* ''VideoGame/MakaiToshiSaGa'' (a.k.a. ''Final Fantasy Legend'')
** BigBad: Ashura
** TheDragon: Su-zaku
** TheBrute: Gen-Bu
** EvilGenius: Byak-ko
** DarkChick: Sei-ryu
** [[spoiler:TheManBehindTheMan: God/Creator]]

* ''{{Manhunt}}''
** BigBad: Lionel Starkweather, aka "The Director"
** TheDragon: Ramirez
** The EvilGenius: Mr. Nasty and Gary Shaffer
** TheBrute: The Cerberus Commander
** The DarkChick: The White Rabbit

* ''{{Manhunt}} 2''
** BigBad: Daniel Lamb
** TheDragon: Leo Kasper
** EvilGenius: Dr. Pickman
** TheBrute: Michael
** DarkChick: Dr. Whyte
** SixthRangerTraitor: Judy

* The Masters of Evil in ''MarvelUltimateAlliance''
** BigBad - DoctorDoom
** TheDragon - Loki
** EvilGenius - Baron Mordo
** TheBrute - Ultron (he seems more violent than the others)
** DarkChick - Enchantress
** SixthRangerTraitor - Mandarin (who was forced out of the group)

* ''[[VideoGame/MarvelVsCapcom3 Marvel vs. Capcom 3: Fate Of Two Worlds]]''
** BigBad - {{Galactus}}
** TheDragon - SelfDemonstrating/DoctorDoom
** EvilGenius - [[Franchise/ResidentEvil Albert Wesker]]
** TheBrute - [[Comicbook/DoctorStrange Dormammu]]
** SixthRanger - [[StreetFighter Akuma]]

* ''Franchise/MassEffect'':
** VideoGame/MassEffect2 doesn't have one of these, with there being only one main antagonist, Harbinger, [[spoiler: who uses the Collector General as a mouthpiece.]] However, the mercenary groups that [[VillainTeamUp team up against Archangel]] have leaders that fit this mold nicely.
*** BigBad: Tarak
*** TheDragon[=/=]DarkChick: Jentha
*** TheBrute: Garm
*** EvilGenius: Jaroth

** There's also the Shadow Broker in Mass Effect 2.
*** BigBad - The Shadow Broker
*** TheDragon / TheBrute - [[spoiler:Tela Vasir]]
*** EvilGenius - The Observer
*** SixthRangerTraitor - Feron

** Cerberus in ''VideoGame/MassEffect3''
*** BigBad: The Illusive Man
*** TheDragon: Kai Leng
*** EvilGenius: Henry Lawson, Oleg Petrovsky
*** DarkChick: Dr. Eva Coré
*** SixthRanger: [[spoiler:Udina]]
*** TheManBehindTheMan: [[spoiler:Harbinger]]

* ''VideoGame/MaxPayne''
** The BigBad: Nicole Horne
** TheDragon: Angelo Punchinello
** The EvilGenius: Vinnie Gognitti
** TheBrute: Jack Lupino
** The DarkChick: Mona Sax
** The SixthRanger: Vladimir Lem

* ''VideoGame/MaxPayne 3''
** The BigBad: Victor Branco
** TheDragon: Armando Becker
** The EvilGenius: Dr. Arthur Fischer
** [[TheBrute The Brutes]]: Alberto Nieves, Milo Rego, and Bachmeyer
** TheDarkChick: Marcelo Branco
** SixthRangerTraitor: Raul Passos

* The FM-ians in ''VideoGame/MegaManStarForce'':
** BigBad: Cepheus
** TheDragon: Gemini
** The EvilGenius: [[GreenEyedMonster Cygnus]]
** TheBrute: [[BullSeeingRed Taurus]]
** The DarkChick: Ophiuca
** SixthRangerTraitor: Lyra

