!![[center: [-''WesternAnimation/{{Animaniacs}}'' '''[[Characters/{{Animaniacs}} Main Character Index]]'''\\
[[Characters/AnimaniacsTheWarnerSiblings The Warner Siblings]] | '''Pinky and the Brain''' | [[Characters/AnimaniacsSlappySquirrel Slappy Squirrel]] | [[Characters/AnimaniacsGoodfeathers Goodfeathers]] | [[Characters/AnimaniacsRitaAndRunt Rita and Runt]] | [[Characters/AnimaniacsButtonsAndMindy Buttons and Mindy]] | [[Characters/AnimaniacsOtherSupportingCharacters Other Supporting Characters]] -] ]]

"Gee Brain, what do you wanna do tonight?"\\
"The same thing we do every night, Pinky --- try to {{take over the world}} by reading the character tropes about [[WesternAnimation/PinkyAndTheBrain our]] [[WesternAnimation/{{Animaniacs}} car]][[WesternAnimation/Animaniacs2020 toons]]!"\\
"But are there any unmarked spoilers on this page, Brain? Narf!"\\
"Definitely, Pinky. Tropers, Administrivia/YouHaveBeenWarned."

[[foldercontrol]]

!The Main Duo

[[folder:General]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/pinky_and_the_brain_1.jpg]]
[[caption-width-right:350:One is a genius, the other's insane. You tell us which is which.]]

The main duo. If you would like to see how they would describe themselves and each other, go to [[SelfDemonstrating/PinkyAndTheBrain their self-demonstrating page]].
----
* AreYouPonderingWhatImPondering: The TropeNamer. OnceAnEpisode Brain asks Pinky if they're thinking the same thing, only for Pinky to say something idiotic, which in turn causes Brain to DopeSlap Pinky. In one instance, they even [[LampshadeHanging lampshade]] the whole bit.
-->'''Brain:''' Pinky, are you pondering what I'm pondering?\\
'''Pinky:''' Whoof, oh, I'd have to say the odds of that are terribly slim, Brain.\\
'''Brain:''' True.\\
'''Pinky:''' I mean, really, when have I ever been pondering what you've been pondering?\\
'''Brain:''' To my knowledge, never.\\
'''Pinky:''' Exactly. So, what are the chances that this time, I'm pondering what you're pondering?\\
'''Brain:''' Next to nil.\\
'''Pinky:''' Well, that's exactly what I'm thinking, too.\\
'''Brain:''' Therefore, you ''are'' pondering what I'm pondering.\\
'''Pinky:''' Poit, I guess I am!
* BigGuyLittleGuy: Pinky is the Big Guy to Brain's Little Guy, although Pinky is not any stronger than Brain.
* BreakoutCharacter: The duo's segments proved to be among the most popular to viewers that they were the only ones to have received a [[WesternAnimation/PinkyAndTheBrain spin-off]] and a [[WesternAnimation/PinkyElmyraAndTheBrain sequel]] to said spin-off. As a result, the theme song to ''Animaniacs'' no longer mentioned the two, replacing the lyrics "Meet Pinky and the Brain who want to rule the universe" with "Meet Ralph and Doctor Scratchansniff, say hi to Hello Nurse". Their popularity played a part in why they were the only returning characters besides the Warners in the 2020 series. As a result, their ThemeTune (and they themselves) are even more popular and more referenced by others than even '''Warners''' themselves.
* GleefulAndGrumpyPairing: Pinky is the Gleeful (cheerful and kind) and Brain is the Grumpy (short-tempered and sarcastic).
* HeterosexualLifePartners: They're rarely seen apart and both have been shown to be devastated if one were to leave or betray the other. Brain has even repeatedly stated that the goal is for him to rule the world ''with'' Pinky, and has never even considered of sacrificing him or abandoning him once his goal is reached.
* IronButtMonkey: Both of them suffer physical abuse regularly. However, Brain gets the worst of it.
* ResourcefulRodent: Brain routinely concocts [[Franchise/JamesBond Bond villain-esque]] plans to take over the world, some of which nearly succeed. Meanwhile, Pinky, despite his psychosis, is remarkably good at improvising when Brain hits a wall.
* RudeHeroNiceSidekick: The Brain is an InsufferableGenius who is mean and condescending to everyone, while Pinky is a MinionWithAnFInEvil who still likes and admires Brain, no matter how much abuse he gets from him.
* SmartJerkAndNiceMoron: Pinky is a [[KindheartedSimpleton kindhearted goofball]] and Brain is the [[InsufferableGenius more snarky, sarcastic & short-fused genius]].
* TakeOverTheWorld: The main draw of their skits is the duo's various, convoluted attempts to try and take over the world. Most episodes naturally end in failure, but the times they do succeed ends with them losing that chance or giving it all back.
* VileVillainLaughableLackey: Of the VillainProtagonist variant. While neither one is very threatening physically (what with being lab mice and all), the Brain, with his serious demeanor and great intellect, is far more of a threat than the spastic, dimwitted Pinky, who isn't even aware that he's a villain.
* VillainProtagonist: They are the main characters whose main goal is world domination, though they are rarely out-and-out villainous.
[[/folder]]

[[folder:The Brain]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/Brain10_7439.jpg]]
[[caption-width-right:350:"I am a mind -- a Brain! I am ''[[SpellMyNameWithAThe the]]'' [[SpellMyNameWithAThe Brain]]!"]]
-> Voiced by: Creator/MauriceLaMarche (English), Creator/KenichiOgata (Japanese), Orlando Noguera (Latin American Spanish), Hércules Franco (Brazilian Portuguese), Creator/PierreHatet (French), Creator/GunnarErnblad (Swedish)

