* ''{{Starflight}}''
** In ''2'', [[spoiler: the free Leghk killed themselves than be subjected to Uhl's influence.]]
** If you have a G'nunk crewmember and speak to another alien in a weak manner, she'll kill herself rather than been stuck on your ship.
* 'Videogame/DukeNukem3D' has a hanged monk in Deathrow as a reference to Rise of the Triad as well as a literal hung jury in Pigsty.
* In ''VideoGame/FinalFantasyVI'', after spending a year in a coma after TheEndOfTheWorldAsWeKnowIt, if you fail to save Cid, [[spoiler:Celes]], having lost everything, decides to climbs a cliff to leap off onto the rocks below (which, according to Cid, all other survivors in the island had done when they succumbed to despair). [[spoiler:She survives on a miracle, sees Locke's bandanna wrapped around a pigeon's wing, and regains her will to live]].
** Shadow does this in his segment of the game's ending if you have him in your party. To sum up his motivations, he'd [[spoiler:let a friend die a very painful death instead of finishing him himself]] and has carried the guilt for years with him. With the world saved, he stays in the [[CollapsingLair collapsing final dungeon]] to die and join his friend in death. Complete with him [[ShooTheDog telling his dog to go on without him]]. TearJerker, ahoy.
* In ''VideoGame/FinalFantasyVII'', When Barret confronts his old friend Dyne, they duke it out. After defeat brings him back to his senses, Dyne [[MyGodWhatHaveIDone realizes the horrible things he's done]] and tells Barret to keep taking care of Marlene, who was his child by birth, saying his hands are too stained to carry her anymore. Then he drags himself to a cliff and throws himself off it. The game conveniently forgets that he actually survived that same drop years before.
* ''VideoGame/GodOfWar'' starts with Kratos throwing himself off a cliff, with the game being a HowWeGotHere. The Gods decide that YouKillItYouBoughtIt and therefore promote him as the new God of War. This turns out badly for them when they renege on this decision.
* In the ''VisualNovel/PhoenixWrightAceAttorney'' universe, quite a few people in backstories. Redd White in particular is apparently responsible for a large number of instances of this (as the driver, not the drivee).
** Notably subverted in ''Justice For All''. [[spoiler:"Prosecutor Miles Edgeworth Chooses Death." [[JourneyToFindOneself No, he didn't.]]]]
*** And played straight in the same case, regarding Adrian Andrews' former mentor Celeste Inpax, who hung herself two years ago [[spoiler:after being dumped by Juan Corrida, after he had learned that she was ALSO dumped by his rival Matt Engarde and refused to "accept his leftovers"]].
*** In addition to that, [[spoiler: Adrian Andrews attempted to kill herself less than a week later, unable to bear living without Celeste. She failed.]]
** [[spoiler:Terry Fawles]] does it ''onscreen'' in the courtroom in ''Trials and Tribulations''. His girlfriend [[spoiler:Dahlia]] really messed him up.
*** Speaking of [[spoiler:Dahlia]], in 3-5, [[spoiler:she taunts Phoenix by drawing the conclusion that Maya accidentally killed her mother, then killed herself out of sheer guilt. Fortunately, she's proven wrong on both accounts a bit later.]]
** Also happens in [[VisualNovel/ApolloJusticeAceAttorney the fourth game]]: [[spoiler: not in any of Apollo's cases, but in the flashback segment of 4-4, the supposed murder victim, Magnifi Grammarye, committed suicide]].
* In ''VideoGame/TheWorldEndsWithYou'', [[spoiler:Joshua, supposedly.]] [[spoiler:He's likely to be lying, but if it was suicide it didn't occur recently.]]
** It's implied somewhat that [[spoiler:Shiki]] committed suicide too.
* In the VisualNovel ''Heart de Roommate'', the gang attempt to befriend a rather lonely schoolgirl with a past history of attempted suicide. This leads to one of the darkest scenes in the game, when during a conversation with the main character on the roof she accuses him of only being interested because he fancies her and offers to have sex with him if he'll leave her alone. When he refuses she proceeds to make another offer... sleep with her or she'll scream that he's a rapist and jump off the roof, something that seems quite plausible given her past history and self destructive personality. She doesn't go through with it no matter what the player chooses, though accepting her offer leads to a rather bleak NonstandardGameOver.
