[[quoteright:290:http://static.tvtropes.org/pmwiki/pub/images/osmosis_351.jpg]]
[[caption-width-right:290:He's one ''[[JustForPun cell]]'' of a guy, and his partner's [[JustForPun a real pill.]]]]

-->''"Every body needs a hero."''\\
--The movie's {{Tagline}}

Alrighty then, let's see if we can keep this from being gross...

2001's ''Osmosis Jones'' is a [[BuddyCopShow Buddy Cop Movie]] featuring Chris Rock and David Hyde Pierce. The two are paired up to stop a nasty criminal (played by LaurenceFishburne) from destroying their beloved city, hindered by a self-centered mayor (WilliamShatner), whose assistant (R&B singer {{Music/Brandy}}) is the main love interest.

Also, this all takes place inside a human body.

Osmosis Jones is a white blood cell (voiced, humorously enough, by ''black'' comedian Chris Rock) who lost his reputation after a nasty incident that happened to ruin Frank (the human this movie takes place in, played by Creator/BillMurray) out in the real world. Frank eats a contaminated egg that happened to carry a deadly virus by the name of Thrax, whose goal is to kill Frank within 48 hours.

After Thrax starts doing some damage, Osmosis is paired up with a cold pill named Drix. The two clash frequently, as most new cop partners do in movies, until Drix sees Thrax himself, and takes Ozzy's side.

Meanwhile, while all this is happening in the animated world of the City of Frank, we get a few peeks at what Frank is going through, in the live-action sequences of the movie, trying to care for his health-conscious daughter Shane.

Body jokes abound, and there are a couple of rather... [[NauseaFuel disgusting]] live-action scenes, but the movie itself is not bad. The way it stands, it's either funny and sadly underrated, or disgusting and unappealing. It spawned a somewhat popular spinoff cartoon called ''WesternAnimation/{{Ozzy and Drix}}''.

It's also notable that one of the two guys who directed the animated parts of the movie was responsible for animating [[Film/WhoFramedRogerRabbit another animated/live action film]].

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!!Tropes:

* OneHundredAndEight: As mentioned on the trope page, a body temperature this high usually kills. Note the attention paid to it in the climax, as Frank toes the line and cheats death.
* AesopAmnesia: The spin-off cartoon's first episode shows that whatever Frank learned about health didn't take, and his life seems to have spun out of control. For the brief time we see him, he's eating chicken in a trailer park.
* AnAesop: Watch your health, at least for the sake of your loved ones.
* ArtMajorBiology: All anthropomorphization aside, anyone who's passed high school biology knows that viruses don't work even remotely like they're depicted in the film. Though they can be harmful to the organisms that they infest, they aren't biologically programmed to just cause their host as much harm as possible. They infest a host's cells so that they can reproduce by multiplying and spreading throughout its body--any harmful symptoms are simply side-effects of this, and killing the host would simply kill the virus in the process. If Thrax actually behaved like a virus, he would have spent the movie making an army of Thrax-clones or pulling GrandTheftMe on cells la ''InvasionOfTheBodySnatchers'', not trying to kill Frank by stealing his hypothalamus.
* AttackItsWeakPoint: Thrax goes after the Hypothalamus, causing his poor victim to undergo a life-threatening fever. On the cellular level, this is represented as ''the city burning down.''
* ApocalypseHow:
** Well, while Frank's death wouldn't even make a dent in our society, for the ''cells'' it'd be a Class 6. And there's your FridgeHorror for the day.
** Thrax has done this at least three times before, which in terms of casualties is the equivalent of burning the entire world to the ground ''three thousand times over''.
* BadassLongcoat: Thrax. It's also practical: he can spread it to act as wings or a [[ImprovisedParachute parachute]].
* BecomingPartOfTheImage: A car crashes on a billboard for "the Land Down Under" (Frank's butt), the car wedged right in the crack.
* BigRedButton: The incident that ruined Ozzy's reputation? Causing Frank to forcefully vomit on a teacher. How did Ozzy do this? By hitting the large, glowing button in The Stomach labeled (of course) "VOMIT".
* {{Bizarrchitecture}}: Frank's subconscious definitely counts.
* BlackBugRoom: Thrax accidentally stumbles into Frank's towards the climax, [[TooSpicyForYogSothoth which freaks him out]].
-->'''Thrax''': (Stunned) This cat was sick before I even got here.
* ButNotTooWhite: Drix, played by David Hyde Pierce. The producers were ''looking'' for someone as white-bread as possible. [[Series/{{Frasier}} Niles Crane]] is about as white-bread as you can get.
* ByTheBookCop: Drix.
* CassandraTruth: Osmosis is the only one who knows about Thrax's plans.
* ChekhovsGun:
** When Thrax is destroying the saliva boat, he's humming [[http://www.youtube.com/watch?v=SIQGwRniyNo "Fever"]] , which gives you [[spoiler: his method of killing making this a classic use of this trope]] .
** There's also [[spoiler: Frank's allergy to pollen pods. Thrax uses it to escape Frank's body.]]
** The false eyelash that Shane's friend gives her. [[spoiler: In the climax, Ozzy and Thrax duke it out on top of it. Thrax doesn't realize that it's fake until he gets his hand stuck in it...just before it falls off of Shane's eye into a beaker of alcohol. Cue dramatic death scene.]]
* ChekhovsSkill: Ozzy's ability to change shape comes in very handy in the climax.
* ConspicuousCG: Drix, the cars, and most of the high-up shots of Frank City.
** Especially when Drix tries to distort himself like Ozzy (before they sneak into The Zit) and his crushed-up head is temporarily animated in 2D.
* CoolCar: Thrax's car.
* CoversAlwaysLie: Due to contract issues, the Farrelly Brothers (of ''DumbAndDumber'' fame) are listed as primary directors. They only did the live-action footage, and didn't have any input on the animation and script.
* CowboyCop: Osmosis
* ADateWithRosiePalms: Also counts as GettingCrapPastTheRadar.
-->'''Osmosis:''' "What you talkin' 'bout? I'm a legend, girl! Chicks line up to divide with me!"
-->'''Leah:''' "Oh really? Because to me, you look like the kind of cell who mostly divides with himself."
* DeceasedParentsAreTheBest: Averted. We don't hear much about her, but Shane's mother was apparently even worse to her body than Frank is, and presumably died for it.
