Scott Turner, an obsessively neat police investigator, acquires Hooch, a large and slobbery Dogue de Bordeaux, after the murder of Amos Reed, a local junk-yard owner who was a friend of Turner's. Turner is bored with little police work in the fictional town of Cypress Beach, California and is set to transfer to a better job in Sacramento while fellow investigator David Sutton is to be his replacement.
Turner pleads with police chief Howard Hyde to let him take on Amos' murder case. Believing that Hooch is the only "witness" he has, Turner brings him home. The energetic dog promptly destroys Turner's house, his car, and turns his life upside-down. On a positive note, however, Hooch also instigates a romance between Turner and the new town veterinarian Emily Carson.
* BigFriendlyDog: Averted at first, but played straight towards the end.
* ChekhovsGun: Hooch has a patented trick, in which he can hold a grown human in a chokehold with his mouth without biting unless commanded. Turner uses that trick to intimidate a thug connected to Hooch's Master's murder.
* [[spoiler: BirthDeathJuxtaposition]]
* DirtyCop: [[spoiler: Howard Hyde.]]
* HeroicSacrifice: [[spoiler: Hooch.]]
* JackBauerInterrogationTechnique: Hooch's Chokehold.
* LongList: The "House Rules."
** RunningGag: "This is not your room."
* MakeTheDogTestify: The driving force behind the plot; Hooch has the murderer's scent and witnessed it happen so he's the only lead the cops currently have.
* NeatFreak: Turner, so very much.
* WhatCouldHaveBeen: There were apparently plans at one point for a ''Turner & Hooch'' television series. Tim Allen has said he was approached to star in it, but he turned it down, preferring to do something original, which lead to ''HomeImprovement''.