* ''{{Drakengard}}'' has two examples. The first one is Leonard, who comes home to see his family dead and his home razed by [[TheEmpire the evil Empire]]. Feeling that he has failed to protect them, he gets very close to cutting his own throat, only being stopped by [[TheFairFolk a malicious fairy.]] The second is the protagonist's sister, who, due to MindRape and her brother being disgusted by her incestuous feelings for him, commits suicide to escape disgrace.
* One of the bad endings in ''VisualNovel/SchoolDays'' has this too: [[spoiler:Kotonoha Katsura, the Ojou of the story, throws herself off a building if Makoto (in the main player's shoes) goes with Sekai instead. And she actually dies ''in front of Sekai and Makoto'' (HighPressureBlood and all), traumatising them so badly that Makoto not only breaks up with Sekai, but [[AllergicToLove swears off romance]] ''forever''.]]
* In ''SystemShock2'', [[spoiler:Dr. Janice Polito was driven to suicide when she found out that she unleashed SHODAN. You find her corpse in her office, and her suicide note in the Rickenbacker church.]]
** A "ghost" crew member snaps under the horror of what's happening, says sorry to his wife and children, and shoots himself. Several corpses are found sitting with a gun in their hands, implying they've chosen the same way out.
* In the ''Anime/{{Mai-HiME}}'' video game, if the main player gets Natsuki Kuga as a love interest, Natsuki's best friend [[TheOjou Shizuru Fujino]] [[SpurnedIntoSuicide will go mad and kill herself.]]
* In the end of ''VideoGame/SuperRobotWars Original Generation 2'' (and ''Advance'' too), being the 'only survivor' of the Shadow Mirror, Lamia Loveless thought that she has failed her mission, killed her teammates and superiors, and is a defective product all around, and thus she attempts to self destruct... only to be stopped by her new teammates just in time and be persuaded to live her life in the current world. She actually has more self-destruct attempts throughout the series, but only this occasion fits the trope.
* ''{{Starcraft}}'': [[spoiler:Gerard [=DuGalle=] commits suicide after his defeat, in remorse over his gullibility and murder of Alexei Stukov.]]
* If Joshua has failed to save both of his {{Unlucky Childhood Friend}}s in ''VideoGame/VandalHearts 2'', he will arrive at the parapets of his third UnluckyChildhoodFriend and love Adele's castle just in time for her to say she's had enough of being used and leap off.
* ''Super FireProWrestling Special'' featured a story where, about halfway through, things get worse, and worse, and worse... [[spoiler:First, you suffer a string of defeats. Then, your coach winds up dead. Then, you accidentally kill your opponent in one match. Then, your girlfriend leaves you. Then, your opponent for the championship, a RicFlair {{Expy}}, kills your tag-team partner AND reveals that he was the one who killed your coach. Once you defeat the murderer and take the championship for your own, though, the hero realizes that [[PyrrhicVictory it really is lonely at the top]]. He shoots himself in the head three days later.]] Would it be any surprise that this particular game's story was written by a rookie {{Suda51}}?
* ''YumeNikki'': [[spoiler:After dropping the 24 effects off in the Nexus, Madotsuki wakes up from her dream, walks out onto the balcony... and leaps off the edge. Cut to black and a bloody red smear on the canvas.]]
* In ''IllusionOfGaia'' - Will is forced into a game of Russian Roulette using a poisoned drink. Will's psychic powers allow him him to dodge the poison, but the other player, Straw Hat, drinks the poisoned shot anyway, out of sheer wounded pride. [[spoiler:After this, you read a letter from him telling you he had a terminal disease and was playing the Russian Glass Game so that his pregnant wife would be finacially secure after his death. He had nothing to lose by drinking the poison.]]
* You can talk the BigBad LoadBearingBoss of ''VideoGame/{{Fallout 1}}'' into activating the SelfDestructMechanism of his SupervillainLair, thus committing suicide, by bringing evidence that as Super Mutants are infertile, his plan to have them be the wasteland's dominant species will fail.
** You can talk the BigBad LoadBearingBoss of ''VideoGame/{{Fallout 3}}'' into activating the SelfDestructMechanism of his SupervillainLair, thus committing suicide.
