This page is for characters introduced in ''VideoGame/ResidentEvil4'' only. For characters in other games or films in the game continuity, go to their respective debut media.

* ''Characters/ResidentEvil1''[[labelnote:Introducing]]Chris Redfield, Jill Valentine, Barry Burton, Rebecca Chambers, Brad Vickers, Richard Aiken, Enrico Marini, Albert Wesker, Lisa Trevor[[/labelnote]]
* ''Characters/ResidentEvil2''[[labelnote:Introducing]]Leon Scott Kennedy, Claire Redfield, Ada Wong, Sherry Birkin, William Birkin, Annette Birkin, Brian Irons, Marvin Branagh, HUNK, T-00 (Mr. X), Tofu[[/labelnote]]
* ''Characters/ResidentEvil3Nemesis''[[labelnote:Introducing]]Carlos Oliviera, Nemesis T-Type (T-02), Nikolai Ginovaef[[/labelnote]]
* ''Characters/ResidentEvilGunSurvivor'' [[labelnote:Introducing]] Ark Thompson, Lott and Lilly Klein, Vincent Goldman, Andy Holland, Bruce McGivern, Fongling, and Morpheus D. Duvall[[/labelnote]]
* ''Characters/ResidentEvilCodeVeronica''[[labelnote:Introducing]]Steve Burnside, Albert Ashford, Alexia Ashford[[/labelnote]]
* ''Characters/ResidentEvil0''[[labelnote:Introducing]]Billy Coen, Dr. James Marcus[[/labelnote]]
* ''Characters/ResidentEvilOutbreak''[[labelnote:Introducing]]Kevin Ryman, Alyssa Ashcroft, Cindy Lennox, Mark Wilkins, David King, Jim Chapman, George Hamilton, Yoko Suzuki, Linda, Carter, Monica, Rita, Regan Mallet[[/labelnote]]
* ''Characters/ResidentEvilTheUmbrellaChronicles''[[labelnote:Introducing]]Colonel Sergei Vladimir, The Red Queen[[/labelnote]]
* ''Characters/ResidentEvilDegeneration''[[labelnote:Introducing]]Senator Ron Davis, Angela Miller, Curtis Miller, Frederic Downing[[/labelnote]]
* ''Characters/ResidentEvil5''[[labelnote:Introducing]]Sheva Alomar, Josh Stone, Oswell E. Spencer, Excella Gionne, Ricardo Irving, Alex Wesker[[/labelnote]]
* ''Characters/ResidentEvilTheDarksideChronicles''[[labelnote:Introducing]]Manuela Hidalgo[[/labelnote]]
* ''Characters/ResidentEvilRevelations''[[labelnote:Introducing]]Parker Luciani, Jessica Sherawat, Raymond Vester, Clive R. O'Brian, Quint Cetcham, Keith Lumley, Rachael, Morgan Lansdale, Jack Norman[[/labelnote]]
* ''Characters/ResidentEvilOperationRaccoonCity''[[labelnote:Introducing]]Vector, Spectre, Beltway, Bertha, Four-Eyes, Lupo, Umbrella Security Service Command, Crispin Jettingham (Callsign: DEE-AY), Erez Morris (Callsign: HARLEY), Lawrence Kimbala (Callsign: SHONA), Marisa Ronson (Callsign: TWEED), Carolyn Floyd (Callsign: WILLOW), Sienna Fowler (Callsign: PARTY GIRL), Government Spec Ops Command[[/labelnote]]
* ''Characters/ResidentEvil6''[[labelnote:Introducing]]Jake Muller, Helena Harper, Piers Nivans, Carla Radames, Derek Clifford Simmons, Ustanak, Haos, Agent, President Adam Benford[[/labelnote]]
* ''Characters/ResidentEvilDamnation''[[labelnote:Introducing]]Svetlana Belikova, "Buddy"/Alexander "Sasha" Kozachenko, JD[[/labelnote]]
* ''Characters/ResidentEvilRevelations2'' [[labelnote:Introducing]]Moira Burton, Natalia Korda, [[spoiler:Alex Wesker]], Neil Fisher, Gina Foley, Pedro Fernandez, Gabriel Chavez, Cipher, Evgeny Rebic, Stuart[[/labelnote]]
* ''Characters/ResidentEvil7Biohazard'' [[labelnote:Introducing]]Ethan Winters, Mia Winters, Jack Baker, Marguerite Baker, Lucas Baker, Zoe Baker, The Grandmother/[[spoiler:Eveline]], David Anderson, Alan Douglas/Droney, Peter Walken, Andre Stickland, Clancy Jarvis, Hoffman, The Molded[[/labelnote]]
* ''Characters/ResidentEvilTheMarhawaDesire'' [[labelnote:Introducing]]Ricky Tozawa, Merah Biji, Doug Wright, Bindi Bergara, Gracia Delenikas, Alisa Lin, Nanan Yoshihara, Tahir Kapoor, Ray Hsu, Gwen Ti Quan[[/labelnote]]
* ''Characters/ResidentEvilHeavenlyIsland''
* ''Characters/ResidentEvilVendetta'' [[labelnote:Introducing]]Nadia, D.C., Damien, Kathy White, Zack White, Glenn Arias, Maria Gomez, Diego Gomez, Patricio[[/labelnote]]


[[folder: Luis Sera]]
->'''Voiced by:''' Creator/RinoRomano

->''"A little rough, don't you think?"''

