* ''LightNovel/BakaAndTestSummonTheBeasts'':
** Boys: Akihisa Yoshii (choleric), Yuuji Sakamoto (phlegmatic), Hideyoshi Kinoshita (melancholic), and Kouta Tsuchiya (sanguine).
** Girls:Minami Shimada (choleric), Shouko Kirishima (phlegmatic), Mizuki Himeji (melancholic), and Aiko Kudou (sanguine).
* Although everyone in ''Manga/BigWindup'' gets his/her turn to shine, the story tends to focus on four core members of the baseball team:
** TheCaptain Hanai (choleric), TheStrategist Abe (melancholic), FragileFlower Mihashi (phlegmatic), and CloudCuckoolander Tajima (sanguine).
* ''Manga/BlackLagoon'':
** SociopathicHero Revy (very choleric), WideEyedIdealist Rock (melancholic), BaldBlackLeaderGuy Dutch (phlegmatic), and MissionControl Benny (sanguine).
* The original ''Anime/BubblegumCrisis'':
** Choleric: HotBlooded badass Priss.
** Melancholic: [[TheStoic Stoic]] leader Sylia.
** Phlegmatic: Linna the average Jane.
** Sanguine: Perky and [[TheDitz ditzy]] Nene.
* ''Manga/ChronoCrusade'':
** Sanguine: [[NunTooHoly Rosette]] (HotBlooded, cares a lot about others but has a violent temper).
** Choleric: [[MsFanservice Satella]] (prideful, determined, and focused on her revenge).
** Melancholic: [[HeroicAlbino Azmaria]] (a prodigy singer, very caring about others, but insecure and hard on herself).
** Phlegmatic: [[FailureKnight Chrono]] (compassionate and nurturing, but easily discouraged)
* The four Dark Masters in ''Anime/DigimonAdventure'' fit this trope:
** Choleric: The leading element Piedmon.
** Melancholic: The cold and calculating EvilGenius Machinedramon.
** Phlegmatic: Pragmatic Metalseadramon, who's a good boss towards his minions as long as they don't fail him.
** Sanguine: Puppetmon, with his HotBlooded PsychopathicManchild demeanor.
* ''Anime/DigimonTamers'': Rika (choleric), Henry (melancholic), Takato (Phlegmatic) and Jeri (sanguine)
** ''Anime/DigimonSavers'' has two sets:
** The main cast:
*** HotBlooded Marcus (choleric), TeenGenius Thomas (melancholic), FauxActionGirl Yoshi (phlegmatic), and WildChild Keenan (sanguine).
** The original expedition:
*** GeniusBruiser Spencer (choleric), BigBad Kurata (melancholic), CoolOldGuy Yushima (sanguine), and {{Good Parent|s}} Criers (phlegmatic).
* ''The Melancholy of LightNovel/HaruhiSuzumiya'': Haruhi (sanguine, despite the title), Koizumi (choleric), Kyon (melancholic), Mikuru (melancholic), and Yuki (phlegmatic). Tsuruya, [[SixthRanger an honorary member of the Brigade]], also fills the purely choleric position.
* ''Manga/{{Hellsing}}'' has three:
** The Hellsing Organization: Alucard (choleric), Seras (phlegmatic), Walter (melancholic), Pip (sanguine) and Integra (leukine).
** The Iscariot Organization: Alexander Anderson (sanguine), Heinkel Wolfe (choleric), Yumie Takagi (phlegmatic), and Enrico Maxwell (melancholic).
** Millennium: The Major (sanguine), The Captain (melancholic), Doctor (phlegmatic) and Schrodinger (choleric).
* ''Franchise/{{Jewelpet}}''
** ''Anime/JewelpetHappiness'' has the boys quartet: Kousuke is phlegmatic, Takumi is melancholic, Mouri is sanguine and Taira is choleric.
