* The girls in the dorm from ''Manga/AiKora'' fit into this: Tsubame (sanguine), Kirino (choleric, for the most part), Sakurako (melancholic), and Yukari (phlegmatic).
* ''Manga/AzumangaDaioh'': [[GenkiGirl Tomo]] (choleric), [[TheStoic Sakaki]] (melancholic), [[CloudCuckoolander Osaka]] (sanguine), [[CheerfulChild Chiyo-chan]] (leukine), and [[StraightMan Yomi]] (phlegmatic).
* Shuya's closest friends before the program begins in ''Manga/BattleRoyale'' fit into this. [[WideEyedIdealist Shuya]] (sanguine), [[PlayfulHacker Shinji]] (choleric), [[MartialPacifist Hiroki]] (melancholic), and Yoshitoki -- killed before we get to learn much about him -- seems to be phlegmatic.
* The eponymous band in ''Manga/{{BECK}}'' fits this even better than the FiveManBand pattern: Chiba (choleric), Taira (melancholic), Koyuki (phlegmatic), Saku (sanguine), and Ryusuke (leukine).
* ''{{Beyblade}}''.
** The Blade Breakers: Kai (choleric), Ray (phlegmatic), Max (sanguine), and Tyson (melancholic).
** White Tigers: Kevin (choleric), Lee (melancholic), Gary (phlegmatic), and Mariah (sanguine).
** All Starz: Michael (sanguine), Eddie (phlegmatic), Steven (choleric) and Emily (melancholic).
** The Majestics: Robert (melancholic), Johnny (choleric), Oliver (phlegmatic), and Enrique (sanguine).
** Demolition Boys: Spencer (choleric), Tala (melancholic), Bryan (phlegmatic), and Ian (sanguine).
* ''Manga/BlackButler'': The Phantomhive Manor: [[SourOutsideSadInside Ciel]] & [[NobleDemon Sebastian]] (Melancholic), [[TheJeeves Tanaka]] (Leukine), Finnian (Sanguine), Mey-Rin (Phlegmatic), Baldroy (Choleric).
** Other Characters: [[RoyallyScrewedUp Grell]] (Sanguine disturbingly so), [[YellowPeril Lau]] (Leukine), [[TheStoic Ran-Mao]], [[StoicSpectacles Claude]] (Phlegmatic), [[ThePerfectionist William Spears]] (Melancholic), [[TheCaligula Alois Trancy]] (Choleric).
* ''Manga/BlackLagoon'': [[SociopathicHero Revy]] (''very'' choleric), [[WideEyedIdealist Rock]] (melancholic), [[BaldBlackLeaderGuy Dutch]] (phlegmatic), and [[MissionControl Benny]] (sanguine).
* {{Manga/BlueExorcist}}: The Sons of Satan: [[JerkWithaHeartofGold Rin]] (Choleric), [[KnightTemplar Lucifer]] and [[BadassBookworm Yukio]] (Melancholic), [[EccentricMentor Mephisto]] (Sanguine), [[DissonantSerenity Amaimon]] (Phlegmatic)
* In BoscoAdventure, we have Princess Apricot (Sanguine), Frog (Choleric), Tutti (Melancholic) and Otter (Phlegmatic).
* The original ''BubblegumCrisis'': Hot-blooded badass Priss (choleric), stoic leader Sylia (melancholic), Linna the average Jane (phlegmatic), and perky and ditzy Nene (sanguine).
* ''ChronoCrusade'':
** Sanguine: [[NunTooHoly Rosette]] (HotBlooded, cares a lot about others and has a violent temper).
** Choleric: [[MsFanservice Satella]] (prideful, determined, and focused on her revenge).
** Melancholic: [[HeroicAlbino Azmaria]] (a prodigy singer, very caring about others, but insecure and hard on herself).
** Phlegmatic: [[FailureKnight Chrono]] (compassionate and nurturing, but easily discouraged).
* ''VisualNovel/{{Clannad}}'' has Kyou (choleric), Tomoyo (melancholic), Nagisa/Ryou/Kotomi (phlegmatic), Youhei/Fuuko (sanguine), and Tomoya (leukine).
