'''Sheriff Andrew Jackson "Andy" Taylor (Andy Griffith)'''

* [[TheAllAmericanBoy The All American Man]]
* ByTheBookCop: Serves as this particular "voice of reason" for Barney.
* TheCastShowoff: Griffith was able to showcase some of his singing skills in a few episodes.
* CharacterizationMarchesOn: He and Barney are cousins in the first two episodes, something that isn't brought up again; also, for much of the first season, Griffith played Andy as more of a country bumpkin than the straight man role he played in later episodes.
* ChildhoodFriends: With Barney.
* TheConfidant: Several characters often entrust Andy to keep secrets for them.
* DaChief
* TheDanza
* DoesntLikeGuns: See TechnicalPacifist.
* {{Expy}}: Some fans consider ''{{Matlock}}'' and Andy to be the same character due to their many similarities.
* TheFace: If you're in trouble and need someone to help you find the words to get out of it, Andy's the guy you want doing the talking.
* FairCop
* {{Flanderization}}: Andy being the OnlySaneMan in Mayberry becomes more and more obvious, especially in the last three seasons, almost to the point where it seems he harbors some contempt for the Eccentric Townsfolk around him.
* {{Foil}}: To Barney.
** BigGuyLittleGuy: The Big to Barney's Little.
** RedOniBlueOni: The Blue to Barney's Red.
** SensitiveGuyAndManlyMan: The Manly Man to Barney's Sensitive Guy.
** StraightManAndWiseGuy: The Straight Man to Barney's Wise Guy.
*** This was originally planned to be reversed, with Barney being the Straight Man to Andy's Wise Guy. However, the creators (and Griffith himself) was quick to realize that the show was funnier with Andy as the Straight Man.
* TheHeart
* TheHero
** IdealHero
* HeroesWantRedheads: Specifically with Opie's teacher, Helen Crump.
* HeterosexualLifePartners: With Barney.
* HiddenBadass: Andy isn't one to pick a fight over a meaningless argument, but he will put you down if absolutely necessary.
* TheMatchmaker: There are numerous episodes where he plays this role, mostly for Barney or a one-time character searching for love.
* MoralityChain: For Barney and Opie.
* NamedAfterSomebodyFamous: President Andrew Jackson, the seventh president of the United States.
** Oddly enough, the "Jackson" part of his name is in question, as his newborn son in "Mayberry R.F.D." is named Andrew Samuel Taylor, Jr.
* NiceGuy
* OfficialCouple: According to "Mayberry R.F.D.", he and Helen Crump have gotten married, which is carried over to the 1986 TV movie "Return to Mayberry."
* OnlySaneMan
* RealitySubtext: Mayberry is a pastiche of Mt. Airy, where Griffith grew up.
* ReasonableAuthorityFigure
* TheSheriff
* SitcomCharacterArchetypes: The Sage.
* SmokingIsCool: On a few notable occasions.
* StraightMan
* TechnicalPacifist: Hates carrying guns unless the situation calls for as such and he needs to borrow Barney's (one-bullet) gun, preferring instead to outwit criminals rather than rough them up.
* WhatCouldHaveBeen: Originally, Andy was supposed to be the comedic lead with Knotts as his straight man (similar to their roles in ''No Time For Sergeants'', but they quickly discovered it was funnier the other way around: "By the second episode, I knew that Don should be funny, and I should play straight."

'''Opie Taylor (Ron Howard)'''

* AdorablyPrecociousChild
* TheAllAmericanBoy
* CheerfulChild
* HeIsAllGrownUp: More or less, at the end of the series.
* ImaginaryFriend: "Mr. [=McBeevee=]." [[NotSoImaginaryFriend Or maybe not.]]
* IntergenerationalFriendship: With most characters, notably Barney and Aunt Bee.
* KidAppealCharacter
* [[BratsWithSlingshots Kids With Slingshots]]
* [[LittleMissSnarker Little Mister Snarker]]
* MissingMom
* ThePrankster: At times, but usually it's because one of his friends turns out to be a bad influence.
* SitcomCharacterArchetypes: The Precocious.