** ''Anime/LadyJewelpet'' has two sets: the Petit Ladies are Momona (sanguine), Lillian (melancholic), Mizuki (choleric) and Charon (phlegmatic); the SixthRanger Elena is leukine. The Princes are Cayenne (leukine), Romeo (phlegmatic), Soarer (melancholic) and Levin (sanguine); the SixthRanger Miura is choleric.
* ''Manga/JoJosBizarreAdventure Startdust Crusaders''
** Joseph Joestar (eclectic), Jotaro Kujo (choleric), Noriaki Kakyoin (phlegmatic), Mohammad Avdol (melancholic), and Jean Pierre Polnareff (sanguine).
* ''LightNovel/KaraNoKyoukai''
** Ryougi Shiki (melancholic), Kokutou Mikiya (phlegmatic), Aozaki Touko (choleric), Kokutou Azaka (sanguine)
* ''{{Anime/KillLaKill}}'' has three groups:
** Main Characters:
*** [[TheHero Ryuko]] is Choleric due to her {{Hot Blooded}} nature and single minded determination to get the answers she wants out of Satsuki.
*** [[TheStoic Senketsu]] is Phlegmatic, mostly being interested in assisting Ryuko's quest and protecting her from harms way, as well as try to keep her extreme temper under control.
*** Mako is Sanguine being the {{Plucky Comic Relief}} interested in having fun with Ryuko, and seems to know just what to say in a given situation to snap people out of their funk.
*** [[KnightTemplar Satsuki]] is Melancholic. She focuses on accomplishing her plans and using [[TheUnfettered whatever means necessary]] to do so, and cares [[NoNonsenseNemesis very little for anything]] that hinders her progress.
** The Elite Four:
*** [[UndyingLoyalty Gamagoori]] is Melancholic, the firm disciplinary officer and enforcer of Satsuki's rules, and the most overt in their loyalty towards her.
*** [[BloodKnight Sanageyama]] is Sanguine, the fight-happy swordsman interested only in finding opponents that can challenge him.
*** [[NonActionGuy Inumuta]] is Phlegmatic, preferring to gather and study as much data as possible rather than take an active field role like the others.
*** [[DeadpanSnarker Jakuzure]] is Choleric, Has a driest sense of humor. She also takes great pride in the fact that she's known Satsuki the longest.
** The Kiryuin Conglomerate:
*** [[TheBaroness Ragyo]] is Melancholic. She's the {{Big Bad}} of the series and an [[EvilisHammy all-around pompous]] character whenever she gets her moments. She showcases the negatives more than the positive features, had abnormally high wants when she was testing her own daughters, but when they do fulfill them, she is filled with glee.
*** [[CuteandPsycho Nui]] is Choleric. Arguably {{Co Dragons}} with Rei to Ragyo, and the one who gets the most work done initially while Ragyo sits around and controls REVOCS. Showcases the downsides by being a outwardly nice, extremely crazy inside, and even more insane after normal Ryuko cuts off her arms.
*** [[TheDragon Rei]] is Phlegmatic. The person who's able to serve at a moment's notice, and without question. However, she showcases the downsides by being an outwardly cold person. Exemplifies this part of her personality in the OVA by being a Defrosting Ice Queen when she heard of Ragyo's death, and was able to be swayed by Satsuki.
*** [[BrainwashedandCrazy Mind Controlled Ryuko]] is Sanguine. Instead of unable to express her emotions, she says them bluntly, taking them (sometimes literally) to the person she speaks to. Ryuko even kisses Nui, showcasing their love for each other. She balances out the other's negative emotions by being compassionate with them and follows after Ragyo by being WAY over-the-top in battles, but she showcases the negatives by being mind-controlled into finally finding her wants of being with an actual family and comes off as harsh to others.
* ''Manga/TheLegendOfZelda'': The [[http://www.newgrounds.com/portal/view/328825 flash animations by Hadouken Dude]] took this to absolutely hilarious levels, with Green Link being loyal/humble, determined and moralistic/uptight (Melancholic), Blue Link being analytical/calm, collected and sarcastic/condescending (Phlegmatic), Red Link being hot-tempered/brash, insecure and impatient/self-centered (Supine), and Purple Link being naive/greedy, idealistic and clumsy/excitable (Choleric), also accused of being gay because of personality and color.
