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[[folder:Films -- Animation]]
* ''WesternAnimation/AllDogsGoToHeaven2'':
** Flo, Charlie's implied possible dog love interest in the first movie, is never mentioned.
** Anne-Marie, although she's briefly mentioned in one scene, but not by name.
** Killer, Carface's sidekick, which makes this the only entry in the series without him.
* In the DirectToVideo sequels to ''WesternAnimation/AnAmericanTail'', Bridget, the love interest of Fievel's older friend Tony Toponi, vanishes without even a mention and Tony starts lusting after other women. This could possibly be because Bridget's voice actress was terminally ill when the movies were made and died soon after (for their faults, the 3rd and 4th films did manage to get most of the original voice talents from the first two movies). It could also have been because the writers wanted Tony to be single so he could interact with Fievel more.
* In the DirectToVideo sequels to ''WesternAnimation/{{Balto}}'', Steele, along with Nikki, Kaltag, and Star, along with Dixie and Sylvie, do not appear or mentioned. In the third film, the grizzly bear was also absent.
* In ''WesternAnimation/{{Bambi}}'', Thumper the rabbit has five sisters, but in ''WesternAnimation/BambiII'' (which is supposed to take place after the scene where [[ItWasHisSled Bambi's mother dies]] but before Bambi becomes an adult), he now only has four sisters! FridgeHorror, really; the reason rabbits breed so quickly is because they tend to get eaten a lot.
* In ''WesternAnimation/BrotherBear2'', Kenai's village and the characters in it, such as his brothers Denahi and Sitka, along with the shaman Tanana, are not seen or mentioned in this sequel, not even at Kenai and Nita's wedding in the epilogue.
* ''WesternAnimation/Cars3'': Finn [=McMissile=], Holley Shiftwell and the other agents from ''Cars 2'' are not seen or mentioned in this movie. It is also never mentioned whether or not Mater and Holley became a couple after the implications at the end of that film.
* Significant characters from the ''Franchise/DisneyFairies'' franchise frequently fall victim to this when the next movie comes along. Some of the lucky ones are DemotedToExtra but others have simply disappeared without explanation by the next installment even though they had top billing right below Tinker Bell in the previous film.
* ''WesternAnimation/FindingDory'':
** Bruce, Anchor, and Chum are never mentioned by name once during the whole movie. Likely justified as most of the film is spent away from their neck of the woods and there isn't really a good place for them to show up in the plot, but their absence is still noticeable.
** The pelican Nigel failed to return or get a mention. He was last seen in the first movie sadly flying off after placing Dory and Marlin back in the sea, thinking Nemo was dead. (While it's also a possible sign that they could be saving him to reappear in a later film as well, it's most likely that he found out about Nemo being alive from the Tank Gang shortly afterwards.)
** The dentist Dr. Sherman, along with his niece, Darla are also absent.
* ''WesternAnimation/TheFoxAndTheHound2'': Big Mama, along with Dinky and Boomer do no appear or mentioned.
* In ''WesternAnimation/AGoofyMovie'', Roxanne is shown to be Goofy's son Max's love interest. In the sequel, ''WesternAnimation/AnExtremelyGoofyMovie'', Roxanne and her best friend Stacey (Max's friend Bobby's love interest) never appear and are not mentioned, despite all the trouble Max went on that summer. Roxanne ''does'' appear in an episode of ''WesternAnimation/HouseOfMouse'', though. Meanwhile, ''WesternAnimation/AGoofyMovie'' itself removed Pete's wife, Peg and PJ's sister, Pistol along with both the family pets, Chainsaw and Waffles, from ''WesternAnimation/GoofTroop'', without even a passing mention of any of them in either movie, and with a line in the sequel that explicitly proves Pistol's not around anymore.
* Although ''WesternAnimation/TheIceAgeAdventuresOfBuckWild'' explicitly takes place after ''Collision Course'', Shira and Brooke are not seen or even mentioned (nor are Granny and Peaches, but this is excusable since she and Julian left the herd at the end of the movie). This is also the only ''Ice Age'' media ever where Scrat is absent due to trademark issues.
* Despite being paired up with [[Franchise/TheLordOfTheRings Gandalf]] in the first film, [[Franchise/HarryPotter Dumbledore]] doesn't reappear in ''WesternAnimation/TheLEGOMovie2TheSecondPart''. Creator/ShaquilleONeal also doesn't reappear and he seems to be replaced by Gary Payton and Sheryl Swoopes.