* The Neo Mu Empire in ''Mega Man Star Force 2'':
** BigBad: Dr. Vega
** TheDragon: [[ReplacementGoldfish Hollow]]
** The EvilGenius: [[SmugSnake Dark Phantom]]
** TheBrute: [[LastOfTheirKind Rogue]]
** The DarkChick / SixthRangerTraitor: Harp Note

* Dealer in ''Mega Man Star Force 3'':
** BigBad: Mr. King
** TheDragon: [[ScaryBlackMan Dread Joker]][=/=]Acid Ace
** The EvilGenius: [[LightIsNotGood Queen Virgo]]
** TheBrute: [[KillItWithFire Jack Corvus]]
** The DarkChick: Heartless
** SixthRangerTraitor: Acid Ace[=/=]Dread Joker

* ''VideoGame/MegaManX3'':
** BigBad - Sigma
** TheDragon - Dr. Doppler
** EvilGenius - Bit (though Doppler qualifies as well)
** TheBrute - Byte
** WildCard[=/=]EnigmaticMinion - Vile Mk. II

* ''VideoGame/MegaManX6'':
** BigBad - Gate
** TheDragon - High Max
** EvilGenius - Isoc
** TheBrute - [[SuperpoweredEvilSide Nightmare Zero]]
** SixthRanger[=/=]WildCard - Dynamo
** GiantSpaceFleaFromNowhere - Sigma

* ''VideoGame/MegaManXCommandMission''
** BigBad - Epsilon
** TheDragon - Scarface
** EvilGenius - Botos
** TheBrute - [[spoiler:[[TheMole Shadow]]]]
** DarkChick - Ferham
** [[spoiler:TheManBehindTheMan - Redips]]

* ''VideoGame/MegaManZero'': Copy X and the Four Guardians (although the latter [[HeroAntagonist aren't actually]] [[AntiVillain "villains"]])
** BigBad - [[KnightTemplar Copy X]]
** TheDragon - [[MyCountryRightOrWrong Harpuia]] (who [[DragonAscendant ascended]] in the second game as a [[ElCidPloy secret replacement]] for Copy X)
** EvilGenius - [[UndyingLoyalty Phantom]][[note]]the only one of the five to try both a sneak attack and a boss fight before his stage even begins. His division in the Neo Arcadian army is also stated as the Intelligence Unit. He could also be considered the second Dragon as well, considering he's the most loyal to Copy X, to the point of trying to [[TakingYouWithMe take Zero with him.]][[/note]]
** TheBrute - [[BloodKnight Fefnir]] (He's not so big compared to his fellow Guardians, but he's definitely [[HotBlooded the most impulsive]].)
** DarkChick - [[DarkActionGirl Leviathan]] (who fits the trope by being [[FemmeFatale a playful teaser]] [[FoeYay to Zero]].)

* ''Mega Man Zero 3'':
** BigBad and EvilGenius - Dr. Weil
** TheDragon - [[RoboticPsychopath Omega]]
** TheBrute - [[DiscOneFinalBoss Copy X Mk. II]]
** {{Dark Chick}}s and {{Sixth Ranger}}s - [[CreepyTwins The Baby Elves]]
** {{Sixth Ranger Traitor}}s - [[HeroAntagonist Harpuia, Fefnir & Leviathan]]

* ''VideoGame/MegaManZX Advent'':
** BigBad - [[MagnificentBastard Master]] [[AGodAmI Albert]]
** CoDragons[[spoiler:[=/=]TheStarscream]] - [[WoobieDestroyerOfWorlds Prometheus & Pandora]]
** EvilGenius - [[SmugSnake Aeolus]]
** TheBrute - [[TheLadette Atlas]]
** DarkChick - Thetis
** SixthRanger - [[RoboSpeak Siarnaq]]

* ''VideoGame/MetalGearSolid's'' Fox-Hound:
** The BigBad - Liquid Snake
** TheDragon - Revolver Ocelot
** The EvilGenius - Psycho Mantis
** TheBrute - Vulcan Raven
** The DarkChick - Sniper Wolf
** SacrificialLamb - Decoy Octopus

