* The Starry Night (1889), perhaps Vincent van Gogh's most famous and arguably best work was made shortly before his apparent suicide in 1890.
* Creator/BillCosby had his entire attitude shift after his son, Ennis, was killed. Cosby has since become a rather outspoken critic of African-American youth who focus on [[StopBeingStereotypical "looking cool"]] rather than doing well in school or finding a job.
* ''Website/TheOnion'''s resident "political cartoonist" Stan Kelly shows signs of this on a regular basis. While most of his cartoons are takes on issues of the day, he frequently uses his panel to rage about his ungrateful kids, shrewish wife, and generally reveal what a terrible, messed up individual he is. This being TheOnion, it's all played for laughs, of course.
** Quite clearly a parody of most cartoonists' tendency to [[AuthorTract shove their personal issues and biases into their cartoons]]. Also, watch for Kelly [[RunningGag getting fatter in every strip]].
* ''The GoonShow'' may be considered as a product of Spike Milligan's manic phases.
** A fair chunk of his poetry was written in a depressive phase, such as a poem about a child grabbing a rose:
-->''The child screams\\
The rose is silent\\
Life is already telling lies.''
* Parodied in the WebVideo/DerrickComedy sketch "Girls Are Not to Be Trusted".
* This ''[[BlatantLies might]]'' have happened to Tara, the author of ''MyImmortal''.
* Camille Bacon-Smith, in her book ''Enterprising Women'' (one of the first ethnographical studies of FanFic writers) admitted shock over how many fanfic writers were dealing with serious Real Life issues (divorce, abandonment, family strife, rape recovery, poverty, discrimination) and using their work as an outlet to address it because there were few other outlets available.
* [[http://en.wikipedia.org/wiki/Francisco_Goya Francisco Goya]] for a majority of his career as an artist painted bright and colorful portraits, mostly of people [[http://upload.wikimedia.org/wikipedia/commons/3/3d/La_cometa.jpg enjoying life]] or of pleasant scenes like the [[http://upload.wikimedia.org/wikipedia/commons/f/fc/Francisco_de_Goya_y_Lucientes_054.jpg Spanish Royal Family.]] However, towards the end of his life he began to paint much, ''[[http://upload.wikimedia.org/wikipedia/commons/8/82/Francisco_de_Goya%2C_Saturno_devorando_a_su_hijo_%281819-1823%29.jpg much darker]]'' scenes. This is primarily blamed on a debilitating illness that deafened him and left him mentally scarred and the war that left his life in ruins.
** The infamous painting of Saturn devouring his children in particular takes on a new significance if you know your Classical Mythology and that Goya had six children, only one of whom lived to adulthood.
* Played for laughs by stand-up comedian/singer Stephen Lynch when he sings the last verse of the song "Superhero," where at one point he seems to get angrier by the second:
-->If you could be a superhero
-->Would you be Justice Guy?
-->Making sure people get what they deserve
-->''Especially women who lie''
-->Like if a wife left her husband with three kids and no job
-->To run off to '''fuckin Hawaii''' with some ''doctor'' named Bob
-->You could skin them and drain them of blood so they'd die!
-->[Especially '''Bob!''']
-->Then you would be Justice Guy!
* Creator/JohnCleese's frequent lapses into psychiatry and self-analysis could in part be blamed on the constant pressure on the man to be funny. A certain sort of creator breakdown must result from being instantly recognisable in the street and being constantly prevailed upon to do the silly walk, or the silly voice, or just to be funny - all of which got to the famously serious-minded Cleese.
** While not as dramatic as some of the examples around, much of Cleese's humour also stemmed from his background -- his typically British middle-class upbringing with rather distant and unexpressive (if not necessarily unloving) parents and his school-life (including suffering a growth spurt that ended up with him being 6ft tall at the age of 13, which naturally made him something of a target). He once remarked that becoming a comedian was a way of at least controlling why people were laughing at him.
** A somewhat specific example of this pressure could be seen from his commentary on the ''Series/FawltyTowers'' episode "The Builders". According the Cleese, the first people who saw the episode were some visiting Icelanders. Icelandic culture dictates that, even if you find something funny, you don't laugh at the show until the very end of it. The whole episode, he was faced with silent stoicisim, thinking that they were hating it when they were in fact finding it rather amusing. Nobody told Cleese this for sometime afterwards and to this day, he repeatedly states how much he hates the episode, seemingly for no other reason than this particular incident.
* British impressionist Mike Yarwood built a career out of being people other than himself. Renowned in the 1970's for his ability to effortlessly "do" politicians of the age such as Ted Heath, Harold Wilson and Jim Callaghan, a career largely based on impersonating Prime Ministers hit the rails in May, 1979, when a ''woman'' was elected PM... Yarwood soon became one of the first victims of Thatcher's mass unemployment because of his inability to do drag, possibly making him unique among British comedians. He also discovered that while his takes on Richard Nixon, Gerald Ford and Jimmy Carter were pretty much spot on, he was incapable of doing Ronald Reagan. He soon learnt nobody was interested in yesterday's politicians, and more than that, the "real" Mike Yarwood had been lost somewhere under all the other personas he put on for a living. Like {{Peter Sellers}}, he bemoned his inability to find the "real me". This personal crisis developed into psychosis and alcoholism from which he never fully recovered.
** [[https://en.wikipedia.org/wiki/Vaughn_Meader Vaughn Meader]] suffered a similar fate after November 22, 1963; even though he was a multi-talented comedian and entertainer, no one wanted to hear jokes of any kind from someone whose main claim to fame was a dead-on impersonation of JohnFKennedy. Fortunately, he was able to pull himself together and settle into a second career as a bluegrass musician in his native Maine.
* [[http://en.wikipedia.org/wiki/The_Last_Judgment_%28Michelangelo%29 Michelangelo's ''The Last Judgment'']] might have reflected his declining physical and mental health.
** There was also the fact that he was coerced by the Vatican to create in a medium he disliked. He even made a subtle Easter Egg as a TakeThat to the papal chamberlain who made him do it (basically, he drew Satan as the unfortunate Chamberlain, depicting him naked with a snake covering his man bits). When the outraged Chamberlain asked the Pope to censor it, the Pope replied that [[DeadpanSnarker he only had authority in Heaven and Earth.]]
* {{Margaret Cho}} spiraled into drug and alcohol addiction after the cancellation of her show "All-American Girl", where she was not only forced to lose weight to play the part of herself but also simultaneously criticized for being "too Asian" and "not Asian enough." She wrote about her experiences in the book "I'm The One That I Want", and her stage show version of the book served to re-launch her career. Her experiences with Hollywood and addiction have since become a regular motif in her stand-up.
* {{Manhua}} author and artist Ai Ou apologised at the end of volume one of ''Manhua/InfinityGame'' because he started writing/drawing chapter 1.5 (D.D.'s backstory) just after he had attended a funeral.
* Famed British scientist Michael Faraday began to suffer memory lapses in his later life, which caused him to fall into deep depression.
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