* ''Anime/CodeGeass'':
** Lelouch/Kallen (phlegmatic facade, but actually choleric), Suzaku (melancholic), Rivalz (phlegmatic), Shirley/Milly (sanguine), and Nunally/Nina (leukine).
** [[TheEmpire Britannian]] royalty: TheEmperor/[[LadyOfWar Cornelia]] (choleric), [[ManipulativeBitch Queen Marianne]] (melancholic), [[PrincelyYoungMan Schneizel]] (phlegmatic), and [[RebelliousPrincess Euphemia]]/Clovis (sanguine).
* ''Anime/CowboyBebop'': The Bebop crew fits perfectly, with even the colors of their hair (or clothes in Faye's case) signifying their humors:
** Space-case Ed (sanguine), hot-tempered Faye (choleric), high-strung Jet (phlegmatic), and Spike (melancholic through and through).
* ''Manga/DeathNote'': Light and Mello (melancholic), L and Near (phlegmatic), Watari and Rem (choleric), Misa (sanguine), and Ryuk (leukine).
** Also, the Japanese task force: Soichiro Yagami (melancholic), Aizawa (choleric), Matsuda (sanguine), and Mogi (phlegmatic).
* The boys of ''Anime/DigimonAdventure''.
** Tai (choleric), Matt (melancholic), Izzy (phlegmatic), TK (sanguine), and Joe (leukine).
** Also the four Dark Masters fit this trope: The leading element Piedmon (choleric), the cold and calculating EvilGenius Machinedramon (melancholic), pragmatic Metalseadramon (phlegmatic) who's a good boss towards his minions as long as they don't fail him; and Puppetmon, with his HotBlooded PsychopathicManchild demeanor (sanguine).
** ''Anime/DigimonTamers'': [[ArrogantKungfuGuy Rika]] (choleric), [[ControlFreak Henry]] (melancholic), [[TheHeart Takato]] (phlegmatic), and [[StepfordSmiler Jeri]] (sanguine).
** ''Anime/DigimonSavers'': [[HotBlooded Marcus]] (choleric), [[TeenGenius Thomas]] (melancholic), [[FauxActionGirl Yoshi]] (leukine/phlegmatic), and [[WildChild Keenan]] (sanguine). Even the original expedition could fit: [[GeniusBruiser Spencer]] (choleric), [[BigBad Kurata]] (melancholic), [[CoolOldGuy Yushima]] (sanguine), and the [[GoodParents Criers]] (leukine/phlegmatic).
* The main girls of ''Manga/DoujinWork''. Sora (sanguine), Najimi (choleric), Kaneru (melancholic), and Tsuyuri (phlegmatic).
* The Z-fighters from ''Anime/DragonBallZ'' ([[MyFriendsAndZoidberg excluding Tenshinhan, Yamcha, and Chiaotzu]]): Vegeta (choleric), Piccolo (phlegmatic), Krillin (sanguine), Goku (melancholic), and Gohan (leukine).
* ''Manga/ElfenLied'': Lucy/Kaede (melancholic), Kohta (sanguine), Nana (phlegmatic), Yuka (choleric), and Mayu (leukine).
* Although there are six main characters, this can work for ''Et Cetera'', too: Fino (choleric), Benkate (melancholic), Baskerville (phlegmatic), Mingchao (sanguine), and Alternate and Yaghi (leukine). Mingchao can also be seen as melancholic while Benkate is sanguine.
* ''Manga/{{Eyeshield 21}}'':
** Ojou: Takami (choleric), Shin (melancholic), Sakuraba (phlegmatic), and Ootawara (sanguine).
** Kyoshin: the Hiroshis (choleric), Kakei (melancholic), Kobanzame (phlegmatic), and Mizumachi (sanguine).
* In ''Manga/FairyTail'', [[TheBigGuy Erza]] (choleric), [[TheHero Natsu]] (melancholic), [[TheLancer Gray]] (phlegmatic), [[TheChick Lucy]] (sanguine), and [[TheSmartGuy Happy]] (leukine).