Luis is a smooth-talking cad who shows up mysteriously to aid Leon from time to time before running off. He claims to have been a policeman in Madrid before later admitting that he was also once a researcher for Los Illuminados. He does his best to help Leon and Ashley.
* TheAtoner: He goes well out of his way to help Leon and Ashley because of the responsibility he feels for the situation at hand.
* BadassNormal: Facing down hordes of infected villagers and cultists, along side the likes of Leon and Ada (both having extensive combat and survival training), it's easy to forget that Luis is just a fairly normal scientist. He may have once been a police officer in Madrid, which explains his skill with firearms, but it's still not the same level as his companions.
* TheCasanova: He claims to be "quite the ladies' man." [[spoiler: Subverted, Ashley disagrees.]]
* DashingHispanic: He's a charming Spaniard with both intelligence and skills with a gun.
* SuspiciouslySimilarSubstitute: Of Carlos Olivera from the previous game before Luis. Both are sarcastic, flirty Hispanics with a knack for firearms.
* FireForgedFriends: With Leon over the course of the game, [[spoiler:making his death hit him all the more harder.]]
* GeniusBruiser: He is a brilliant scientist hired to study the Plagas, but he is skilled enough with firearms to keep up with Leon (who is a highly trained U.S. government agent).
* HandsomeLech:
-->'''Luis''': "I see the president has equipped his daughter with ballistics, too."
* HeelFaceTurn: Although he is unusual in that his happens before the beginning of the story proper.
* HeroicWillpower: Before the game, he was fully infected with a Plagas, but his Plagas acted so much like him that [[HeroicSacrifice it killed itself]] to free him from Saddler's control.
* HotScientist: Just look at the guy!
* ImpaledWithExtremePrejudice: [[spoiler:By Saddler's Plaga tentacle.]]
* LetsGetDangerous: While he previously acted sort of helpless and cowardly, when you encounter him in the house while fending off a horde of Ganados, and he finally has a weapon, he twirls it out expertly before saying: [[PreAssKickingOneLiner "It's game time"]]. He then proceeds to kill Ganados by the dozen.
* MadeOfIron: [[spoiler:Manages to tell Leon the truth of his past and gives him the medications to suppress the Plagas, after having suffered an impalement that would have surely damaged his spine, as well as destroying his heart and lungs.]]
* MyGodWhatHaveIDone: He has one of these moments before the start of the game, upon realizing that his research on Las Plagas was being used to make them stronger and more infectious. Leads him to doing whatever he can to destroy the parasites.
* ObfuscatingStupidity: He acts like a sleaze, but as the notes, medication, and the ''laser'' he created attest, he's a genius. Even Ada calls him "brilliant."
* OmnidisciplinaryScientist: Researched the biology of the Plaga parasite (zoology), created a medication to suppress their growth in a host (pharmacology), developed a machine to kill adult parasites (biomedical engineering), and a weapon capable of killing parasites and hosts rapidly (weapons engineering).
* RedemptionEqualsDeath: [[spoiler: Luis manages to give Leon some medicine to fight the parasite trying to take over him, and almost gives him the Dominant Plaga sample, just before dying from being impaled by Saddler.]]
* SacrificialLion: He has a moderate role in the story and goes out of his way to help Leon and Ashley as much as he can. [[spoiler: Because he used to work for Saddler on the Las Plagas project, he feels responsible for everything that happened. Ergo, Luis tries to get a cure ready for Leon and Ashley's parasite problem. Saddler kills him right in front of Leon and steals the sample, forcing Leon to find another way to cure the infection much later on.]]
* SmokingIsCool: The first thing he asks for when Leon finds him is a smoke.
* UnkemptBeauty: Long greasy hair never looked so good.
* VideoGameCrueltyPunishment: During the HoldTheLine segment in the cabin, you can shoot him instead; willingly or via stray bullets. Do it enough times, and Luis will get angry and kill Leon, resulting in a NonStandardGameOver.
* WeaponOfChoice: Luis's personal weapon is a [[CoolGuns 1916 Austria Contract Mauser C96, aka the "Red 9"]]. The most powerful, non-magnum, handgun in the game.

[[folder: Ashley Graham]]
->'''Voiced by:''' Carolyn Lawrence

->''"I'm never turning into one of them! Never!"''

The president's daughter that Leon must rescue in ''4''. A twenty-year-old university student who was abducted and taken to Europe for ransom and to be implanted with Las Plasgas as part of Saddler's plan.
* ArmorIsUseless: Averted. You can shoot the trap she was in with a rocket launcher and not kill her with it, also conveniently preventing any game overs due to a misfire. Later, when you unlock an alternate costume that is a literal suit of armor, she is both too heavy to be captured by mooks and invulnerable. Thus, having her stand in the center of a mob while shooting enemies around her works exceptionally well.
%%* BareYourMidriff: Her first bonus outfit.
%%* BodyguardCrush: On Leon.
* DevelopersForesight: A minor example. When you play with the default outfit, Ashley won't let you look under her skirt if she's above you (she'll close her legs and admonish you for trying). Playing with either of the unlockable, pants equipped outfits, and she doesn't respond if you try the same thing. Leon will also fall to one knee after catching her in his arms when she jumps down from a ledge that's too high for her to safely land if she's wearing the armor and will stand up clutching his back in pain.
* DistressedDamsel: She sticks with Leon for a couple of chapters when he first finds her before traps in the castle separate them. The next two times he finds her, she winds up kidnapped again by the end of the chapter.
* FistPump: During the cable car ride, shooting an enemy and causing them to fall will cause Ashley to do a victory fist pump.
* GagBoobs: Resulting in Luis's {{Lampshading}}. [[note]]She's not ''that'' stacked, and certainly not unrealistically so for her age, but it's still prominent on her figure.[[/note]] Further lampshaded with the trophy for rescuing her.
--> "Secure the Ballistics"
* GameplayAndStorySegregation:
** The [=PS2=] version runs cutscenes off of movie files so everyone has their default outfits, while all other editions use the game engine to show what's actually worn. It also happens in the [[PortingDisaster original PC version]] and the Wii version, but only for the suit of armor/Chicago mobster alternates in the latter.
** When she's kidnapped by flying monsters, Leon just goes on looking for her, but if a mook carries her into a different game zone, it's instant Game Over, even if Leon is on his heels.
** Leon has to protect her from deadly encounters and traps with alarming frequency in spite of Saddler's EvilPlan requiring her to be sent home alive and infected. Even villains who should ''absolutely'' know better than to risk killing her (like Salazar) will still occasionally try to.
* GladToBeAliveSex: She offers Leon some "overtime" during the ending cutscene. He turns her down though, presumably because he'd be in hot water if it was found out that he, a Secret Service agent, bedded the President's little girl.
* HairOfGoldHeartOfGold: She's a sweet girl when things settle down, and in comparing to her blonde predecessor Alexia, she's really nice in comparison.
* IdiotBall: Jokes about her AI intelligence aside, there's one scene in the game where Ashley will overreact to Leon asking if she's fine after coughing some blood and run ''straight'' into one of the castle's obvious traps.
* ImprovisedWeaponUser: She can use candles/lanterns in the rooms when you play her.
* KillItWithFire: One of her few attacks is to throw candles at enemies.
* TheLoad: Averted. She makes herself useful on occasion, and when she's alone she can fend for herself if need be (well, when the player controls her, of course, her AI isn't quite that smart). Quite often Leon can tell her to hide in a dumpster where she can't be discovered, which makes escorting her a lot easier. On the other hand, if Ashley is ordered to wait, she will not move even if she is being attacked by enemies.
* NighInvulnerability: Her second alternate outfit is a suit of armor. Not only does it make her impervious to any and all kind of damage (Even from rocket launchers), but it's also so heavy that it also protects her from being kidnapped, making the segments with her much easier.
* PantyShot: Allegedly, the panties have a rather detailed graphic...
%%%* SensualSpandex: Her white pop star outfit.
* SupportPartyMember: there's a few times in which she makes herself useful, piggybacking over locked gates to unbar them, helping out whenever there's more than one winch to turn, etc. She also drives a massive truck through a tunnel so Leon can focus on shooting up the Ganados trying to halt their progress.
* CoyGirlishFlirtPose: Her menu picture in her playable area shows her standing like this.
* StoneWall: Armor Ashley is completely invincible to any form of attack. It is a perfectly viable strategy to use Armor Ashley to lure enemies away from Leon as he snipes them from a distance... with a rocket. Ashley will be perfectly fine.
%%%* SweaterGirl: Her sleeveless sweater (even though she is wearing a full sweater around her neck).
* VideoGameCaringPotential: Depends on your take on {{Escort Mission}}s, Leon can either be nice to her or [[VideoGameCrueltyPotential a jerk]].
* WrestlerInAllOfUs:
** [[ No kidding!]] Do it right, and you can have [[LethalJokeCharacter her]] performing Leon's [[SuplexFinisher suplex move]] on enemies!
** Ashley uses the same controls as Leon, but since she never finds any weapons in her chapter, you're not supposed to be able to fight. If you manage to hit a monk with one of the doors, though, you can run up and use one of the context-sensitive melee commands. Sadly, said ability only works in the original UsefulNotes/NintendoGameCube release.
* YourPrincessIsInAnotherCastle: Try and count how many times she's been rescued, only to be kidnapped again. Granted, the circumstances are out of Leon's control, ranging from an ambush to [[spoiler:MindControl.]]

