!!Dog
[[quoteright:240:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_dog.png]]
->Voiced by: H.D. Quinn
* AllDrummersAreAnimals: Although the entire cast are animals, Dog is quite feral and ends up with the drums in the episode "Dancing Dog."
* TheSpeechless: Being a non-anthropomorphic animal, he is one of the only characters in the series who does not speak.
* VibrantOrange: A fun-loving orange canine.

!!Duck
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_duck.jpg]]
->Voiced by: H.D. Quinn
* AesopAmnesia: He is prone to forgetting facts he learned in previous episodes.
* CharacterCatchphrase: "Yah and hoo!"
* DeadpanSnarker: He wisecracks often.
* {{Keet}}: He is noisy and full of energy.
* KidAppealCharacter: He is yellow, energetic, and is learning his letters.
* NoisyDuck: He has NoIndoorVoice and quacks in the middle of sentences.
* OddFriendship: With Frog.
* QuackingUp: He's probably the youngest of the main cast. He is often naive and careless in his actions, but he loves to have fun and crack jokes. He acts as an AudienceSurrogate to the young viewers, as he is still learning his letters.

!!Frog
[[quoteright:230:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_frog.png]]
->Voiced by: Daryl Ekroth

* HeterosexualLifePartners: With Duck. They are polar opposites and often get on each other's nerves, but they're still close friends.
* {{Homage}}: Daryl Ekroth's vocal performance appears to be inspired by [[Franchise/TheMuppets Kermit the Frog]].
* TheSmartGuy: He is often the brainiac of the friends, but sometimes he's a KnowNothingKnowItAll.
* StraightMan: He tries to be the sensible one compared to the likes of Duck and Pig, but he too has his own quirks.
%%* LargeHam

!!Pig
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_pig_240.png]]
->Voiced by: George Bailey
* BerserkButton: Pig tends to get upset when his stuff is messed with, as Frog learned in the episode "Waterlogged".
* BigEater: He loves to eat. Ant has to control him whenever he indulges too much.
* ChasteToons: He has three nephews.
* GluttonousPig: Pig is a chef who hosts his own cooking show, but he also likes eating everything in sight. He is working on sharing, though.
* HeterosexualLifePartners: He is very close with Ant, and their relationship is the core of several episodes.
* SweetTooth: He likes eating anything really, but especially cake and pie.
* TeamChef: He's the baker of the bunch, and hosts his own cooking show.

!!Ant
[[quoteright:240:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_ant.png]]
->Voiced by: H.D. Quinn
* AmicableAnts: Ant is one of the many Word Friends of the titular setting. He is best buddies with Pig and with other insect Word Friends like Bee, Fly and Bug, and is always willing to help out the other Word Friends in a pinch.
* HeightAngst: There are rare occasions where he feels sad about his small size. In the FeudEpisode "Shuffleword", Pig exploits this by calling Ant "short" as an insult, and he gets turned into '''GI'''ant in "There's an Ant in Every Giant."
* HeterosexualLifePartners: With Pig.
* OutOfFocus: Despite being a main character, he does not have as much screen time as the others. In fact, Shark and Bug have more screen time than him.
* ShorterMeansSmarter: Ant is unsurprisingly the smallest of his friends, yet he is one of the smartest people in Word World, as said by Pig.
* StraightMan: He helps keep Pig's appetite in check.
* StrongAnts: He is renowned for his strength.

!!Bear
[[quoteright:240:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_bear.png]]
->Voiced by: Mirm Kriegel
* AccessoryWearingCartoonAnimal: She stands out by wearing a purple bow.
* BearyFriendly: She is an amiable ursine.
* CoolBoard: Her purple and yellow skateboard is very cool-looking. Interestingly, it does not appear to be made of letters in the show, but it is made of letters in the merchandise.
* HeterosexualLifePartners: With Sheep.
* WhyDidItHaveToBeSnakes: Despite living in a cave, she is scared of the dark.

!!Sheep
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/wordfriend_sheep.png]]
->Voiced by: Creator/VeronicaTaylor
* ActionGirl: Sheep can be seen as this when she's playing sports, as seen in the episodes "There's An Ant In Every Giant" and "Play Ball".
* DramaQueen: As befitting a theatre fanatic, Sheep often overreacts. Her first instinct when Pig is sneezing is to take him to the hospital.
* GirlyGirl: She loves playing dress up.
* SweetSheep: She is helpful towards her friends when they need help sounding out words.