* ''WesternAnimation/TheLionKingIISimbasPride'':
** Sarabi, Simba's own mother, is never seen and no dialogue mentions her. Apparently, Sarabi's voice actress died before the sequel was made, and it's possible a replacement could not be found.
** Shenzi, Banzai and Ed failed to appear as well, although they are mentioned [[PutOnABus to have fled from Pride Lands]] following the first film.
* In ''WesternAnimation/PocahontasIIJourneyToANewWorld,'' Thomas and Wiggins do not appear.
* ''WesternAnimation/RalphBreaksTheInternet'' notably has [[Characters/SuperMarioBrosBowser Bowser]], who previously appeared in ''WesternAnimation/WreckItRalph'', but is absent from the film without even a mention or explanation as to why. This was because Creator/{{Universal}} acquired [[WesternAnimation/TheSuperMarioBrosMovie the movie rights]] to the ''[[Franchise/SuperMarioBros Super Mario]]'' franchise from Creator/{{Nintendo}} almost a year prior to its release. [[Franchise/SonicTheHedgehog Sonic and Dr. Eggman]], both of whom also appeared in the prior movie, ''[[SubvertedTrope did]]'' return for ''Ralph Breaks the Internet'' despite also having [[Film/SonicTheHedgehog2020 a movie]] in production by [[{{Creator/Paramount}} a different company]] by then.
* ''WesternAnimation/ScoobyDooAndTheCurseOfThe13thGhost'', the FullyAbsorbedFinale to ''WesternAnimation/The13GhostsOfScoobyDoo'', features appearances by and references to nearly all of the ghosts from that show except for the bumbling duo of Bogel and Weerd. Scrappy-Doo would also fall into this by being absent in the flashbacks to the original series and never making a comeback in this movie had Flim Flam not mentioned him in passing at one point.
* ''WesternAnimation/Shrek2'' introduces six dronkeys, one of which is red and doesn't breathe fire. Unlike the other five, this red dronkey does not appear in any other ''Shrek'' installment.
** Arthur Pendragon does not appear in ''WesternAnimation/ShrekForeverAfter'' nor its mentioned at all. According to WordOfSaintPaul (Creator/MikeMyers), his voice actor, Creator/JustinTimberlake, was unavailable to provide the voice as he was on tour.
* In ''WesternAnimation/{{Sing}}'', Buster Moon's friend, Eddie Noodleman (grandson of Nana Noodleman), and contestant Mike the mouse are both key players in the film's story. Yet in ''WesternAnimation/Sing2'', neither character is seen or even mentioned, with no reason given as to why.
* In ''WesternAnimation/SurfsUp2Wavemania'', Zeke is nowhere to be found, and Cody insists it has always been the Hang 5, who inspired him to take up surfing. In the first film, [[RememberTheNewGuy there was no mention of any Hang 5]], and it was Big Z's visit to Shiverpool and gift to Cody.
[[/folder]]

[[folder:Films -- Live-Action]]
* ''Film/AddamsFamilyValues'' introduces the Addamses' newborn son Pubert, who is then never mentioned or referenced again in any subsequent adaptation of the franchise (outside of an episode of ''Series/TheNewAddamsFamily'', where Wednesday claims Pugsley ate him).
* In ''Film/BadSanta2'', it's made clear Thurman goes to Willie because he has no one else with whom to spend Christmas. While we're told his grandma died long ago, there's no mention of his dad. Roger should have been out of prison only two years after the events of the first film and he was only in there for white collar crime; he indicated he still cared about his son.
* In ''Film/BatmanReturns'', Catwoman, Batman's love interest and villain throughout most of the movie, is last seen on the roof of a building before the movie ends, and is never seen again in the two subsequent films (and is only mentioned once, and in a subtle way, when Chase Meridian says "Or do I need skintight vinyl and a whip?"). Ironically, Selina Kyle (Catwoman's civilian identity) does bring up Vickie Vale, Bruce Wayne's love interest from the previous movie, and Bruce explains that they broke up over Vickie being unable to reconcile Bruce's dual identity. Michelle Pfeiffer was meant to get her own film as Catwoman, but the project fell into DevelopmentHell and eventually [[Film/Catwoman2004 crawled out in 2004 with Halle Berry as the star]] and nothing to do with the Burton films.