** Also the most powerful members of the guild: [[BadassGrandpa Makarov]] (melancholic), [[JerkWithAHeartofGold Laxus]](choleric), [[TookaLevelinKindness Mirajane]] (sanguine though used to be very choleric), [[TheQuietone Mystogan]] (phlegmatic).
** Though with the addition of new team members and CharacterDevelopment, it changes to [[TheBigGuy Erza]] and [[TheChick Carla]] (choleric), [[TheLancer Gray]] (melancholic), [[TheSmartGuy Lucy]] (phlegmatic), [[TheHero Natsu]] and [[TheSmartGuy Happy]] (sanguine), and [[TheChick Wendy]] (leukine).
** The four dragon slayers of the titular guild: [[BoisterousBruiser Natsu]] (sanguine), [[TheSocialDarwinist Laxus]] (melancholic), [[HeelFaceTurn Gajeel]] (choleric), and [[BadassAdorable Wendy]] (phlegmatic).
* ''{{Fate Zero}}'':
** Sanguine: Ryuunosuke Uryu, Rider, Caster.
** Choleric: Kayneth Archibald, Waver Velvet, Archer/Gilgamesh.
** Melancholic: Kiritsugu Emiya, Saber, Berserker, Kariya Matou.
** Phlegmatic: Lancer, Kirei Kotomine, Irisveil Von Einsbern, Tokiyomi Tohsaka.
* From ''Anime/FlyingHouse'', we have Justin Casey (choleric), Angie Roberts (sanguine), Corkey Roberts (phlegmatic), SIR (melancholic), and Professor Humphrey Bumble (leukine).
* If you divide the cast in ''Manga/FullmetalAlchemist'' into different groups, it's easy to see this:
** Of the main protagonists: Edward (melancholic), Alphonse (choleric), Winry (sanguine) and Pinako (phlegmatic).
** Of the soldiers: Armstrong (choleric), Roy (melancholic), Riza (phlegmatic), and Hughes (sanguine).
** Roy's male subordinates: Heymans Breda (choleric), Vato Falman (melancholic), Kain Fuery (phlegmatic), and Jean Havoc (sanguine).
** The Homunculi: Envy, Pride (2009), Wrath (2009) (choleric), Lust & Sloth (2009) (melancholic), Greed & Sloth(2003) (phlegmatic), and Wrath (2003), Gluttony, Pride (2003) (sanguine).
* ''GhostInTheShellStandAloneComplex'': Chief Aramaki (choleric), Motoko Kusanagi (melancholic), Togusa (phlegmatic), and Batou (sanguine).
* The Gundam Meisters in ''{{Gundam 00}}'' fit this: Tieria (choleric), Allelujah (melancholic), Setsuna (phlegmatic), and Lockon (sanguine).
* The Le Creuset team in ''GundamSEED'' kinda fits this:
** Yzak (choleric), Athrun (melancholic), Dearka (phlegmatic), and Nicol (leukine). The four main leads as well with Kira and Athrun being phlegmatic and melancholic, respectively, Cagali being choleric and Lacus being sanguine.
** The Minerva pilots in ''GundamSeedDestiny'' possess two temparents: Shinn (both sanguine and melancholic), Athrun (choleric and melancholic), Ray (both melancholic and phlegmatic), and Lunamaria (sanguine and phlegmatic).
* ''GundamWing'': Heero Yuy (melancholic), Duo Maxwell (sanguine), Trowa Barton and Quatre Winner (phlegmatic, leukine), and Chang Wu Fei (choleric).
* The Shuffle Alliance from ''Anime/MobileFighterGGundam'': Domon Kasshu (choleric), George [=De=]Sand (melancholic), Argo Gulskii (phlegmatic), and Chibodee Crockett and Sai Saici (sanguine).
* ''GurrenLagann'' -- Early episodes: Yoko (choleric), Simon (melancholic), Leeron (phlegmatic), and Kamina (sanguine).