A genetically altered lab mouse with a large head who plans to -- you guessed it -- TakeOverTheWorld.
----
Tropes associated with The Brain:
* AdaptationalJerkass: Brain is much more abusive and outright evil in the ''Animaniacs'' revival. Somewhat Justified as Creator/MauriceLaMarche claims this is caused by Brain cracking under the stress of constant failure for the past 27 years. He still has his occasional nice moments, however.
* AdaptationalVillainy: He and Pinky are {{antihero}}es at best and {{Villain Protagonist}}s at worst in their own show, but they're the antagonists of the video game. He also TookALevelInJerkass for the reboot, and is crueler and more malicious in his methods. Pinky even commented on this once.
* AffablyEvil: The Brain intends to rule benevolently for the good of all, but he ''does'' intend to become the unquestioned dictator of the Earth. In person, he's amiable enough (unless you're Pinky and you've just said something so stupid that the only proper criticism is a sharp smack).
* AmbiguouslyEvil: His attempts to TakeOverTheWorld are the whole point of the series, which you could argue qualifies him as evil, but he is genuinely trying to change it for the better. Beyond that, he doesn't do anything particularly villainous. It's also heavily implied that the world really ''would'' be better off if he took over. However, he ''does'' admire many of the great autocrats of history, including unambiguously evil ones like UsefulNotes/SaddamHussein.
* AntiHero: Brain is constantly trying to take over the world -- hardly heroic -- but he is good-natured (when not hurting Pinky) and truly believes that the world would be a better, happier place if he was in charge; this is justified by portraying real world's leaders as either egotistic, incompetent or plain crazy (or all at once). Also compare to his archrival Snowball, a sadistic villain whom Brain feared would destroy the world if he ruled it.
* AntiVillain: If you interpret him as a VillainProtagonist, though he really blurs the line between this and AntiHero. After all, the rest of the world is portrayed as so messed up and idiotic, so him taking it over might actually lead to some form of utopia.
* AreYouPonderingWhatImPondering: I think so, TropeNamer, but what does having a Website/TVTropes article have to do with taking over the world?
* AwesomenessByAnalysis: You wouldn't think it by looking at him, but if a physical action or sport can be reduced down to physics or mathematics, Brain can do it flawlessly.
* BadBadActing: Doesn't act so much as read his lines. His ''physical'' acting is just fine though -- in "Brain's Song", he bounces a lemon-football around like a basketball during a live broadcast, and in "Cinebrainia" he essentially becomes a silent-film comedy actor this way.
* BerserkButton: Downplayed in the sense that he doesn't go blind with rage, but there are two things that he will give top priority to -- saving Pinky, and stopping Snowball.
* BigYes: Essentially what one of his {{Catch Phrase}}s is.
* BreakTheHaughty: This Old Mouse.
* CartoonyTail: He has a tail like a real mouse, except it is kinked in a way that it looks like stair steps. It's eventually revealed in "The Rodent Trip" that it was once normal-shaped, and became kinked after he was repeatedly shocked in the same Acme Labs experiment that acts as his FreudianExcuse.
* CharacterCatchphrase:
** "AreYouPonderingWhatImPondering"
** "''[[BigYes Yes!]]''"
** "I'm going to have to hurt you."
* CityMouse: Becomes TheLoad in outdoor and non-technical situations.
* TheComicallySerious: He can provide some laughs solely because of his stoic personality and having to deal with Pinky's dim-witted antics.
* CreativeSterility: Seems to be a pet worry of his. A couple of episodes focus on him worrying about how he can't come up with a new plan.
* DeadpanSnarker: Seems he can't tell a normal joke though.
* {{Determinator}}: Tonight's plan failed? Start planning for tomorrow night. Repeat as needed.
* DidntThinkThisThrough: Sometimes Brain's plots will fail because of something he didn't consider or something Pinky actually warned him about.
* DitzyGenius: His plans are quite brilliant, but tend to lack common sense.
* DrBrainpart: Names himself after his superior mouse brain size. [[MeaningfulRename Note that this is not his original name.]]
* DubNameChange: He is named "Cortex" in the European French dub.
* EnragedByIdiocy: When Pinky says something stupid, he insults him and hits him on the head.
* EvenEvilHasStandards:
** His refusal to sell his soul for world domination in the HalloweenSpecial. Usually, an aversion, since he was never particularly evil to being with, and has enough scruples that he doesn't ''need'' Pinky to be a MoralityPet... most of the time.
** In another episode involving time travel, one of Brain's plans ends up rewriting history so that the population of the world consists entirely of moronic Pinky clones. Brain is so horrified that he immediately plans to go back in history to set things right. Pinky asks Brain why he plans to do that because with a population like that, it would be easy to rule the world. Brain confirms that Pinky is right... but who would ''want'' to?
** One VerySpecialEpisode against smoking has Brain playing Brainy The Elf, a spokesman for the tobacco industry, who use him as a mascot to get children to smoke. While he initially planned to put an additive in the tobacco as part of a plan to take over the world, he has a MyGodWhatHaveIDone when he sees children about to start smoking, and turns against the tobacco industry.
** In ''Wakko's Wish'', when Dot is seemingly killed by King Salazar, Brain looks just as horrified and distraught as everyone else.
* EvilGenius: Subverted, in a couple of ways -- he ''is'' a genius, but Brain works for himself and was never particularly evil in the traditional sense (he'll take direct action against actual evil) -- but we don't have "AntiHero Genius" as a trope yet.
* FatalFlaw: His lack of common sense. He has a few other glaring flaws, but this is what kills his nightly plan the most.
* FourLegsGoodTwoLegsBetter: Walks and runs upright as a rule, even in the mouse wheel.
* FutureMeScaresMe:
** In "This Old Mouse", Brain invented a way to see the future and is terrified upon seeing an elderly Brain still [[FailureIsTheOnlyOption trying]] to take over the world.
** In the reboot, Brain ends up meeting his future self in one episode, who tries to steer him away from Pinky under the claim that Pinky would betray him. Brain figures his future self has gone delusional on account of knowing Pinky to be too dense and loyal to ruin his plans intentionally.
* FreudianExcuse:
** Being taken from his home and family when he was younger. Where were they living? A can with a globe (i.e. the world) on it.
** As a lab mouse, he's subject to testing; in "Where No Mouse Has Gone Before" at least, he holds a mild grudge over this.
** It is suggested in "Project: B.R.A.I.N." that his desire to take over the world stems from his shame at never getting a chance to show the research scientists his newfound intellect.
** In "Rodent Trip" Brain reveals that his desire to take over the world is a result of his being used as a subject for experiments in [[https://en.wikipedia.org/wiki/Learned_helplessness learned helplessness]]. He wants to take over the world so he will never be powerless again.
* FriendlyEnemy: He tries to be this to Snowball. It never works, though.
* GadgeteerGenius: Brain's strongest suit. Quite often, the gadget or means to world domination is assumed to be an automatic success, and their 'twilight campaign' is typically the duo filling in a minor cog in the plan. However, it only applies to ''gadgets'' -- take away his lab access, and he's completely lost.
* GladIThoughtOfIt: Averted...? Though he ''will'' criticize the original comment as being unhelpful or irrelevant, quite a few world domination plans happen to be Brain's extrapolation(s) of something Pinky said or did, and he's more than happy to dole out credit for it.
* GuileHero: ...''Hero'' might be pushing it a little, but he shows a clear preference for plans involving as little physical violence as possible, with (temporary) MindControl and other forms of influence being favorites.
* HiddenHeartOfGold: It has been proven on numerous occasions that behind the megalomaniac outer layer lies a complete softy who cares deeply about the ones he loves, especially Pinky. The Christmas Special has to be the best example of his sweeter side. He also
* HisOwnWorstEnemy: Brain could take over the world... if he wasn't blinded by his own ego or accounting for Pinky messing it up. His robot son B.R.A.I.N. even points this out, that Brain's plans are too complicated while putting him at the center of attention. It's even suggested at one point that he's sabotaging himself because if he got what he wanted, then he would lose his purpose. Brain treats that as an IgnoredEpiphany.
* HoistByHisOwnPetard: The nightly plan for world domination usually fails because of something Brain did that boomerangs on him, such as trusting Pinky with a crucial part of the plan (more common early on), or some [[ChekhovsGun minor detail]] that turns out to be a lynchpin. Sometimes it's not even Pinky's incompetence but Brain's reaction to it that wrecks his plans.