'''Deputy Bernard Milton "Barney" Fife (Don Knotts)'''

* AndStarring: "Also Starring Don Knotts."
* BerserkButton: Whenever people don't take him seriously and fix whatever mistakes he insists they have made, which often leads to DisproportionateRetribution.
** And don't let him catch you chasing after his girl Thelma Lou, neither.
* BetaCouple: With Thelma Lou.
* BoundAndGagged: In a few episodes where a scheme to catch a nesting criminal goes awry; he is the one that always gets captured.
* BowtiesAreCool: Barney, along with Knotts in general, would often touch up his outfit with a bowtie.
* BreakoutCharacter
* BumblingSidekick: To Andy.
* ButtMonkey
* CatchPhrase: "Nip it in the bud!"
** Also: "Heartaches! Nothing but heartaches!" and "What's the matter? Haven't you ever seen a man (performed action) before?"
* CharacterizationMarchesOn: In the first two episodes, he and Andy were cousins, not referred to again later on.
* ChildhoodFriends: With Andy.
* {{Cloudcuckoolander}}: At times, whenever he thinks there is an overblown explanation for the situation at hand.
* CluelessDeputy: Probably the most prominent example, which paves the way for a lot of the show's biggest laughs.
* TheComicallySerious: Whenever he's trying to be intimidating to someone and treat the situation like official police business, they'll automatically assume he's leading them on.
* {{Determinator}}
* {{Expy}}: While Knotts carried his comic persona to most of his roles in general, Ralph Furley of ''ThreesCompany'' was more or less an identical character in personality, albeit with a flashy style of dress and different demeanor towards women.
* {{Foil}}:
** BigGuyLittleGuy: The Little to Andy's Big.
** RedOniBlueOni: The Red to Andy's Blue.
** SensitiveGuyAndManlyMan: The Sensitive Guy to Andy's Manly Man.
** StraightManAndWiseGuy: The Wise Guy to Andy's Straight Man.
* TheGhost: His waitress girlfriend, Juanita, who never appeared on the show but talked to him over the phone.
* HeterosexualLifePartners: With Andy.
* IdiotBall: Carries this ''a lot'', usually to misinterpreting a situation that seems to be a hard-core federal crime, but later turns out to be something much less than that.
* IntergenerationalFriendship: With Opie.
* TheKlutz
* TheLancer: To Andy.
* LovableCoward
* MilesGloriosus
* MotorMouth
* NonActionGuy: In WWII, at least, in contrast to Andy. Barney was never allowed to leave his post in office as a file clerk, while Andy was stationed in France.
* OfficialCouple: With Thelma Lou at first, but the two call it quits when he leaves Mayberry. In Season 6's "The Return of Barney Fife", Barney discovers Thelma Lou has married someone else. But, in 1986's TV movie "Return to Mayberry", the couple end up getting officially married.
* OnlyKnownByTheirNickname
* PluckyComicRelief
* PutOnABus: At the end of Season 5 so that Knotts could work on a movie career, although he returns for a couple of episodes each season until the show's end.
* RecklessSidekick: Regardless of the situation and no matter how dangerous it may be, Barney is always ready to nip the problem in the bud.
* SitcomCharacterArchetypes: The Goofball.
* SmallNameBigEgo: Ignoring all that happens under his nose, Barney considers himself an expert lawman, as well as a specialist on women, singing, history, etc. Andy regularly lets Barney carry on as he pleases, although he only allows him a single bullet in his gun for prime safety reasons.
* SuddenlyShouting: Happens when he expresses discomfort, anger, or surprise.
* WackyGuy
* WhatCouldHaveBeen: See Andy's entry.

'''Beatrice "Aunt Bee" Taylor (Frances Bavier)'''

* [[AllGirlsWantBadBoys All Women Want Bad Boys]]: In the early seasons, Aunt Bee has romances with several men that turn out to be complete jerks. Averted in the color era, when she finds happiness with respectable gentlemen such as a professor and a congressman.
* TheBusCameBack: In-universe, when Aunt Bee returns to Mayberry in the show's first episode after living in West Virginia for 5 years.
* CoolOldLady
* IntergenerationalFriendship: With Opie.
* MamaBear: To Opie. Andy as well.
* MoralityChain: For Opie and Andy.
* [[NiceGirl Nice Lady]]
* OnlyKnownByTheirNickname: Though she is the aunt of Andy, everybody in Mayberry calls her "Aunt Bee."
* ParentalSubstitute: For Opie's mother. In the first episode, Opie was originally not too happy with accepting another mother figure into the household, but he warmed up to Aunt Bee by the end of the episode and they became instant friends.
* RealitySubtext: The show's presence in Mayberry endeared Bavier to move to adjacent Siler City in real life.
* SitcomCharacterArchetypes: The Sage.
* TeamChef / TeamMom
* TheTeetotaler
* WomenAreWiser

'''Gomer Pyle (Jim Nabors)'''