** According to Batman Wikia, Catwoman was supposed to appear in the then planned second sequel directed by Tim Burton, but Warner Bros considered Burton’s dark toned-movies to be difficult to sell to young audiences, so the project was then passed to Schumacher. We know what happened.
* ''Film/{{Blade}}'' gave us Karen Jenson, a haematologist who develops a biochemical weapon against vampires and even finds a freakin' cure for vampirism. The movie ends on the note that, if she wants to be useful, she'll have to make Blade a better serum to suppress his bloodthirst. She never shows up or is mentioned in the sequels, but Blade doesn't have any serum-related problems (so presumably she did make him a better one), and other characters are mentioned as being cured of vampirism.
* In ''Film/CitySlickers'', Ed was the most active of the main characters. In ''City Slickers II: The Legend Of Curly's Gold'', he is missing without explanation.
* ''Film/TheDarkKnightRises'': Due to Creator/HeathLedger's [[TheCharacterDiedWithHim death]], the Joker is not released by Bane with all of Gotham's other prisoners. There is speculation that he would have played Scarecrow's role in the plot, were the actor still alive.
* ''Film/DrDolittle'': Rodney the guinea pig is nowhere to be found come the sequel, probably because his voice actor, Creator/ChrisRock, declined to return. While Rodney may likely have died of age by ''Dr. Dolittle 2'', this is never addressed at any point.
* In ''Film/EddieAndTheCruisers'', Frank Ridgeway plays a key role in the band and the story. When the sequel comes out, there's no mention of Ridgeway at all. They even go so far as to replace Frank's image with Sal in recycled footage from the first film.
* Predating Chuck by nearly half a century, the first Film/{{Andy Hardy}} movie, ''Film/AFamilyAffair'', features the family's eldest child Joan (Julie Haydon), who actually plays a bigger role in the plot than Andy does. She disappears without explanation for the remainder of the long-running series.
* Frenchy, one of only two students from the original film to be in ''Film/Grease2'', has very little to do in the sequel and just disappears midway through ... the production had started with the script not finished, and when midway through it ''was'' finished and the writers had decided to completely write her out, they let actress Didi Conn collect her check and go. In postproduction they decided to use most of the scenes with her anyway.
* John Tate and Molly Cartwell were last seen "driving down to the Becker's" at the end of ''Film/HalloweenH20TwentyYearsLater'', and are nowhere to be found or mentioned in ''Film/HalloweenResurrection''. And we will almost certainly never know, as the series producer DiedDuringProduction, then Rob Zombie [[Film/{{Halloween 2007}} rebooted the series]].
* In ''Film/{{Halloweentown}},'' Luke was a fairly important character, and he became even more important in the first sequel. He disappears completely in the third and fourth films, just in time for Marnie to get a cuter, human LoveInterest instead.
* ''Film/HarryPotter'':
** Crabbe disappears from ''Film/HarryPotterAndTheDeathlyHallowsPart2'', when he always appeared alongside Goyle in all of the first six films. Although the filmmakers had a reason for cutting him out [[RoleEndingMisdemeanor (his actor was arrested for drug possession)]], no mention is given to him at all, Harry never asks where he is, and Malfoy doesn't seem to notice, as he specifically gets Goyle and Blaise Zabini (another Slytherin ally in the books) when he Apparates into the dungeons. [[spoiler: Crabbe was supposed to die in this movie too, but due to the character omission they killed off Goyle instead.]] [[WordofGod David Yates]] apparently stated that the most plausible explanation for the character's sudden absence was to tweak the continuity so that Crabbe didn't exist in the first place and it was always Goyle and Zabini, to the point that the Prince's Tale sequence which uses footage from previous films has Crabbe edited out of the scenes he was previously in.
** Parvati Patil, who does not appear alongside her sister Padma in the last film (who was seen less in the series than Parvati).
** Viktor Krum, Cornelius Fudge and Buckbeak, among others. While they're not exactly main characters in the books after their main plotlines end, they do appear in later books. In the films, on the other hand, they're not even mentioned after they've gone.