[[folder: Ingrid Hunnigan]]
->'''Voiced by:''' Sally Saffioti

->''"May I remind you that you're still on duty?"''

Leon's MissionControl in ''Resident Evil 4'', ''Degeneration'', ''Damnation'', and ''6''.
* AmbiguouslyBrown: She's Caucasian, or at least American according to Wiki/TheOtherWiki, but she has a nice tone of olive skin. This supports the theory that she is either tanned, or has Latino/Mediterranean ancestry. Not that it subtracts any points of her [[SexySecretary beauty]] at all.
* BeautifulAllAlong: Normally, she dresses and looks rather plain (not that Leon minds), but once she tidies up a little, well...
* ConsummateProfessional: Even people she's worked with for years know next to nothing about her personal life. The closest thing we get to hint is an anecdote in a file of her telling off her mother for calling her at work about her personal life, insisting her work is her number one priority.
* FriendshipMoment: In ''6'', when Leon asks Hunnigan to fake his and Helena's deaths so they can chase [[spoiler:Simmons]] to China, she barely hesitates. In fact, the reason they know where he's going is because she already put a tail on him. They're accusing a respected superior of a crime they themselves are the prime suspects in, without any evidence to back them up, and she believes them immediately.
* TheGlassesGottaGo: At the end of ''Resident Evil 4'', her last conversation with Leon has her without the glasses and Leon immediately notices it.
* HeKnowsAboutTimedHits: "I'm sending you a playing manual!"
* LastNameBasis: Almost always referred to as Hunnigan.
* {{Meganekko}}: Wears glasses all the time. It led to a lot of WildMassGuessing that she was an established character in disguise.
* MissionControl: Acts as Leon's mission control on both ''4'' and ''6''.
* MultiEthnicName: She's AmbiguouslyBrown, but "Ingrid" is Germanic and "Hunnigan" is an Irish surname.
%%* SexySecretary
* SpellMyNameWithAnS: The games and original source material seem to flip-flop between her last named being spelled Hunnigan or Hannigan, respectively.
* WhatBeautifulEyes: She has them. Hazel eyes.

[[folder: The Merchant]]
->'''Voiced by:''' Paul Mercier

->''"Got a selection of good things on sale, stranger!"''

A strange [[WebAnimation/ZeroPunctuation pirate-merchant guy]] introduced in [=RE4=]. Clad in a black, hooded coat and purple neckerchief, the Merchant would be available at some point during the level to sell and buy items. He's a mysterious and quirky fellow and gained quite the fanbase as a result.
* CatchPhrase: "Wot're ye buyin'?" and "Wot're ye sellin'?"
* EveryoneCallsHimBarkeep: He sells stuff and has no official name, therefore he's just "The Merchant".
* GlowingEyesOfDoom: Subverted. While he has glowing red eyes like the rest of the Ganados, he's a neutral guy looking for profit.
* IntrepidMerchant: No matter how far you go, he'll always be ahead of you to sell his wares.
* LargeHam: He's always happy to see Leon or Ada, emphatically calling them "STRANGER!" when making good deals, possibly because they are the only ones trading with him.
* SignatureLaugh: If you know the Merchant, you'll recognize his laugh in an instant.
--> "I got sumthin' that might interest you. Eh heh heh".
--> "Eh heh heh, thank ya!"
* TokenHeroicOrc: His eyes glow red at night, indicating that he is also a host for a Plagas. Yet he does not attack any of the protagonists and actively helps them in the form of selling them much needed weaponry and gear.
* VideoGameCrueltyPotential: You can show your "appreciation" towards the Merchant's high prices by slashing him with your knife or shooting him, which will kill him on the spot, though he will continue to appear later in the game, even on Professional difficulty, meaning you can murder him to your heart's content on all difficulty settings.
* WeBuyAnything: "I'll buy it fer a high price."
* WeSellEverything: Well, everything you need to survive a zombie-infested Spanish town. Except ammo, despite occasionally being shown with ''crates'' of the stuff, and obviously having enough to completely restock a weapon each time whenever Leon has its capacity increased.
* WhatHappenedToTheMouse: Only shows up in 4, and the last time you see him is before the final battle with Saddler. And after Ada activates the bombs to destroy the island, it's unknown whether or not he escaped. The odds are he did, since [[InexplicablyAwesome he has a habit of showing up in (often dangerous) places in seemingly impossible ways]] ''before you do,'' he probably had a ticket out of there somehow.

