* ''WesternAnimation/TheRealGhostbusters'' had "The Collect Call of Cthulhu" episode, where the Busters managed to electrocute Cthulhu himself. In a follow up episode, the 'Busters take care of another Old One by sucking it into an artificially created black hole (probably not a bad way to take care of a powerful being).
** ''WesternAnimation/ExtremeGhostbusters'' had them dealing with [[NorseMythology Fenrir]], who was trying to bring about the end of the world but apparently the original crew had already captured his master Surt in an untold tale. In Ragnarok, it's Surt who actually kills the most humans.
* A ''[[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Billy and Mandy]]'' episode, "The Prank Call of Cthulhu", ended with Cthulhu [[SealedEvilInACan trapped in interdimensional phone lines]], sucking off his shoes in the process (an episode RunningGag).
** And let's not forget that the whole series centers around two kids bossing around the GrimReaper.
*** Who was subdued and captured by Mandy making a geriatric hamster bite him no less.
*** Ah, but that was merely to cheat at [[ChessWithDeath limbo]].
* The ''WesternAnimation/JusticeLeague'' episode "The Terror Beyond," [[InWhichATropeIsDescribed in which]] A Cthulhuesque EldritchAbomination tries to invade earth. Given that the beatdown is delivered courtesy of the Justice League, but especially Solomon Grundy and Hawkgirl, the "Punch" part is extremely literal.
-->(Monsters burst out of giant pods and attack.)
-->'''Solomon Grundy''': Grundy crush Pimple-man!
** They had actually set up her [[{{Unobtanium}} Nth Metal]] mace as pretty much designed to kill {{Eldritch Abomination}}s. Aquaman's trident as well, in another badass moment for the [[WhatKindOfLamePowerIsHeartAnyway (oft parodied)]] King of the Seas has him ''beating back'' a legion of eldritch abominations that are trying to invade Earth.
* ''[[WesternAnimation/JusticeLeague Justice League Unlimited]]'', "Divided We Fall": The Flash versus the fledgling god that is Braniac-Luthor. Judging by the way the fusion of Luthor and Braniac is implied, shortly after [[spoiler: running around the entire world in seconds for a hypersonic clothesline punch ''four separate times,'' the Flash punches every single braniac molecule out of Lex Luthor's body before simply fading out of existence due to the impossible speeds involved.]]
* The near universal BigBad of ''Franchise/{{Transformers}}'' is Unicron, who would have been impossible to defeat if it wasn't for the power of the Autobot [[ChekhovsGun Matrix of Leadership]], which Optimus Prime had presented earlier as being prophesied as there being a ChosenOne to use The Matrix to "Light our darkest hour."
** Megatron was just as BAMF as Optimus, when he literally punched out Unicron (or a stone effigy of him anyway) at the penultimate season 1 episode of WesternAnimation/TransformersPrime.
* In Disney's ''Disney/SleepingBeauty'', the evil witch Malificent is imbued with [[InformedAbility "all the powers of Hell."]] The prince defeats her anyway.
** In ''Disney/TheLittleMermaid'', OneWingedAngel Ursula is defeated by being [[RammingAlwaysWorks rammed by a ship]].
* Invoked - ironically, by a ''villain'' - in ''Disney/{{Hercules}}''. Hades poses this hypothetical question to his lackeys Pain and Panic: How do you kill a god? Pain and Panic, playing along, remark that this is impossible, since gods are immortal. Hades then explains to them his plan to use his dark magic to turn the baby Hercules into a human just so he can be killed.
* The title character of ''WesternAnimation/SamuraiJack'' almost killed the almost-invincible BigBad EldritchAbomination Aku in the ''second'' episode, and anytime the two meet later on Aku barely manages to escape.
* Azula from ''WesternAnimation/AvatarTheLastAirbender''. At the end of Book 2, [[spoiler:while Aang is rising into the air in the Avatar State after finally unlocking the final chakra, she shot down Aang with a bolt of lightning straight to the back, which nearly killed him (dying in the Avatar State would break the cycle of reincarnation).]]
** Azula has nothing on Admiral Zhao, who killed the moon. Crosses over with BrokeYourArmPunchingOutCthulhu, 'cause the ocean was ''fucking pissed'' about that, and [[spoiler:Zhao died.]] [[note]]Or, well, his body did, at least. ''WesternAnimation/TheLegendOfKorra'' Book 2 finale shows that his soul is still alive in a spirit prison, tortured by his own worst fears[[/note]] [[spoiler:What's worse is that Zuko could have saved him, but Zhao refused to grab his hand.]]
** In Book 2 Episode 10, ''The Library'', the gang succeeds in escaping from the Knowledge Spirit not with bending...but with Sokka dropping down with a [[DominicDeegan death from above]] style blow to the head with a ''[[ThrowTheBookAtThem book.]]'' It practically knocks the spirit out cold.