* The four main boxers from ''HajimeNoIppo'' fit this well: Takamura (both choleric and sanguine), Aoki (melancholic), Kimura (phlegmatic), and Ippo (sanguine).
* ''HunterXHunter'': Killua (choleric), Kurapika (melancholic), Leorio (phlegmatic), and Gon (sanguine).
* InazumaEleven has the managers fit into the arrangement perfectly: Natsumi (choleric), Fuyuka (melancholic), Aki (phlegmatic), and Haruna (sanguine).
* The main cast of ''Manga/InuYasha'': Inuyasha (phlegmatic/sanguine), Kagome (sanguine/melancholic), Miroku (sanguine/choleric), and Sango (melancholic/phlegmatic)
* ''{{K-on}}!'' has a slight variation: Yui (sanguine/phlegmatic), Ritsu (choleric/sanguine), Mugi (melancholic), and Mio (phlegmatic).
* ''[[Series/KamenRiderDenO KamenRider Den-O's]]'' four Imagin: Momotaros (choleric), Urataros (melancholic), Kintaros (phlegmatic), and Ryutaros (sanguine).
* The main cast of ''Manga/KatekyoHitmanReborn'': Tsuna (phlegmatic), Gokudera (choleric), Yamamoto, Lambo and Ryohei (sanguine), Hibari (melanchonic), Mukuro (sanguine/choleric), and Chrome (leukine).
* ''KeroroGunsou'' follows the 5-humor style: Giroro (choleric), Dororo (melancholic), Kururu (phlegmatic), Tamama (sanguine), and Keroro (leukine).
* ''Manga/KotouraSan'' has this among five people but nobody is Leukine:
** Haruka Kotoura: Phlegmatic; she's highly insecure, timid to a fault, wants people to understand her and vice-versa, and is a complete sweetheart.
** Yoshihisa Manabe: Sanguine; a kooky clown with insatiable humor and energy and is a fun-lover with a love of life.
** Hiyori Moritani: Choleric; easy to anger and upset, often ignores others' feelings, and gets things done once her mind is set on it.
** Yuriko Mifune: Choleric/Sanguine blend; highly excitable and takes charge of situations in a tactical manner, a people-person who enthusiastically sets her sights on her goals but sometimes ignores the feelings of her teammates.
** Daiichi Muruto: Melancholic; unfeeling but highly analytical of everything around him and speaks with precision that often "stings" people.
* ''Anime/LuckyStar:'' Kagami (choleric), Miyuki (melancholic), Tsukasa (phlegmatic), and Konata (sanguine). (None of the main characters qualify as Leukine).
* ''Characters/LupinIII'': It's because the characters have a consistent interaction that makes them function in nearly any setting or plot.
** Melancholic: Lupin and Fujiko (when she's also an ActionGirl) are the most extroverted cast members, and pretty self-indulgent, too. They love showing off, and getting people to do what they want.
** Choleric: Zenigata is obsessed with the success of arresting Lupin. To the point where he will allow Fujiko and others to escape, for a chance at capturing Lupin. Even when the character is more mature, he is as HotBlooded as Lupin, and will instruct his subordinates to follow his instructions ''exactly''. It's a good thing that when he does have subordinates, they're intensely loyal to him, or he'd be considered a BadBoss.
** Sanguine: The brooding Jigen, and his eternal slouch, is an example of a melancholic who has learned how to relax. When he's ""[[ColdSniper on the job]]", his hard-working and detached nature come to the fore.
** Phlegmatic: Goemon, whose introversion is done as a part of training, does not ''need'' to be around other people for his training, but does so for the socialization.
** Leukine: Whatever DamselInDistress is around, including Fujiko, if the writers forgot her spunk.
* ''Manga/MagicKnightRayearth''
** The heroines: Hikaru (sanguine), Umi (choleric), Fuu (Melancholic), Mokona (phlegmatic)
** The first season's villains: Caldina (sanguine), Alcyone (choleric), Ascot (melancholic), Lafarga (phlegmatic- though it is more obvious in the second season).