* The Hinata House Girls in ''Manga/LoveHina'':
** Naru Narusegawa & Motoko Aoyama (choleric), Mitsune Konno (melancholic), Kaolla Su (sanguine), Shinobu Maehara (phlegmatic), and Mutsumi Otohime (eclectic).
* ''Anime/MagicalGirlLyricalNanohaStrikers''. natural leader (former) {{Tsundere}} Teana (choleric), knight-in-training Erio (melancholic), Caro (phlegmatic), and GenkiGirl [[ThePollyanna Pollyanna]] Subaru (sanguine). The last two's personalities actually caused a bit of family drama for their also melancholic adopted mother in the second [[AudioAdaptation StrikerS Sound Stage]], since [[NonverbalMiscommunication their combined introvertedness caused some communication problems]].
* The current lineup of the Taishiro in ''Manga/SamuraiDeeperKyo'' fits almost flawlessly.
** Sanguine: Yuan is extroverted, fond of wisecracks, and very protective of the people he cares about. He uses fire techniques and wears red.
** Choleric: Tokito is quick to anger, perfectionistic, and impulsive. Wears shades of yellow, and fights with a very aggressive energy.
** Melancholic: Hishigi is exceedingly introverted and the epitome of TheStoic, analytical and extremely task-focused. He shows textbook signs of severe depression. His color scheme is almost entirely black.
** Phlegmatic: Fubuki leads the Taishiro. He is level-headed, cultured and elegant. His fighting style revolves around water and his color scheme is mainly blue.
* ''Anime/{{Superbook}}'' (second season): Christopher Peepers (choleric), Joy (melancholic), Uriah (sanguine), and Gizmo (phlegmatic).
* The four main characters from ''Anime/{{Texhnolyze}}'': [[HotScientist Doc]] (sanguine), [[OnlySaneMan Onishi]] (choleric), [[TheStoic Ichise]] (phlegmatic), and [[WaifProphet Ran]] (melancholic).
* Five-temperament ensemble in ''Manga/TokyoMewMew'': At first [[IJustWantToBeNormal not happy about leading]], but accepting her responsibility later on, Ichigo (choleric); Minto (melancholic), Retasu (phlegmatic), the GenkiGirl Bu-ling (sanguine), and Zakuro (eclectic).
* ''Anime/TheTowerOfDruaga'':
** Jil's Group: Jil (melancholic), Ahmey (phlegmatic), Melt (choleric), Coopa (sanguine), and Kaaya (eclectic).
** Neeba's Group: Neeba (melancholic), Fatina (choleric), Kally (phlegmatic), and Utu (sanguine).
* ''Manga/{{Trigun}}'' more often averts this trope in favor of the [[TheDrifter Lone Hero]] or the PowerTrio. Adding Wolfwood to the cast has a subtractive effect instead, generating a [[RedOniBlueOni duo dynamic]] that leaves Meryl and Millie on the sidelines. When they participate equally they fit the four temperaments: Meryl (choleric), Vash (melancholic, though pretending to be sanguine), Wolfwood (phlegmatic), and Millie (sanguine).
* In the original ''Anime/WeissKreuz'' Aya (choleric), Omi (melancholic), Youji (phlegmatic), and Ken (sanguine).
* In ''Anime/WolfsRain'': Tsume (choleric), Kiba (melancholic), Toboe (phlegmatic), and Hige (sanguine).
* ''Manga/YourLieInApril'': Arima Kousei (melancholic), Miyazono Kaori (choleric), Watari Ryota (sanguine), Sawabe Tsubaki (phlegmatic).
* ''Anime/YuGiOh5Ds'': Jack (choleric), Yusei (melancholic), Akiza (phlegmatic), and Crow (sanguine).
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