--> "That's called 'Sokka Style.' [[CrowningMomentOfAwesome Learn it!"]]
** The season finale of ''WesternAnimation/TheLegendOfKorra'' Book 2 contains the series' most triumphant example -- [[spoiler: Korra takes down Vaatu, the [[GodOfEvil eternal spirit of Darkness himself,]] ''after'' he's [[FusionDance merged with]] [[EvilUncle her uncle,]] killed his counterpart Raava, the [[GodOfGood Avatar Spirit,]] and turned into [[OneWingedAngel a Kaiju-sized squid-man.]] And what a victory it is! Korra uses her uncle's own [[LightEmUp spirit conversion technique]] [[HolyHandGrenade to purify him out of existence...]] but even before that, she completely manhandles him. She turns her own soul into a [[AttackOfThe50FootWhatever 50 Foot Korra,]] grabs him by his tentacles, picks him up over her shoulder, chucks him into a mountain, slams his head into the mountainside, and later, with Jinora's help, ''rips Raava right out of his chest.'' She doesn't so much punch out Cthulhu as hand him a NoHoldsBarredBeatdown, proving once and for all that she's not going to get a minor issue like the end of the Avatar line stop her from saving the world.]]
* ''WesternAnimation/Ben10AlienForce'' had one in The Final Battle, where the lead villain Vilgax [[OneWingedAngel actually becomes a Cthulhu-like being]] when underwater. Sadly, the fight isn't really shown.
** ''WesternAnimation/Ben10UltimateAlien'' reveal the existance of an actual EldritchAbomination named Diagon, who [[DimensionLord conquered several universes]] and tried conquering Earth in the Middle Age. He was defeated by [[KnightInShiningArmor Sir George]], the founder of the [[AncientConspiracy Forever Knights]], who tore his heart apart and [[SealedEvilInACan sealed him away]]. The main plot of season 2 focus around the Flamekeeper's Circle, a ChurchOfHappyology that worship Diagon with the belief he [[ETGaveUsWiFi gave us all our technology]], and the Forever Knights, who attempt to prevent his return.
** In the finale, [[spoiler:Vilgax successfully ''kills'' Diagon by baiting him into attacking a device that absorbs energy. Since Diagon is an EnergyBeing, that allow Vilgax to absorb him, turning in a PhysicalGod in the process]]
** [[spoiler:Ironically, Ben then defeats Vilgax in his Diagon-powered form thanks to George's sword.]]
* ''Dante's Inferno: An Animated Epic'' - At first it seems like Dante broke his arm punching Cthulhu, since he ends up only defeating Lucifer's shadow form which accidentally releases his true monstrous form from his frozen prison in the ninth circle of hell. However, being a fallen angel of god and ruler of hell, Lucifer proves a rather unimpressive villain as the fight between him and Dante was not completely one-sided. But Dante doesn't truly defeat him until (with a little help from God) he reseals Lucifer back into his prison.
* ''WesternAnimation/SouthPark'' plays this ''hilariously'' straight: [[spoiler:Mint-Berry Crunch, easily the [[WhatKindOfLamePowerIsHeartAnyway lamest member of Coon and Friends]] barring Iron Maiden, singlehandedly vanquishes Cthulhu and banishes him back to his dimension.]]
* [[OnceAnEpisode An everyday occurrence]] in ''RegularShow''. Though it's almost always in an outrageous fashion. Example; defeating a giant floating eye monster in a ''staring contest!''
** Better example is beating Death in an arm wrestling competition.
* The Lich in ''WesternAnimation/AdventureTime'' is an OmnicidalManiac UltimateEvil and the most powerful entity in the show. The legendary hero Billy [[{{Badass}} pummeled him into a tree]] and [[SealedEvilInACan sealed him in amber]] to save the world.
** When he gets loose, Finn ultimately beats him once by [[spoiler:using the PowerOfLove to tear the top part of his skull off with a sweater. When he returns possessing Princess Bubblegum and goes OneWingedAngel, Finn has an EnemyMine with Ice King and they manage to freeze him solid to beat him.]]
** Finn gets this earlier by [[spoiler:defeating the Lord Of Evil, Marceline's dad, and [[SealedEvilInACan sealing him back in the Nightosphere]].]]
** When [[EldritchAbomination Marceline's]] [[AbusiveParents Dad]] is about to suck the soul of [[EverythingsBetterWithPenguins Gunter]], the penguin smacks him.
* In the pilot of ''WesternAnimation/MyLittlePonyFriendshipIsMagic'', Twilight Sparkle and her TrueCompanions manage to defeat [[SuperpoweredEvilSide Nightmare Moon]], a FallenHero and MadGod who plunged the world into TheNightThatNeverEnds.
