Take a shot:
* Whenever someone cries
* Whenever someone says "Jesus!"
* Whenever Tennenbaum says "little ones"
* Whenever Frank Fontaine addresses you as "Kid"
* Whenever Sander Cohen says "masterpiece"
* Alternatively, for the strong of heart, whenever Atlas/[[spoiler:Fontaine]] asks you to do anything, drink...''would you kindly?''
* Every time you get a new plasmid
* Every time you get a new weapon
* Whenever you save a Little Sister
** Two shots if you harvest one
Finish your drink:
* Whenever you kill a Big Daddy
* Upon encountering a new type of splicer
* Upon killing a named character
* Every time you fail a hack
* Every time you come across a Little Sister draining ADAM from a corpse.