* IndyPloy: Averted. Brain's not all that good at dealing with a SpannerInTheWorks that he didn't account for (separate from his lack of common sense), though this is due to an element he ''couldn't'' have predicted as often as it is just him dismissing something as irrelevant. In some cases, the plan gets as far as it does on [[BornLucky sheer dumb luck]].
* InsaneTrollLogic: Every so often, he concocts a plan so farfetched, it's hard to imagine how exactly he expects to go from step one to world domination. B.R.A.I.N. even lampshades this in the reboot, telling him using the moon to mess with astrology is stupid when he could use it to control the tides and force the world to surrender.
* InsufferableGenius: He is usually condescending to everyone. Although he's pretty tolerable compared to Snowball...
* IntellectualAnimal: A scheming, inventive, and amazingly well-educated mouse.
* IronButtMonkey: Usually gets it worse than Pinky.
* JerkWithAHeartOfGold: It's implied that he ''does'' have a small soft spot for Pinky deep down. And by 'implied', we mean 'all but publicly stated with a megaphone from the rooftops'. (It's most obvious when he thinks he might have accidentally hurt or killed Pinky through a device.) Multiple times he has stated his conquests as "our," and though he repeatedly snarks at Pinky, he would go out of his way to help him, even if it means aborting every single plan.
* KavorkaMan: Has no trouble attracting women when playing a human.
* KickTheDog: Brain has a few moments in the revival series.
** "Pinko and the Brain": He starts an anti-mouse campaign during the Red Scare, leading to the Mouseketeers being arrested. Even Pinky questions the morality of this, pointing out they are mice and it's hypocritical. Fortunately, Brie interferes and exposes them.
** "Mousechurian Candidate": Brain plants an obedience chip in Julia's brain. He had also planned on using child labor to build bombs (though this is only stated in a single throwaway line).
* LargeHam: His voice actor described Brain as "65% Creator/OrsonWelles, 35% Creator/VincentPrice."
* LaughablyEvil: To a large extent, even though he's TheComicallySerious. To quote him, "I am not devoid of humor."
%%* LetsGetDangerous
* MeaningfulRename: Whatever his name was before, he goes by 'Brain' now. In the Italian dub, his name is [[DubNameChange "Prof"]] (short for professor). Subverted in the French dub where his name is "Cortex".
* MobileSuitHuman: His mech suit is a human body... that has ''no fake head''.
* MultipleChoicePast: His origin and/or reasons for taking over the world are never the same. In one episode of the SpinOff where he was psychoanalyzed by Sigmund Freud, it was shown that he wanted to rule the world to reclaim what he lost when he was captured by Acme Labs[[note]]His family lived in a can with the Earth on the label[[/note]]. In another episode, his transformation happened alongside Snowball after an accident. Yet another one showed that he and Pinky were experimented on as part of Project B.R.A.I.N. (where he got his name) and set out to take over the world to prove his worth. Finally, in the reboot he reveals to Pinky that when he was a normal mouse, the scientists experimented on him by having him electrically shocked every time he tried to eat a piece of cheese, driving ''him'' to want to be the puppetmaster.
* MyBrainIsBig: You only need one look at the title characters to know which is the smart one.
* MyGreatestFailure: In "All's Fair in Love and Door", he admits that it's his fault Julia went crazy and he genuinely regrets it.
* TheNapoleon: He is short and very passionate (specially when he's angry), so that's a given. An episode even has him taking the place of UsefulNotes/NapoleonBonaparte himself!
* NobleDemon: Wants to conquer the world to make it a place of kindness, equality, and happiness for all. In the original series of ''Animaniacs'' and ''Pinky and the Brain'', he showed there were some lines he wouldn't cross.
* NoCelebritiesWereHarmed:
** Creator/OrsonWelles. One ''Animaniacs'' skit even had Brain mimicking the "frozen peas" take.
** Possibly UsefulNotes/MaximilienRobespierre as well, or at least [[DatedHistory the popular conception of him as a power-hungry]] intellectual driven mad with power.
* PaperThinDisguise: When not using a mech suit as part of it, a lot of his human disguises are just himself with a wig. Even with the suits, his head is exposed, and sometimes includes a wig.
* ParentalAbandonment: One episode gave it as his FreudianExcuse. He meets his parents again in another episode; it doesn't exactly work out.
* PragmaticVillainy: In "A Meticulous Analysis of History", Brain espouses the view that historical rulers like UsefulNotes/AttilaTheHun and UsefulNotes/{{Caligula}} were thwarted by their own senseless brutality and warmongering, which is part of the reason why his own plans for world domination are almost always nonviolent.
* SarcasticConfession: Quite often, Brain will be forthright with people that he and Pinky are lab mice scheming to take over the world. Whoever he says this to thinks he's just joking around (and that's probably what he intends).
* SesquipedalianLoquaciousness: He can speak in layman's terms when he wants to (he switches over when dealing with people as part of the nightly plan), and Pinky understands him just fine most of the time. It's only gotten in the way of a plan when he tried to be a stand-up comedian -- even then, he became popular as a highbrow insult comic.
* ShorterMeansSmarter: He and Pinky provide the page image. Even though they're genetically engineered lab mice and already pretty small by default, Brain is shorter than Pinky, who is a {{Cloudcuckoolander}}.
* SophisticatedAsHell: He doesn't dabble in this too often, but it's there. "Opportunity Knox" provides this little gem when they take the Lab's van:
-->'''Brain''': Now Pinky, let us, in their vernacular, take this hog out on the road and show who's boss.
* SpellMyNameWithAThe: 'The Brain', though in practice it's more of a 'full name' thing and he's not particularly insistent about it.
* TakeOverTheWorld: He tries to, but always fails.
* TechnicalPacifist: There's a number of explanations for it, but Brain's plans rarely involve direct physical harm for anyone, even when that would greatly simplify things.
* ThrowTheDogABone: In ''Wakko's Wish'', the Warners make him Prime Minister and charge him to run their kingdom, since they're just kids and don't know how government policy works. Brain is actually happy with this because he got his wish, on a small scale. While he tells Pinky they'll take over the world in the sequel, they'll lay low for now and focus on taking over the kingdom, and making it better at the same time.
* TVGenius: Averted. Though he's a brilliant engineer and scientist, he clearly has social skills (as well as a low tolerance for stupidity), and is sometimes seen studying.
* UpliftedAnimal: Due to being part of the B.R.A.I.N. project, Brain was turned from a normal field mouse into a super-intelligent talking mouse prone to human behaviors.
* UtopiaJustifiesTheMeans: He wants to take over the world, sure, but it's implied he really plans to make the world a better place for everyone.
* VillainProtagonist: Brain can be interpreted this way, since his goal after all is to take over the world.
* VillainsNeverLie: Parodied. Whenever Brain uses his mech suit and is asked why his head looks like a mouse, instead of coming up with an excuse (i.e. skin condition), he outright '''tells them the truth''' in a SarcasticConfession... and they laugh it off.
* VitriolicBestBuds: Brain supplies all the vitriol, Pinky cheerfully thinks ([[HeterosexualLifePartners rightly]]) that they're best buds.
* VocalDissonance: He's a mouse who's tiny even for his species that has the voice of Orson Welles. His rather baggy eyes do make his voice seem a little less out of place though...
* VocalEvolution: His voice is slightly higher in the 2020 reboot and gains Orson Welles' mid-Atlantic accent, which he prevously lacked.
* WellIntentionedExtremist:
** It's not often you get a character who wants to TakeOverTheWorld so he can change it for the ''better'', but there you go.
** This was a bit of CharacterDevelopment on Brain's part; the notion of making the world better was a result of events in the episode "Megalomaniacs Anonymous" ...and even then, he's still doing it just a little for his own ego.
** Even before that, there's every indication that he plans to rule the world far more benevolently than Snowball.
** There are even quite a few implications that if he succeeded, the world actually ''would'' be better off -- in the ''WesternAnimation/{{Freakazoid}}'' episode "Freakazoid is History", Freakazoid inadvertently changes history and finds himself in a world where the Brain is president of the United States and the world is better off for it -- among other things, cold fusion works and Creator/SharonStone [[TakeThat is a good actress]].
* {{Workaholic}}: The other side of being a [[TheDeterminator Determinator]], and occasionally to an uncomfortable degree. ("This Old Mouse" points out that he's around 2 human years old, and can [[WeAreAsMayflies expect to reach 4]].)
[[/folder]]

