A very long-running comic strip created in 1954 and still run to this day by one Brad Anderson. Originally, Anderson was aided by Phil Leeming and later Dorothy Leeming, but he has held the strip solo since 1969.

Marmaduke is a monstrous Great Dane owned by Phil and Dottie, a stereotypical fifties husband and wife, and their kids, Barbara and Billy. Most of the "jokes" center on Marmaduke being big and/or thinking he's human. The strip seems to exist mainly as the target of SnarkBait, mainly on the repetitive nature that the strip seems to be locked in.

Incredibly, a live action/CGI ''Film/{{Marmaduke}}'' movie was released in June 2010, with Owen Wilson voicing the title character.

!Tropes present:

* AnimatedAdaptation: The 1980 ''ComicStrip/{{Heathcliff}}'' TV series (the Creator/RubySpears version, not the ''WesternAnimation/HeathcliffAndTheCatillacCats'' version) featured animated ''Marmaduke'' segments as well.
* BigFriendlyDog: Marmaduke.
* CanisMajor: Guess who?
* {{Crossover}}: Marmaduke appeared at the beginning of a [[http://www.garfield.com/comics/vault.html?yr=1991&addr=910331 Sunday]] ''{{Garfield}}'' strip. As Garfield realized the fence he was painting his name on was Marmaduke's, he apologized stating [[BreakingTheFourthWall "wrong strip"]].
* DogWalksYou: A regularly recurring gag.
* LiveActionAdaptation
* PrintLongRunners: 50+ years.
* SquareCubeLaw: Bent over and thoroughly violated. [[MemeticMolester Much like owner-man]].
* SuddenlyVoiced: In TheMovie.