*** Rivet City has Mister Lopez, a suicidal senior whose family was killed by Raiders, standing at the top of the Bridge Tower. You can either convince him to jump to his death (bad Karma), or talk him out of it (good Karma).
** In ''VideoGame/FalloutNewVegas'', if you tell Ranger [[spoiler:Chief Hanlon]] that you know he's the one behind the bizarre intelligence reports [[spoiler:to get the Rangers out of what he considers a HopelessWar]], he'll excuse himself, announce his misdeeds to [[spoiler:Camp Golf]], and shoot himself in the head.
*** Captain Curtis, [[TheMole a Legion mole]] in Camp [=McCarran=], also kills himself after you report him to Colonel Hsu, providing you didn't kill him yourself.
*** Also in Fallout: New Vegas, when the security came on-line at the Sierra Madre Casino, some of the guests killed themselves to avoid dying of starvation or being killed by security. [[spoiler:This was the ultimate fate of Vera Keyes, the singer for whom the casino was built]].
*** If General Oliver was talked down in the House ending, Mr. House will state that Oliver has a roughly 40% chance of committing suicide since he'll be publicly disgraced and held responsible for losing the war once he returns to NCR territory, with his hopes of pursuing a political career dashed to the ground. The same probably applies in the Independent Vegas ending.
*** [[spoiler: Arcade Gannon]] [[{{Seppuku}} disembowels himself]] in his ending if you [[spoiler: turn him into a slave for Caesar.]]
*** Near the end of ''VideoGame/DeadMoney'', you have to stop Dog from blowing himself up and taking the whole casino with him, by turning off the gas valves in the kitchen without being spotted. After that, you can have him die a less overkill death via self-inflicted NeckSnap, or talk him out of it.
*** In Boone's Vengeful NCR ending, he takes his own life after sniping the ranger who ordered the attack on Bitter Springs. In the Vengeful Legion ending, he stages a suicidal charge against the Legion, leading to him being crucified.
* In ''VideoGame/TheElderScrollsIVOblivion'', you can find the corpse of a troll floating in a river with a badly written suicide note about how it couldn't get people to pay its bridge toll, so it was going to get drunk and kill itself. Possibly PlayedForLaughs, considering that [[AllTrollsAreDifferent they're not usually that kind of troll]].
** In its sequel ''VideoGame/TheElderScrollsVSkyrim'', if Nilsine Shatter-Shield dies, her mother Tova will commit suicide.
* In ''VideoGame/MetalGearSolid2'', it is revealed that [[spoiler: Otacon's father drowned himself after finding out that his wife (Otacon's step-mother) and son were having an affair.]] In the same game, Fortune's mother committed suicide after her husband's death and her son-in-law's imprisonment.
** In ''VideoGame/MetalGearSolid3'', it's implied that the reason why the Cobra Unit was still utilizing their microbombs essentially delt with this trope.
** In ''MetalGearSolid4'', [[spoiler:Vamp]] and [[spoiler: Naomi]] go out this way after disabling the nanomachines keeping them alive.
* In ''ObsCure 2'', one of the playable characters commits suicide after his girlfriend, and most of his friends have been killed in the 'incidient' at the school. (By incident we mean the surivial horror plot.) The sequel is DarkerAndEdgier than the orginal, which is no small feat seeing as in the first game everyone dies in horible experiments, or a the hands of the horrible experiments, except for the playable characters.
* One popular backstory of the ''VideoGame/{{Touhou}}'' character Yuyuko Saigyouji is her committing suicide after learning about her power evolving from controlling dead spirits into invoking the death of ''anything''. Fortunately(?) [[RealityWarper Yukari]] ensured her spirit could never "cross over" completely, allowing her to continue existing as a CuteGhostGirl.
** Many popular Yuyuko/Yukari fan works have the two be friends, or even a couple, back when Yuyuko was still human. This delves far past TearJerker and into soul-crushing territory when you realize Yuyuko doesn't seem to remember anything about her past life, or Yukari. Indeed, some of Yukari's personality characteristics, such as constant sleeping and over-friendliness, are symptoms of depression.
* [[spoiler:Tai Kaliso]] in ''GearsOfWar 2'', after enduring an impossibly brutal series of tortures at the hands of the Locust Horde, puts a shotgun to his chin the moment it is offered to him.