[[folder:Pinky]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/Pinky08_8.jpg]]
[[caption-width-right:350:"[[MadLibsCatchPhrase I think so, Brain, but]] [[AreYouPonderingWhatImPondering then I would have to know what pondering is, wouldn't I?]]"]]
-> Voiced by: Creator/RobPaulsen (English), Hideyuki Umezu (Japanese), Frank Carreño (Latin American Spanish), Alexandre Moreno (Brazilian Portuguese), Creator/VincentViolette (French), Niclas Wahlgren (Swedish)

Another genetically engineered lab mouse: the Brain's closest friend, devoted assistant and part-time SpannerInTheWorks.
----
Tropes associated with Pinky:
* AdaptationalJerkass: He noticeably shows more of a jerkish side to him in ''WesternAnimation/PinkyElmyraAndTheBrain''. Lampshaded by the Brain in "My Fair Brainy".
-->'''Brain:''' You used to be a hindrance. Now you're a hindrance with an attitude.
* AmbiguouslyBi: There's a lot of examples for this. For example, Pinky doesn't seem to care much that Brain and him have literally had a son together (compared to Brain) nor does he mind acting as Brain's wife from time to time. In the comics, there's a lot more of innuendos about this. It could be because of a type of comedy used as a caricature of heterosexual couples in the 50's.
* AntiHero: An example of ClassicalAntiHero.
* AntiVillain: The only reason he's a villain at all is because he helps Brain.
* AttentionDeficitOohShiny: This is ''much'' more common earlier on, but continues to play a large role in his side of the "AreYouPonderingWhatImPondering" exchange.
* BadLiar: In the reboot, he mentions that he hates lying because he's not good at it. Brain later forgives him for spilling the beans during their Red Scare plot because he put too much pressure on him.
* BreakTheCutie: "A Pinky and the Brain Christmas", "A Pinky and the Brain Halloween", "That Smarts: and "The Pink Candidate" to name a few episodes. He can easily go from PluckyComicRelief to {{Woobie}} under the right conditions.
* BumblingSidekick: Though Brain clearly trusts him as an assistant, and they both think of it as a partnership[=/=]friendship anyway.
* CharacterCatchphrase:
** "I think so Brain, but [*improvises idea that has nothing to do with taking over the world*]" after Brain's AreYouPonderingWhatImPondering.
** "NARF!"
** "Poit!"
** "Zort!"
** "Troz!"
** "Oh, wait... no, no..." [always said before he points out a flaw in one of Brain's plans]
* {{Cloudcuckoolander}}: In particular, he has a tendency to bring up celebrities at random and he always replies to Brain's statements of "Are you pondering what I'm pondering" with a completely irrelevant question.
* TheCloudcuckoolanderWasRight: Every so often Pinky will bring up a "flaw" with one of Brain's plans that seems completely illogical and random, but often turns out to be exactly how the plan ends up failing.
* CrouchingMoronHiddenBadass: While he may be a massive {{Cloudcuckoolander}}, when he gets his act together, he can come up with plans to take over the world that actually WORK.
* TheCutie: In contrast to Brain, he's usually cheerful and lovable.
* ADogNamedDog: The less obvious version -- "pinkie" is a term for a newborn mouse (or other rodent), due to their lack of fur at birth.
* TheDragon: Generally TheLancer, as his {{Cloudcuckoolander}} status makes him a less than useful Dragon.
* DubNameChange: He is named "Minus" in the European French dub.
* DumbassHasAPoint: Subverted. Despite his {{Cloudcuckoolander}} status, Pinky is quick to realize and point out the logical fallacies regarding a plan's logistics only for Brain to have already taken them into account.
** He once defied the usual AreYouPonderingWhatImPondering schtick in "Brain Food" by pointing out to Brain that they've never been on the same page when he asks that and even questions the odds that for once it would work. In an odd way, Brain realizes they kind of were pondering the same thing, just not about his latest plan.
** Played straight in the reboot when he points out to Brain that their plan to scapegoat mice during the Red Scare is a bad idea because Pinky can't lie for him well, and ''they'' are mice so the plan can go wrong.
* DumbIsGood: Though, when events conspire to make him 'smarter' than usual, he doesn't get any less good.
* FirstPersonPerspective: One episode is done entirely from [[ThroughTheEyesOfMadness Pinky's literal point of view]], revealing that Pinky's flights of fancy take on literal form in his eyes (for instance, Pinky ruminates about hippos when listening to Brain. Brain turns into a hippo). Capped by a first-person perspective view of what it is like to be blasted out of the Space Needle.
* FourLegsGoodTwoLegsBetter: Usually walks upright, but runs on all fours in the mouse wheel.
* GeniusDitz: The theme song doesn't specify ''which one of them'' is the genius or insane... But in a more literal sense, Pinky's wide-ranging knowledge of pop culture (current and past) comes in handy from time to time -- and he supplies them with no hesitation whatsoever. It's worth noting that, by mouse standards, Pinky ''is'' genuinely a genius: he's capable of speech, tool use, and higher-level reasoning. It's just that, by human standards (to say nothing of ''the Brain's'' standards), he's kind of a dim bulb.
* GeniusSerum: One episode had Brain decide that it's [[TheMillstone Pinky's idiocy]] that causes his plans to fail, so he uses an intelligence-enhancing device to make Pinky smarter. Unfortunately for Brain, rather than helping him succeed in his world domination plans, Pinky used this newfound intellect to point out they were deeply flawed and were never going to work in the first place.
* GoofyBuckteeth: He has large buckteeth and is a scatterbrained mouse who regularly spouts {{Non Sequitur}}s.
* HiddenDepths:
** Most of the time he's goofy and hyperactive, but has a strong moral compass that shows on occasion. Particularly when he became president of the U.S for one episode and turned Brain down when he tried to get him to abuse some of his new powers because "it would go against everything I've come to stand for."
** Besides that, while he doesn't have Brain's sheer intelligence, he is still keenly observant and humanistic, and by far the more grounded of the two.
** You wouldn't think being easygoing and adaptable would ever be useful, but it saves their lives in "Welcome to the Jungle" -- Pinky manages to come up with stone age-level solutions to being trapped outside, while Brain is reduced to complete reliance.
** In the "Around The World In Eighty Days" spoof, he's trying to communicate with the locals of several given countries by using a phrasebook. He's able to pronounce languages he's never even spoken before remarkably well.
* IndyPloy: Pinky's fast talking has been the only thing keeping the plan going on many, many occasions.
* InsaneTrollLogic: A POVCam episode reveals that while Pinky mostly hears Brain's lectures as [[BlahBlahBlah constant "blah blah blah"ing]], he'll occasionally lock onto a particular word or idea, then wander down a series of bizarre associations to himself ("My, Brain has a big head. Hippopotamuses have big heads..."). When Brain asks for his input, Pinky responds with whatever thought he's currently reached in his chain. So it's not that he's speaking in non-sequiturs -- it's that his idea of logic is bizarre.
* InterspeciesRomance: With Pharfignewton (a horse), [[RhymesOnADime of course]], but also with a sea lion and a pig in other episodes (unsuccessfully).
* IronButtMonkey: Of course, Pinky doesn't really mind when Brain bops him on the head, so perhaps he's okay with it.
* {{Keet}}: He's an very hyperactive mouse.
* KindheartedSimpleton: Usually goofy and scatter-brained, but certainly nicer and happier than the Brain.
* MadLibsCatchphrase: "I think so Brain, but [*improvises idea that has nothing to do with taking over the world*]" after Brain's AreYouPonderingWhatImPondering.
* TheMillstone:
** On occasion, though Brain's plans tend to fall apart without outside help. Early on in the ''Animaniacs'' segments, he tended to be the latter ''far'' more often; by the time of the series, he's rarely even TheLoad.
** Brain at one point makes a calculation that shows it's always through Pinky's idiocy that his schemes fail, so he uses an intelligence-enhancing device to make Pinky smarter. Pinky uses this newfound intellect to point out that [[SubvertedTrope it's Brain's nonsensical plans that are doomed to fail in the first place]].
** In the ''Animaniacs'' reboot, a version of Brain from the future comes to the conclusion that Pinky is ''actively sabotaging'' his world domination schemes, which the modern Brain does not believe at all.
* MinionWithAnFInEvil: He's just too ditzy and sweethearted to realize that hanging around someone who wants to TakeOverTheWorld doesn't put you on the side of good.
* MoralityPet: On the rare occasions Brain's megalomania gets the better of him. If Pinky gets seriously hurt, physically or emotionally, Brain will pull the breaks on his latest plan.
* NiceGuy: A contrast to his friend, Pinky is a nice, though pretty dim, guy with everyone.
* NiceMice: Between the two, he balances them out to this.
* OnlyFriend: Considering Brain's plans are for world domination, it's a wonder he has at least one friend who helps him.
* PluckyComicRelief: He provides comic relief with his occasionally random comments.
* SimpletonVoice: His voice is very goofy-sounding (with what Rob Paulsen described as "a goofy whack job" of a British accent) and it matches his dim-witted nature.
* SmarterThanYouLook: There are hints that Pinky is actually very intelligent, the genius in the opening theme song, but his poor connection with reality and the fact that he's quite content with his lot in life hides it too well.
* TenderTears: Despite his cheerful personality, he cries fairly easily.
* TooDumbToLive: In the "Animaniacs Stew" segment "Pinky And The Cat", he gets devoured by Rita... ''and enjoys it!''
* TooKinkyToTorture: "This is more fun than the coat-me-in-peanut-butter-and-shove-me-in-the-anthill game!"
* TrademarkFavoriteFood: Cheese. He enthusiastically sings a song about all the cheeses of the world in "Cheese Roll Call." And when he and Brain go to a fancy restaurant on Brain's day off, Pinky is content to order macaroni and cheese rather than something fancy.
* UndyingLoyalty: To Brain, for the most part.
* UnexplainedAccent: He's a mouse who was genetically modified in a lab in California. Nevertheless, he speaks with a Cockney accent, including one of his {{Verbal Tic}}s in the early days being "Zounds". In the episode "Bride of Pinky" in WesternAnimation/Animaniacs2020, Dr. Brainenstein even points out that his assistant Pigor (Pinky) has an inexplicable Cockney accent.
* UpliftedAnimal: Part of the B.R.A.I.N. project with Brain, he too was an ordinary mouse, obtained from a pet store. Their origins episode reveals that the experiment actually had the same effects on both of them; Pinky was specifically chosen because he was the worst mouse in the lab at running mazes prior to the experiment.
* VerbalTic: Narf! Zort! Egad! Poit! Troz!
* VocalEvolution: Pinky's speech impediment is more pronounced in the earliest segments. His voice is also a notch lower in the earlier ''WesternAnimation/{{Animaniacs}}'' segments.
* TheWatson: Grows into this as the show progresses. Brain is aware of this, and will occasionally rework the plan based on Pinky's observations.
* WholesomeCrossdresser: He sometimes dresses as a woman as part of Brain's plans.
[[/folder]]

