The newest comic book incarnation of the popular TeenageMutantNinjaTurtles franchise, and the first new material produced after Nickelodeon's acquisition of the property, launched in 2011. Set in a new continuity unconnected to any others, it features the return of TMNT co-creator Kevin Eastman to regular creative duties after more than a decade away from the fold.

In ancient Japan, Hamato Yoshi and his four sons are murdered by the Foot Clan and their leader Oroku Saki. Centuries later, they are (apparently) reincarnated as a rat and four turtles, who are then used as test subjects for geneticist Baxter Stockman's experiments on brain enhancers (Splinter), mutagens, and super-soldier formulas (The Turtles). Later, after an attempt at corporate espionage gone awry, they become exposed to mutagens, which metamorphose them into the characters we know and love.

But there's one problem. Before the mutation took effect, one of the turtles was taken by an alley cat. Though Splinter managed to fight the cat off, the turtle ended up lost. Fifteen months later, while Splinter, Leo, Don, and Mike rumble with Old Hob (the cat got mutated too), Raphael has spent this time wandering the city as a homeless vagrant.

The origin is not the only marked change. April, in this incarnation, was familiar with the unmutated turtles and in fact gave them their renaissance artist names. Casey Jones is a college student living with his father who takes Raphael in. Baxter Stockman is affiliated with Krang, now a general, but not the Shredder. Human versions of Bebop and Rocksteady have been introduced their first appearance not directly connected to their original cartoon incarnations. All in all, it serves to give the series a "[[UltimateUniverse Ultimate TMNT]]" vibe: for the first time in the franchise's history, all of its disparate elements and characters are seen in one place. [[WesternAnimation/TeenageMutantNinjaTurtles2012 The 2012 cartoon]] also goes for the same vibe, but this started first.

For a breakdown of the more prominent characters in the series, visit the [[Characters/TeenageMutantNinjaTurtles franchise character page]]. For information the various comic book series by original Turtles publisher Mirage, visit the [[ComicBook/TeenageMutantNinjaTurtlesMirage Mirage TMNT]] page. For an overview of the franchise in general, see [[TeenageMutantNinjaTurtles the franchise page]].