* ''Franchise/MassEffect'': not only does [[spoiler:Fai Dan]] shoot himself to escape the Thorian's mind control, but other characters can also be DrivenToSuicide depending on the player's decisions, including [[spoiler:Saren]].
** Also a Salarian researcher, who shot himself to escape being ripped apart by the [[spoiler: rachni]].
** [[spoiler: Ronald Taylor]] can be left a pistol with which to kill himself.
** In ''VideoGame/MassEffect3'', both [[spoiler: Tali]] and [[spoiler: Samara]] can potentially commit suicide. The former if [[spoiler: the geth destroy the entire Migrant Fleet]], and the latter because [[spoiler: she's forced to make a choice between obeying the Justicar Code or killing her daughter.]]
** [[spoiler:Like Saren before him, The Illusive Man can also be convinced to kill himself to escape Reaper indoctrination in the GrandFinale]].
** The third game ''loves'' this trope. The characters listed here? That's not even half the number that this can happen to. [[DarkestHour For understandable reasons.]]
** [[spoiler: Clone!Shepard]] does this in the Paragon Ending of the ''Citadel DLC'', refusing to take Shepard's hand and letting themselves fall from the edge of the ''Normandy'' ramp. It's implied that their DespairEventHorizon cames after Shepard's friends rushed to save them from falling, while [[spoiler: s/he]] was callously left to die by [[spoiler: Brooks]], thus answering their earlier rant "What makes you so damn special?" Shepard has ''[[TrueCompanions friends]]''.
* If the Warden sides with Caridin in the "Paragon of Her Kind" quest in ''VideoGame/DragonAgeOrigins'', he gives the Warden a crown before jumping to his death from a high ledge, into a river of lava, to atone for [[BodyHorror making golems]] [[AndIMustScream from living dwarves]]. Zathrian can also be persuaded to end his life--which ends the curse on the werewolves, and frees the Lady of the Forest--in "Nature of the Beast"; it's considered the best ending, being a [[TakeAThirdOption third option]] between killing all the werewolves and killing all the elves.
** Anders very clearly has a death wish by the end of ''VideoGame/DragonAgeII'', and it is both creepy and heartbreaking.
* In one of ''SilentHill2'''s MultipleEndings, [[spoiler:James drowns himself so that he can be TogetherInDeath with his wife, Mary.]]
* Setsumi from ''{{Narcissu}}'' since she had terminal disease, she's going to die anyway, and she doesn't want to die at home or in the hospital.
* [[spoiler:Archer, AKA Emiya Shirou]] of ''FateStayNight'', except as a spirit existing primarily outside of time he's actually incapable of death, so his suicide plan is [[spoiler:killing Shirou so that he can't make the contract with the world and become Archer, hopefully canceling himself out of existence.]] Several characters point out, including himself, that this is very unlikely to work.
* In ''VideoGame/DeadSpace'' several members of the USG Ishimura crew who already haven't been turned into Necromorphs commit suicide; examples include the man who headbutts a bulkhead until his head is pulped, the woman in the medical bay who severs her throat with a surgical saw, and a woman in [[MadScientist Doctor Challus Mercer's]] evil Unitology RoomFullOfCrazy who blasts her own head off. Also [[spoiler:Isaac's girlfriend Nicole killed herself via lethal injection before the game began; Isaac just doesn't realize it until the end]].
** And in the sequel, the Unitology cathedral contains groups of dead bodies with plastic bags over their heads and an empty chalice nearby. It's implied that they committed mass suicide so they could be reborn as Necromorphs.
** This can also happen to Isaac himself near the end of the second game, [[spoiler: if you let Nicole grab him]]. And, like every other death scene, it's...not pretty, to say the least. [[spoiler: He puts himself out with the javelin gun. TO THE HEAD.]]
* Many, ''many'' examples can be found in ''TheSuffering.'' At the beginning of the game, for example, several inmates in Cell Block T hang themselves following the earthquake.
** In a vision of the past, a military commander shoots himself rather than face a court-martial.
** Another flashback reveals that in 1681, three little girls hurled themselves off a cliff after realising that their seemingly harmless prank had resulted in the execution of eleven innocent people. Unfortunately, [[UndeadChild they don't stay dead.]]
** Hermes Haight, the prison's most infamous executioner, killed himself in the gas chamber; according to his [[DeadlyGas poisonous ghost]], this was the final step in a very long obsession with learning what his victims felt.