[[folder: Osmund Saddler]]
->'''Voiced by:''' Michael Gough

The true mastermind behind the events of ''VideoGame/ResidentEvil4''. He had Krauser capture the president's daughter in order to infect her with Las Plagas and then return her to the White House (after collecting ransom, of course), where she would presumably attack and spread Las Plagas throughout the United States. His plans were foiled by Leon and his crew.
* AmericaSavesTheDay: Saddler references this trope before fighting Leon and promises to subvert it. This, of course, is ultimately played straight.
* AxCrazy: He's very good at hiding it. After his OneWingedAngel reveal, he's the living embodiment of this trope.
* BigBad: This is the man behind both Mendez and Salazar.
* CatchAndReturn: If you pump enough bullets into him during the ''Separate Ways'' boss fight, he fires them back at Ada by forcing them out his finger.
* CombatTentacles: These are most prominent during his boss fight in ''Separate Ways''. [[spoiler:He also kills Luis with a tentacle from between his legs, in a move that fans affectionately call the "Wangpale."]]
* DeadpanSnarker: Conversations between Saddler and Leon can best be described as snark-offs.
* EyesDoNotBelongThere: He's got an eye in his mouth that only pops out when he's taken a lot of damage. He also has eyes on the legs that grow out of his face in OneWingedAngel mode.
* FantasticRacism: Makes it quite clear he not fond of Americans.
* FauxAffablyEvil: All the way. When Leon makes quips at his expense, Saddler always responds with a good-natured chuckle before telling him in a conversational tone how he's going to kill him, and never lets on that Leon is anything more than a source of amusement for him. Even when Leon manages to rescue Ashley at the Island after being cured of Las Plagas via the Plagas Removal Laser, Saddler's only reaction is to express amusement at him for managing to foil his plans before transforming.
* FlashStep: He's quite fond of using this during his boss fight with Ada. Unlike Wesker, he doesn't use it to [[DodgeTheBullet dodge bullets]].
* GoodHairEvilHair: Slicked back hair, sterotypical for a villain.
* HiveMind: Using supersonic waves from his staff, he can control anyone or anything who hosts a Plaga, with a few possible exceptions.
* IdiotBall: The entire plot of ''Resident Evil 4'' makes considerably more sense on every possible level if you assume that receiving his master Plaga turned Saddler into a delusional psychopath who's unwilling to admit that he could possibly be wrong or be defeated. And as part of his research, Saddler had [[spoiler:Luis build a machine in the research building that could kill Las Plagas without damaging the host under certain conditions. Knowing full well that the machine was still operational and that it was very near where he was holding Ashley, Saddler made no effort to destroy the machine. Lo and behold, Ashley and Leon found it and used it to get rid of their parasites.]]
* InterimVillain: Unlike other antagonists in the series, he is not connected to Umbrella. Albert Wesker takes the role as main villain in ''VideoGame/ResidentEvil5''. Makes sense, Leon's stories were never tied with Wesker.
* InTheHood: Wears a hood for most of the game.
* LastNameBasis: No one calls him Osmund.
* NoYou:
-->'''Saddler:''' Perhaps you are disillusioned with overconfidence just because you killed my small-time subordinate?
-->'''Leon:''' Saddler, '''you're''' small-time.
* OneWingedAngel: As noted above, he has legs that grow out of his face.
* PhallicWeapon: See CombatTentacles above.
* ProperlyParanoid: [[spoiler:He never really trusted Krauser, who was indeed [[TheMole working for Wesker]].]]
* ReligionOfEvil: Whether or not Saddler actually believes in the religion of Los Illuminados is unclear, but he is their leader and is at least using them as a cover for his own goals.
* SinisterMinister: Sinister ''Pope'', more like. The Head Honcho of the Los Illuminados cult.
** Also if the credits pictures are anything to go by, he came to village initally as a priest.
* SmugSnake: He brushes off every defeat Leon hands him with condescending arrogance. His VillainousBreakdown mentioned below is basically him making a frowny face for about a second before resuming his usual smarmy tone and going OneWingedAngel.
* SoftspokenSadist: He almost never raises his voice and speaks in a polite, soft tone, even when faced with defeat.
* SuperSpeed: In human form, Saddler can move very quickly. He almost seems to hover along the ground as he does so.
* UnderestimatingBadassery: Constantly. He sees Leon as nothing but a small fry despite Leon managing to survive everything he throws at him, ''especially'' when he does have Leon dead to rights a few times but doesn't bother to finish him. By the time he finally decides to get serious, Leon more then apt at killing Las Plagas. And the area he fights him in was more advantageous to Leon than him, ultimately leading to his death.
* VillainBall: It's not clear why he's persistent in keeping Ashley for ransom. Had he just quietly returned her, or allowed Leon to rescue her before he could get to the bottom of things, nobody would've known [[spoiler:she was infected]] until it was too late. On the other hand, it's hinted that he couldn't give her up [[spoiler: even with her infected]], as more needed to be done with her as shown on the island.
* VillainousBreakdown: A severely understated one. He keeps his smug tone, and only shows how angry he is with a small scowl and a DeathGlare, but once he discovers that [[spoiler:Leon found a way to remove his Plaga, and Ashley probably did too]], Saddler decides to [[OneWingedAngel get serious.]]
* VillainousFriendship: One of the papers the player can find at the Island indicates that he was rather disheartened when both Bitores Mendez and Ramon Salazar were both slain by Leon.
* WhyDontYaJustShootHim: Despite multiple opportunities to kill Leon personally, Saddler never gives up hope that Leon will succumb to Las Plagas and, in turn, his mind control. This comes back to bite him in the end.