** The second season's villains: Tatra (sanguine), Tarta (choleric), Aska (melancholic), Eagle (phlegmatic).
* ''MagicalGirlLyricalNanoha [=StrikerS=]''.
** Natural leader (former) {{Tsundere}} Teana (choleric), knight-in-training Erio (melancholic), Caro (phlegmatic), and GenkiGirl [[ThePollyanna Pollyanna]] Subaru (sanguine). The last two's personalities actually caused a bit of family drama for their also melancholic adopted mother in the second ''[[AudioAdaptation StrikerS Sound Stage]]'', since [[NonverbalMiscommunication their combined introvertedness caused some communication problems]].
** Similarly, Hayate's four knights. Vita (choleric), Signum (melancholic), Zafira (phlegmatic), and Shamal (sanguine).
** After StrikerS, the four Combat Cyborgs [[spoiler:who were adopted into the Nakajima family]] are this: Nove (choleric), Dieci (melancholic), Cinque (phlegmatic), and [[GenkiGirl Wendi]] (sanguine).
* ''MagicalPokaan'''s four girls match: Pachira (choleric), Aiko (melancholic), Liru (phlegmatic), and Yuuma (sanguine).
* Kozu's five personalities in ''{{Mahoraba}}'': Saki (choleric), Natsume (melancholic), Chiyuri (phlegmatic), and Kozue and her kid-version Nanako (sanguine).
* ''MahouSenseiNegima'':
** Asuna (choleric), Setsuna (melancholic), Yue (phlegmatic), Kuu (sanguine), and Nodoka and Konoka (leukine).
** The four sports stars include Yuna (choleric), Ako (melancholic), Akira (phlegmatic), and Makie (sanguine).
* ''Manga/{{Monster}}'': Eva (choleric), Tenma (melancholic), Johan (phlegmatic), and Anna/Nina (sanguine).
* In ''Manga/{{Naruto}}'': We have the nine rookie genin as well as Team Guy from the Leaf Village collectively fitting this type of ensemble with their contrasting personalities: Naruto and Rock Lee (sanguine, although each of them has a bit of choleric as well since they both have notable HotBlooded streaks), Kiba (choleric/sanguine), Ino (choleric), Sasuke and Shino (melancholic), Neji (melancholic/choleric, particularly before his HeelFaceTurn, although he still embodies a lot of the positive traits of this afterwards), Hinata (phlegmatic), Shikamaru (phlegmatic/choleric), Choji (phlegmatic/sanguine), Sakura (leukine/choleric) and Tenten (leukine). This also applies to their respective mentors: Guy (sanguine/choleric), Kakashi (phlegmatic), Asuma (sanguine/phlegmatic) and Kurenai (leukine).
** The Sand Shinobi (their mentor included) form a temperament combo ensemble: Gaara (melancholic/phlegmatic through and through), Kankuro (sanguine/choleric), Temari (a somewhat unusual mix of choleric and phlegmatic) and Baki (choleric/melancholic).
** The Four Uchiha Legends: Madara (Choleric), Tobi (Sanguine-Choleric), Sasuke (phlegmatic/melancholic), Itachi (Phlegmatic).
* The Akatsuki from ''Anime/NarutoShippuden'' has every member involved:
**Choleric: [[TheBully Hidan]], [[EvilRedHead Sasori]], [[MadArtist Deidara]].
**Sanguine: [[BloodKnight Kisame]],
** Sanguine-Choleric: [[CloudCuckooLander Tobi]]/[[spoiler: [[BeneathTheMask Obito]]]].
**Melancholic: [[AGodAmI Pain]]/[[spoiler:[[BreakTheCutie Nagato]]]], [[GeniusBruiser Kakuzu]].
**Phlegmatic: [[LovableTraitor Itachi]](was this all along especially to people he cared for), [[BrokenBird Konan]].
**Leukine: [[SplitPersonality Zetsu]].
* A good example is ''Anime/NeonGenesisEvangelion'': Asuka/Mari (choleric), Ritsuko/Gendo (melancholic), Shinji/Rei (phlegmatic), and Misato/Kaji (sanguine). You could actually also fit in Kaworu here as phlegmatic since he seemingly has absolutely no internal turmoil whatsoever at all. Of course, he only appears once (and when he does appear, Asuka is unconscious) so he doesn't completely count.
