!! Bessie Higgenbottom
->'''Voiced by:''' Creator/AmyPoehler
* AdaptationDyeJob: In-universe example, her pale skin and her dirty blonde hair from season one changes into her tan skin and orange hair from season two.
* {{Adorkable}}
* ButtMonkey: The show's TerribleTrio (Portia, Gwen and Penny) seem to enjoy seeing her suffer.
* CatchPhrase: "Awwwwwsome!"
* {{Cloudcuckoolander}}
* CoolBigSis: To Ben, even though she's more eccentric than cool.
* {{Determinator}}[=/=]PluckyGirl
* DisappearedDad
* DitzyGenius: Bessie has many talents, including being able to create cold fusion. Also creating a functioning spaceship when she was 5.
* EmbarrassingMiddleName: [[spoiler: Elizabeth Kajolica Higgenbottom. [[TheScottishTrope And it's cursed.]] No, not the Elizabeth part, but that's equally as embarrassing.]]
* {{Expy}}: Of a character AmyPoehler (the series' creator, and voice of Bessie) once played on UprightCitizensBrigade. See ActorAllusion on the main page.
* {{Gasshole}}
* GenkiGirl
* GirlishPigtails
* TheHero
* IdiotHero
* KidHero
* LittleMissBadass
* {{Meganekko}}
* MotorMouth
* SmallNameBigEgo
* SpeechImpediment: Bessie's missing her front teeth, so she slurs a little. It's cute. Even when she has her teeth back, she still slurs.
* TomboyAndGirlyGirl: The tomboy to Penny's girly girl.

!! Happy Walter Higgenbottom
->'''Voiced by:''' Creator/DeeBradleyBaker
* AlliterativeName
* CharacterDevelopment: Oh, by the way, did you know that Happy is a highly trained secret agent?
* {{Expy}}: Happy seems a bit similar to [[WesternAnimation/{{Doug}} Porkchop]].
* NonHumanSidekick
* {{Omniglot}}: Happy is fluent in 12 different languages, including French, German, Italian, Russian, Chinese, Swahili, Pomeranian, and even Pandaren.
* OnlySaneMan
* TheUnintelligible

!! Ben Higgenbottom
->'''Voiced by:''' Andy Richter
* DisappearedDad
* KidAppealCharacter
* OnlySaneMan
* TagAlongKid

!! Hilary Higgenbottom
->'''Voiced by:''' Megan Cavanagh
* AlliterativeName
* BigBeautifulWoman
* BigFun
* NewAgeRetroHippie

!! Portia Gibbons
->'''Voiced by:''' Creator/GreyDeLisle
* AlphaBitch
* BeautyBrainsAndBrawn: The beauty to Gwen's brains and Penny's brawn.
* BlondeBrunetteRedhead: The blonde to Gwen and Penny's brunettes and Mary Frances' redhead.
* BlondesAreEvil
* TheBully
* DisappearedDad
* TheDragon[=/=]TheLancer
* DumbBlonde
* EvilIsPetty
* ForTheEvulz
* {{Jerkass}}
* SitcomArchNemesis
* ThoseTwoBadGuys: With Gwen.
* TomboyAndGirlyGirl: She's the Girly Girl to Gwen's Tomboy.
* TomboyishPonytail: Although she isn't a tomboy.
* TrueBlueFemininity
* ValleyGirl
* ZettaiRyouiki

!! Gwen Wu
->'''Voiced by:''' Jessica DiCicco
* AsianAirhead: Type A.
* BeautyBrainsAndBrawn: The brains to Portia's beauty and Penny's brawn.
* BetaBitch
* BlondeBrunetteRedhead: The brunette to Portia's blonde and Mary Frances' redhead (One of two).
* TheBully
* TheDarkChick[=/=]TheSmartGuy
* {{Jerkass}}
* MassiveNumberedSiblings
** OutnumberedSibling: She has five brothers.
* SitcomArchNemesis
* ThoseTwoBadGuys: With Portia.
* TomboyAndGirlyGirl: The Tomboy to Portia's Girly Girl.

!!Penny Lefcowitz
->'''Voiced by:''' Dannah Feinglass
* BeautyBrainsAndBrawn: The brawn to Portia's beauty and Gwen's brains.
* BlondeBrunetteRedhead: The brunette to Portia's blonde and Mary Frances' redhead (One of two).
* TheBrute[=/=]TheBigGuy
* CargoShip: In-universe: Fell in love with a robotic kangaroo.
* TheDitz
* DumbMuscle: Penny, the ShallowParody to DonkeyKong.
* TheEeyore
* EvilAllAlong: In "Super Secert Weakness".
* FatBastard
* FatBestFriend: To Bessie, though sometimes she joins Portia to gang up on Bessie.
* FatIdiot
* GirlishPigtails
* {{Gonk}}
* HeelFaceRevolvingDoor
* MissingMom
* SimpletonVoice
* TomboyAndGirlyGirl: The girly girl to Bessie's tomboy.
* WithFriendsLikeThese: She cows to peer-pressure very easily and is willing to bully Bessie to get on her Portia's good side. Exactly why Bessie continues to be her friend after this is anyone's guess.

!! Ms. Mary Frances Gibbons
->'''Voiced by:''' Sarah Thyre
* ApatheticTeacher
* BigBad
* BlondeBrunetteRedhead: The redhead to Portia's blonde and Gwen and Penny's brunettes.
* EvilRedhead
* HartmanHips
* JerkAss
* TheMentor
* TrueBlueFemininity
* WoobieDestroyerOfWorlds

!! Anton St. Germain
->'''Voiced by:''' Matt Besser
* BigBad
* {{Gonk}}
* GrumpyBear
* TheRival
* SitcomArchNemesis
* UngratefulBastard
* WoobieDestroyerOfWorlds

!! Ganiva
->'''Voiced by:''' N/A
* CompanionCube: To Anton.
* TrueBlueFemininity

!! The Hippie
->'''Voiced by:''' Matt Besser
* NewAgeRetroHippie
* NoNameGiven

!! Millie Millerson
->'''Voiced by:''' Creator/GreyDeLisle
* AlliterativeName[=/=]RepetitiveName
* AmbiguousDisorder: According to some members of the production staff, she was supposed to be autistic.
* AscendedExtra
* BracesOfOrthodonticOverkill
* ADayInTheLimelight: "Mr. Turtleton's Wild Ride".
* DumbBlonde
* HairOfGoldHeartOfGold
* TheHeart