[[folder: Ramon Salazar]]
->'''Voiced by:''' Rene Mujica

The eighth castellan of the Salazar family castle and a high-ranking member of Los Illuminados, Salazar played a huge part in Saddler's plans by excavating fossilized Las Plagas and donating them to his cause. His goal was to create a world without sin: after all, [[TheEvilsOfFreeWill if people have no free will, how can they do evil?]] He causes Leon a lot of trouble when Leon and Ashley wander into his castle.
* BodyHorror: Due to a genetic defect, he's the size of a child, but he's already got gray, stringy hair and wrinkled skin that makes him look like a dying old man.
* BrattyHalfPint: A twisted version. He's a grown man with a midget body, and his tantrums is that of a little spoiled brat.
* ButtMonkey: To Leon. You can tell Leon enjoys trolling the guy.
* CompensatingForSomething: Giant mecha Salazar GO!!!
* DeathTrap: His castle is chock full of them, from [[SpikesOfDoom spiked pits]] to [[TheWallsAreClosingIn closing walls]], making it actually more dangerous
* DepravedDwarf: He's short, but he's actually much more gleefully sadistic than the previous villain Bitores Mendez.
* DevourTheDragon: He absorbs the second Verdugo when going OneWingedAngel.
* DudeWheresMyRespect: He was unfavorably compared to the first Salazar castellan, who was known to the villagers as a folk hero who eliminated the Los Illuminados cult centuries ago. In addition to his current faith in Los Illuminados, Salazar could have released the Plagas as a way to spite his ancestor.
* FaithHeelTurn: He was once a Christian but converted his faith to the local Los Illuminados cult shortly before being approached by Saddler.
* {{Foil}}: To Bitores Mendez. While Bitorez Mendez is a rather serious character and his encounters with Leon are typically rather frightening, Leon's encounters with Ramon Salazar tend to be rather humorous. While Bitores Mendez is typically rather cold and unfeeling, Ramon Salazar is gleefully sadistic. While Bitores Mendez fights Leon himself, Ramon Salazar fights Leon using his bodyguards and a giant plant monster. Finally, while Bitores Mendez initially decides against killing Leon himself due to him possessing a Plaga, Ramon Salazar is quite eager to do so.
* GigglingVillain: He has this obnoxious little giggle that he busts out whenever he thinks he has the situation under control. Fortunately, as you progress, he finds less and less reason to laugh.
* HannibalLecture: Subverted. Just as Salazar prepares to deliver a presumably well-rehearsed lecture on the nature of terrorism, Leon delivers a brilliant, wordless ShutUpHannibal [[MomentOfAwesome using violence]], which leaves Salazar whimpering like a sick puppy, [[{{Metaphorgotten}} only less adorable and more pathetic]].
* ImMelting: [[spoiler:His final fate.]]
* ImpaledPalm: Leon's aforementioned ShutUpHannibal moment involves him flinging his knife at Salazar and nailing his left hand to the wall.
* KnightTemplar: He wanted to rid the world of sin. However, his method of doing so is to sap people's will by allowing the Los Illuminados cult to plant Las Plagas into them.
* LonersAreFreaks: Before the Los Illuminados incident, Ramon Salazar was the only surviving member of a Spanish noble family that has governed the local region for eight generations. Alone in a huge, sprawling castle and likely only a few servants for company, Salazar's extreme loneliness contributed to his stunted mentality, leaving him vulnerable to Saddler's persuasions to release the Plagas into the world once more.
* MisterBig: He's not ultimately in charge of the operation, but he's got ''loads'' of guys working for him, and is constantly flanked by two massive bodyguards.
* TheNapoleon: Not only is he short, he wears a Napoleon-esque outfit (including the CoolHat). The fact that he spent money on a giant robotic statue of himself also suggests a Napoleon complex.
* ObliviouslyEvil: Sort of. He definitely takes glee in using his death traps, but his diary reveals Los Illuminados fed him lies about what exactly Las Plagas was and painted his heroic ancestor as a bad guy who was persecuting them. He felt the need to unleash them as [[TheAtoner atonement for this]]. Having been infected by Las Plagas himself, it's hard to say how he ''really'' feels now.
* OneWingedAngel: He and his remaining Verdugo become one some sort of plant thing for his respective boss battle.
* PraetorianGuard: The two Verdugo that follow him around serve this purpose. The first one is sent to fight Leon but the second one is a subversion because it's merely absorbed to help fuel Ramon's fusion with the Queen Plaga.
* PsychopathicManchild: Oh so much.
* SmugSnake: He's nowhere near the the threat he thinks he is.
* TrapDoor: Leading into a spike pit. Ramon Salazar: [[JustForFun/XMeetsY Part Napoleon Boneparte, part Vlad the Impaler]].
** TrapDoorFail: He tries to kill Leon by having him fall into a pit of spikes. It fails of course.
* TheTeamBenefactor: He provided Saddler with the Plagas.
* VillainousBreakdown: The first major villain of the game, Mendez, ends up nearly killing Leon every time they meet. In contrast, Leon ''always'' has a cool head when talking down Salazar, despite Salazar's efforts, and that drives him ''insane''.
--> '''Salazar:''' I've sent my right hand to dispose of you.
--> '''Leon:''' [[MemeticMutation You're [sic] right hand comes off?]]
--> '''Salazar:''' Say whatever you please. '''[=DIE YOU WORM!=]''' (''breaks the camera'')
* TheWallsAreClosingIn: Pulls this trick on Leon. ''Twice.''
* YoungerThanTheyLook: "It may come as a surprise, but I am only twenty years old!"

[[folder: Jack Krauser]]
->'''Voiced by:''' Creator/JimWard

->''"Been a long time, comrade."''