** A heroin addict blows his brains out with a shotgun, apparently unable to "weather the low."
** Three inmates in solitary confinement at East Baltimore Correctional committed suicide rather than spend another six months alone in the darkness.
** It's revealed that inmate Ranse Truman tried to slit his wrists with a sharpened spoon after spending a few months on Carnate Island and exploring its [[DarkAndTroubledPast unique history.]] When you meet him in the second game, he appears to have tried to cut his throat at some point.
* In ''Robot Alchemic Drive,'' Nanao kills herself if the building where she works is crushed too many times.
* HK-47 of ''KnightsOfTheOldRepublic'' fame jokes about this in the sequel, however [[ICannotSelfTerminate he cannot self-terminate]].
-->'''HK-47''': Statement: Oh, yes. [[DysfunctionJunction My master had quite the collection of tortured individuals that seemed unable to confront their basic personality conflicts.]] Let me cite some specific examples. Mockery: [mimicking Carth's voice] "Oh, master, I do not trust you! I cannot trust you or anyone ever again!" Mockery: [mimicking Bastila's voice] "Oh, master, I love you but I hate all you stand for, but I think we should go press our slimy, mucus-covered lips together in the cargo hold!" Conclusion: Such pheromone-driven responses never cease to decrease the charge in my capacitors and make me wish I could put a blaster pistol to my behavior core and pull the trigger.
* [[GameOver If you go bankrupt]] in ''VideoGame/ThemePark'', the game shows a cutscene of the park owner jumping from a window while a family photograph fades, and Chopin's Funeral March plays. Though it turns out he was actually jumping out of a first-story window, as he turns around, grabs the windowsill, and pulls himself back up. As it was a game for all ages, even joking about suicide was pretty controversial. It even describes what will happen if you go bankrupt in the manual. It's actually pretty creepy; [[https://www.youtube.com/watch?v=cmc5KR8dEJE watch at your own risk]].
** The Mega Drive/Genesis version contains only a still image of that scene, which happens to be the park owner in mid jump.
* [[spoiler:Kohaku]] in ''{{Tsukihime}}'' in Hisui's route. [[spoiler:The True End she succeeds. The Good End Shiki saves her at the cost of some of his lifespan.]] Either way, she points out that she has nothing left to live for anymore and did not really want to do what she did.
* In ''[[{{Myst}} Myst III: Exile]]'', if you make the [[VideoGameCrueltyPotential crueler choice]] at the end, it is implied Saavedro kills himself.
* Erica in the backstory for ''VideoGame/{{Malicious}}'', she was weak and frail, the girl was in the middle of a grand scale war started by her own father King Eldrake, the tyrant corrupted his own kingdom and had his wife, Queen Ashlelei, imprisioned. When Erica and her brother freed their mother to start a revolution, Eldrake started an alliance with barabarians, in the battlefield Erica could not fight so she choose to hurt her father by killing herself in front of him, to no avail as King Eldrake felt not remorse at the sight of his daughter taking her own life before him.
* [[TheWoobie Semolina]] from ''[[MagicalVacation Magical Starsign]]'' allows herself to be eaten by a heterotrophous plant. It's partly HeroicSacrifice, but mostly this. If Semolina didn't, [[TheOjou Sorbet]] WOULD have. [[WhamEpisode Yeah...]]
* The second ''{{Oddworld}}'' game has several kinds of Mudokons working as slaves for the evil meat-making corporation. Inbetween others there are hyperactive ones who you have to slap to snap them back to sanity, and depressed mopey ones who need to be cuddled to bring up their spirits. But slap a depressed one and watch as he goes over the edge, and repeatedly hits himself in the head until he dies.
* Intentionally done to the local priest, Minase, in VisualNovel/{{Suika}}. And he deserves it too. [[spoiler:First, he strangled his insane wife to death, which... might be overlookable since she was ''nuts.'' But then he comes across his daughter Itsuki, kills her with a shovel and buries the two together. He puts his other daughter Sayo, unconscious and badly bleeding after Itsuki herself threw her down a flught of stairs, in the hospital and doesn't even recognize which of the twins she is.]] When Akira finds all this out, he confronts him and recommends suicide.
* In the ''The Thing'' video game, if your teammates get scared enough, they will pull out a pistol and shoot themselves in the head.