* ''VideoGame/MetalGearSolid2SonsOfLiberty'''s Sons Of Liberty:
** The BigBad - Solidus Snake
** TheDragon - Revolver Ocelot
** The EvilGenius - Fatman
** TheBrute - Fortune
** The DarkChick - Vamp
** SixthRangerTraitor - Olga Gurlukovich

* ''VideoGame/MetalGearSolid3SnakeEater'''s main bad guys:
** The BigBad - Volgin
** TheDragon - The Boss
** The EvilGenius - None, so they have to kidnap one.
** TheBrute - Major Ocelot
** The DarkChick - EVA
** QuirkyMinibossSquad - The Cobras

* The Cobras in more detail (formerly a FiveManBand)
** The BigBad - The Joy
** TheDragon - The Fury
** The EvilGenius - The End
** TheBrute - The Fear
** The DarkChick - The Pain
** The SixthRanger - The Sorrow (PosthumousCharacter)

* ''VideoGame/MetalGearSolid4GunsOfThePatriots'''s B&B Corp A.K.A. Snakehound
** The BigBad - Liquid Ocelot
** TheDragon - Screaming Mantis
** The EvilGenius -Laughing Octopus
** TheBrute - Crying Wolf
** The DarkChick -Raging Raven
** The SixthRanger - Vamp [[spoiler: Turns out he just wanted someone to [[DeathSeeker kill him]]]].

* ''VideoGame/MetalGearRisingRevengeance'''s [[PrivateMilitaryContractors Desperado Enforcement LLC.]]
** BigBad - [[DarkMessiah Senator Armstrong]]
** TheDragon - [[LargeAndInCharge Sundowner]]
** EvilGenius - [[WarriorPoet Monsoon]]
** TheBrute - [[MechanicalMonster Metal Gear Ray]]
** DarkChick - [[DarkActionGirl Mistral]]
** SixthRanger - [[BloodKnight Jetstream Sam]]
** SixthRangerTraitor - [[spoiler:[[RobotDog Blade Wolf]]]]

* ''VideoGame/SuperMetroid'':
** The BigBad: Mother Brain
** TheDragon: Ridley (literally)
** TheBrute: Kraid (two screens tall; ironically the weakest of the five)
** The EvilGenius: Phantoon (responsible for the power failure in the Wrecked Ship)
** The DarkChick: Draygon (appears to be a [[MonsterIsAMommy mother figure]] to a pack of Evirs)

* ''VideoGame/{{MOTHER 3}}'': The Pigmask Army
** BigBad: [[spoiler:[[PsychopathicManchild Porky Minch]]]]
** TheDragon: [[CyberneticsEatYourSoul The Masked Man]]
** The EvilGenius: [[SnakeOilSalesman Fassad]]
** TheBrute: [[KingMook Fierce Pork Trooper]]
** DarkChick: [[RobotMaid Lil' Miss Marshmallow]]
** TeamPet: [[SuperPersistentPredator Ultimate Chimera]]
** SixthRanger: [[spoiler:[[ReluctantMadScientist Dr. Andonuts]]]]

* ''VideoGame/NeedForSpeed: Carbon'' - Stacked Deck
** BigBad / EvilGenius: Darius
** TheDragon: Kenji
** TheBrute: Wolf
** DarkChick: Angie

* ''VideoGame/NicktoonsUnite''
** BigBad: [[TheAdventuresOfJimmyNeutronBoyGenius Professor Calamitous]]
** TheDragon: [[DannyPhantom Vlad Plasmius]]
** EvilGenius: Between Calamitous, Vlad, Plankton, and Crocker.
** TheBrute: [[SpongeBobSquarePants Plankton]]
** DarkChick: [[TheFairlyOddParents Crocker]]