An antagonist in ''4,'' he literally shows up in the last section of the game, though he's one of the causes of the whole mess: He's the one who originally kidnapped Ashley. Also a playable character ''Darkside Chronicles'', which serves as his StartOfDarkness, showing the actual mission he worked with Leon and why he hooked up with Wesker.
* BladeBelowTheShoulder: [[spoiler:In addition to increased speed and endurance, the infection also mutates his left arm into a ''gigantic metal blade'' which you can use in the Mercenaries minigame.]]
* BloodKnight: He enjoys the thrill of the battle, and acts like he's having a ball during his duel with Leon in ''4''.
* CareerEndingInjury: Which leads to his StartOfDarkness.
* CompensatingForSomething: Implied by Ada.
* DirtyCoward: Played with in ''Darkside Chronicles''. In the last few missions, Krauser essentially breaks under the strain, scrambling with fear from the giant viral monsters attacking him and Leon, even (mentally) desperately begging Leon to save his ass when he thought the odds were too great. Despite all this, and an extremely injured arm, he fights competently and professionally and never really lets any of this show, so really closer to CowardlyLion.
* DisneyDeath: Played straight and subverted. [[spoiler:You would ''think'' beating the tar out of him with Leon ''and'' having a stone tower explode and collapse on him would be enough to kill Krauser. It doesn't, but Ada later manages to put him down for good anyways.]]
* EmpoweredBadassNormal: ''Darkside Chronicles'' shows us that he was pretty badass ''before'' [[spoiler:getting infected.]]
* EvilCounterpart: For Leon. Both are {{Knife Nut}}s, worked for the US government, and even served on the same mission in ''Darkside Chronicles.'' Ironically, Krauser falls to the dark side because he ''liked'' his work with SOCOM so much, so when he [[spoiler:all but loses one arm and faces an end to his military career, he turns to Wesker.]]
* FaceHeelTurn: Ends up turning to Wesker (and presumably faking his own death). One of the major factors in his allying himself with Wesker was because of deep anger about feeling used by the United States Military, especially when they didn't even request for him to join up with the organization to stop bioweapon threats, yet they allowed Leon to join, and later their firing him because the Javier mission had him injured in his arm with it not fully recovering. That would probably explain why Krauser, despite swearing an oath to his native country, was perfectly willing to undergo a mission to kidnap the President's daughter.
* {{Foil}}: To Leon:
** Both are blond guys, except Leon is [[HairOfGoldHeartOfGold good]] and he's not.
** Krauser has a nasty scar, and Leon has a [[{{Hunk}} perfect face.]]
** Leon, while not short, he's a bit above average height (5'10"), Krauser towers him at 6 ft.
** Leon has long-ish hair, Krauser has a buzzcut.
** Both were working for the government, but Krauser turned to evil.
** Both are very [[KnifeNut good]] with the knife.
** Both have IcyBlueEyes, the difference however is that Leon is compassionate individual, but [[DeadpanSnarker fairly snarky]], Krauser is very [[StraightMan serious]].
* GoodEyesEvilEyes
* GoodScarsEvilScars: The giant scar on his face is supposed to make him look more intimidating. When he puts war paint on his face, it lessens the appearance of it.
* GreenEyedMonster: Has shades of this when he learns about Leon's being ordered to join the secret organization to stop bioweapons, despite the fact that Krauser, at least in his viewpoint, would have willingly joined up to aid the government to get rid of the bioweapons, and yet was not even given that chance.
* {{Hypocrite}}
* {{Irony}}: He's introduced with a knife fight, is a KnifeNut, and [[spoiler:his Plagas mutation is a giant blade in his arm]]. That said, the best weapon to use in his boss fight is the knife.
* LastNameBasis: Everybody refers to him as "Krauser", making his first name, Jack, hard to find.
* LightningBruiser: Of the Mercenaries, he's got the largest health bar, his bow is extremely powerful, his physical attacks will ''demolish'' just about anyone, ''and'' he can run at a pretty good pace.
* MirrorBoss: During the first part of his boss battle, Jack Krauser fights much like Leon and would, using a gun and grenades to attack from a distance, using a knife to attack him up close, and uses a kick takedown move similar to Leon and Ada. He also flees when he finds himself being attacked, much like the player most likely would if the Ganados were approaching him so that he could pick them off with his gun. While he doesn't use it against Ada, he uses an explosive bow against Leon, similar to Ada's explosive crossbow.
* NervesOfSteel: Played with, see DirtyCoward.
* NiceHat: He wore a raspberry beret, [[Music/{{Prince}} and not the kind you'd find in a secondhand store.]]
* TheParagonAlwaysRebels: The bio for Krauser in Darkside Chronicles noted that he had a long and outstanding service in the military prior to his ultimate fall.
* SociopathicSoldier: After being discharged from service due to his arm injury, he goes rather insane and readily becomes a Las Plagas host in order to regain the use of his arm and increase his combat ability so he can keep being a soldier, even if it means fighting for an insane cause.
* PsychoSupporter: By VideoGame/ResidentEvil4, he is very much loyal to Wesker, presumably because of his healing his arm so he can be a soldier again.
* RememberTheNewGuy: "I died in the crash 2 years ago... Is that what they told you?" What [[NoodleIncident crash]]? What mission? Who are you?
* RivalTurnedEvil: ''Darkside Chronicles'' lays out the rather tragic story. Leon and Krauser only knew each other for the one mission, but they earned each other's respect and friendship and from Leon's point of view, parted as friends. [[BeneathTheMask In reality]], because of a combination of the insane stress of the mission, fear of rejection by the government after major injury, and subsequent fascination for power with which he could liberate himself from others' control, Krauser sought after organic weaponry to augment himself immediately after that mission, breaking all bonds with Leon and the US government (although the fact that the US government fired him because of his injury was probably a huge factor in that last part of his viewpoint).
* ShellShockedVeteran: Similar to [[Franchise/MetalGear Gray Fox]], Jack Krauser feels he is useless outside of the battlefield, and that being a soldier is his calling, to the extent that he often underwent mercenary missions even when he was off-duty from SOCOM. This is a large part of the reason why he ultimately turned to Wesker's help after [[spoiler:the US Government fired him due to his arm injury never really recovering.]]
* StabTheScorpion: In ''[[VideoGame/ResidentEvilTheDarksideChronicles Darkside Chronicles]]'', he stabs a snake that's about to strike Leon.
* WarriorPoet: He develops into a rather cynical philosopher over the course of ''The Darkside Chronicles''.
* YouHaveOutlivedYourUsefulness: [[spoiler:Inverted. Even after death, he still served some use to Wesker with the latter autopsing his body and retrieving the Dominant Plaga to gain his plans.]]

[[folder: Bitores Mendez]]
->'''Voiced by:''' Jesse Corti

->''"You carry the same blood as us, it seems."''

Another member of Los Illuminados and the village chief, Mendez personally led the hunt for both Leon and Ashley as they tried escaping from the clutches of the Plagas.
* AdvertisedExtra: Appeared prominently in much of the ad materials, implying he was the BigBad, when in reality he was just a StarterVillain who's killed barely a quarter of the way into the game.
* AuthorityEqualsAsskicking: He's the village chief, and every time he runs into Leon, he comes within a hair's breadth of killing him.
* BadassBeard: It even remains when he turns OneWingedAngel. Also a BeardOfEvil.
* BadassLongcoat: Though it's burned off when he goes OneWingedAngel.
* BaldOfEvil: Not a hair on his head.
* BewareTheQuietOnes: He only speaks to Leon once in the entire game.
* TheBrute: He's the only major villain to take on Leon physically without being mutated and is a huge physical threat.
* {{Expy}}: Clearly resembles Rasputin.
** Also looks a lot like [[VideoGame/ResidentEvil2 the T-103/Mr. X]], leading to some early speculation that he was one.
* GeniusBruiser: His notes reveal him to be very good at planing traps for Leon and that he's smart enough to know the problems he and Luis can cause. This doesn't stop hum from being very dangerous foe.
* HalfTheManHeUsedToBe: When half of his health is depleted during his Boss Fight, his upper body rips away from his legs, forcing him to climb on the rafters to attack you.
* HandicappedBadass: Has a [[RedEyesTakeWarning red]] GlassEye in his left eye socket. It does little to slow him down.
** ChekhovsGun: The glass eye serves as a key out of the village.
* ImplacableMan: Has shades of this pre-OneWingedAngel, as Leon's completely unable to overpower the giant village chief when they encounter each other.
* KnightOfCerebus: He is a very serious threat to Leon.
* LargeAndInCharge: Serves as a contrast to Salazar's MisterBig.
* LightningBruiser: Pre-OneWingedAngel, at least. When Leon first enters the barn, Mendez practically {{Flash Step}}s across his line of sight, then appears behind him.
* MookLieutenant: He's in charge of the villagers.
* NeckLift: Has a habit of doing this to Leon whenever they meet.
** NeckSnap: He will do this to Leon if you fail the Quick Time Event before his Boss Fight.
* OneWingedAngel: Resembles some manner of monstrous praying mantis.
* PragmaticVillainy: After Leon is infected with a Plaga, Mendez almost strangles him to death, but when he sees the tell tale [[RedEyesTakeWarning red eyes]] of a Plaga host, he spares him. It doesn't last long.
* TheQuietOne: He only speaks once in the entire game, to foreshadow Leon's status as a Plaga host, but otherwise settles for quietly glaring.
* StarterVillain: He's the first major bad guy Leon encounters, and he serves as the main boss of the village section of the game.