!Other Characters
[[folder:Snowball]]
[[quoteright:200:https://static.tvtropes.org/pmwiki/pub/images/Snowball_5804.jpg]]
->'''Voiced by:''' Creator/RoddyMcDowall

A hamster who was put through the same gene splicer as the mice and also schemes to TakeOverTheWorld, but does not intend on making it a better place like Brain would. As such, he is TheRival to the Brain. He's eventually changed back to an ordinary hamster in his last appearance.
----
* AlwaysSomeoneBetter: He's actually smarter and more efficient than Brain. He's also more evil and doesn't need a sidekick, making him much more dangerous.
* BroughtDownToNormal: His final appearance has him turned back into a normal hamster.
* TheCaligula: It's suggested that Brain doesn't want Snowball to win because he's insane and the world under '''his''' rule would fall into chaos.
* CreativeSterility: Despite his genius intellect, he doesn't have much imagination, and he sometimes steals Brain's world-domination plans.
* EvilBrit: He was voiced by Roddy [=McDowall=] after all.
* EvilCounterpart: To Brain, and evil enough that Brain will drop everything to stop him.
* EvilFormerFriend: He and Brain were friends before their intellects were enhanced.
* EvilGenius: He's a highly intelligent mastermind and is much less scrupulous than the well-intentioned Brain.
* FauxAffablyEvil: He may act sophisticated and polite, but he's much worse than Brain.
* FluffyTheTerrible: Snowball isn't a very scary-sounding name, but he is still a force to be reckoned with.
* FromNobodyToNightmare: From a harmless hamster to Brain's rival in achieving world domination.
* KillerRabbit: He may be a hamster, but he isn't to be underestimated.
* KnightOfCerebus: Snowball-centric episodes are always darker.
* MobileSuitHuman: Like the Brain, he also has a human mech, although he has a fully working head.
* PerpetualFrowner: He rarely smiles.
* RivalTurnedEvil: When he and Brain became highly intelligent, they turned against one another because of a disagreement on which of them should be ruler of the world. One that stems from the fact that Snowball completely lacks The Brain's noble intentions for taking over the world
* SanitySlippage: He appears to get more and more unhinged every time he comes back to battle Brain again.
* ShadowArchetype: Snowball is what Brain could've been if he didn't have Pinky as an anchor.
* SesquipedalianLoquaciousness: Like Brain, he has a large vocabulary.
* UpliftedAnimal: Formerly an ordinary hamster. Though he wasn't in the duo's origins episode, he was apparently part of Project B.R.A.I.N. like the main characters, or a related experiment.
* VillainousCrush: Like Brain, he has a crush on Billie.
[[/folder]]

[[folder:Billie]]
[[quoteright:166:https://static.tvtropes.org/pmwiki/pub/images/Pinky_and_the_brain_billie_8164.png]]
-> Voiced by: Creator/TressMacNeille