* ''[[VideoGame/NicktoonsUnite Nicktoons Attack of the Globs]]''
** BigBad: [[WesternAnimation/SpongeBobSquarePants Plankton]]
** TheDragon: [[VideoGame/TakAndThePowerOfJuju Traloc]]
** [[EvilGenius "Evil" Genius]]: [[WesternAnimation/InvaderZim Dib]]
** TheBrute: [[WesternAnimation/DannyPhantom Technus]]
** DarkChick: [[TheAdventuresOfJimmyNeutronBoyGenius Beautiful Gorgeous]]

* ''VideoGame/NinjaGaiden''(NES):
** The BigBad: Jacquio
** TheDragon: Bloody Malth
** The Evil Genius: Bomberhead
** The Brute: The Barbarian
** The DarkChick: Basaquer
** SixthRangerTraitor: The Masked Devil/Ken Hayabusa

* ''NinjaGaiden Black/Sigma'':
** The BigBad: The Vigoor Emperor
** TheDragon: Doku
** The EvilGenius: Gamov
** TheBrute: Murai
** The DarkChick: Ishtaros & Nicchae
** The SixthRangerTraitor: Alma

* ''VideoGame/NoOneLivesForever'' (the first game)
** The BigBad - Baroness Felicity Dumas
** TheDragon - Dmitrij Volkov
** The EvilGenius - [[spoiler:Mr. Smith]]
** TheBrute - Magnus Armstrong
** The DarkChick - Inge Wagner
** The SixthRanger - [[spoiler:Tom Goodman]]
** [[spoiler:TheManBehindTheMan]] - [[spoiler:The Director]]

* ''VideoGame/{{Nostalgia}}''. The Ancient Father's Cabal:
** The BigBad: Emperor Terra
** TheDragon: Carmine
** TheBrute: Kakyo
** The EvilGenius: Hartmann
** The DarkChick: Yang Gui

* The Magog Cartel from ''VideoGame/{{Oddworld}}'':
** The BigBad: Lady Margaret
** TheDragon: Molluck
** TheBrute: General Dripik
** The EvilGenius: Vice-President Aslik
** The DarkChick: Director Phleg

* The Oni bosses from ''VideoGame/{{Okami}}''
** The BigBad - [[spoiler:Yami]]
** TheDragon - [[spoiler:Orochi]]
** The EvilGenius - Blight and the twin demon owls Lechku & Nechku
** TheBrute - Crimson Helm
** The DarkChick - The Spider Queen
** The SixthRanger - Ninetails

* ''VideoGame/{{Otomedius}}''
** The BigBad: Dark Force (The Gofer Sisters L.B. and R.B. also fulfill this role)
** TheDragon: Meta Lium, pilot of Big Core DX
** EvilGenius: The Gofer Sisters
** TheBrute: Ryukotsuki
** DarkChick: T.B. Rika

* ''VideoGame/{{Overlord}}''
** The BigBad: The Overlord
** TheDragon: Gnarl (Minion Master), possibly Mortis (Minion GrimReaper), The Browns or The Reds
** TheBrute: Giblet (Forgemaster), The Browns
** The EvilGenius: [[EvilChancellor Gnarl]], possibly Quaver, The Greens
** The DarkChick: The Mistresses, The Blues

* ''VideoGame/PacMan''
** The BigBad / TheBrute: Blinky (chases Pac-Man)
** TheDragon: Inky (follows and aids Blinky)
** The EvilGenius: Pinky (tries to trap Pac-Man)
** The DarkChick: Clyde (flees from Pac-Man); Sue serves as this in ''Ms. Pac-Man'', as is Tim in ''Pac-Man Junior''
** The SixthRanger: Funky and Spunky (jumping ghosts in ''Pac-Mania'') and Kinky (can merge with other ghosts to make them stronger; a secondary EvilGenius exclusive to ''Pac-Man Arrange'')

* ''VideoGame/PaperMario''
** BigBad: Bowser
** TheDragon: Chrystal King
** EvilGenius: Tutankoopa, General Guy
** TheBrute: Tubba Blubba (Also TheDarkChick) Huff'n'Puff, Lava Piranha
** DarkChick: Goomba King
** QuirkyMinibossSquad: The Koopa Bros.