! The series includes examples of the following tropes:
* AbusiveParent: Casey Jones' father, Arnold Jones
* AdaptationDyeJob: Splinter--perhaps taking a nod from the [[TMNT2003 second cartoon]]--now has gray fur.
* AdaptationalBadass: In the original cartoon, Bebop and Rocksteady were nothing more than ineffective idiots, but here, while they're still dumb as can be, they're also insanely powerful fighters who present a genuine threat to the good guys, to the point that in issue 40, it takes a total of ten people to fight them, and the only thing they managed to do was slow Bebop and Rocksteady down long enough to escape rather than actually defeat them. And as of #44, [[spoiler: they come ''damn'' close to killing Donatello.]]
* AgeLift: Princess Tribble, a baby in the '87 cartoon, is now the turtles' age. (Well, their biological age, anyway)
* AlcoholicParent: Arnold Jones [[spoiler:at least until he becomes Hun]].
* AscendedExtra: Chet, in the Mirage comics, was the name of the little kid who originally owned the pre-mutated turtles--a one-page character. Here, he is April's supervisor at [=StockGen=].
** [[spoiler:Potentially subverted into CompositeCharacter upon the reveal that surprisingly, he's also secretly the Fugitoid!]]
* BigDamnHeroes: After the Turtles and Splinter are trapped in a warehouse, beaten by [[spoiler:Dark Leonardo]] and completely surrounded by the Foot, [[spoiler:Slash]] literally [[DynamicEntry crashes in]] to save them.
* BioAugmentation: [=StockGen's=] ''real'' (ahem!) [[StealthPun stock]] in trade.
* BitchInSheepsClothing: Alopex initially appears to be a timid DamselInDistress on the run from whoever created her. But Raphael quickly deduces that she's actually playing the sympathy card to try and infiltrate the turtles, at which point she reveals herself to be one of the Shredder's deadliest and loyalist minions.
** [[spoiler: Subverted as of recently, where it's revealed that she's only been loyal to Shredder all this time so she can get close enough to kill him. And not because she's TheStarScream, but because [[YouKilledMyFather he butchered her old pack to leave her with nothing but the FootClan.]] ]]
* BodyDouble: Shredder set up one of his Foot soldiers in his place during a failed attempt to ally with General Krang.
* CanonForeigner: A lot. Old Hob, Alopex, Kitsune, Koya, Bludgeon, Woody, Harold, Lindsey, Herman...
* CompositeCharacter: Krang now is an Utrom and a serious villain like Ch'rell from the 4kids show.
** Casey's father, who is now also [[spoiler: Hun]].
** A variation. While Kala does still exist, Princess Tribble is instead Mikey's Neutrino LoveInterest.
** After taking an exo-suit Harrold has been working on, Angel is now [[spoiler:Nobody.]]
* EnemyMine: [[spoiler:Splinter and the other three turtles end up working together with Old Hob and Slash in order to take back Leonardo from the Foot Clan after he has been brainwashed into joining them, and their alliance has continued even after getting Leonardo back. While Hob helps out just to further his own agenda, Slash does end up befriending Michelangelo.]]
** The Turtles and Splinter team up with the Foot due to a mutual goal of preventing General Krang from terraforming Earth.
* EvilVersusEvil: The "New Mutant Order" and "Attack on Technodrome" arcs has Shredder and the Foot Clan battling General Krang and his forces.
* {{Expy}}: Alopex is one of Ninjara from TeenageMutantNinjaTurtlesAdventures. Both are fox-women who start off as minions of one of the Turtles' enemies and turn into allies of some sort.
* EyepatchOfPower: Old Hob.
* FaceFramedInShadow: General Krang.
* FantasticFoxes: Alopex is a mutant Artic fox. Kitsune is a {{kitsune}}.
* FeatheredFiend: Koya, Shredder's mutant falcon.
* FunWithAcronyms: Issue 6 reveals Stockman's new '''M'''inefield '''O'''rdnance '''U'''narming '''S'''ystem '''E'''nhanced '''R'''obots
* GeneticMemory: Since only 15 months have passed when the series begins, the Turtles didn't grow up learning to be ninjas - [[{{Reincarnation}} in this life]], and their training in the present day is like re-learning and improving skills they somehow already knew.
** Also unwittingly displayed by Mikey as he can read Japanese, surprising everyone including himself.
** Possibly subverted, as heir fighting skills and reflexes might be caused (partly) by the super-soldier serum (which WAS created for military use and tampered with by [[spoiler: an alien scientist]]).
* GiantEnemyCrab: Herman the Hermit Crab, who wears a dumpster on his back with machineguns and missile launchers hidden inside it.
* HesBack: [[spoiler: At the end of #31, when Koya has ambushed the turtles at the O'Neill farm, Leonardo comes out of nowhere to face her, once again donning his trademark blue eyemask.]] Mikey even gets to [[LampshadeHanging acknowledge the trope]] at the beginning of the following issue.
* HollywoodMedievalJapan: Where Hamato Yoshi, Oroku Saki, and the original incarnations of the turtles lived.
* HostileTerraforming: Krang plans to turn the Earth into a new Utrom throne world by changing its atmosphere to be compatible with his species.
* {{Hypocrite}}: Oroku Saki will not shut up about the importance of loyalty and family. This despite betraying almost everyone he's ever worked with, murdering his father and abandoning his children, and routinely demanding his followers abandon or even kill their own family members.
* KlingonPromotion: Oroku Saki's father Oroku Maji killed the original leader of the Foot Clan. This is presented as a good thing since he was evil, and had his lifespan extended through dark magic. Oroku Maji then reformed the Foot into an honorable force. Later, Saki killed his own father and returned the Foot to their villainous ways.
* MadScientist: Aside from Baxter Stockman, Harold Lillja from the Donatello one-shot.
* MoreDakka: New character Herman the Hermit Crab specializes on this, thanks to the arsenal he carries on the dumpster that he uses as a "shell".
* MoreThanMindControl: [[spoiler:Thanks to some evil Foot Clan magic, Leonardo unwillingly becomes '''Dark Leonardo'''.]]
* MythologyGag: Multiple. In the first issue alone, a t-shirt inscribed with "cowabunga" to April's yellow shirts to the opening fight with Old Hob's gang, which could be considered a nod to a similar opening in the original Mirage comic book.