* DisneyDeath: There are actually 3 of these in this movie. [[spoiler: First, in a rare instance where a villain suffers a Disney Death, but is KilledOffForReal later on, after Osmosis Jones and Thrax blew up The Zit, they thought Thrax was dead, but when Osmosis goes to the movie theater, he finds out Thrax is alive. Second, Frank's death caused by a high fever. And finally, after Ozzy travels back to Frank in a tear drop, he appears to be dead, but wakes up.]]
* DisneyVillainDeath: [[spoiler:Thrax falls to his death into a beaker of alcohol.]] Although we see the death. And it is horrifying.
* DisproportionateRetribution: Mrs. Boyd gets a little embarrassed due to Frank throwing up on her after eating some bad oysters (which was revealed to be Ozzy flushing a virus out of his system) and places a ''restraining order'' against him for it. Sheesh, lady, it's just a little bile, not stalker harassment!
** Also, she starts screaming at him and refuses to remove said order when his zit pops on her. Yes, it's disgusting, but he didn't do it on purpose.
** And because he vomited on a woman, ''he gets fired from his job?!'' The fuck?!
* DoubleEntendre: [[DoesThisRemindYouOfAnything "This guy was sick before I even got here!"]]
* EvilLaugh: Thrax pulls this off in a way that makes him seem demented or schizophrenic. Don't misunderstand--it's still really creepy.
* EvilIsPetty: Only partially with Thrax. He wants to kill Frank in a record time so he can be in medical textbooks.
* {{Expy}}: Drix bears a strong resemblance to ComicBook/IronMan.
* FamilyUnfriendlyDeath and FamilyUnfriendlyViolence: Used rather disturbingly for a PG movie--cells exploding into red lava goo and the villain [[spoiler:turning sickly green and becoming hideously warped in a beaker of alcohol]], although the latter happened to a being of pure evil...
* FanDisservice: That picture of the chief's disgustingly obese wife, which can be seen during the scene when Ozzy is first seen talking his boss. The shot lingers long enough to ''make sure'' you've seen it and absorbed its grandeur.
* FantasticVoyagePlot: They're already permanently inside the body.
* FauxAffablyEvil: Thrax. At least at first. As the film progresses, he slips more and more frequently into a bloodthirsty, manic persona until he hits a full-on VillainousBreakdown.
* GettingCrapPastTheRadar: Here's one example:
-->'''Osmosis''': What the heck is an uvula?!
-->'''Drix''': It's that little dangly thing that hangs down in Frank's--
-->'''Osmosis Jones''': [[FreudWasRight Boxer shorts!]] Okay, here we go!
-->'''Drix''': Not ''that'' little dangly thing! The one in his ''throat''!
-->''({{Beat}})''
-->'''Osmosis''': I knew that. ''I knew that!''
** When they arrive at The Zit, there are clearly some strippers roaming around there. How did they sneak THAT past the radar?
*** [[http://www.lyrics007.com/Kid%20Rock%20Lyrics/Cool,%20Daddy%20Cool%20Lyrics.html Just read the lyrics of this song that plays during this scene for crying out loud!]]
* GreenAroundTheGills: Ozzy as a germ drinking phlegm for a beverage in the club. In addition to this trope, this causes his head to twist and stretch as well.
* {{Homage}}
** [[spoiler:Thrax's death is extremely reminiscent of T-1000's bath in molten lava.]] Also, the part where Jones reassembles himself after getting split in two looks a lot like the part in {{Terminator}} 2 where the T-1000 pulls its head back together after getting blasted point blank by a shotgun.
** The fight on Shane's eye, and Thrax's design are shout outs to Film/TheMatrix. (Not to mention the fact that Thrax is voiced by Laurence Fishburne)
** [[{{Titanic}} "Gentlemen, it's been a pleasure playing with you this evening."]] Including the fact that this line is followed by the band playing "Nearer My God To Thee."
** Film/TheGodfather scene in the armpit.
** "El Muerte Roja" or "The Red Death" possibly refers to Creator/EdgarAllanPoe's "The Masque of The Red Death", also, both diseases are written in without much identity other than that they kill in awful ways.
* HurricaneOfPuns: The DVD menu does this when an option isn't highlighted. "Play movie" becomes "[[ToiletHumor Bowel Movie]]", "Choose A Foul Scene" (Scene Selection) becomes "Frank's Gross Anatomy", "Scene Celections" becomes, "Spleen Cellections", "Special Features" becomes, "[[YouMakeMeSic Smelly Feetures]]", and "Languages" becomes "Lunguages".
* AnIcePerson: Drix's painkilling abilities are represented this way. Inevitably, this leads to the line "[[HumanPopsicle You just iced my witness]]!"
* InfantImmortality: Averted. Thrax not only plans to kill Shane, but reminisces about killing a "little girl" who "didn't like to wash her hands."
