeldaTwilightPrincess'' exhibits this: Auru (choleric), Shad (melancholic), Ashei (phlegmatic), and Telma (sanguine).
* ''{{Tsukihime}}'' has Akiha (choleric), Ciel/Kohaku (sanguine facade but actually melancholic), Hisui (phlegmatic), and Shiki/Arcuied (sanguine).
* ''VisualNovel/VirtuesLastReward'': Dio and Tenmyouji (choleric), Alice and K (melancholic), Phi and Quark (phlegmatic), Sigma and Clover (sanguine), and Luna (leukine).
* {{Xenogears}} has the Neo-Elements: Seraphita (sanguine), Tolone (choleric), Dominia (melancholic), Kelvena (phlegmatic).
----