* ''Anime/NerimaDaikonBrothers'': Hideki (choleric), Ichiro (melancholic), TeamPet Pandaikon (phlegmatic), and Mako (sanguine).
* ''OnePiece'''s main male cast. Zoro (melancholic/sanguine), Usopp (sanguine), Sanji (choleric/phlegmatic), Luffy (sanguine/phlegmatic), and Tony Tony Chopper (phlegmatic/melancholic).
** Oddly enough is that the remanining members of the crew fit the bill perfectly: Nami (sanguine/melancholic), Brook (melancholic), Robin (melancholic/phlegmatic), and Franky (sanguine).
** Also Baroque Works' operatives from Little Garden arc: [[SmugSnake Mister]] [[OnlySaneMan 3]] (choleric), [[CreepyChild Miss]] [[MadArtist Goldenweek]] (melancholic), [[HavingABlast Mister]] [[TheStoic 5]] (phlegmatic) and [[TheHyena Miss]] [[PerkyFemaleMinion Valentine]] (sanguine).
* Although everyone in ''OokikuFurikabutte'' gets his/her turn to shine, the story tends to focus on four core members of the baseball team: [[TheCaptain Hanai]] (choleric), [[TheStrategist Abe]] (melancholic), [[FragileFlower Mihashi]] (phlegmatic), and [[CloudCuckoolander Tajima]] (sanguine).
* ''PantyAndStockingWithGarterbelt'': [[LoveableSexManiac Panty]] (sanguine), [[BigEater Stocking]] (melancholic), [[DaChief Garterbelt]] (choleric), [[ShrinkingViolet Brief]] (phlegmatic)
**[[DramaQueen Scanty]] (choleric), [[ProperLady Kneesocks]] (phlegmatic), [[SpiritedCompetitor Fastener]] (sanguine), [[MagnificentBastard Corset]] (melancholic)
* ''Anime/{{Pokemon}}'' anime:
** Bulbasaur (melancholic), Pikachu (choleric), Charmander/Charmeleon/Charizard (phlegmatic), and Squirtle (sanguine).
** ''Original Series'' - Ash (choleric), Misty (phlegmatic), Brock/Tracey (melancholic), and Pikachu (sanguine).
** ''Advanced Generation'' - Ash (choleric), Max (melancholic), May (sanguine), and Brock (phlegmatic). If you count Pikachu here, he becomes the leukine.
** ''Diamond and Pearl'' - Ash (choleric), Brock (melancholic), Pikachu (phlegmatic), and Dawn (sanguine).
** ''Best Wishes'' - Ash (choleric), Cilan (melancholic), Pikachu (phlegmatic), and Iris (sanguine).
** ''X & Y'' - Ash (choleric), Clemont (melancholic), Serena (phlegmatic), and Bonnie (sanguine).
* ''Anime/PrincessTutu'' has Fakir (choleric), Rue (melancholic), Mytho (phlegmatic), and Ahiru (sanguine).
* The four ARMS teenagers in ProjectARMS: Hayato (choleric), Kei (melancholic), Ryo (phlegmatic), and Takeshi (sanguine).
* ''Anime/PuellaMagiMadokaMagica'': Kyoko (choleric), Homura (melancholic), Mami (phlegmatic), Sayaka (sanguine), and Madoka (leukine).
* ''RanmaOneHalf'': Despite not always acting as a group: Ranma (sanguine), Akane (choleric), Ryoga (melancholic), and Genma (phlegmatic).
* RedGarden: Kate (melancholic), Rachel (choleric), Claire (phlegmatic), and Rose {sanguine)
* ''RoseOfVersailles'': Marie Antoinette (sanguine), Oscar (choleric), Rosalie (melancholic), Fersen (phlegmatic), and Andre (leukine).