* ''VideoGame/PaperMarioTheThousandYearDoor''
** BigBad: Grodus
** TheDragon: Lord Crump
** TheEvilGenius: Beldam
** TheBrute: Marilyn
** TheDarkChick: Doopliss
** BiggerBad: [[spoiler: Shadow Queen]]

* ''VideoGame/{{Persona 3}}''
** The BigBad - [[spoiler: Nyx]]
** TheDragon - Nyx Avatar/ [[spoiler:Ryoji]]
** TheBrute - Takaya
** The EvilGenius - Jin
** The DarkChick - Chidori

** The Full Moon Shadows could also fit:
*** The BigBad - Hanged Man
*** TheDragon - Strength and Fortune
*** TheBrute - Emperor and Chariot
*** The EvilGenius - Hierophant, Lovers and Hermit
*** The DarkChick - Priestess, Empress and Justice
*** The SacrificialLamb - Magician

* ''VideoGame/{{Persona 4}}''
** The BigBad - [[spoiler: Izanami]]
** TheDragon - [[spoiler: Ameno-sagiri]]
** TheBrute - [[spoiler: Namatame/ Kunino-sagiri]]
** The EvilGenius - [[spoiler: Adachi]] (Unlike [[spoiler: Namatame]] and [[spoiler: Kunino]], he and [[spoiler: Ameno]] at least have separate personalities
** The DarkChick - Two of them, one also a SixthRanger, the other also a SixthRangerTraitor :
*** The SixthRanger - [[spoiler: Mitsuo]]
*** The SixthRangerTraitor - [[spoiler: Yourself/ [[FanNickname Souji Seta]], since you find a different use for your power]].

* Kane's Court In ''VideoGame/{{Pirate 101}}''
** The BigBad - Kane
** TheDragon - Deacon
** The EvilGenius - Bishop
** TheBrute - Rooke
** The DarkChick - [[NoNameGiven The Unnamed Female Clockwork]]

* The Cipher Syndicate in ''VideoGame/PokemonColosseum''
** The BigBad - Evice
** TheDragon - Nascour
** The EvilGenius - Ein
** TheBrute - Dakim
** The DarkChick - Lady Venus, Miror B

* The Cipher Syndicate in ''VideoGame/PokemonXDGaleOfDarkness''
** The BigBad - [[spoiler:Greevil]]
** [[CoDragons The Dragons]] - [[spoiler:Ardos and Eldes]]
** TheBrute - Gorigan
** The EvilGenius - Lovrina (Seems to be The DarkChick at first, but [[ObfuscatingStupidity it's a ruse.]])
** The DarkChick - Snattle (''Acts'' like the EvilGenius, but turns out to [[SmugSnake not be that smart.]])

* Team Galactic In ''[[VideoGame/PokemonDiamondAndPearl Pokémon Platinum]]''
** BigBad - Cyrus
** TheDragon - Saturn
** EvilGenius - Charon
** TheBrute - Jupiter
** DarkChick - Mars

* Team Dim Sun from ''VideoGame/PokemonRanger: Shadows of Almia''. It's scary how well they fit their respective parts.
** The BigBad - [[spoiler:Blake Hall]].
** TheDragon - [[spoiler:Kincaid]]
** The EvilGenius - Ice (after [[spoiler:Isaac taught him programming]], anyway).
** TheBrute - Heath
** The DarkChick - Lavana
** The SixthRanger - [[spoiler:Isaac]], who does both a FaceHeelTurn ''and'' a HeelFaceTurn.

* Neo Team Rocket from ''[[VideoGame/PokemonGoldAndSilver Pokémon HeartGold & SoulSilver]]''.
** The BigBad - [[spoiler:Giovanni]], as [[spoiler:event Celebi]] shows.
** TheDragon - Archer, the final executive, who disbands Team Rocket.
** The EvilGenius - Petrel, the master of disguise.
** TheBrute - Proton, who is "often labeled as the scariest and cruelest guy in Team Rocket".
** The DarkChick - Ariana, though she introduces herself as "interim boss in the place of Giovanni", Archer seems to be the true leader of executives.

