* Parodied in Creator/DonHertzfeldt's [[https://www.youtube.com/watch?v=MuOvqeABHvQ short film]], ''WesternAnimation/{{Rejected}}''. The creation quite literally falls apart.
* ''WesternAnimation/SouthPark'':
** [[WordOfGod According to]] co-creator Trey Parker, the episode "Raisins" (in which Stan's girlfriend Wendy breaks up with him) was based on the trials and tribulations he went through when he found his fiancée in bed with another man. Stan's thoughts in the episode reflect Parker's.
** The character of Cartman's mom was created and named after Parker's ex-fiancée who left him at the altar. Liane Cartman has slept with virtually every inhabitant of South Park, although as of late she's actually become more firm and less slutty, indicating that Parker's feelings on the matter have died down at this point.
*** The same girlfriend was the name of the horse in ''Film/CannibalTheMusical'' -- who leaves Parker's character during the film. In fact, just listen to the drunken commentary on the DVD.
** This trope appears to be the theme and driving force of the episode "You're Getting Old". Parker and Stone, however, [[{{Jossed}} have stated that fans "took the episode too seriously" and deny being unhappy with the show]].
* The opening crawl in the third episode of ''WesternAnimation/FamilyGuyPresentsLaughItUpFuzzball'' states that the show's staff was sick of doing the ''Franchise/StarWars'' parodies. The DVDCommentary for the episode makes it clear that they were definitely ''not'' joking.
* At a convention, Meghan [=McCarthy=] said of writing ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' that the reason that one of the main characters [[SanitySlippage goes crazy]] in many of the episodes she's written is because they were mostly composed in the wee hours of the morning under a tight deadline, reflecting her stress.
* Shortly after the first season of ''WesternAnimation/RockosModernLife'' Joe Murray's first wife [[DrivenToSuicide committed suicide]], so Murray started spending less and less time working on the series, until he finally just gave up on it altogether. Thus seasons 3 and 4 are not produced by him, and the series came to an end after season 4. For a while out of grief, he MisBlamed the series for his wife's suicide.
** A similar turn of events happened with ''WesternAnimation/CampLazlo'', this time a result of his second wife divorcing him.
* Towards the end of his theatrical career Creator/TexAvery suffered from depression and was convinced that he couldn't be funny anymore.
* Skyler Page, creator of ''WesternAnimation/{{Clarence}}'', had problems with bipolar disorder that, combined with the stress of running a show, caused a psychotic episode where he groped female co-workers and ran out into the street shirtless yelling at police officers, speaking in different characters voices, riddles and They Might Be Giants songs. His disorder having caused some trouble in the past, as well as the sexual harassment incidents becoming public and creating a PR panic, led to him being fired by Cartoon Network and the role of Clarence being recast.
** The breakdown actually came way before that. He tried smoking cigarettes with his nose, charging into the street shirtless while screaming at cops, drinking olive juice, staying up for days, answering questions with riddles, and when going to a mental hospital after the event he began to sing Music/TheyMightBeGiants songs while strapped to a hospital bed.

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