* In the [[http://www.kickstarter.com/projects/295102457/rpgs-are-evil-dark-dungeons-the-movie "Dark Dungeons: The Movie!"]], Debbie ends up summoning Cthulhu by playing too much D&D and in the end she defeats him through the power of prayer.
* In ''Roleplay/TheGamersAlliance'', the heroes of the Grand Alliance work together and defeat Nergal, the God of War, in combat.
* In the Roleplay/{{Crinoverse}}, this happens a lot. The final Chicago Avengers adventure had the heroes facing off with Omega, a being who destroys entire universes. First his armor is blown off, and then he's punched so hard he explodes.
* In the Literature/WhateleyUniverse, Sara Waite fights The Kellith in dreamspace with a knife. And wins. Even if Sara Waite [[spoiler:''is'' The Kellith, or one is part of the other, or they're a duality, or something.]]
** It actually makes sense in context: the 'Kellith' in the dream represents [[spoiler:the magical brainwashing her supposed high priest was trying to inflict on her.]] Of course, that technically makes it not quite an example of this trope -- but then the Whateleyverse also has Tennyo, who apparently ''eats'' {{Eldritch Abomination}}s, demons, and the like. (The jury's still out on whether she counts as one herself.)
* [[http://www.youtube.com/watch?v=ykwqXuMPsoc Narwhals stop Cthulhu eating ye]]
* In ''TheSalvationWar'', this trope is definitely in play. In ''Armageddon?'', the human race kills off [[spoiler:Satan]] and in ''Pantheocide'' [[spoiler:Yahweh, the entity behind the Abrahamic deity]] is next on their list. Powerful as heck and incredibly long-lived (functionally immortal against old age? ''Maybe''), but not invulnerable...
** As it happens, [[spoiler:Yahweh]] was punched out by [[spoiler:the Archangel Michael]], but the human race did manage to punch out [[spoiler:Uriel, the Angel of Death]] though.
* About 8 minutes into [[http://www.thatguywiththeglasses.com/bt/the-sage/fanfic-theatre/12844-mftep10a this dramatic reading of a fanfic on TGWTG]], Robin Hood kills Cthulhu. With a bigger arrow. In the eyehole. To be fair, the guy who wrote this fanfic [[DoomRepercussionsOfEvil was the demons]].
* Various episodes of ONA [[NyarkoSan Haiyore! Nyarko-san]] have [[OrdinaryHighSchoolStudent Mahiro Yasaka]] stab Nyarko's hand with an ''elder sign'' (read "mundane fork"). Of cause it's parody, but consider that she's Nyarlathotep...
* ''TheOnion'' gives us [[http://www.theonion.com/articles/nasa-completes-52year-mission-to-find-kill-god,19263/ NASA Completes 52-Year Mission to Find, Kill God]].
* "But this was the [[Creator/UrsulaVernon House of Red Fireflies]], the greatest whorehouse in the world, and the mistress was a plump, matronly woman who had once killed a god with a broken beer bottle, and [[ItMakesSenseInContext she looked at the fish]], and she nodded."
* In MarvelsRPG, the Earth's heroes defeated [[EldritchAbomination the]] [[HiveMind Galactus]] [[ZergRush Swarm]], being the first species in the universe to complete this task. Generation X defeating [[EldritchAbomination Nyx]] had the same effect.
* WarningReadersAdvisory: [[spoiler: Averted! The Bard's not dumb enough to try it.]]
* WebVideo/EpicMealTime: [[http://www.youtube.com/watch?v=0ITsGZJustI Did they just eat Cthulhu?]] (Meat Cthulhu, that is.)
* In the second season finale of MarbleHornets, Jay is sleeping inn his hotel room when he [[spoiler: hears Jessica scream from the adjoining room. He jumps up to help her, but then stops and turns around. [[EldritchAbomination The Operator]] has materialized into his room behind him. Jay pauses for a minute, as if considering whether to run away or not, but then just takes [[TakeAThirdOption the]] [[CrowningMomentOfAwesome path of greatest awesomeness]] and tackles the Operator out a window.]]
* In the famed {{creepypasta}} ''Russian Sleep Experiment'', the best defense against [[spoiler:the physical embodiment of mankind's daytime fears]] is found to be [[spoiler:a TT-33 pistol.]]