* Team Plasma in ''VideoGame/PokemonBlackAndWhite''
** BigBad - N
** TheDragon - Zekrom/Reshiram
** TheBrute - The Shadow Triad
** TheEvilGenius - The Seven Sages, as well as the scientists in the P2 Laboratory
** TheDarkChick - Anthea and Concordia
** TheManBehindTheMan - Ghetsis, who pretends to be TheDragon earlier in the story.

* Neo Team Plasma in ''VideoGame/PokemonBlack2AndWhite2''
** BigBad - Ghetsis
** TheDragon - Sage Zinzolin and Kyurem
** TheBrute - Neo Team Plasma Grunts
** TheEvilGenius - Researcher Colress
** TheDarkChick - Team Plasma Shadow

* The [[spoiler: Societea]] in ''VideoGame/PokemonRanger: Guardian Signs''
** BigBad - [[spoiler: Dr. Edward]]
** TheDragon - [[spoiler: Purple Eyes, while not actually part of The Societea, still acts as their main enforcer by heading the Pinchers.]]
** TheBrute - [[spoiler: Arley]]
** The EvilGenius - [[spoiler: Hocus]]
** The DarkChick - [[spoiler: Kasa]]

* ''VideoGame/{{Police 911}}'' - The Gokudo-kai
** The BigBad - Katsuji Haraguchi
** TheDragon - Keisuke Matsuoka
** The EvilGenius - Richard Hansen
** The Brute - Shigenobu Matsuyama
** The DarkChick - Noriko Nagata

* ''VideoGame/PrinceOfPersia2008''
** The BigBad - Ahriman
** TheDragon - The King
** EvilGenius - The Alchmist
** TheBrute - The Warrior
** The DarkChick - The Concubine
** SixthRangerTraitor - The Hunter (He's just kind of doing his own thing, really.)\\
\\
(Note that these are the game-play dynamics. Story-wise, The Alchemist is the Dragon, and the King is the SixthRangerTraitor. That leaves Evil Genius to The Hunter, who also fits the role, just to a lesser extent.)

* ''VideoGame/ProjectXZone'' - Oros Phlox
** BigBad: [[spoiler: [[TheManBehindTheMan Meden Traore]]]]
** TheDragon and TheDarkChick: Due Frabellum
** TheBrute: Drei Belanos
** TheEvilGenius: Eins Belanos

* ''VideoGame/{{Prototype}}'': Blackwatch
** BigBad: General Peter Randall
** TheDragon: Captain Robert Cross
** EvilGenius: Director Raymond [=McMullen=]
** TheBrute: Colonel Ian Taggart
** DarkChick: [[spoiler:Karen Parker]]
** SixthRangerTraitor: [[spoiler:The real Alex Mercer]]

* ''VideoGame/{{Prototype 2}}'': [[spoiler:Evolved]]
** BigBad: [[RogueProtagonist Alex Mercer]]
** TheDragon: Roland
** EvilGenius: [[spoiler:Dr. Koenig]]
** TheBrute: Commander Keith Gallagher
** DarkChick: [[spoiler:Sabrina Galloway]]
** SixthRangerTraitor: [[spoiler:James Heller, [[UnwittingPawn unwittingly at first]]]]

* ''Psychic Force 2012'': The Psychiccer Army
** BigBad: Wong
** TheDragon / TheStarscream: Setsuna
** TheBrute: Gudeath
** DarkChick: Emilio [[spoiler:Later a SixthRangerTraitor]]
** SixthRanger[[spoiler:/SixthRangerTraitor: Might, unwittingly doing Wong's agenda]]

