''Mr. & Mrs. Smith'' may refer to:

* ''Film/MrAndMrsSmith1941'', a screwball comedy film directed by Creator/AlfredHitchcock, starring Creator/RobertMontgomery and Creator/CaroleLombard
* ''Film/MrAndMrsSmith2005'', an action comedy film directed by Creator/DougLiman, starring Creator/BradPitt and Creator/AngelinaJolie
* ''[[Series/MrAndMrsSmith2024 Mr. & Mrs. Smith (2024)]]'', an action comedy series starring Creator/DonaldGlover and Creator/MayaErskine

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