Another genetically altered lab mouse that Brain sometimes romantically pursues, despite her being as ditzy as Pinky.
----
* AbhorrentAdmirer: She becomes this towards Pinky in "Brain Noir". After Billie reveals that she loves Pinky rather than Brain or Snowball, Pinky himself is rather disturbed by Billie's advances and runs for it after she kisses him.
* DistaffCounterpart: She's basically a female Pinky.
* GeniusDitz: Her intelligence is about as high as Pinky's, but her vocabulary expands greatly after receiving electric shocks.
* LoveDodecahedron: Between her, Brain, Pinky, Pharfignewton and Snowball. Specifically, both Brain and Snowball love her, but she has a crush on Pinky, who in turn is in love with Pharfignewton.
* SesquipedalianLoquaciousness: Speaks with much less simplistic terms after being subjected to electric shocks.
[[/folder]]

[[folder:Pharfignewton]]
A grey and white race mare whom Pinky fell in love with in the segment "The Kentucky Derby". She reciprocates his feelings, but sadly, they come from different worlds... not to mention different biological orders. The relationship between them obviously disgusts Brain.
----
* InterspeciesRomance: With Pinky (a mouse).
-->'''Brain''' ''(impatiently):'' Pinky, [[CaptainObvious you are a mouse. That is a horse.]]\\
'''Pinky:''' [[DoesThisRemindYouOfAnything Oh, now don't start ''that'' again, Brain...]]
* NearlyNormalAnimal: For the most part appears to be an ordinary horse, but is clearly shown reciprocating Pinky's affections.
%%* TheVoiceless
[[/folder]]

[[folder:Roman Numeral 1 "Romy"]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/Romy_5894.jpg]]
-> Voiced by: Creator/MauriceLaMarche (as an infant), Creator/RobPaulsen (as an adult)

A mouse created from Brain and Pinky's combined DNA.
----
* DeadpanSnarker: He makes a few sarcastic remarks, particularly about Pinky and Brain's arguments and quarrels.
* DoesThisRemindYouOfAnything: Romy's creation is played similarly to a baby being born in addition to Brain and Pinky's disagreements on raising him being reminiscent of dysfunctional parents.
* InterspeciesRomance: He ends up in a relationship with Pat "the Bunny" (a human).
* ItIsDehumanizing: While the ethical problems it raises aren't addressed, Brain constantly refers to Roman Numeral 1 as "it" while he is still a baby.
* MixAndMatchMan: He looks like a cross between Pinky and Brain.
* PatchworkKids: If you decide to look at him as Pinky and the Brain's son rather than a scientific experiment.
* TwoDonorClone: He was supposed to be a standard clone of Brain but a clip of Pinky's toenail got mixed in, making him more of a composite of the two.
[[/folder]]

[[folder:Brain's Parents]]
->'''Voiced by:''' Creator/ErnestBorgnine and Tress [=MacNeille=]

* IWantGrandkids: Brain's mother at one point chides her son for not giving her grandchildren.
* JerkWithAHeartOfGold: They do nothing but berate Brain for being untidy after gaining the ability to speak and threaten him whenever he tries to get a word in edgewise, but after they are sent away at the end of the episode, Brain mentions that his parents invited him and Pinky over for Thanksgiving, hinting that they care about their son at least a little bit.
* UpliftedAnimal: They are ordinary mice at first, but gain human-like posture and speech after Brain equips them with devices enabling them to talk.
[[/folder]]

[[folder:Pinky's Parents]]
->'''Voiced by:''' Creator/EricIdle

* AttentionDeficitOohShiny: They make Pinky seem focused.
* CloudCuckooLander: It's clear where Pinky gets it from... if anything, his parents are ''worse''.
* DumbBlonde: Pinky's mother has blonde hair after being exposed to the gene splicer and is every bit as idiotic as her son.
* TookALevelInJerkass: In reboot episode "Roadent Trip", Pinky mentions that his father is incapable of feeling and opening up. What happened to him in the 22 years since he was last seen that reduced him to a bitter, emotionless mouse is unknown.
* UpliftedAnimal: They're put through the same machine that made the main characters sapient.
[[/folder]]

[[folder:Pinky's "Sister"]]
* CompanionCube: "She's" a spool of thread.
[[/folder]]

[[folder:Larry]]
[[quoteright:240:https://static.tvtropes.org/pmwiki/pub/images/larry3.jpg]]
[[caption-width-right:240:"Hi there! I'm the one named Larry."]]
->'''Voiced by:''' Creator/BillyWest, Creator/RobPaulsen (theme song)

A dopey chubby mouse with frizzy hair that sticks out in the sides like Larry Fine of the Three Stooges. He accompanied the duo during one of their schemes, doing little except constantly introducing himself and providing useless observations. Eventually, Brain tires of him and tells him to leave. He later joins up with Music/PaulSimon.
----
* BigThinShortTrio: He becomes the big to Pinky's thin and Brain's short.
* BitingTheHandHumor: The entire reason for his existence. Larry was created in response to the [[ExecutiveMeddling network's request]] that Pinky and the Brain be joined by a third main character. Naturally, the writers thought this to be completely pointless, so they created Larry to demonstrate just how pointless a third main character would be. However, the network eventually won out, with Elmyra of ''WesternAnimation/TinyToonAdventures'' being shoehorned into the show in ''WesternAnimation/PinkyElmyraAndTheBrain''.
* TheBusCameBack: Larry returns 23 years later in the ''Animaniacs'' reboot segment "The Flawed Couple". He makes a silent cameo during the "Narfs" musical number.
* CaptainErsatz: Of [[Film/TheThreeStooges Larry]], naturally.
* CatchPhrase: "Hi there!", "Hello!", and "I'm Larry!".
* ChromaticArrangement: If you look closely, you'll see that he has green eyes to complete the arrangement (Pinky has blue eyes and Brain has pink ones).
* FlatCharacter: Deliberately so. Larry contributes absolutely nothing to the episode's plot, and doesn't do anything except introduce himself and point out that he's Larry. He's merely there to demonstrate just how useless adding a third wheel to Pinky and the Brain would be.
* FurryBaldness: He has tufts of hair around his head implying baldness even though his body's covered in white fur like Brain and Pinky.
* TheGenericGuy: A parody of one. His entire character revolves around the fact that he's Larry (which he points out often), and he has no other real traits to speak of. He's even named after [[Film/TheThreeStooges a well-known example of the trope]]. So is [[Creator/MarxBrothers Zeppo]], the mouse who replaces him at the end of his episode.
* HereWeGoAgain: Finally, Brain managed to get rid of Larry, and be just a duo with Pinky again. Now it's time to take over the world, without Larry... and the scientist opens the cage and introduces a new mouse, Zeppo. And HereWeGoAgain
* MyFriendsAndZoidberg: Done deliberately by the writers. Whenever the character is mentioned, it's usually ''after'' Brain or Pinky mention one another, almost as if Larry's just an afterthought.
-->'''Brain:''' Tonight's plan is my masterpiece, Pinky... and, uh, Larry.\\
'''Larry:''' Hi there!\\
'''Pinky:''' I like the lines, Brain, and, uh, Larry.\\
'''Larry:''' I'm Larry!\\
(this gag continues throughout the episode)
* NoCelebritiesWereHarmed: Larry from Film/TheThreeStooges. There's even a point in the episode where Brain gets a piece of wallpaper stuck to his head that looks like Moe's bowl-cut hair.
* RememberTheNewGuy: The one episode featuring him treats him as if he always was part of the main cast.
* ShooOutTheNewGuy: After their latest scheme gets foiled, Pinky and the Brain both agree that Larry (who literally just joined them) needs to go.
-->'''Brain:''' It's all about teamwork. That special chemistry. The Yin and the Yang.\\
'''Larry:''' And Larry!\\
'''Brain:''' No, that's it! It's ''just'' yin and yang! There shouldn't ''be'' a Larry!\\
'''Pinky:''' Zort! Am I the yin or the yang?\\
'''Brain:''' I don't know, Pinky. But ''he'' is definitely the Larry!
[[/folder]]