** Some of the Hogwarts ghosts didn't make it past the first film. Nearly Headless Nick managed to stick around a little bit longer and was last seen in the second film [[note]]though Creator/JohnCleese confirms that he filmed scenes for the fifth movie that later got cut, while Simon Fisher-Becker, who played the Fat Friar, states that scenes involving him and the other ghosts were filmed for the second movie and then deleted [[/note]]. Moaning Myrtle disappears after the fourth film. In fact there was a rumored line from the original draft of the last movie where Harry explicitly refers to the Grey Lady as the ONLY ghost in Hogwarts.
** Colin Creevey has a sizable role in the second film and is then never seen again. He's sort-of replaced by CanonForeigner Nigel. What's particularly odd is that when there are pictures of Nigel in companion media, he's often referred to as 'Colin Creevey'.
** Every previously recurring Hufflepuff student such as Ernie [=MacMillian=] completely vanish from the films. Their absence is never brought up and their scenes are replaced by "more important characters".
** Madam Hooch is only in the first movie due to a conflict with the actor.
** Charlie Weasley is mentioned a couple of times in the first film and appears in a photo in the third and is never mentioned again. Seamus even states Ginny has "Four" brothers possibly excluding Percy as well.
** Percy no longer has a speaking role after the third film. He appears briefly in the background in the fifth and eighth films but is never referred to by name. And Seamus implies that the character who Chris Rankin portrays has been demoted to a nameless cousin.
** Kreacher doesn't appear for the Battle of Hogwarts in the film like he does in the book. No house elves are ever mentioned.
** Cornelius Fudge simply disappears after the fifth film and his two scenes in the sixth book are removed. His fate is left ambiguous in the books as well, but no minister is even referred to in the sixth film and the Billy Nighy character is just the minister which may cause less inquisitive viewers to assume this as an instance of TheOtherDarrin.
** Michael Corner, who was for a time Ginny's boyfriend in the books, appears in one scene saying one line and is never seen or mentioned afterwards even in the scenes where Harry enters the Ravenclaw common room in Deathly Hallows part 2.
** The Fat Lady is never seen after the third movie and that appearance was a case of TheOtherDarrin.
** Barty Crouch Jr. who was SparedByTheAdaptation, yet never appears in any of the later movies. In the book, he got his soul sucked out by the Dementor's Kiss. The film merely states he will be sent back to Azkaban. In later movies, Voldemort frees all of the Death Eaters from Azkaban yet Crouch Jr. never appears alongside any of them.
* In ''Film/HighSchoolMusical'', during the "Stick to the Status Quo" musical number, three characters decide to follow after Troy and confess their HiddenDepths: a member of the school's basketball team bakes, a smart girl dances hip-hop, and a skater boy plays the cello. While the first two, Zeke Baylor and Martha Cox, become major supporting characters, the skater boy is never seen or mentioned again once the song is done.
* ''Film/InspectorGadget2'': Dr. Brenda Bradford is never seen nor mentioned in the film. This is despite the fact that she was not only Gadget's LoveInterest in the [[Film/InspectorGadget1999 first film]], but she was the one who turned him into a cyborg in the first place. A scientist named Baxter takes her place as the one in charge of the Gadget program and Gadget Model 2 becomes Gadget's new love interest. According to [[https://www.youtube.com/watch?v=--hqmmJ2fqw this early animatic]], which may or may not be canon, Brenda and Gadget parted ways some time between the two films.
* Harmony from ''Film/KissKissBangBang'' is not mentioned in the epilogue despite being one of the main characters.
* Jodi from ''Film/KnockedUp'' is TheHeart of the gang but she vanishes halfway through the film.
* At the end of ''Film/LegallyBlonde'', Elle becomes best friends with [[spoiler: Vivian Kensington, her rival for her boyfriend]]. However, in the sequel, [[spoiler: Vivian]] is never even mentioned.
* Franchise/MarvelCinematicUniverse:
** Betty Ross was Bruce Banner's love interest and a major character in ''Film/{{The Incredible Hulk|2008}}''. She hasn't been seen or mentioned since, and Bruce is instead shown being interested in ComicBook/BlackWidow in ''Film/AvengersAgeOfUltron''. Even her father, Thunderbolt Ross, got [[TheBusCameBack a bus ticket back]] for ''Film/CaptainAmericaCivilWar''. The only major factor even defending her canonicity to the MCU is that [[spoiler:she was cited as one of the victims of the Thanos snap]].
