* Take a shot every time somebody:
** starts going out with someone.
** breaks up with someone.
** has sex.
** gets married.
** has a baby.
* Take a shot every time Chandler [[DeadpanSnarker makes a joke]].
** Two if it involves sarcasm.
* Take a shot every time Joey tries to flirt with a girl.
** Two if he succeeds.
* Take a shot every time Monica [[NeatFreak freaks out]] about something not being clean/being in the wrong place.
* If there's a big secret, take a shot whenever [[KeepingSecretsSucks someone finds out]].
* Take a shot whenever you can see someone's nipples through their shirt.

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An alternative, simpler game:
* Drink every time the audience makes a noise. Laugh track, "Oooooh" etc.