!Mass Effect 1:
* Take a sip every time Shepard says [[CatchPhrase "I should go,"]] "we'll talk later," or "that's all for now."
* Take a sip every time you find an item that is part of a collection sidequest.
* Take a sip on every successful hack attempt. Two if it fails.
** Take a shot if you lack the technical skills to even try to hack it.
** Take an extra sip if you fail because you're too drunk to complete the minigame in time. Then ponder the downward spiral you have created.
* Take a shot every time you hear someone yell "Enemies everywhere!" or "I will destroy you!"
* Take a shot every time you kill a thresher maw. Finish your drink if you do it on foot.
* Take a shot every time you lack the paragon or renegade points to charm or intimidate someone.
* Take a shot every time someone describes Reaper indoctrination as being "subtle."
* Take a shot every time you are forced to convert a load of equipment to omnigel in the field to free up space.
** Take a second shot if doing so makes you hit the maximum amount of stored omnigel.
* Finish your drink upon the completion of every planet's major story missions (Eden Prime, The Citadel, Therum, Feros, Noveria, Virmire, Ilos). For your own safety, maybe limit yourself to one drink per planet.
* Take a sip every time Shepard does something badass. Suggested drinks include full strength beer or low alcohol mixers.
* Driving the Mako:
** If the Mako takes damage from driving without being shot by enemies, take a sip.
** IF the Mako flips or rolls in any direction, take a shot.
** If the Mako ends up in a position where it can't be driven (upside-down or wedged in the planet's geometry), finish your drink, then return to the Normandy and try again.

!Mass Effect 2:
* Take a sip every time Shepard says [[CatchPhrase "I should go,"]] "we'll talk later," or "that's all for now."
* Take a sip every time someone says Cerberus.
* Take a sip every time Harbinger possesses a nearly-dead Collector. Take another once you kill him... And / or if his mook takeover involves him saying '''[[Memes/{{Bioware}} ASSUMING DIRECT CONTROL]]'''.
* Take a shot every time you use an interrupt.
* Take a shot every time someone judges or refuses assistance to Shepard because of their association with Cerberus.
* Take a shot every time you pick up or build a new weapon.
* Take a shot every time Creator/YuriLowenthal pops up as a random NPC.
* Finish your drink every time you finish a mission against the Collectors.
* Take a sip every time Shepard does something badass. Suggested drinks are [[TookALevelInBadass low strength beer.]]

!Mass Effect 3:
* Take a sip every time Shepard says [[CatchPhrase "I should go,"]] "we'll talk later," or "that's all for now." The Citadel DLC may be tough on you.
* Take a sip every time you gain access to a new weapon or piece of equipment.
* Take a sip every time you upgrade or modify a weapon.
* Take a sip every time you get a new mission from eavesdropping on people's conversations on the Citadel.
* Take a shot every time you have to buy something from the Spectre Requisitions Terminal because you missed it on the mission. Pace yourselves.
* Take a shot every time you use an interrupt.
* Take a shot every time Creator/LauraBailey pops up as a random NPC. Take two shots if she voices a character that you actually interact with.
* Finish your drink any time a past squadmate or other major character dies.
** Chase it with a shot if it's your fault.
* Take a shot every time you gain a new war asset.
* Take a sip every time Shepard does something badass. Suggested drinks include [[SerialEscalation the soft drink or cordial or your choice.]]
* Take a sip every time someone references something badass Shepard did in a past game. Call the [=EMPs=] in advance.

!!Addendum: The ''From Ashes'' DLC Special Edition:
* Take a sip if [[spoiler:Javik]] says the words "[[WhileYouWereInDiapers In my Cycle]]", "My People", or "Reaper".
** A full swig if he uses the word "Primitive".
* Another sip if he does narrate an event that happened during his time.
* And another sip for when he expresses disbelief.
* Take a sip if he gets a laugh at making the listeners believe his stories.
* A shot for every {{Troll}} moment he makes on your teammates and/or crew members.
* A shot for when he perceives the current races of the game as "food". Double shot if it's a race other than the Salarians.
* A shot for any moment he speaks in a demotivating manner, then another for when he turns it around into a RousingSpeech.
** Followed by a full swig if it did not require an interrupt.
* A shot for every time he says anything to the effect of tossing people out an airlock. Three if its Joker he's suggesting it about. Chug if you have him in the party and do the renegade interrupt chain that involves Shepard threatening to toss [[spoiler: Brooks and your clone's heads]] out the airlock in Citadel.