* InkSuitActor: [[KidRock Kidney Rock]].
* {{Jerkass}}: Mayor Phlemming. It's largely thanks to him that Frank's health and family relationships are in such a wreck.
* KillItWithFire: Thrax's way of dealing with people.
* LogoJoke: The Warner Bros. logo appears as a one-celled organism floating in a dark background.
* MayorPain: Phlemming.
* MeaningfulEcho - You want Osmosis? You got Osmosis!
* MediumBlending - The entire concept behind this movie. Live action humans and cartoon insides ''a la'' ''Film/FantasticVoyage.''
* MoodWhiplash: The briefing scene at the Zit is rather disorienting, swinging from Thrax's ominous plan and rant to Ozzy's ridiculous attempts to trick information from him.
* MostWritersAreHuman
* MyGodWhatHaveIDone: [[spoiler:Mayor Phlemming when he sees the City of Frank getting burned up.]]
* NearVillainVictory: Boy, is it ever.
* NiceJobFixingItVillain: [[spoiler: During the final fight, Thrax tries to use his chain, which holds Frank's as well as his previous victims' hypothalamus chromosome, to strangle Ozzy with. However Shane winds up blinking (they're fighting on her eye) separating the two with the chain still around Ozzy's neck. After Thrax's last attack fails, Ozzy manages to escape with the chain while Thrax falls into a bottle of alcohol.]]
* NonMammalMammaries: Leah, along with pretty much every other female cell in the movie.
* ObstructiveBureaucrat: Mayor Phlemming. Who only cares about his upcoming election and [[spoiler:nearly inadvertently kills Frank with his negligence.]]
* OddNameOut: Osmosis Jones', being a normal last name and a human-body-themed first name instead of other cells' like "Tom Colonic" and "Leah Estrogen". "Drixobenzo Methapherdramine" also counts as one.
* OhCrap: Thrax's reaction when Drix's massive grenade gets uncapped.
* OhMyGods: Cells use "Frank" either as their term for "God" or as an expletive.
* OmnicidalManiac:
** Thrax, on a cellular scale. His stated goal is to kill Frank in two days, faster than any other virus has ever killed, and give himself a whole new chapter in the [[strike:history]] medical books.
* OurFounder:
** A sperm cell, naturally.
** Also doubles as ParentalBonus, since many children will not see the statue in the shot, much less recognize it for what it is.
* PaperThinDisguise: Drix disguises himself to get into the Zit... by wearing a frozen germ on his head. And ''it works''.
* PhlebotinumRebel‎: Drix rebels on his function of being a temporary relief by throwing away his description after Ozzy convinces him to stay for his confrontation with Thrax.
* ReverseMole - The Flu Shot who hangs out with germs while providing info to Frank's Finest.
* RogerRabbitEffect - Surprisingly averted. For most of the movie the two worlds have no direct interaction. There are a couple moments, such as Frank's subconscious, and the fight on the fake eyelash, although that uses rather poor CGI rather than live action.
* ScaryBlackMan: Thrax played by LaurenceFishburne.
* SeekerWhiteBloodCells: The film anthropomorphisizes the entire human body, giving all the various cells and such names and allowing them to speak and develop friendships with other cells. The white blood cells are treated like the police, so they get a lot of chase scenes with equally anthropomorphic pathogens.
* SesquipedalianSmith: Osmosis Jones.
* ShoutOut: When Drix and Ozzy return to the police station from [[spoiler:blowing up The Zit]], Ozzy accidentally calls Leah "Brandy," which is the name of her voice actor.
** It might have only been intended to be NauseaFuel, but Jones' and Drix's first conversation is very similar to the [[http://www.youtube.com/watch?v=13JK5kChbRw Four Yorkshiremen]] sketch, at least for Jones' part of it.
** [[spoiler:Thrax being knocked into cleaning alcohol]] is a recreation of the T-1000's death in ''{{Terminator}} 2''.
** Also one to the Ohio Players. When Thrax and his Mooks are gloating over the newspaper article about the heroes stopping the cold. When asked about the possibility of the protagonists intervening, Thrax responds: "Fire".
* ShownTheirWork: The portrayal of anatomy is pretty impressive for a movie where ''everything'' in the body is anthropomorphic, such as Osmosis mentioning his parents coming over on the umbilical cord. Also, the creators worked with a professional martial artist to make Thrax's fighting more accurate.
* SlasherSmile:
** Thrax at points; and though probably unintentional Ozzy does it at times.
** Drix dons one when they are trying to intimidate the flu shot
* SpockSpeak: Subverted--in a flashback, Frank speaks to a kid at a science fair who talks in this manner about his project to leach the toxins out of polluted oysters. Certain that the kid's a genius and the project worked, Frank picks one out of the container and ''eats it raw''. Then finds out the kid is actually of very low intelligence and the oysters are ''still'' polluted. (This, incidentally, is what led to Jones's disgrace--he panicked at the thought of all of those toxins going into Frank and pressed an emergency "vomit" button at exactly the wrong time.)
* StealthPun: After Thrax first appears, he saunters along the boat while humming the melody from "Fever".
* SwissArmyTears: Justified--[[spoiler:after defeating Thrax, Osmosis jumps into one of Shane's tears that falls into Frank's mouth to return the hypothalamus chain.]] It probably appeared this way to the doctors, though.
* TenMinuteRetirement: [[spoiler: Mayor Phleming fires Ozzie from the police force after blowing up The Zit, using his poor record and breaking of regulations as a smokescreen to cover up the existence of Thrax's infection, and orders Drix to leave Frank's body. Fortunately, both of them come around when Thrax makes Frank's body go to hell in a handbag, and they end up getting their jobs back.]]
* TheCameo: [[http://postimage.org/image/3o6ohiasl/ Pikachu makes an appearance]] at the bladder. No, [[{{Franchise/Pokemon}} Pikachu]] was NOT photoshopped there.
* TheInformant: The flu shot.
-->That's funny. He doesn't look [[IncrediblyLamePun fluish]].
* TooDumbToLive:
** Frank. Sorry Shane, but it's true. Eating raw, polluted oysters. Eating the egg dropped in a filthy monkey cage, where not even the ten second or even the ONE second rule should apply. All his knowledge goes to promoting his laziness or retaining sports statistics.
** Well, considering that Mayor Phlemming has been running his brain...
* TorsoWithAView: Self-invoked by Osmosis to avoid succumbing to the trope below.
* TouchOfDeath: One of Thrax's primary weapons. Everything he even so much as pricks with his long claw seems to burn up.
* UnflinchingWalk: Thrax pulls one off particularly well.
* VileVillainSaccharineShow: Due to the previously mentioned [[ExecutiveMeddling sanit]][[IncrediblyLamePun izing]], as the movie became a light-hearted comedy, Thrax didn't change much, resulting in a disproportionately dark villain. It gives an odd feeling of MoodWhiplash when he is placed up against the goofy protagonists.
* VillainousBreakdown:
** Thrax has a subtle one during the final confrontation on Shane's eye. His normally slick dreadlocks fall out of place, his voice gets rougher, and his EvilLaugh gets a lot creepier.
** Another slight one happens when Thrax enters the subconscious and sees all Frank's repressed memories. He stumbles around in confusion, visibly unnerved, before running out in a panic.
-->'''Thrax''': This cat was sick before I even got here.
* VisualPun: All the signs and graffiti throughout the movie contain these.
* VoluntaryShapeshifting: Most cells have a limited variant of this--for instance, when Osmosis wants to fit in with a looser crowd, he makes himself one-eyed. Drix ''cannot'' do this, so he winds up using a [[HumanPopsicle small frozen cell]] as a NiceHat.
* VomitIndiscretionShot: Though the actual scene isn't shown, it's shown on the front page of the paper in all its disgusting glory.
* WittyBanter: Provided by two cells who act as newscasters.
* WorstNewsJudgementEver: Somehow an ill man who ate a bad oyster and throws up on a teacher becomes a huge story, so huge that Frank lost his job and the teacher's daughter had to transfer schools.
* WouldHurtAChild: Apparently, one of Thrax's victims was a little girl that didn't enjoy washing her hands. Also, after infecting Frank with a deadly fever, he mentions to Osmosis Jones that he's going to break his current record by killing Shane even faster.
* YetAnotherBabyPanda: Parodied with panda animal crackers.
* YouHaveOutlivedYourUsefulness:
** No killing here, but the Mayor said that Drix is only temporary.
-->'''Mayor Phlegming:''' Son, do me a favor and read what it says on your arm.
-->'''Drix:''' 'For the temporary relief of symptoms associated with... '
-->'''Mayor Phlegming:''' Exactly! Temporary. You're nothing but a wannabe, a placebo, a generic brand. Marked-down, over-the-counter, useless Tic-Tac! Now, get out of MY BODY!
** Thrax burns his thugs alive once they become a hindrance.
-->'''Thrax:''' Medical books aren't written about losers!

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