* In ''VideoGame/ResidentEvilOutbreak'', certain members of your team will commit suicide if they have a gun and have been cornered by zombies or have incurred too much damage. Also, in the first level, you can recruit a sick (infected) security guard named Bob; if you help him up to the roof, he says something akin to the hunger being too painful and that he can't go on, then blows his brains out.
* This happens if you scare the teddy bears enough in ''VideoGame/NaughtyBear''.
* At the end of Toshiko's series of missions in ''VideoGame/GrandTheftAutoLibertyCityStories'', which she has Toni perform against her husband Kazuki in revenge for [[WomanScorned neglecting her]], culminating in his death, she realizes that she has lost everything, and commits suicide by defenestration as Toni watches.
** In ''TheBalladOfGayTony'', Tony tries to shoot himself, but the gun ends up being empty.
* At the end of ''SyphonFilter: Logan's Shadow'', Shen Rei shoots himself [[CyanidePill to prevent his capture and interrogation.]]
* Ethan Mars from ''HeavyRain'' kills himself in three of his possible endings. They all require him to survive the main storyline but fail to rescue his son, Shaun.
** Jayden will kill himself via drug overdose if he survives the storyline but Shaun dies.
* ''VideoGame/FinalFantasyXIII'' has [[spoiler:Sazh almost doing this after his 6-year old son got turned into crystal, and upon learning that his partner Vanilie was involved with his son's fate.]]
* In ''VideoGame/{{Turgor}}'' the [[spoiler: Nameless Sister]] does this about in the half of the game. Some of the Void dwellers think it was murder, a HeroicSacrifice or simply a SenselessSacrifice.
* In ''ObsCure II'', [[spoiler:Kenny drives Corey to kill himself]] right before the FinalBattle, just to twist the knife.
* The ultimate fate of [[spoiler:Priscilla and Raven's parents, Lord and Lady Cornwell]] in ''[[FireEmblemElibe Fire Emblem 7]]''. For worse, [[spoiler:Raven believes they were murdered, thus fueling his {{Revenge}}.]]
** Also, it's hinted that [[spoiler:Ninian and Nils]] seriously considered killing themselves at some point, driven into despair after [[spoiler:being summoned, captured and hunted down by the Black Fang.]] Thankfully, they don't go through it.
** In [[FireEmblemJugdral Seisen no Keifu]], Alvis and Azel's father Lord Victor of Velthomer commited suicide when Alvis was a pre-teen and Azel was a little boy. [[PromotionToParent Alvis starts raising his half-brother from then on.]]
** Someone killing themselves is actually ''a plot point'' in ''VideoGame/FireEmblemAwakening''. [[spoiler: The dead person is Chrom's sister Emmeryn, who throws herself off a cliff to avert a war between Plegia and Ylisse that would tear the world apart. This selfless HeroicSuicide raises the Ylissean cause and causes almost everyone to desert Gangrel, the King of Plegia. Subverted later: Emmeryn is found to have survived (though at the cost of suffering TraumaInducedAmnesia) and can be recruited as a playable character.]]
*** In a more traditional manner, [[ComedicSociopath Henry]] commits suicide in his ending if he's unmarried. Then again, it's Henry we're talking about, so no one (even in-universe) is surprised.
* Late in ''VideoGame/ValkyriaChroniclesII'', [[spoiler:when the Rebels actually ''succeed'' in completely taking over Gallia, the sheer hopelessness of the situation causes Lanseal's headmaster to have a mental breakdown that ultimately culminates in him shooting himself in the mouth.]]
* ''ShadowWarrior'' has a humorous version: the standard mooks that shoot Uzis at the player character seem to have a high enough sense of honour that they'll take their failure to kill him in the only way a honourable warrior would: by eating their gun and shooting half their skull off.
* In the epilogue of ''KingdomHearts: BirthBySleep'', [[spoiler:Aqua]] ends up all alone in the realm of darkness and seriously considers [[DrivenToSuicide fading into the darkness]]. [[spoiler:She]] thankfully snaps out of it due to [[spoiler:Terra and Ven's keyblades appearing]], [[FridgeHorror but if they hadn't]]...
* [[spoiler:Mamiya Shinzo]] commits suicide out of guilt and possibly as atonement in several endings of ''KaraNoShoujo,'' possibly after [[spoiler:killing his son Shinji, who is the second serial killer.]]