[[folder:Zeppo]]
%%* TheGenericGuy: Like Larry, he is a parody of one.%%How?
* HereWeGoAgain: Pinky and Brain manage to get rid of Larry... and the scientist opens the cage and introduces a new mouse, Zeppo.
* NoCelebritiesWereHarmed: Of the Marx Brother, Zeppo.
[[/folder]]

[[folder:Trudy]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/trudy_0.png]]
->'''Voiced by:''' Creator/PamelaHayden

A black-haired mouse from the black and white episode "The Third Mouse".
----
* FurryFemaleMane: She has hair like that of a human woman.
* HumanoidFemaleAnimal: She has a more humanoid body shape than Brain and Pinky.
* TheOneWhoWearsShoes: Unlike most other mice, she doesn't go barefoot.
[[/folder]]

[[folder:Mousey Galore]]
[[quoteright:246:https://static.tvtropes.org/pmwiki/pub/images/Pinky_and_the_Brain_Mousey_Galore_4897.jpg]]
->'''Voiced by:''' Creator/DianeMichelle

A Russian lab mouse and rival to Pinky and the Brain in "To Russia With Lab Mice".
----
Tropes associated with Mousey Galore:
* FemmeFatale: She's very pretty and also attempts to play Brain for a chump.
* FurryFemaleMane: She has hair like a human woman.
* HumanoidFemaleAnimal: Has a curvaceous body and looks notably more humanoid than Pinky and Brain.
* TheOneWhoWearsShoes: As with Trudy, another example.
* PoliticallyIncorrectVillain: She makes some very prejudiced statements about Americans, such as remarking that Americans are so fond of being in charge and that Pinky's idiocy is a common trait among Americans.
* SexyBacklessOutfit: She wears a dress that shows off her bare back.
[[/folder]]

[[folder:Dr. Mordough]]
[[quoteright:344:https://static.tvtropes.org/pmwiki/pub/images/DrMordough_3222b_4157.png]]
->'''Voiced by:''' Creator/JeffBennett

The scientist who built the gene splicer that turned Brain, Pinky, and Snowball into their anthropomorphic forms. He appears only in part three of "Brainwashed".
----
* NamedAfterSomebodyFamous: Sort of; his name references [[Literature/TheIslandOfDoctorMoreau Dr. Moreau]], possibly made into a portmanteau with "Brando."
* NoCelebritiesWereHarmed: He's a blatant parody of Creator/MarlonBrando, who'd played Dr. Moreau in [[Film/TheIslandOfDrMoreau1996 a then-recent adaptation]].
* UnwittingInstigatorOfDoom: He probably never would've expected his experiments to make the lab pets hungry for world domination.
[[/folder]]

[[folder:The Evil Clown]]
[[quoteright:261:https://static.tvtropes.org/pmwiki/pub/images/EvilClown_2_4724.png]]
->'''Voiced by:''' Creator/CoreyBurton

Precious's confidant.
----
* TheDragon: He does the physical work for Precious.
* EveryoneCallsHimBarkeep: His name is never given. In fact, his name was shown only on Creator/KidsWB's website.
* EvilLaugh: He's constantly laughing.
* MonsterClown: He's an evil clown.
* TheVoiceless: He never talks, but he does laugh constantly and later screams in pain when Bobby Bob pours coffee on him.
[[/folder]]

[[folder:Precious]]
[[quoteright:280:https://static.tvtropes.org/pmwiki/pub/images/PreciousTheCat_5001.jpg]]
->'''Voiced by:''' Creator/NoraDunn

Dr. Mordough's cat who was the DiabolicalMastermind of the scheme the mice had to foil in "Brainwashed". Like the mice, she too gained brainpower from the gene splicer, but lost her feline beauty and swore vengeance on humanity as a result.
----
%%* CatsAreMean: Though originally averted.
* DisproportionateRetribution: Precious' motive for wanting to annihilate civilization is revenge for what science did to her. The gene splicer made her highly intelligent, but at the cost of making her '''NOT''' adorable anymore.
* FreudianExcuse: She wants to destroy the world as revenge because her increased intelligence robbed her of her good looks and therefore made her an outcast.
* OmnicidalManiac: Unlike Brain or Snowball, she just wants to destroy humanity and bring everything to ruin out of anger and has no intention of ruling anything.
* PartiallyCivilizedAnimal: While she is highly intelligent, she still is susceptible to common feline instincts such as playing with small shiny objects.
* RevengeBeforeReason: She's dead set on making the world pay for ostracizing her for not being pretty anymore. Even when Snowball points out [[StatingTheSimpleSolution she could easily send herself back through the gene splicer and turn herself back into a normal cat]], she shoots this down in favor of carrying out her revenge.
* UpliftedAnimal: Like the main characters, but unlike them, she hates what she's become.
[[/folder]]

[[folder:Zalgar]]
->'''Voiced by:''' Jeff Bennett

A humanoid alien who scouts planets to eat the brain of the local being with the highest intellect. He attempts to steal Brain's after sending him an email promising to help him take over the world, and after his defeat he decides to settle for Dick Cavett's.
----
* BrainFood: He eats brains.
* LittleGreenMen: His minions Synapse (whose brain he's already eaten) and Neuron.
[[/folder]]

[[folder:Mr. Sultana]]
->'''Voiced by:''' Creator/PaulRugg

A self-described paranoid recluse who lives in a damp, messy house next to Acme Labs.
----
* FunnyForeigner: He's a huge weirdo with an accent that's definitely not from the United States.
* TheHermit: Apparently he became a recluse on the advice of a career consultant.
-->"The pay is not so good, but the hours are very flexible."
* RecurringCharacter: Shows up in several episodes, including a major role in "My Feldmans, My Friends."
* RepetitiveName: His full name is Sultana Sultana, though he asks Brain to call him "Barry."
%%* TrashOfTheTitans: His house is crowded with weird stuff, including boxes labeled things like "People I Look Like" and "People I Look Like But Hate". And canned larvae.
[[/folder]]

!''WesternAnimation/PinkyElmyraAndTheBrain'' Characters

[[folder:Elmyra Duff]]
->'''Voiced by:''' Creator/CreeSummer
The annoying redhead from ''WesternAnimation/TinyToonAdventures''. She turned up to chase the Warners in one of their segments, but is listed here because of her being shoehorned into ''Pinky and the Brain''. See ''Characters/TinyToonAdventures'' for her tropes.
[[/folder]]

[[folder:Pussy Wussy]]
->'''Voiced by:''' Creator/FrankWelker
Elmyra Duff's pet cat.
----
* AllAnimalsAreDogs: He started out as a cat hungry for Pinky and the Brain (because, you know, they're mice). But then came "The Cat Who Cried Woof", where Brain turns him into a dog, and he stays that way for the rest of the series, averting StatusQuoIsGod.
* {{Expy}}: Of Furrball from ''WesternAnimation/TinyToonAdventures''.
[[/folder]]