** ''Film/{{The Incredible Hulk|2008}}'' also introduced Samuel Sterns, aka The Leader, who was the Hulk's ArchEnemy for years in the comics. At the end of the movie, some of Bruce's gamma-irradiated blood drips into a gash on his head, which starts swelling like his comics counterpart. [[ComicBook/TheAvengersPreludeFurysBigWeek a tie-in comic]] established that he was taken into custody by S.H.I.E.L.D. shortly after the events of the film, leading to a lengthy period where he was never seen or mentioned again until it was confirmed that he would appear in ''Captain America: New World Order''.
** ComicBook/{{Thanos}}' servant, The Other. While his death in ''Film/{{Guardians of the Galaxy|2014}}'' would obviously prevent him from appearing in the present of ''Film/AvengersInfinityWar'' or ''Film/AvengersEndgame'', he does not appear in the former's flashback to Thanos taking Gamora's planet (Ebony Maw is shown in his place), nor does he appear [[spoiler:when an alternate timeline version of Thanos and his entire army from a point in time where he would still be alive come to the main timeline for a final battle, where the Black Order is still shown]]. Although, [[spoiler:the alternate Thanos does quote The Other slightly when he recognizes the Avengers and calls them "unruly wretches."]]
** ''Film/AvengersAgeOfUltron'' introduced a Korean scientist named Helen Cho, who was an ally to the Avengers. Despite last being seen in Avengers Compound at the close of the movie, Helen has not yet appeared in any of the subsequent films.
* Film/GoodBurger: Both Mr. Bailey and Mr. Weat weren't mentioned once throughout the [[Film/GoodBurger2 second film.]]
* At the end of ''Film/TheMazeRunner2014'', there are nine Gladers who escaped from the maze. However, in ''Film/MazeRunnerTheScorchTrials'', only eight Gladers return. One of them disappears after just two scenes and another one disappears after one-third of the movie. What makes it even weirder is that a deleted scene shows that the last one dies in a scene that was included in the trailers and many other promotional materials. The director said that test audiences weren't noticing the background character so when he died everyone was confused who he was. The other two have gotten no explanation for their disappearances.
* In the first ''Film/MenInBlack'' movie we're told that K was in love with his old girlfriend throughout his career and his original partner was D. In the third movie, J time travels back to the early years of K's career. K is shown to be romantically interested in O and there's no mention of his old girlfriend or D.
* In ''Film/MrsMiniver'', the title character and her husband have three children. The eldest son, Vin, is nowhere to be seen in the sequel ''Film/TheMiniverStory''. (This was likely due to the fact that Creator/GreerGarson, who played Mrs. Miniver, and Richard Ney, who played Vin, [[CastIncest married and then divorced]] in the eight-year span between the two films.)
* Due partly to its long-running status and not-insignificant gaps between movies, the ''Film/MissionImpossibleFilmSeries'' has had several cases of this:
** The series is rather infamous for its failure to retain leading actresses — not because the characters were disliked or there were problems on set, but because the actresses in question simply haven't been available to return for subsequent films. Notably, [[Creator/ThandiweNewton Nyah]] from [[Film/MissionImpossibleII the second movie]], [[Creator/MaggieQ Zhen Lei]] from [[Film/MissionImpossibleIII the third movie]], and [[Creator/PaulaPatton Jane Carter]] from [[Film/MissionImpossibleGhostProtocol the fourth movie]] disappeared from the franchise inexplicably. It wasn't until [[Creator/RebeccaFerguson Ilsa]], who debuted in ''[[Film/MissionImpossibleRogueNation Rogue Nation]]'' and reprised her role in [[Film/MissionImpossibleFallout two]] [[Film/MissionImpossibleDeadReckoning more films]], that the series actually managed to keep a leading actress on an ongoing basis.
** Creator/VanessaRedgrave had a memorable role as arms dealer [[GenderBlenderName Max]] in the first movie, but did not reprise her role in later films. However, ''Fallout'' reveals that [[spoiler:she is the mother of the White Widow, Alanna Mitsopolis, while ''Dead Reckoning: Part One'' offhandedly mentions that [[KilledOffscreen Max died a while back]].]]
** Ethan's wife, Julia Meade, seems to follow in the path since she didn't appear in ''Rogue Nation'', but she reappeared in ''Fallout'', where it is revealed that [[spoiler:she and Ethan divorced sometime ago, explaining why she is no longer around in his life]].