* The main cast of Manga/RurouniKenshin: [[HotBlooded Sano]] and [[BrattyHalfPint Yahiko]] (choleric), [[TheMedic Megumi]] (melancholic), [[AllLovingHero Kenshin]] (phlegmatic), and [[PluckyGirl Kaoru]] (sanguine).
* ''Anime/SaberMarionetteJ'': Bloodberry (choleric), Cherry (melancholic), Otaru (phlegmatic), and Lime (sanguine).
* ''Franchise/SailorMoon'':
** The Inner Senshi: Rei/Sailor Mars (melancholic), Ami/Sailor Mercury (phlegmatic), Makoto/Sailor Jupiter (choleric), and Minako/Sailor Venus (sanguine).
** The Outer Senshi: Haruka/Sailor Uranus (choleric), Michiru/Sailor Neptune (sanguine), Hotaru/Sailor Saturn (melancholic), and Setsuna/Sailor Pluto (phlegmatic).
* ''SaintBeast'': [[TheHero Goh]] (choleric), [[TheChick Rei]] (melancholic), [[TheLancer Shin]] (phlegmatic), and [[KidAppealCharacter Gai]] (sanguine).
* ''Manga/{{Saiyuki}}'' also has two. For the Sanzo party: Sanzo (choleric), Hakkai (melancholic), Gojyo (phlegmatic), and Goku (sanguine). For Kougaiji's group: Kougaiji (choleric) and Lirin (sanguine). Yaone and Dokugakuji switch off between melancholic and phlegmatic, although neither of them is actually lazy.
* ''Anime/{{Samurai Champloo}}'': Fuu (choleric), Jin (melancholic), and Mugen (sanguine).
* ''SayonaraZetsubouSensei'':
** Chiri (choleric), Itoshiki-sensei (melancholic), Nami (phlegmatic), and Kafuka (sanguine).
** Also in the show: Kuniya (choleric), Aoyama (melancholic), Jun (phlegmatic), and Haga (sanguine).
** Kaere (choleric), Abiru (melancholic), Harumi/Kiri/Matoi/Other relatively sane characters (phlegmatic), and Maria (sanguine).
* ''SchoolRumble'''s main girls: Mikoto (choleric), Eri (melancholic), Akira (phlegmatic), and Tenma (sanguine).
* The ''{{Slayers}}'' characters fit perfectly into these categories, with the Choleric Lina, Phlegmatic Gourry, Sanguine Amelia, and Melancholic Zelgadis. Any of their secondary allies, Sylphiel in particular, also fit into the Leukine temperament.
* ''Manga/SoulEater'': Maka is choleric, Soul is melancholic/sanguine, Death the Kid is melancholic/choleric, Tsubaki and Liz are leukine [[note]] Of course, Liz can be a little bit choleric herself.[[/note]], Black☆Star and Patti are sanguine.
* The four main characters from ''{{Texhnolyze}}'': [[HotScientist Doc]] is Sanguine, [[OnlySaneMan Onishi]] is Choleric, [[TheStoic Ichise]] is Phlegmatic and [[WaifProphet Ran]] is Melancholic.
* ''Anime/{{Superbook}}'' (second season): Christopher Peepers (choleric), Joy (melancholic), Uriah (sanguine), and Gizmo (phlegmatic).
* ''Manga/TheLegendOfZelda:
** Four Swords Plus'' manga by Akira Himekawa takes a literal spin with this trope by dividing Link into four different entities with personality traits that reflect the color tunic each is wearing: Green is choleric, Red is sanguine, Blue is phlegmatic and Purple is melancholic.
** The [[http://www.newgrounds.com/portal/view/328825 flash animations by Hadouken Dude]] took this to absolutely ''hilarious'' levels, with Green Link as the phlegmatic (calm/rational/leader) one, Blue Link being the melancholic (analytical/reflective/smart) one, Red Link as the choleric (severe testosterone imbalance/lack of foresight) one, and Purple Link being the sanguine (along for the ride/accused of being gay because of personality and color) type.