** The next season, they manage to defeat Discord, the [[RealityWarper reality-warping]] [[AnthropomorphicPersonification spirit of]] [[GodOfEvil disharmony and chaos]] who plunged the world into [[WorldGoneMad never-ending madness]]. Both of these instances, however, were possible because of [[EmpathicWeapon the Elements of Harmony]], stated to be the most potent magic in Equestria by turning ThePowerOfFriendship into what is essentially a massive rainbow cannon.
** Turns out that even ''without'' the Elements, ThePowerOfFriendship is capable of taking out {{Eldritch Abomination}}s. The founders of Equestria managed to defeat the Windigos, monsters that [[EmotionEater feed off of hatred]] and tried to freeze the entire world in a never ending winter, using the spark of friendship.
** [[RetiredBadass Celestia and Luna]]'s original defeat of Discord all those centuries ago, since though the two are {{Physical God}}desses in their own right, [[TheOmnipotent Discord is so many leagues above them in power]] that even they wouldn't have stood a chance without the Elements of Harmony.
** Princess Celestia herself is on the receiving end of this in "A Canterlot Wedding, Part 2", courtesy of [[GodSaveUsFromTheQueen Queen]] [[VileVillainSaccharineShow Chrysalis]]. ''Everyone'', Chrysalis included, was surprised by that outcome.
* In the ''{{WesternAnimation/Gargoyles}}'' two-parter "The Gathering", Oberon, lord of the Third Race, arrives to claim Xanatos's child, changing into a half mile tall version of himself and putting the whole city to sleep while attacking the building. Xanatos and the gargoyles fight back with all manner of high technology and get him on the ropes (though Xanatos Sr.'s harpoon gun and Fox's magi-blast seem to do the most damage). Ultimately, though, they end up negotiating with him.
* Season3 of ''WesternAnimation/StarWarsTheCloneWars'' had Anakin simultaneously defeat the Daughter and the Son, the embodiments of the Light and Dark Sides of the Force respectively.
* ''WesternAnimation/GreenLanternTheAnimatedSeries'': [[spoiler: An emotionless Aya]] takes out [[spoiler: the Anti-Monitor]] with a single blow. [[spoiler: Then she [[FaceHeelTurn takes his place as the BigBad]] [[GrandTheftMe by fusing with his corpse.]]]]
* In the ''WesternAnimation/FamilyGuy'' episode "Boys Do Cry", Brian starts shooting a gun in the air and accidentally kills the Super-Devil (a demon more evil than the Devil).
* ''WesternAnimation/ScoobyDooMysteryIncorporated'' has the Gang [[spoiler:destroy the Nibiru Entity, a {{Satan}}-like interdimensional alien with god-like power, [[RetGone erasing him from time in the process]].]] Like the ''TheRealGhostBusters'' example above [[spoiler:they do so by sucking it into a black hole, in this case created by destroying the crystal sarcophagus it was using to draw power from another dimension, causing the connection to implode.]]
* In ''WesternAnimation/TheSpongebobSquarepantsMovie'', [=SpongeBob=] himself uses the PowerOfRock [[Awesome/SpongebobSquarepants to defeat]] [[PhysicalGod Neptune]] (God of the Sea). [[http://www.youtube.com/watch?v=wcsI6eD2CmQ It's especially obvious in the GBA game]] but is [[http://www.youtube.com/watch?v=Rt3z5WEhex0 in the movie as well]].
* In ''WesternAnimation/FantasticFour'', Galactus comes calling again and a number of Marvel's heroes come in for the save. The one who drops Galactus? ''ComicBook/GhostRider'', who nails him with his Penance Stare, making Galactus ''scream out in agony over the countless lives he's snuffed and drop to the ground.''
* In an episode of ''WesternAnimation/GodTheDevilAndBob'', no one gets killed, but Bob does win a fight against The Devil by singing a Tony Orlando song. ItMakesJustAsMuchSenseInContext.
* One Halloween episode of ''WesternAnimation/CelebrityDeathmatch'' had one of the fights be between TheUndertaker and a demon named Captain Doody. The Undertaker wins, though he only manages to drive Doody out of his human vessel, not kill him.
* On ''WesternAnimation/{{Reboot}}'', specifically the episode "Showdown" in season 3, we get a pretty epic example of this trope. Enzo by now is no longer a BrattyHalfPint - he's become Matrix, [[TookALevelInBadass took a thousand levels in badass]] [[IGotBigger and considerably bulked himself up.]] The first thing Matrix does upon coming face to face with [[BigBad Megabyte]]? He drops his gun, [[CrowningMomentOfAwesome and dents Megabyte's chest with one punch.]] [[UpToEleven And then spears him through a wall!]]
* ''WesternAnimation/StevenUniverse'' has the human-sized Pearl managing to knock out Sugilite, the fusion of her two teammates the size of a ''building''.