* ''Film/{{Ghostbusters}}'': The eponymous busters have to [[ForbiddenChekhovsGun Cross The Streams]] to do it, but they defeat Gozer the Gozarian, an ancient god worshipped by the Hittites, Mesopotamians, and the Sumerians around 6000BC that would take on a Destructor Form from the thoughts of humans in the area and wreak havoc once it was summoned into our world.
-->We came, we saw, we ''kicked its ass!''
* ''Film/ConanTheDestroyer'': What to do when you involuntarily helped the return of an ancient monstrous god? Wrestle him and rip off his horn with your bare hands, of course!
* ''Film/StarTrekVTheFinalFrontier'' has [[spoiler:the God imposter]] blown up by a torpedo then vaporized by ship-mounted disruptors. Spock did it.
* In ''Film/{{Dogma}}'', when Silent Bob [[spoiler:kills the demon Azrael with Cardinal Glick's driver. Granted, the clubs in question were blessed by a priest (because [[SmugSnake the priest would be the kind of guy to do that]]), but when mortals are taking out demons you can't be picky about the methodology.]].
* Subverted in ''Film/SinCity'' where this very act is invoked (sarcastically) as a metaphor for doing something that is completely impossible.
--> '''Hartigan:''' And after I pull off that miracle, maybe I'll go punch out God.
* ''BillAndTedsBogusJourney'' has the titular duo give a "Melvin" (a front-side wedgie) to TheGrimReaper. [[FridgeLogic Even though technically Death has no genitals.]]
* In ''Film/GreenLantern'', [[spoiler: Hal Jordan literally does this to Parallax with a giant light construction in the shape of a fist.]]
* In ''Film/{{Thor}}'', the titular character is comically tazered after boasting of his power. Thor is also later injected with a sedative after [[RunningGag once again boasting of his power.]] He later also gets backed over with a truck, [[OverlyLongGag once again, knocking him out.]] [[JustifiedTrope However]], he had been BroughtDownToNormal during that time.
* ''Film/TheAvengers'':
** Loki taunts every hero he speaks to and at minimum holds his own in direct combat. During the final battle he comes face-to-face with the ComicBook/IncredibleHulk. He's barely gotten 3 sentences out before Hulk grabs him and starts with the MetronomicManMashing, knocking him silly and taking him out of the fight. "Puny God."
** There's also the matter with the hordes of aliens, their flying fighters, and space whales that invade Manhattan. The team manages to make several great god-killing punches [[spoiler: (starting with the Hulk's OneHitKO and ending with Tony Stark's NukeEm at the end the game.]]
* ''Film/{{Hellboy}}'' features its titular [[AntiHero demonic hero]] being swallowed by the tentacled [[GodOfEvil God of Chaos]]. Fortunately Hellboy was wearing a belt of grenades which he then detonated, blowing the creature up from the inside, leaving Hellboy remarkably unharmed.
* ''Film/PacificRim'': [[{{Kaiju}} Giant horrifying monsters]] rise from beneath the depths to destroy us all, and what is humanity's reaction? Build HumongousMecha and literally [[http://www.youtube.com/watch?v=0L73VjWmiis punch them in the face]].
-->'''Stacker Pentecost''': I've never believed in the End Times. We are mankind. Our footprints are on the moon. When the last trumpet sounds and the Beast rises from the pit we will ''kill'' it.
* In ''Film/EndOfDays'' (1999): Arnie solves the problem of universal evil by simply shooting the Devil with a bigger gun than previously attempted.
* In the [[http://www.kickstarter.com/projects/295102457/rpgs-are-evil-dark-dungeons-the-movie "Dark Dungeons: The Movie!"]], Debbie ends up summoning Cthulhu by playing too much D&D and in the end she defeats him through the power of prayer.
* The SyfyChannelOriginalMovie ''Ba'al: The Storm God'' plays with this trope. While the military succeeds in severeing Ba'al from his power source with a nuke, the ''actual'' one to punch him out is another god, El, who the heroes summon to defeat him. Humanity still weakened Ba'al and gave El the opening, however.
* In ''Film/ManOfSteel'', the military manages to [[spoiler:knock Faora unconscious with a missile.]]
** [[spoiler:Understandable, given that Clark had just damaged her Cool Helmet, causing her to begin experiencing the same sensory overload that had crippled Zod moments before. A missile exploding in her face would no doubt be overwhelming, super-powered or not.]]
* In ''Film/GokaigerGoseigerSuperSentai199HeroGreatBattle'', the Series/KaizokuSentaiGokaiger defeat Black Cross Colossus, the ultimate form of ''Series/HimitsuSentaiGoranger'''s BigBad, by using the ultimate attack of the Goren Gokai-Oh, a large friggin' sword!
* In ''Film/BackToTheFuture'', everybody is amazed when [[ExtremeDoormat the notoriously weak-willed]] George [=McFly=] [[CrowningMomentOfAwesome punches out Biff]] when he [[DateRapeAverted tried to rape Lorraine]].
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