* [[spoiler: Claus, aka the Masked Man,]] commits suicide [[spoiler:by reflecting a lightning attack off of Lucas's Courage Badge]] at the end of VideoGame/{{Mother 3}}. [[spoiler:Shortly after he came to his senses.]]
* Because of a certain split-second image in a certain scene in ''LuigisMansion'' of all games, it is speculated by some that [[spoiler: Luigi]] may have committed suicide [[spoiler: and that his appearance in said game is him as a ghost.]]
* [[spoiler:Rehm]] in ''VideoGame/TheReconstruction'' after passing the DespairEventHorizon, though he isn't even able to finish it; some Nalian Officers find him and sell him into slavery instead.
* In Demon's souls, mistress Astria will be kill herself, only if you manage to kill her loyal guard first, and considering the game it's actually the easier path as it's only him, becoming an AntiClimaxBoss depending on how you take out the guard, you can wear enchantments and stand just out of his sight of you and make a cloud of poison to slowly kill him.
** Also, Ostrova, son of the king, will be driven to this no matter what, if you don't [[VideogameCrueltypotential kill him first anyway]], and you have to face his vengeful/sorrowful spirit a second a later, people's bad side being able to materialize as black phantoms, actually just dark red with a black motif.
* In ''SwordOfTheStars'', Liir Black Swimmers who have had to put enemy civilians to the torch usually pilot their spacecraft into nearby stars after hostilities conclude.
* In ''VisualNovel/HatofulBoyfriend'' it is revealed that [[spoiler: Nageki killed himself five years ago.]] The full version gives context, and it's rough.
* In KatawaShoujo, it's all but stated that [[spoiler: Rin Tezuka]] might end up doing this, since in her route [[spoiler: she becomes more and more self-destructive in her despair to get enough inspiration to create art, which does ''not'' mix well with how she cannot exprress herself unless it's through art itself.]] Also, that same route says that [[spoiler: the husband of her sponsor, Sae Saionji, was a talented artist who also committed suicide, [[GenerationXerox for exactly the same reason]].]]
** Something that's kinda overlooked by fans during early playthroughs is that [[spoiler: Shiina Mikado aka Misha]] also has suicidal tendencies. In [[spoiler: Shizune]]'s route, during a talk with Hisao, she tells him "Wouldn't it be better if I disappeared...?"
** In [[WhatCouldHaveBeen the beta to the game]], [[spoiler: Misha ''would'' have committed suicide if you-as-Hisao took the SexForSolace offer. She would've run in the path of a speeding car after a last talk with Shizune, if you wonder]]. And for worse, [[spoiler: Hanako's bad end would've had her throwing herself in front of a train in front of Hisao.]]
*** To make matters worse, [[spoiler:''Shizune'' could commit suicide after Misha's death.]] She'd become depressed and lock herself in her room . One day you get a call from [[spoiler: her brother Hideaki]] saying she's in the hospital due to dehydration. After you leave the hospital you learn [[spoiler:she died a few hours later. She refused to sign to you so you wouldn't notice the IV she had pulled out, or the mess it was making]].
* In the 2012 reboot of ''VideoGame/{{Syndicate}}'', it's possible to hack other people's DART chips to force them to kill themselves.
* In the [[ShoddyKnockoffProduct pirated game]] ''Disney/TheLionKing 5'' [[http://www.youtube.com/watch?v=wuSgevd1EwY Simba, Timon and Pumbaa will do this on the game over screen]]. [[WhatDoYouMeanItsForKids And they sold this to kids?]]
* Dead Rising 2 has Brandon Whittaker, who [[spoiler:slits his throat with a shard of glass after getting bitten by a zombe he kept in a bathroom stall to "spread the goodwill",]], Leon Bell, who [[spoiler:lit himself on fire for quadruple points rather than get killed by Chuck]], and Amber or Crystal Bailey depending on [[spoiler:which one you killed.]]
* Fairly late in ''The Way 2'', the main character comes across a guy threatening to jump off a cliff. Given the proper dialogue choices, you can talk him down or convince him to jump, or, if you're feeling ''really'' cruel, push him off yourself.