[[folder: Mike]]

Leon's evac personnel. A good deal of Leon's story involves him attempting to get extraction from him, and Mike even gives missile assistance late in the game.
* FlatCharacter: Sadly, he only gets a couple of lines.
* EscortMission: Inverted. By all accounts, he is escorting you.
* GatlingGood: His helicopter's armed with one.
* TheCavalry
* INeedAFreakingDrink: He and Leon agree they both need a drink after the game. [[spoiler:Too bad his helicopter is immediately blown up after that, and him with it.]]
* TalkingIsAFreeAction: Averted. Pausing to talk to Leon about bars was his fatal mistake.

[[folder: Las Plagas and Hosts]]
Behavior-altering macroparasitic organisms that infest other life forms and compel them to form hive-like social structures, existing only to spread and to defend the group, though they leave behind some human intelligence unlike the T-Virus zombies. First unearthed centuries ago in a remote part of Europe, implicitly somewhere near Spain, they became the centerpiece of a mad cult, Los Illuminados, before being sealed away by the Castellan of the region. Generations later, Ramon Salazar, eight of his line, unearthed them from the depths of his castle and revived the cult, which made plans to spread itself to the United States of America.

Although that plan was thwarted by Leon Kennedy, samples of the plagas were recovered and joined the T-Virus and its derivatives on the bio-terror black market. Tricell would later develop and deploy genetically upgraded Type 2 and Type 3 Plagas in the African country of Kijuju, and derivatives of the Type 2 Plaga would be used as bio-weapons in the Eastern Slav Civil War incident.