* BreakoutCharacter
* TheCastShowoff: Like Griffith, Nabors was able to showcase his singing talents in some episodes, although these were more reserved for the spin-off, ''GomerPyleUSMC.''
* CatchPhrase: "Well, golll-leeee!" and "Shazam!"
* {{Cloudcuckoolander}}
* CluelessDeputy: Whenever the situation called for it, Andy and Barney would usually get someone inept like Gomer to become one of their sworn-in deputies.
* CountryMouse: In ''GomerPyleUSMC.''
* TheDitz
** GeniusDitz: His astounding singing talents, something that amazes Andy and Barney's choir in one episode.
* IncorruptiblePurePureness
* PluckyComicRelief
* PutOnABus: For his own spin-off show, the aforementioned ''GomerPyleUSMC.''
* SouthernFriedPrivate: The quintessential example.
* SitcomCharacterArchetypes: The Goofball.

'''Goober Pyle (George Lindsey)'''

* {{Cloudcuckoolander}}
* CluelessDeputy: Like Gomer, Goober was often made a temporary deputy, whether it be for better or for worse.
* TheDitz
** GeniusDitz: He can take apart a police car, reassemble it, and take it apart all over again, as evidenced in one episode.
* TheGhost / HeWhoMustNotBeSeen: Originally.
* NiceHat: His unique Beanie.
* PluckyComicRelief
* SitcomCharacterArchetypes: The Goofball.
* SuspiciouslySimilarSubstitute: For his cousin, Gomer.

'''Otis Campbell (Hal Smith)'''

* TheAlcoholic
** AlcoholHic
* {{Cloudcuckoolander}}
* CluelessDeputy: Whenever Andy or Barney enlisted him as one of their deputies, Otis would be entirely off the case.
* DropInCharacter: To the jail; every week, he drunkenly lets himself in using the keys that hang on the wall and spends the night in one of the cells.
* FatComicRelief
* FatSlob
* TheTeetotaler: By ''Return to Mayberry'', he's become this, giving up drinking and driving an ice cream truck.

'''Floyd Lawson (Walter Baldwin, Howard [=McNear=])'''

* TheBarber
* {{Cloudcuckoolander}}
* ThePeteBest: [=McNear=] took over the role of Floyd after Baldwin's one-time appearance as the character.
* RealLifeWritesThePlot: [=McNear=] died less than a year after the final episode of Season 7, so that he was not able to return for Season 8. A SuspiciouslySimilarSubstitute named Emmett Clark, a fix-it man, was added to fill in the character's absence. In-universe, Floyd was announced as having retired because he had earned enough money.
* RealitySubtext: As the result of a stroke, [=McNear=] was always shown from that point on sitting down or leaning against an object because the actor could not walk. Declining health caused him to leave the show entirely (see above).

'''Thelma Lou (Betty Lynn)'''

* BetaCouple: With Barney.
* LoveInterest: To Barney.
* NiceGirl
* NoLastNameGiven
* OfficialCouple: After Barney leaves Mayberry, she ends up marrying somebody else, and the episode "The Return of Barney Fife" in Season 6 serves as her last appearance on the show. However, she does return for the 1986 TV movie ''Return to Mayberry'', where she and Barney end up getting married.
* YoureJustJealous: In the episode where Andy and Barney help a friend of theirs find a bride and he selects Thelma Lou as the girl he wants to marry, Thelma Lou claims this is the reason Barney is so jealous, although she never wanted to marry anyone else in the first place, and she and Barney get back together at the end of the episode.

'''Helen Crump (Aneta Corsaut)'''

* HotTeacher
* LittleBoySeeksBigGirl: Opie had a crush on Helen in the opening episode of Season 5.
* OfficialCouple: With Andy, in "Mayberry R.F.D."
* {{Tsundere}}

'''Warren Ferguson (Jack Burns)'''

* CatchPhrase: Not catch ''phrase'', per se, but he did have a habit of asking, "Huh?" after a long succession of questions.
* ChuckCunninghamSyndrome: He disappeared without a trace after eleven appearances in Season 6. In the 1986 TV movie "Return to Mayberry", it is mentioned that he became Sheriff of Mayberry after Andy left, and remained at that post until his death.
* CluelessDeputy: Like Barney, but not to the same hilarious effect.
* HeyItsThatGuy: Yes, he is played by ''that'' Jack Burns, remembered as the guy who got into a fight with Creator/AndyKaufman on an episode of ''Fridays.''
* SuspiciouslySimilarSubstitute: For Barney.