** Among the men, Billy Baird and [[Creator/AnthonyHopkins Swanbeck]] from ''II'', and [[Creator/JonathanRhysMeyers Declan Gormley]] and [[Creator/LaurenceFishburne Theodore Brassel]] from ''III'' disappeared after their debut movie. [[Creator/HenryCzerny Kittridge]], Ethan's original boss in the IMF, eventually averted this when he reprised his role in ''Dead Reckoning: Part One'', six films and more than twenty five years after his debut. William Brandt initially looked to be a permanent addition to Ethan's team since he appeared in two consecutive films (''Ghost Protocol'' and ''Rogue Nation''), but Creator/JeremyRenner was unable to return for ''Fallout'' due to shooting ''Film/AvengersEndgame'' at the time, and Brandt has subsequently been written out of the series.
* In the international cut of Creator/JackieChan's ''Film/MrNiceGuy'', Tara ([[DubNameChange aka Sandy]]) and Diana seem to suffer from this, with the former severely bloodied in the construction site fight and the latter last seen getting punched in the face by one of the bad guys. The original uncut version has a later-{{deleted scene}} where Romeo visits the two in the hospital and learns where Giancarlo has taken Jackie and the other two women.
* In the Franchise/MonsterVerse, all the surviving humans who debuted in ''Film/KongSkullIsland'' sans Dr. Brooks (and a post-movie cameo by his wife Dr. San Lin) are completely absent without explanation from all the subsequent [=MonsterVerse=] movies and other media, even stories which went back to Skull Island and expanded on Monarch's presence there with Dr. Brooks involved; despite the movie's [[TheStinger post-credits scene]] setting up James Conrad and Mason Weaver to join Monarch after their experiences. At least Weaver and Conrad's syndrome ended after two subsequent movies, four graphic novels and an animated series; six years after their original movie was released, when the characters were brought back for the post-movie storyline of the tabletop game ''Kong: Skull Island Cinematic Adventure''.
* In ''Film/TheNeverEndingStoryIIIEscapeFromFantasia'', Atreyu -- who the co-protagonist of the first film and a major character as Bastian's best friend in the second -- is nowhere to be seen. The very noticeable actor changes for both Atreyu and Bastian between each film created a lot of dissonance anyway.
* This happens in the ''Film/{{Night at the Museum}}'' franchise as well with Creator/CarlaGugino's character Rebecca Hutman, who despite playing a pivotal role in the first film from 2006, mysteriously and suddenly vanishes from the sequels for no given reason. With ''Battle of the Smithsonian'', the second film from 2009, it would have made sense for her not to appear seeing as we already had Creator/AmyAdams as SuspiciouslySimilarSubstitute Amelia Earhart, and it would have been complicated for Gugino and Adams' characters to make a love triangle with Larry, and Gugino was likely filming ''Film/RaceToWitchMountain'' around the same time this movie was being made, so it would have made sense for her not to return for the second film, anyway. Though she ''could'' have suitably returned in the franchise's third film ''Secret of the Tomb'', released in 2014 (heck, even the BigBadDuumvirate from the first film [[TheBusCameBack returned!]]), but Gugino was probably busy finishing up filming the first season of ''Series/WaywardPines'' which was still being filmed when this movie started filming, and the screenplay was already written, so it was too late for her to even negotiate a deal to return, anyway. Her character's absence was never even acknowledged at all in the sequels, nor is she even mentioned or seen again, but if there were an InUniverse explanation, it's likely that her character quit her job as the docent of the museum (probably out of protest against most of the exhibits being moved to the Smithsonian Museum in the second film, and her love for history being ruined for her as a result or because of the success of her biography on Sacagawea and no longer needing to go the museum to research about her) and/or she moved away (but then again, this is never even acknowledged in neither sequel). Ditto for Amy Adams' [[ActingForTwo other character]] Tess, who first shows up at the end of the second film as the museum's new docent, but is herself mysteriously absent nor is she ever acknowledged in ''Secret of the Tomb'' (which, unlike Gugino's case, does not make any sense as Adams had a free schedule and therefore could have showed up, and her character's the new docent, but it's likely she probably wasn't interested in returning for a sequel, though if she ''did'' return, it probably would have been another case of SuspiciouslySimilarSubstitute to compensate for Carla Gugino's character's absence, or she would have at least appeared in TheCameo).
* Miss Perty from the Creator/EddieMurphy version of ''Film/{{The Nutty Professor|1996}}'' vanishes in the sequel. Even Buddy Love doesn't know what happened to her and has to ask Sherman (who is his ''split personality'').
