* Sip every time:
** It's mentioned that John is missing.
** The apocalypse is mentioned.
** They get the monster wrong and have to do more research.
** Someone cuts their arm.
** The boys use a {{shoutout}} alias.
** Dean says "[[{{catchphrase}} Son of a bitch.]]"
** "Awesome" is used sarcastically.
** Dean says "Yahtzee".
*** Dean says "Ganked" or "Skeevy".
** Sam has a psychic vision (in seasons one and two).
** [[LeaningOnTheFourthWall The fourth wall is leaned upon.]]
*** Do a shot if the wall is obliterated.
** Castiel invades someone's personal space.
** Someone is bleeding from the mouth. [[note]] If you somehow haven't died of alcohol poisoning beforehand, the latter half of Season 8 ''will'' kill you in a matter of episodes.[[/note]]
** One of the main characters (Dean, Sam, Castiel, etc.) dies. [[note]]We advise you against watching [[GroundHogDayLoop Mystery Spot]] or Goodbye Stranger. Have an ambulance on alert if you choose to watch those.[[/note]]
*** Take two every time they come back.
** There is a scene in which Dean eats and Sam does not.
*** Finish your drink when Dean refuses food.
** Dean says "Chuckles," "Chucklehead," or any variant thereof.
*** Take three every time someone parodies this.
** Someone says 'get this.'
*** Take two if it's not Sam or Dean.
** If the intro has Dean saying "She's a demon, Sam!"
*** Take two if it's in reference to someone other than Ruby.
** When asked to justify an extremely dangerous, costly, painful, or downright irresponsible decision, the answer is, "Because you're my brother" (or some variant thereof).
** A random female character dies.
** A ceiling fire occurs.
** You hear "Carry On My Wayward Son".
** Dean cries one single tear.
** Bobby says "balls" or "idjits". Finish your drink if the "idjits" comes from season 7's episode "Death's Door".
** A dick joke is made. [[note]] If you're watching season 7, you should either be drinking water or ready for liver failure. [[/note]]

* Shot every time:
** Someone makes a deal with a crossroads demon.
** A character makes a [[BigEntrance big entrance]].
*** Finish your drink when it's Death. And then think about ordering pizza.
** Someone's impending destiny/doom is mentioned.
*** Take two if said character responds with "ScrewDestiny" or a variation thereof.
** Dean and Sam exchange their "jerk"/"bitch" insults.
** The brothers are mistaken for a gay couple.
** A ''named'' female character dies.
*** Two shots and a middle finger to the screen if she lasted more than one episode.
*** Do two if she died from [[DeathBySex Death By Sam]].
*** Finish your drink if she was an important character who never got into a sexual or romantic relationship with the boys. (i.e. their mom, Mama Tran, Pamela, Ellen.)
** A hunter's funeral occurs.


* Rules:

** Drink every time a character you love dies.
** Die of alcohol poisoning or sadness, whichever comes first.

As always, TV Tropes is not responsible for the state of your liver.