** Donatello's online name as revealed in the first Micro-Series is "[[TeenageMutantNinjaTurtles1987 Duz_Machines]][[ComicBook/TeenageMutantNinjaTurtlesMirage 84]]".
** In Krang's backstory, a scarred Utrom resembling Ch'rell was his commanding officer in a war where he made his name.
** The symbol of the ancient Foot Clan is the human foot from the Mirage comics and 1987 show, while the modern Foot Clan uses the symbol from the 2003 show.
** Leo, Mikey and Don all wear red headbands like the Mirage comics until they find Raphael again, then they switch to their individual colors as seen everywhere else. Explained as they were honoring the missing Raphael by wearing his color.
** Krang's robot body in the past looks very similar to the one he used in the 1987 cartoon (especially the head).
** In the seventh issue of the Villains microseries, Bebop asks Rocksteady if the Shredder would like him if he wore turtle shells on his shoulders.
* NeverBringAKnifeToAGunFight: General Krang invoked this trope word by word while mocking Shredder, who is alone and cornered by Krang and his men. However, Shredder takes the opportunity to summon his new mutants Koya and Bludgeon into the fray.
* NeverBringAKnifeToAFistFight: During the initial fight in issue #1, Michelangelo, Donatello, and Splinter all manage to hit their opponents with their weapons, while Leo is reduced to the old stand-by of cutting his opponents weapons. Old Hob's gang, which is armed with chains, crowbars and guns doesn't manage to land a hit at all.
* PastLifeMemories: The turtles and Splinter appear to have slivers of these. Splinter more than the turtles, possibly because of the additional brain enhancements he received pre-mutation.
** Oroku Saki's own past life memories are awakened by Kitsune.
* Really700YearsOld: Back in medieval Japan, Oroku Saki's lifespan and youth was extended for many decades with a magic potion made by his lover Kitsune. The potion was actually derived from [[{{Magitek}} ooze supplied by Utroms]] (later the basis of the mutagen that transformed the Turtles and Splinter). Desiring "true" immortality, Saki had Kitsune conduct a magic ritual using undiluted ooze to preserve his body for centuries, until he was revived in the present day by his descendant Karai.
* {{Reincarnation}}: A huge part of the turtle and Splinter's origin.
** [[spoiler: And the Shredder's as well. He's the reincarnation of Tatsuo Takeshi, founder of the Foot Clan and the original lover of Kitsune.]]
* SecretProjectRefugeeFamily: Subverted: while the Turtles and Splinter initially seem to be this, it turns that the reality is much more complicated.
* ScrewLearningIHavePhlebotinum: Splinter's blood is the key ingredient for the psychotropic serum that creates mutants with higher intellects. Slash became the first mutant in Hob's Mutanimals to taking the serum and becoming well articulate and more intelligent [[spoiler:to the point that he can infiltrate the Turtles' lair and effortlessly disabling Donatello's security system]].
* ShipTease: During one fight between the Turtles and the Foot, Karai berates Leonardo for his lack of skill and poor form. Raphael then says "Hey, Leo. [[SarcasmMode I think she likes you.]]"
** As of issues 30 and 31, [[spoiler:Raphael and Alopex, all over the place.]]
* StartOfDarkness: Oroku Saki was an arrogant rival of Hamato Yoshi but not truly evil, until Kitsune awakened the memories of his past life. Then he started acting like his past self.
* SuperSoldier: The Turtles DNA was used to create super-soldiers for Krang with impenetrable skin.
* SweetTooth: [[spoiler: Slash, whom Mikey befriends after giving him a candy bar.]]
* ThouShaltNotKill: Ordered by Splinter.
* TookALevelInBadass: [[spoiler:Old Hob starts off the series as little more than a dumb thug. As the series advances, though, he becomes far smarter, more cunning, and playing all sides while technically not betraying anybody, all the while having recruited the powerful Slash to his side as well. He's later seen in ownership of a huge stash of firearms, manages to convince Splinter to get him a big canister of mutagen in exchange for helping him find Leonardo (with plans to create a mutant army) and he and Slash blow [=StockGen=] up right afterwards.]]
** [[spoiler:Casey's dad starts off as an antagonist if only because he's physically and emotionally abusive towards Casey. Later on, he resumes his old identity as Hun, becoming a very strong fighter and taking over the Purple Dragons with ease.]]
** Bebop and Rocksteady were originally down on their luck human gangsters until joining the Foot Clan and rising up from wannabes to low ranking muscles out of [[{{Determinator}} pure determination]]. They then willingly become mutants after going through a life-or-death brawl set up by Karai to defeat the other candidates.
* TroubledButCute: Casey, perhaps moreso than any other adaptation.
* UltimateUniverse: Technically, anyway, due to the fact Peter Laird still has the option of creating new comics set in the original Mirage Universe if he wishes.
* VillainProtagonist: The whole point of the Villains microseries, which features origins and stories for Krang (issue 1), Baxter Stockman (issue 2), Old Hob (issue 3), Alopex (issue 4), Karai (issue 5), Hun (issue 6), Bebop and Rocksteady (issue 7), and the Shredder (issue 8).
* VillainTakesAnInterest: The Shredder, who wants Leonardo to serve as his heir.
* VillainTeamUp: Averted when Shredder tried to reforge his alliance with General Krang by ruling Earth together; Krang flatly refuses on the basis that he never trusted Shredder, he already has the technology and power to annihilate Earth's military forces, and lastly he has no intention of sparing a single human when he has the Technodrome in his possession.
* WellDoneSonGuy: Krang sought the approval of his father Emperor Quanin until he finally TookALevelInBadass.
* WhamEpisode: Issue 50 - [[spoiler:Splinter kills Shredder and takes over the Foot Clan, leaving Mikey to bail in anger and confusion, afraid of [[HeWhoFightsMonsters just ending up like how Shredder was.]]]]
* YoungerThanTheyLook: The Turtles and Splinter are exposed to the mutagen only 15 months before the events of the first issue, making them chronologically much younger than usual. They are mutated into their present "teenage" and "older adult" appearances instead of aging over some years in the sewers. This makes "Teenage" Mutant Ninja Turtles sort of an ArtifactTitle.