* ''Film/OurDailyBread'' was Creator/KingVidor's sequel to his silent film masterpiece ''Film/TheCrowd''. John and Mary Sims return, but their son is nowhere to be seen.
* In the early ''Film/OlsenBanden'' movies, Kjeld and Yvonne had two children: A son Børge and a smaller daughter. As the series went on Børge became an important regular while his sister vanished into thin air.
** At least in the Norwegian versions, Kjell had two sons and a baby daughter in the first movie, and while the middle son Basse becomes a regular character, the other two have disappeared completely by the second one. Likewise, Benny ends up fathering a kid during the first movie, but both kid and fiance are never again referred to, and the only supporting cast member to reappear is Hansen the bartender. After movie 2, he's gone too.
* Anamaria is never seen or heard from again after the [[Film/PiratesOfTheCaribbeanTheCurseOfTheBlackPearl first]] ''Franchise/PiratesOfTheCaribbean'' movie. Interestingly, the cast was told in ''[[Film/PiratesOfTheCaribbeanDeadMansChest Dead Man's Chest]]'' that Anamaria ''would'' appear at the ending of the film, so the shock and surprise of [[BackFromTheDead Captain Barbossa]] greeting them was [[EnforcedMethodActing genuine]].
* The ''Film/PoliceAcademy'' franchise has a nasty case of the syndrome with characters disappearing between each of the sequels:
** ''Their First Assignment'': Cadet Leslie Barbara, Cadet Karen Thompson, and Cadet George Martín.
** ''Back in Training'': Capt. Pete Lassard and Sgt. Vinnie Schtulman.
** ''Citizens on Patrol'': Cmdnt. Mauser, Sgt. Kyle Blankes, Mrs. Fackler, Cadet Hedges, and Cadet Karen Adams.
** ''Assignment Miami Beach'': Sgt. Carey Mahoney, Officer Tomoko Nogata, Sgt. Chad Copeland, Officer Sweetchuck, Officer Zed, Officer Bud Kirkland, and Sgt. Kathleen Kirkland Tackleberry.
** ''City Under Siege'': Officer Tommy "House" Conklin.
** ''Mission to Moscow'': Sgt. Nick Lassard, Sgt. Laverne Hooks, Sgt. Douglas Fackler, Lt. Proctor, Lt. Moses Hightower, and Commissioner Henry Hurst.
* What's so strange about ''Film/RoadHouse1989'' is that Dalton, the ''main character'', vanishes in the last moments of the film. No epilogue, no last kiss with his love interest. No nothing.
* In ''Film/TheRoom2003'', OnlySaneMan Peter abruptly disappears before the climax, as his actor had schedule conflicts. As as result, he was replaced by Stephen, a character [[RememberTheNewGuy we'd never seen before whose name isn't even mentioned except for in the end credits.]]
* All of Carter's colleagues at the LAPD from the first ''Film/RushHour'' vanish in the sequels (save for Captain Diel, who appears in a DeletedScene in the second film and had a brief cameo in the third film.) since they focus more on his and Lee's partnership.
* In ''{{Film/Sanctum}}'', both Liz (Nicole Downs) and J.D. (Christopher James Baker) disappear about twenty minutes into the film, during a scene wherein Josh (Rhys Wakefield) is trying to climb a rock formation to save himself from the flooding cave, and they're trying to help him. Despite being two of the very small group of cave divers, no one ever sees or mentions them again.
* Puppy Paws, the son of Santa Paws in ''Santa Buddies'', is nowhere to be seen in ''Santa Paws 2'', despite the latter film being about Santa Paws's pups.
* Bernard is absent in ''Film/TheSantaClause3TheEscapeClause'' and no one mentions him at all. This is particularly noticeable because he was in a high position of authority in the previous movies. Creator/DavidKrumholtz was too busy with the TV show ''{{Series/Numb3rs}}'' and couldn't appear. He is in the Novelization, however. The SequelSeries ''Series/TheSantaClauses'', [[TheBusCameBack which does bring Bernard back]], would eventually explain where he was: he had fallen in love with a human woman and had been living with her for the past several years before the new crisis at the North Pole drew him back to help Scott.
* ''Film/ScaryMovie'': Shorty and Ray are completely absent in the third film onwards, having prominently been there for the first two.