The hosts of Las Plagas are referred to as Ganados (literally "The Herd" or "The Cattle") in Europe and as Majini (literally "Wicked People") in Africa.
* AnAxeToGrind: Handaxes are among the many weapons commonly carried by Plaga hosts.
** The Executioner Majini carries an ''enormous'' executioner's axe/[[DropTheHammer sledgehammer]] hybrid as a melee weapon.
* AttackItsWeakPoint: Exposed Plagas are generally the only way to quickly take down their hosts.
** Garradors ''cannot'' be killed any other way, due to being covered in thick armor.
** Duvalias can only be harmed by attacking the "tail" made from their host body's shredded upper torso that they drag behind them.
* BigCreepyCrawlies: On a technical level, the Plagas themselves, which as macroparasites are much larger than the viruses that were used in earlier games. The more mature Plagas look sort of like bugs and other creepy crawlies; centipedes, worms, spiders, leeches, and other squiggly things you'd find under a rock.
** The Novistadors are Plaga-based insect hosts which look something like a locust, something like a mantis, and something more like something out of an entemophobe's nightmare. They're giant flying bugs that can ''turn invisible'' and ''melt your face off with HollywoodAcid'' to eat your brains.
* BeardOfEvil: Ndesu are basically El Gigantes from [=RE4=] with a thick beard
* BodyHorror:
** Averted with most general Plaga hosts; it's the fact you can't tell that they're infected that makes them scary.
** Played straight when Plagas expose themselves in response to damage. Most generally emerge from the neck, bursting the head in the process, but upgraded versions can burst through the entire upper body and create a massive jaw on human legs.
** The Marshland Majini, the members of the Ndipaya and Sodibaya tribes infected with the experimental Type 3 Plagas, play it straight, with corpse-green skin, flayed-looking arms, hearts that have swollen until they visibly burst through the chest, and cheeks that rot away to expose a permanent rictus snarl of teeth.
** Ndesu's body is covered in crudely-stitched gashes, from which ''huge'' leech-like Plagas burst forth after it takes enough damage.
** Regeneradors and Iron Maidens have mutated into {{Monstrous Humanoid}}s with rubbery grey skin that pulsulate, appendages that they can extend to inhuman lengths, triple-jawed, otherwise featureless faces, and they self-repair by growing Plaga tentacles. Not to mention, the Iron Maiden literally has spikes coming out of its every single skin surface.
** U3 has a tentacle in lieu of an arm, an oversized lolling tongue, a lower jaw that's crudely broken into mandibles, and has mutated into a vaguely tauric body configuration composed of what seems like three or more human bodies.
** Dominant Strain Plagas take everything bad about how normal plagas emerge from their hosts, turns them to the top rank and customizes them to how their hosts want. Mendez walks around with an inhumanly long and fully exposed spine as well as tentacle spikes grown out of his shoulders, Salazar (merged with the Queen Plaga and a Verdugo) turns into a monstrous tentacle head that grows out of a flesh wall, Krauser's arm turns into a giant scythe, Saddler has legs that are bigger than his entire body burst out of his neck, carrying his face with an eye in the mouth.
* BreakoutCharacter: The Chainsaw Man is consider one of the franchise most popular enemy to the point that every game after [=RE4=] have their own chainsaw wielding creature (Chainsaw Magini, Scagdead, Ubistvo, Mutated Pedro, Jack Baker and Mia Winters). A chainsaw-wielding zombie also appears in the fifth Resident Evil movie.
* ChainsawGood: Both the Spain and Kijuju outbreaks have special Plaga hosts who carry chainsaws as weapons (Dr. Salvador and the Bella Sisters in Spain, the Chainsaw Men in Kijuju). These mini-boss characters can soak up a disproportionately high amount of damage and dish out a OneHitKill attack.
* CombatTentacles: The "Plaga Type 1 A" from the European outbreak and the "Cephalo" Type 2 from the African outbreak both wield a strange combination of this and EpicFlail. The Type 1 A is a shapeless mass of tentacles, with one huge tentacle tipped with a serrated bone blade, which it whips around to hack Leon with. The Cephalo is a tentacle/centipede hybrid that ends in jagged spurs of bone; it spins itself around and around in constant arcs as the host strides forward, slashing at anyone in its way.
* DeadWeight: The aptly named "Big Man Majini", a hulking and stout-bodied Type 2 Plaga host with SuperToughness and SuperStrength, sits somewhere between this and FatBastard.
* EliteMooks: Both outbreaks have specialised Plaga hosts who aren't "true" bosses, but are much, much more dangerous than the normal Plaga hosts. The chainsaw-wielding Dr. Salvador, Bella Sisters, and Chainsaw Men are {{Mighty Glacier}}s who can dish out a OneHitKill. The Garradors are armored {{Lightning Bruiser}}s who can only be hurt if you AttackItsWeakPoint. The Regeneradors and Iron Maidens have a HealingFactor that makes them almost impossible to kill without specialised equipment and precise aim. The Executioner Majini is a massively powerful MightyGlacier. The Big Men and Giant Tribal Majini are both MadeOfIron even by Majini standards and deal far more damage than their basic comrades.
* {{Expy}}: The Verdugos look a ''lot'' like the titular xenomorph from ''Franchise/{{Alien}}''.
** El Gigante and Ndesu are clearly based on the Cave Troll from Film/TheLordOfTheRings
* FromBadToWorse: The Type 2 Plaga was literally designed to be this compared to its ancestor. It spreads much more quickly, can take control of a host in seconds, and is resistant to sunlight.
** Also, the switch over from Tribal/Marshland Majini in acts 3 and 4 to Base Majini in acts 5 and 6; now ''they have guns too''.
* HealingFactor: The Plaga-based B.O.Ws called Regeneradors and Iron Maidens have this ability, but have lost their human form as a result.
* HiveQueen: The Dominant Strain Plagas, which command the obedience and loyalty of all subordinate strain Plagas -- and thusly their hosts.
* ItCanThink: What sets them apart from zombies is the fact that they have all the intelligence of a human, wielding weapons and acting strategically.
* LovecraftianSuperPower: Hosts of a Dominant Strain Plaga can command the obedience of lesser Plagas and often have far greater strength and durability, as well as a OneWingedAngel form of truly horrific appearance.
* MadeOfIron: Thanks to the Plagas' coopting of their hosts' nervous systems, those under a Plaga's control are far more resistant to pain and injury than is normally the case.
* MeaningfulName:
** ''Resident Evil 4'' started a trend to name monsters after a [[GratuitousForeignLanguage foreign word]] in the game's foreign setting, which ''5'' and ''6'' followed. In ''4'', some of the monsters have full Spanish names:
*** Las Plagas itself literally means "the plagues".
*** Spanish plaga hosts are called "Los Ganados", meaning "the herd".
*** The salamander monster in the village lake is called "Del Lago", meaning "from the lake".
*** Wolves infected with plagas are called "Colmillos", meaning "fangs".
*** El Gigante is simply "the Giant".
*** Garrador roughly translates as "the clawer".
*** The invisible insect monsters in the castle are called Novistadores, meaning "the Unseener".
*** The plaga infested armors in the castle are called Armadura, literally "armor".
*** Verdugo means "executioner".
** The various Type 2 Plagas in ''5'' receive these kinds of names from Swahili; the spider-like unhosted adults are referred to as "Bui Kichwa" ("Big Spider Head"), the head-replacing tentacle-like "Cephalo" ("Head", and short for the Kenyan root vegetable "Cephalopentandra"), the flying bat-leech "Kipepeo" ("Butterfly") and "Duvalia" (after a kind of African carrion-flower). The name "Majini", which refers to the infected hosts, translates to [[DemonicPossession "Evil Spirit"]].
* MercyKill: Plagas latch onto the spinal column and are virtually impossible to extract, so once they have control, killing the host is really this.
* MoreDakka: The Base Majini all wield AK-74s, having enough of their old minds to shoot guns, but not really enough to aim very well. Taken UpToEleven with the Gatling Gun Majini (and their spiritual predecessor, J.J the unique Gando), who all wield [[GatlingGood massive gatling guns]].
* MoreThanMindControl: As Plagas take over the brain and nervous system as part of their parasitism, they alter the host's behavior, causing them to descend into savage barbarism.
* NoWomansLand: Zigzagged; there are female hosts, but these generally only appear in the first region and are far rarer than males, being replaced entirely by male hosts in later areas. Somewhat justified; there were plans for female Zealot Ganados, but these were scrapped, and the "Mercenary Ganados" are, well, based on mercenaries, so they wouldn't be likely to have any female members. Meanwhile, the Type 3 Plagas from the Kijuju incident are genetically incompatible with female and child hosts, killing them if they try to infect them.
* OneHitKill: Chainsaw-wielding hosts, the centipede-like "Type 1 B" Plaga in ''4'', and the Duvalia in ''5'' can all kill you with a single strike.
* OurDemonsAreDifferent: The Ganados worship the things (apparently being linked to the HiveMind is a religious experience) by performing HumanSacrifice and attacking anyone not part of their cult, whereas the Kijuji think they're "evil spirits" (the direct translation of "Majini") that cause the mortals they [[DemonicPossession indwell]] to go AxeCrazy. They're actually a PuppeteerParasite with similarities to ''Cordyceps'' fungi and insects.
* OurGiantsAreBigger: The ogre/giant-like El Gigante and Ndesu are massive, hugely strong and dangerously violent Plaga hosts.
* RaisingTheSteaks: Plaga-infested canines appear in both outbreaks. Spain's Colmillios lash out with CombatTentacles, whilst Kijuju's Adjules can split their heads in half to bite your player character in half.
* RedEyesTakeWarning: The eyes of a Plaga's host turn bright red once it has control. When a Type 2 Plaga infects a new host, they actually bleed from their eyes, nose and mouth as a side effect of the physical control.
* ScaryBlackMan: J.J.'s from [=RE4=] (along with their expies, the Gatling Majini from RE5) as well as Big Man Majini from RE5 fit this archetype
* SuperSoldier: Technically, any Plaga host will do, since it turns them into unnaturally tough vicious killers who feel no fear for their own lives and will hunt down anyone and kill them without a qualm. However, further experiments with Plagas have produced unique and horrifying monsters in their own right, such as the Regeneradores and their Iron Maiden cousins, the bug-like Novistadores, the salamander-based Del Lago, the insectile Verdugos, the brutal Garradors, and the hideous failed experiment "U3".
* SuspiciouslySimilarSubstitute: Several of the Majini in ''5'' are clearly based on and fulfill the same roles as some of the Ganados in ''4'':
** Chainsaw Majini is very similar to Dr. Salvador, both being chainsaw wielding EliteMooks
** Ndesu is seemingly a bearded El Gigante, although it is not fought in the same way.
** Reapers [[CompositeCharacter combine]] the worst parts of the Novistadors and Regenerators
** The Town, Wetlands, and Base Majini are roughly equivalent to the Pueblo, Zealot, and Mercenary Ganados
** Most blatantly is the Gatling Majini, which is more or less just the reused model of J.J. from ''4''
* TechnicallyLivingZombie: A Plaga's host displays some zombie like traits, such as a resistance to pain, mindless violence towards those not infected, bloodlust, savage and impulsive behaviors, and a hunger for flesh, but are still living creatures, just subsumed by the bestial urges of the parasite within them. This is slightly more pronounced in Type 2 Plaga hosts, who have an instinctive directive to "spread the infection" as far and as fast as possible.
* WeakenedByTheLight: Ultraviolet light is anathema to Plagas. Consequently, Type 1s won't expose themselves until night falls. Type 2s have had this trait weakened and so will operate in the day without harm. Both types, however, cannot withstand the concentrated light released from a Flash Grenade, making these {{Trick Bomb}}s a OneHitKill weapon against them.