* ''VideoGame/RatchetDeadlocked'':
** The BigBad: [[CorruptCorporateExecutive Gleeman Vox]]
** TheDragon: Ace Hardlight
** The EvilGenius: Reactor (was originally a teacher)
** TheBrute: Shellshock (has the A.I. of a coffee maker)
** The DarkChick: The Eviscerator

* ''VideoGame/RatchetAndClankFutureACrackInTime'':
** The BigBad: Dr. Nefarious
** TheDragon: [[ServileSnarker Lawrence]]
** The EvilGenius: [[CorruptCorporateExecutive Pollyx]]
** TheBrute: Lord Vorselon
** The DarkChick: Cassiopeia

* ''VideoGame/RedDeadRedemption'' -Dutch's old gang
** The BigBad: Dutch van der Linde
** TheDragon: John Marston
** The EvilGenius: Javier Escuella
** TheBrute: Bill Williamson
** The DarkChick: Abigail Marston

* ''VideoGame/RedDeadRedemption'' -The Mexican Army
** The BigBad: Agustin Allende
** CoDragons: Vincente de Santa and Espinoza
** The EvilGenius: Javier Escuella
** TheBrute: Raul Zubieta and Bill Williamson.
** The DarkChick: Quique Montemayor

* ''Franchise/RedFaction II'', after Molov's FaceHeelTurn:
** The BigBad: Molov
** TheDragon / The EvilGenius: Shrike
** TheBrute: Repta
** The DarkChick: Quill

* ''Franchise/ResidentEvil'' series: Umbrella
** BigBad: Ozwell E. Spencer
** TheDragon: Albert Wesker
** EvilGenius: William Birkin
** TheBrute: Sergei Vladimir
** DarkChick: Alexia Ashford

* ''VideoGame/ResidentEvil2''
** The BigBad: William Birkin
** TheDragon: Albert Wesker
** The EvilGenius: Chief Irons
** TheBrute: Mr. X
** The DarkChick: Annette Birkin

* ''VideoGame/ResidentEvil4'':
** The BigBad: Osmund Saddler
** TheDragon: Jack Krauser
** TheBrute: Bitores Mendez
** The EvilGenius: Ramon Salazar
** SixthRangerTraitor: Luis Sera

* ''VideoGame/ReturnToCastleWolfenstein''
** The BigBad: Wilhelm "Deathshead" Strasse
** TheDragon: General von Schuber
** The EvilGenius: Professor Zemph
** TheBrute: Helga von Bulow
** The DarkChick: Marianna Blavatsky

* ''VideoGame/ResidentEvilOperationRaccoonCity'': Umbrella Security Service
** BigBad: Lupo
** TheDragon: Vector
** EvilGenius: Four-Eyes
** TheBrute: Beltway
** DarkChick: Bertha

* ''VideoGame/RomancingSaGa2''
** BigBad - Wagnas (however it is debatable since all Seven of the villains act on their own)
** TheDragon - Kujinshi
** EvilGenius - Bokuohn
** TheBrute - Dantarg
** DarkChick - Rockbouquet
** SixthRangerTraitor - Noel (You can make peace with him provided [[spoiler: you don't kill Rockbouquet before talking with him]]), Subier

* ''VideoGame/RomancingSaGa3''
** BigBad - Destroyer
** TheDragon - Forneus
** EvilGenius - Aunas
** DarkChick - Byunei
** TheBrute - Arakes

* ''[[VisualNovel/{{Rosenkreuzstilette}} Rosenkreuzstilette Freudenstachel]]'' - The Black Cross
** BigBad - Pamela Arwig
** TheDragon - Eifer Skute
** TheBrute - Schirach Fühler
** EvilGenius - Lecht Refraktia
** DarkChick - Rink Refraktia

* The Red Crayon Aristocrats in ''VideoGame/RuleOfRose''
** The BigBad - [[spoiler:Wendy]]
** TheDragon - Diana
** The EvilGenius - Meg
** TheBrute - Amanda
** The DarkChick - Eleanor
** The SixthRangerTraitor - Jennifer