!! Bessie Higgenbottom
->'''Voiced by:''' Creator/AmyPoehler
* AdaptationDyeJob: In-universe example, her pale skin and her dirty blonde hair from season one changes into her tan skin and orange hair from season two.
* {{Adorkable}}
* ButtMonkey: The show's TerribleTrio (Portia, Gwen and Penny) seem to enjoy seeing her suffer.
* CatchPhrase: "Awwwwwsome!"
* {{Cloudcuckoolander}}
* CoolBigSis: To Ben, even though she's more eccentric than cool.
* {{Determinator}}[=/=]PluckyGirl
* DisappearedDad
* DitzyGenius: Bessie has many talents, including being able to create cold fusion. Also creating a functioning spaceship when she was 5.
* EmbarrassingMiddleName: [[spoiler: Elizabeth Kajolica Higgenbottom. [[TheScottishTrope And it's cursed.]] No, not the Elizabeth part, but that's equally as embarrassing.]]
* {{Expy}}: Of a character AmyPoehler (the series' creator, and voice of Bessie) once played on UprightCitizensBrigade. See ActorAllusion on the main page.
* {{Gasshole}}
* GenkiGirl
* GirlishPigtails
* TheHero
* IdiotHero
* KidHero
* LittleMissBadass
* {{Meganekko}}
* MotorMouth
* SmallNameBigEgo
* SpeechImpediment: Bessie's missing her front teeth, so she slurs a little. It's cute. Even when she has her teeth back, she still slurs.
* TomboyAndGirlyGirl: The tomboy to Penny's girly girl.

!! Happy Walter Higgenbottom
->'''Voiced by:''' Creator/DeeBradleyBaker
* AlliterativeName
* CharacterDevelopment: Oh, by the way, did you know that Happy is a highly trained secret agent?
* {{Expy}}: Happy seems a bit similar to [[WesternAnimation/{{Doug}} Porkchop]].
* NonHumanSidekick
* {{Omniglot}}: Happy is fluent in 12 different languages, including French, German, Italian, Russian, Chinese, Swahili, Pomeranian, and even Pandaren.
* OnlySaneMan
* TheUnintelligible

!! Ben Higgenbottom
->'''Voiced by:''' Andy Richter
* DisappearedDad
* KidAppealCharacter
* OnlySaneMan
* TagAlongKid

!! Hilary Higgenbottom
->'''Voiced by:''' Megan Cavanagh
* AlliterativeName
* BigBeautifulWoman
* BigFun
* NewAgeRetroHippie

!! Portia Gibbons
->'''Voiced by:''' Creator/GreyDeLisle
* AlphaBitch
* BeautyBrainsAndBrawn: The beauty to Gwen's brains and Penny's brawn.
* BlondeBrunetteRedhead: The blonde to Gwen and Penny's brunettes and Mary Frances' redhead.
* BlondesAreEvil
* TheBully
* DisappearedDad
* TheDragon[=/=]TheLancer
* DumbBlonde
* EvilIsPetty
* ForTheEvulz
* {{Jerkass}}
* SitcomArchNemesis
* ThoseTwoBadGuys: With Gwen.
* TomboyAndGirlyGirl: She's the Girly Girl to Gwen's Tomboy.
* TomboyishPonytail: Although she isn't a tomboy.
* TrueBlueFemininity
* ValleyGirl
* ZettaiRyouiki

!! Gwen Wu
->'''Voiced by:''' Jessica DiCicco
* AsianAirhead: Type A.
* BeautyBrainsAndBrawn: The brains to Portia's beauty and Penny's brawn.
* BetaBitch
* BlondeBrunetteRedhead: The brunette to Portia's blonde and Mary Frances' redhead (One of two).
* TheBully
* TheDarkChick[=/=]TheSmartGuy
* {{Jerkass}}
* MassiveNumberedSiblings
** OutnumberedSibling: She has five brothers.
* SitcomArchNemesis
* ThoseTwoBadGuys: With Portia.
* TomboyAndGirlyGirl: The Tomboy to Portia's Girly Girl.

!!Penny Lefcowitz
->'''Voiced by:''' Dannah Feinglass
* BeautyBrainsAndBrawn: The brawn to Portia's beauty and Gwen's brains.
* BlondeBrunetteRedhead: The brunette to Portia's blonde and Mary Frances' redhead (One of two).
* TheBrute[=/=]TheBigGuy
* CargoShip: In-universe: Fell in love with a robotic kangaroo.
* TheDitz
* DumbMuscle: Penny, the ShallowParody to DonkeyKong.
* TheEeyore
* EvilAllAlong: In "Super Secert Weakness".
* FatBastard
* FatBestFriend: To Bessie, though sometimes she joins Portia to gang up on Bessie.
* FatIdiot
* GirlishPigtails
* {{Gonk}}
* HeelFaceRevolvingDoor
* MissingMom
* SimpletonVoice
* TomboyAndGirlyGirl: The girly girl to Bessie's tomboy.

!! Ms. Mary Frances Gibbons
->'''Voiced by:''' Sarah Thyre
* ApatheticTeacher
* BigBad
* BlondeBrunetteRedhead: The redhead to Portia's blonde and Gwen and Penny's brunettes.
* EvilRedhead
* HartmanHips
* JerkAss
* TheMentor
* TrueBlueFemininity
* WoobieDestroyerOfWorlds

!! Anton St. Germain
->'''Voiced by:''' Matt Besser
* BigBad
* {{Gonk}}
* GrumpyBear
* TheRival
* SitcomArchNemesis
* UngratefulBastard
* WoobieDestroyerOfWorlds

!! Ganiva
->'''Voiced by:''' N/A
* CompanionCube: To Anton.
* TrueBlueFemininity

!! The Hippie
->'''Voiced by:''' Matt Besser
* NewAgeRetroHippie
* NoNameGiven

!! Millie Millerson
->'''Voiced by:''' Creator/GreyDeLisle
* AlliterativeName[=/=]RepetitiveName
* AmbiguousDisorder: According to some members of the production staff, she was supposed to be autistic.
* AscendedExtra
* BracesOfOrthodonticOverkill
* ADayInTheLimelight: "Mr. Turtleton's Wild Ride".
* DumbBlonde
* HairOfGoldHeartOfGold
* TheHeart