* Pyramid Head was a pretty major villain for the first half of the ''Film/SilentHill'' movie. Then he kills off a side character, goes away, and is never seen or mentioned again for the rest of the film. Interestingly, the originally planned ending [[WhatCouldHaveBeen had six Pyramid Heads come back at the end and butcher most of the characters]], but they ran out of money and just had the [[CreepyChild little girl]] do it.
* On the topic of Marvel Comics movies, Jameson's son John is last seen in the original trilogy at the end of ''Film/SpiderMan2'', where MJ dumps him on what was supposed to be their wedding day, and isn't mentioned or seen at all in the third film, though he was present in earlier drafts.
* Carol Marcus in ''Film/StarTrekBeyond''. The previous film, ''Into Darkness'', ends with her joining the Enterprise crew for its five-year mission, but ''Beyond'' makes no mention of her or her absence.
* Played for laughs in ''Film/SummerSchool''. An early scene has a large black student asking to use the bathroom. He's absent for the entire movie before returning for the big test. When asked what happened, he just says he was in the bathroom for the entire summer. "Door was stuck."
** Even better? He had claimed the computer made an error in his being in summer school. It's then stated that despite not being around for any of the classes, he scored the highest grade on the final exam.
* The ''Film/TransformersFilmSeries'' is bad with this:
** Maggie and Glen played a major part in the [[Film/Transformers2007 first movie]], only to vanish in the sequels.
** In ''Film/TransformersRevengeOfTheFallen'', the Autobot twins, Skids and Mudflap have this happen. After the fight with Devastator, you don't see them again for the rest of the film. They don't even return in ''Dark of the Moon''. This is because everyone, including Creator/MichaelBay [[CreatorBacklash himself]], hated them, considering them unfunny [[EthnicScrappy stereotypes of African Americans]]. They do return in the comic adaptation and novelization for ''[[Film/TransformersDarkOfTheMoon Dark of the Moon]]''... [[BackForTheDead and get blasted into dust by Sentinel after the highway chase along with Ironhide]].
** ''Film/TransformersAgeOfExtinction'' does this to the entire human cast from the first three movies along with most of the surviving Transformers from the previous movie. However, the latter could be attributed to the actions of Cemetery Wind in the period between the two movies. Agent Simmons, Colonel Lennox, and General Morshower return in ''[[Film/TransformersTheLastKnight The Last Knight]]''.
* ''WesternAnimation/TheTransformersTheMovie'' does this to some of the surviving cast members up to that point, as nearly anyone who didn't die or was implicitly shown to have survived is never mentioned again.
** Shortly after Unicron transforms Megatron into Galvatron, Skywarp and Bombshell are transformed into the identical "Cyclonus and his Armada", however, the "Armada" (which is just one guy) is never seen or mentioned after this scene. It is disputed who got reformatted into Cyclonus and who into the Armada. Bombshell is the one shown in front and Skywarp further at the back so the possibility that Bombshell got formatted into Cyclonus is considered. However, Skywarp is the much more prominent character of the two, much more loyal to Megatron (Bombshell and the other Insecticons consider themselves a separate faction from the other Decepticons), had an original alternate form that resembled a flying vehicle, and has the personality suitable for being Galvatron's/Megatron's new NumberTwo.
** If you look closely, whenever Snarl is present, one of the other Dinobots is missing. And the script even refers to "the four Dinobots". It's like the entire production team thought there were only four of them and couldn't decide which four there were.
* ''Film/XMenFilmSeries''
** Nightcrawler was a major character and love interest for Storm in ''Film/X2XMenUnited'', but didn't even appear in ''Film/XMenTheLastStand'' because actor Alan Cumming found the make-up and prosthetic process grueling and refused to return to it without Creator/BryanSinger. Cumming can be seen in the behind-the-scenes footage for ''X2'' already stating that he never wants to go through the ordeal again. The video game based on the films which takes place between the two movies explains that Nightcrawler, a peaceful man, went abroad to distance himself from the X-Men's violent lifestyle.
** Poor Riptide. He goes from NoNameGiven in [[Film/XMenFirstClass the previous film]] to not even earning a mention in ''Film/XMenDaysOfFuturePast''. Particularly notable since Erik takes the time to list all the characters not in this movie because they died in between films. Though it can easily be assumed that Trask killed Riptide along with the others, he still goes unmentioned.
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