%%Zero Context Examples and poorly written examples are been commented out. Examples must explain how these characters fit the tropes before uncomenting.

! The Heroes

* '''[[Characters/{{ThePowerpuffGirls-The Heroes}} The Heroes]]'''- Blossom, Bubbles, Buttercup, and the Professor

! Residents of Townsville

* '''[[Characters/{{ThePowerpuffGirls-Residents of Townsville}} Residents of Townsville]]'''- The Mayor of Townsvile, Sara Bellum, the Talking Dog, the Narrator, Ms. Keane, and Mitch Mitchelson.

! Main Antagonists

* '''[[Characters/{{ThePowerpuffGirls-Main Antagonists}} Main Antagonists]]'''- Mojo Jojo, Him, Fuzzy Lumpkins, the Gangreen Gang, Princess Morbucks, Sedusa, the Amoeba Boys, and the Rowdyruff Boys.

! Minor Antagonists

* '''[[Characters/{{ThePowerpuffGirls-Minor Antagonists}} Minor Antagonists]]'''- The Gnome, Dick Hardly, Femme Fatale, Mr. Mime, Boogie Man, The Smiths, Major Man, Abracadaver, Mike Brikowski, Max Von Nitrate, Lenny Baxter, Mask Scara, The Alien, Giant Monsters, Mojo's Monkey Army, Roach Coach, The Broccoloids and Elmer Sglue.