* [[spoiler:Konrad]] in ''VideoGame/SpecOpsTheLine'', and [[spoiler:Walker]] in several of the game's endings. [[spoiler:Adams]] is last seen making a likely-fatal LastStand, and seems in no doubt that he deserves to die by that point.
* [[spoiler: Sakura Oogami]] from VisualNovel/{{Danganronpa}}, [[spoiler: as a way to release herself from Monobear's blackmail of her without having to murder any of her classmates.]]
* The concept of freeware puzzler {{Karoshi}} is that the player character has been driven to suicide, and the goal is to kill him to advance to the next level.
* A major plot point in VirtuesLastReward is a disease that causes infected individuals to try and kill themselves. [[MultipleEndings In most timelines]] [[TroublingUnchildlikeBehavior Quark]] is the first to attempt to kill himself, however it's Alice that's the first to go. The player character also does this in Clover's ending, though whether or not it was a result of the virus is debatable.
* In one of the secret endings of ''VideoGame/{{Arfenhouse}} 3'', Licorice Guy, the arch-nemesis of Candyland, throws himself over the waterfall, overcome both by the shame of having killed his mother there and by the realization that he's in an Arfenhouse game. Joseph, tired of being the OnlySaneMan in the party, then decides to follow his example.
* In Bioshock Infinite human enemies hit with the possession tonic will kill themselves when it expires, often in gruesome and shocking ways while recounting some sin.
* In ''VideoGame/RememberMe'', one of Nilin's memory remixes makes Forlan believe that he killed his wife, causing him to commit suicide.
* A central element of the plot of ''VideoGame/TheCatLady'', which [[StartsWithASuicide kicks off (no pun intended)]] with Susan, the main character, killing herself by overdosing on sleeping pills.
* In ''VideoGame/{{STALKER}}: Call of Pripyat'', [[spoiler: if you manage to solve the mystery behind the missing stalkers in the first map, you'll find that TheMedic from the main wrecked ship was responsible for their deaths. He explains that he used to work in a surgeon's clinic and became terrified of seeing his patients undergo gruesome procedures. Over time, however, he developed a clinical condition that causes him to crave the taste of blood and made him lose his sanity. When he came to the Zone, he snapped from the inside and started to secretly murder stalkers when they least expected it and disguised them as bloodsucker attacks. After he tells his story, he guns himself on his chin. However, you can avert this by shooting him yourself, though you have a couple of seconds to do it before he offs himself.]]
* The whole goal of ''VideoGame/FiveMinutesToKillYourself'' is to [[ExactlyWhatItSaysOnTheTin commit suicide]] using the various items & events provided.
* In both the [[spoiler:Law and Chaos]] paths of ''VideoGame/ShinMegamiTenseiIV'', you will fight [[spoiler: Isabeau]]. In both cases, you manage to beat [[spoiler:her]]. Saddened both of your paths diverge so wildly, [[FondMemoriesThatCouldHaveBeen and lamenting they could not remain together]], [[spoiler: she]] slits [[spoiler: her]] throat. [[spoiler: In the White/Emptiness/Bad Ending, you are convinced by the White nothing will ever change and that everyone will be better off dead, combining this with PutThemAllOutOfMyMisery.]]
* ''DeadIsland'' has several examples, from a couple in one of the trailers to Jin essentially attempting SuicideByCop.
* In ''VideoGame/{{Persona 2}}: Innocent Sin'', the heroes meet a ghost of a teacher who threw himself into the gears of the school's clock tower. Officially it was ruled a suicide, as he had just gone through a very acrimonious divorce and was showing signs of depression. His ghost says he was trying to prevent the end of the world, having interpreted an obscure prophecy as alluding to the clock signaling the beginning of the end, and he thought that if he killed himself in the tower the school would turn it off permanently. [[spoiler:It was a little of both and then some, because he was haunted by the Big Bad, had his life ruined, and finally at the end was given a little "push."]]
* In ''VideoGame/{{RefleX}}'', Raiwat commander-in-chief Tsukikagerou is so utterly ashamed of failing to capture the ZODIAC Ophiuchus and being forced to retreat that he kills himself.
* ''Videogame/{{Transistor}}'' has a few cases. [[spoiler:Asher and Grant Kendrall kill themselves before you can fight them, after the former confesses to their crimes]]. And in the end, [[spoiler:Red does this to herself to be in the Transistor with her boyfriend]].
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