* [[http://media.photobucket.com/image/candlejack%20batman/NaturallyUnlucky/candlejack_oh_shi-png.jpg Here's]] Franchise/{{Batman}} [[UltimateShowdownOfUltimateDestiny vs.]] JustForFun/CandleJack. [[spoiler: Batman Wins.]]
* In ''DarwinsSoldiers'' the FunnyAnimal WrenchWench Sharon, fought Death with a shotgun and an improvised flamethrower. And ''won''.
* [[PonyDotMov Jappleack]]'s plan to defeat the Titan of Honesty, an EvilGod who can travel through multiple planes of existence and devoured the other five Titans? ''Eat him''. [[spoiler:She succeeds.]]
-->'''Twilight''': You're talking about a centuries-old inter-dimensional leviathan the size of a planet who devours entire planes of existence. Jappleack, what are you thinking? You can't eat Appelox!
-->'''Jappleack''': [[IronicEcho Fuck you, I can't eat Appelox.]]
** [[spoiler:In the GrandFinale, Rainbow Dash, after coming BackFromTheDead and causing reality to reset with a Sonic Rainboom, ends up defeating Discord. Possibly justified since she used the Sword of the Holy Titans summoned by Twilight, which Twilight Prime considered about the only spell that ''may'' have been effective against Discord's father Appelox if they could've found someone to wield it.]]
* The SCPFoundation is devoted to containing and studying Cthulhu-grade anomalies that threaten or endanger human sanity, existence, and reality as we know it merely by existing.
** There are at least two subversions: [[http://www.scp-wiki.net/scp-343 SCP-343]], who is literally omnipotent and only contained voluntarily, and [[spoiler:[[http://www.scp-wiki.net/scp-2317 SCP-2317]], whose containment procedure is all just a farce and whom the Foundation has utterly given up on stopping.]]
** And when they actually have to kill one of these uber-creatures? At least in the case of a RealityWarper, a little distraction and a good SniperRifle tend to work wonders. They have to know you're there to defend themselves from you, after all.
* In 'The Camping Webisode' of ''DSBTInsaniT'', Alex makes a mention to Killer Monster of all the powerful beings he and the others defeated in the past, not fazed by Killer Monster's threat.
-->'''Alex''': We have taken out mismatched freaks of nature created by ancient serpents, mad scientists with powerfull monsters under their command, and demons who can take over the planet! You don't think we can kill some fire-breathing beast?!
* In ''Literature/{{Worm}}'', Taylor manages to [[spoiler:essentially bully a nigh omnipotent world destroying alien to death. By targeting Scion's psychological weakpoints, she drives him past the DespairEventHorizon, and he allows himself to be killed.]]
* [[http://youtu.be/3YgnZ09wZVA This video]] has [[spoiler:[[WesternAnimation/MyLittlePonyFriendshipIsMagic Rainbow Dash]] punch out [[TheSlendermanMythos Slenderman]] to protect Fluttershy.]]
* In the Steve Poling short story [[https://www.libertyislandmag.com/creator/stpoling/content.html?ln=southernfriedcthulhu2 ''Southern Fried Cthulhu,'']] a Cthulhu makes the fatal mistake of invading a southern redneck town. After driving half the townsfolk insane, a handful of those lucky enough to have been shielded from his mind-control rays kill him with tinfoil hats, molotov cocktails, shotguns, and a batch of thermite-- then slice him up and fry him. Then they get a hunting license to go after more...
* In ''WebAnimation/{{Dreamscape}}'', Keela [[spoiler:instantly kills the Master of the Dammed by simply smashing his scythe.]]
* [[http://youtu.be/Sob1t-iUCmE Epic Wub Time]] has [[spoiler: Vinyl [[{{Pun}} soundly]] defeating Discord with [[CurbStompBattle one shot]] of her [[ThePowerOfRock Wub-powered]] "[[WaveMotionGun Bass Cannon]]".]]
* In ''WebVideo/TheNostalgiaCritic'' special "You're a Rotten, Dirty Bastard", the Critic does this to Roger the angel ''three times''. When he first finds Roger in his home, he punches him in the face thinking he's a Jehovah's Witness. The next time Roger comes up to him, he punches him in the groin so hard it temporarily ''paralyzes'' him. Finally, at the end, when Roger [[spoiler:turns evil and attacks him]], the Critic [[spoiler:kills him by shooting him in the face.]]