* ''TheMelancholyOfHaruhiSuzumiya'': Haruhi (choleric, despite the title), Koizumi (melancholic), Yuki (phlegmatic), and Mikuru and Kyon (leukine). Tsuruya, [[TheSixthRanger an honorary member of the Brigade]], fills the sanguine position.
* Five-temperament ensemble in ''TokyoMewMew'': Ichigo, although [[IJustWantToBeNormal not happy about leading]] at first, accepting her responsibility later on (choleric); Minto (melancholic), Retasu (phlegmatic), the GenkiGirl Bu-ling (sanguine), and Zakuro (leukine).
* ''{{Trigun}}'' more often averts this trope in favor of the [[TheDrifter Lone Hero]] or the PowerTrio. Adding Wolfwood to the cast has a subtractive effect instead, generating a [[RedOniBlueOni duo dynamic]] that leaves Meryl and Millie on the sidelines. When they participate equally they fit the four temperaments: Meryl (choleric), Vash (melancholic, though pretending to be sanguine), Wolfwood (phlegmatic), and Millie (sanguine).
* ''TsubasaReservoirChronicle'': Kurogane (choleric), Syaoran (melancholic), and Sakura/Fay (sanguine).
* The four aunts in ''VisualNovel/UminekoNoNakuKoroNi'': Eva (choleric), Natsuhi (melancholic), Kyrie (phlegmatic), and Rosa (sanguine). Probably works with the uncles and cousins too. There are two different ways to categorize the [[VisualNovel/HigurashiNoNakuKoroNi Higurashi]] girls. The first is -- though actually works well no matter who is put in choleric position -- Shion (choleric), Rika (melancholic), Satoko (phlegmatic), and Rena (sanguine). Alternately, if you wanted to include Keiichi, the pattern shifts to Keiichi (choleric), Rika (melancholic), Mion - phlegmatic, Rena (sanguine), and Satoko - leukine. Alternately, if you wanted to just do the girls, just [[spoiler:replace Keiichi with Shion]].
* In the original ''WeissKreuz'': Aya (choleric), Omi (melancholic), Youji (phlegmatic), and Ken (sanguine).
* In ''WolfsRain'': Tsume (choleric), Kiba (melancholic), Toboe (phlegmatic), and Hige (sanguine).
* ''Anime/YesPrettyCure5'' tries to throw us off by having four temperaments among five characters--both Nozomi and Urara are sanguine. Rin is choleric, Komachi is phlegmatic (though not lazy by any stretch), and Karen is melancholic.
** In ''Anime/FreshPrettyCure'': Love is sanguine, Miki is choleric, Inori is more likely Phlegmatic, and Setsuna is a mix of melancholic and leukine.
** In ''Anime/HeartcatchPrettyCure'', [[ShrinkingViolet Tsubomi]] is phlegmatic, [[GenkiGirl Erika]] is sanguine, [[StudentCouncilPresident Itsuki]] is Leukine, and [[BrokenBird Yuri]] is melancholic.
** This dynamic also returns in ''Anime/SmilePrettyCure''. Miyuki is sanguine, Both Akane and Nao are choleric, Yayoi is phlegmatic, and Reika is melancholic.
* ''Manga/{{Voltron}}'':
** Boys: Keith (Leukine), Lance (Choleric), Hunk (Phlegmatic), Pidge (Sanguine), Sven (Melancholic).
** Girls: Allura (Sanguine), Romelle (Melancholic)
* The main four of ''Manga/YuYuHakusho'': Yusuke (melancholic), Hiei (choleric), Kurama (phlegmatic), Kuwabara (sanguine) and Botan (leukine).
* ''Anime/YuGiOh'': Yugi/Yami (melancholic) Tea (phlegmatic) Joey (choleric), Tristan (sanguine), and Solomon (leukine).
* ''Anime/YuGiOh5Ds'': Jack (choleric), Yusei (melancholic), Akiza (phlegmatic), and Crow (sanguine).
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