Painkiller Jane is a SuperHero character that originated in a comic book series, made a brief B-movie appearance, then migrated to a short-lived TV series on the Sci-Fi Channel.

All the three versions have in common are that they are virtually immortal, ass-kicking hot women. The names, backgrounds, occupations and hair color all mutate wildly in transition.

Not related in any way to the ([[BrutalLegend Second]]) '''[[{{Painkiller}} MOST METAL VIDEOGAME EVER.]]'''

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The ComicBook started with Event Comics and is now at Dynamite Comics. Jane Vasko (with a "k") was an undercover cop investigating TheMafia, when she got [[StuffBlowingUp exploded]] by a rival gangster known only as Adam, who was at ground zero without a scratch. Somehow, Adam revives her, makes her unkillable, and then disappears. She drops off the force and becomes a vigilante, [[NotWearingTights eschewing spandex]] in favor of lots of bandages ([[BringMyRedJacket 'cause she bleeds a while]] before healing up), a BadassLongcoat and CoolShades. She is an expert at close-combat and normally carries [[GunsAkimbo twin automatics]].
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The MadeForTVMovie was a SciFiChannel Original, meaning it sucked. Still, it had Emmanuelle Vaugier, even if she spent half the film in a cheap wig.

This version is radically different from the original. Captain Jane Browning, a U.S. Special Forces soldier (never mind that they don't have any female members) is hit by TheVirus and becomes a SuperSoldier. She then tries to discover who to seek revenge against (not just for being CursedWithAwesome, but because her squadmates didn't share her good luck, and died from the bioweapon instead).
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The TV series was another new direction. Former Terminatrix {{Kristanna Loken}} was Jane Vasco (with a "c"), once again a cop (this time in the DEA), recruited for a special quasigovernmental FiveManBand to hunt down "Neuro"s, neurological abberants with [[SuperpowerfulGenetics mutations that gave them superpowers]], and stick a microchip in their brains to [[BroughtDownToNormal depower them]]. Jane discovers [[ContrivedCoincidence quite by accident]] that she has a HealingFactor. From then on it's MonsterOfTheWeek, with every episode [[GoodThingYouCanHeal having Jane find some reason]] to get mauled, mutilated, shot, poisoned or given brain cancer. And [[{{Wangst}} not knowing if she'll get better]], even if the audience has no doubt.
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!Tropes hit in all three:
* AppliedPhlebotinum
* BandageBabe
* EnemyWithin
* GoodThingYouCanHeal
* HealingFactor
* MonsterOfTheWeek
* NotWearingTights

!Tropes in the comic
* IntercontinuityCrossover: With ''{{Terminator}}''
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