[[folder:Mr. Shellbutt]]
Elmyra Duff's pet turtle.
----
* {{Expy}}: Of Tyrone Turtle from ''WesternAnimation/TinyToonAdventures''. Also appears to be this to Byron Basset, since he's the other most frequently seen pet from Furrball.
[[/folder]]

[[folder:Rudy Mookich]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/RudyWithHisPetSnake_2774.jpg]]
->'''Voiced by:''' Creator/NancyCartwright

A fat slob who replaced Montana Max as Elmyra's love interest in ''Pinky, Elmyra and the Brain''. Has the hots for Brain's occasional alter-ego, Patty Ann.
----
Tropes associated with Rudy:
* AttractiveBentGender: He falls for Brain's Patty Ann persona.
* EvenEvilHasLovedOnes: He may be a jerk, but he seems to care for his snake Tunk (pictured next to him).
* {{Expy}}:
** He doesn't like Elmyra any more than [[WesternAnimation/TinyToonAdventures Montana Max]] did.
** He is a copy of [[WesternAnimation/TheSimpsons Nelson Muntz]]. He's a troublesome jerk and even has the same voice actor.
* {{Jerkass}}: He's completely rude to everyone he meets.
* MeaningfulName: Well, he ''is'' rude.
* PetTheDog: At the end of "Party Night", he lets Elmyra walk with him on his way home.
%%* ReplacementGoldfish: Elmyra must have moved on from Montana Max. Lucky him.
[[/folder]]

[[folder:Vanity White]]
[[quoteright:275:https://static.tvtropes.org/pmwiki/pub/images/VanityWhite_3_8173.png]]
->'''Voiced by:''' Jane Wiedlin

* AlphaBitch: Well, with a name like [[MeaningfulName Vanity]]...
* NoCelebritiesWereHarmed: Vanna White.
[[/folder]]

[[folder:Wally Faust]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/WallyFaust_1361.jpg]]
->'''Voiced by:''' Jeff Bennett

The seldom-seen antagonist of ''Pinky, Elmyra and the Brain'', he is a man pursuing the mice to use in his own world domination schemes.
----
* AdaptationDyeJob: He had grey hair in the opening, and brown hair in the show.
* AdvertisedExtra: He only appears a handful of times even though he's seen in the show's intro.
* BigBad: He is the closest thing ''WesternAnimation/PinkyElmyraAndTheBrain'' has to a recurring antagonist, even though we barely see him.
* {{Determinator}}: The opening shows how persistent he is in checking on the mice he needs for world domination. So persistent that they "had to flee constantly, needing a place to hide".
* EarlyBirdCameo: Sort of. Creator/ChristopherWalken has made at least a couple appearances on ''Pinky and the Brain'' before this guy appeared.
* EvilDetectingDog: Okay, evil-detecting ''cat'', but still, a nearby alley cat sees Wally, and yowls in fear.
* GreaterScopeVillain: The Circle as a whole could qualify under this, as it's suggested that he's just an agent, not their leader, but it's hard to tell.
* KnightOfCerebus: Reflected in the opening of the show. Elmyra's house and her surroundings are bright and colorful, but Wally Faust is almost always seen as a shadowy silhouette, and his surroundings are much darker. The few episodes featuring him also tend to be notably more serious in tone.
* ManipulativeBastard: He tried to manipulate Brain into a trap. ''Tried'' to, but he came kinda close.
* NoCelebritiesWereHarmed: He is clearly modeled after and talks like Creator/ChristopherWalken.
* OminousLatinChanting: His presence is accompanied by this. Well, sort of. They're really saying things like "gingivitis", "lactose", and "gluteus maximus".
* SeriesContinuityError: In the show's opening, Pinky and the Brain clearly know who Wally Faust is and what he wants with them, yet in his debut episode, they act like they ''don't'' know who he is ''or'' what he wants with them until it came to Brain's "cheese ray". Their ignorance made it easy for Wally to almost lure them into his trap. Well, that's what happens when you take candy from strangers.
* VerbalTic: He likes to say "crisply" in his sentences.
[[/folder]]

!Characters from ''WesternAnimation/Animaniacs2020''

[[folder:Egwind]]
->'''Voiced by:''' Creator/ChrisCox
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/egwindpatb.jpg]]
A mouse who ends up serving as a third teammate for the duo in some episodes. His time never lasts as he always removed at the beginning of the episodes he appears in.
----
* BigThinShortTrio: Just like Larry before him, Egwind provides the big to Pinky's thin and Brain's short.
* ChromaticArrangement: His eyes are green while Pinky's got blue eyes and Brain's got pink eyes.
* {{Foil}}: To Larry. While Larry was an awkward fit to the group who is shooed out after his only major appearance, Egwind seems to have some sort of chemistry with the duo but his time with them is cut short by tragedy, yet he shows up again as a semi-recurring character.
* TheyKilledKennyAgain: He ends up biting the dust in most of his appearances. The only time he isn't killed off is in a brief appearance of a non-"Pinky and the Brain" segment.
[[/folder]]

[[folder:Benedict]]
->'''Voiced by:''' Creator/FredTatasciore
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/de92kvm_4fcbe108_e7a5_423f_8869_38364a6d8520.jpg]]
A dragon who the titular mice attempt to tame in "How to Brain Your Dragon". He is not as the tales initially make him out to be, however...
----
* NonMaliciousMonster: It turns out he wants to be an actor, and the injuries he inflicted on the knights at the beginning were likely either self-defense, an attempt to submit his credentials, or another dragon entirely.
* WoundedGazelleGambit: Brain ropes him into playing the part of the ''gazelle'', oddly enough, with the mouse playing the role of a knight (and Pinky as his [[HorseOfADifferentColor steed]]) who pretends to slay the dragon in exchange for the kingdom. He ends up accidentally breaking the charade by getting up to ask Brain how his performance was.
[[/folder]]

[[folder:B.R.A.I.N.]]
->'''Voiced by:''' Maurice [=LaMarche=]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/robotbrainreboot_4.jpg]]
A robot built by Brain to act as his son.
----
* AIIsACrapshoot: Betrays his father to try and take over the world by himself.
* LogicBomb: Suffers a fatal one thanks to Pinky's usual stupid question.
* VillainHasAPoint: He tells Brain that the latter doesn't have good plans, because Brain has to be at the center of it.
[[/folder]]

[[folder:Julia]]
->'''Voiced by:''' Creator/MariaBamford
!!WARNING: Julia is a WalkingSpoiler, to the point that her appearances in any episode beyond her debut are intended as surprises. Please read this section with caution.
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/julia_2.png]]
[[quoteright:350:[[labelnote:Click here to see her later appearance]]https://static.tvtropes.org/pmwiki/pub/images/julia_brain_as_supervillain.png]][[/labelnote]]

A mouse whom Brain mutates -- and marries -- to serve as his potential first lady during his Senatorial campaign. His attempt to control her turns her into his ArchEnemy.
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* AIIsACrapshoot: Even though it was never subject to mind control, Brain's virtual duplicate of Julia in "All's Fair in Love and Door" winds up going crazy in the same way she did, even showing an image of the real Julia's mind control chip (which it did not have prior to that point), when it learns that it's [[JustAMachine just a computer program]].
* BarefootCartoonAnimal: She wears various outfits throughout the series (a green pantsuit in "[[Recap/Animaniacs2020Episode8 Mousechurian Candidate]]", a spacesuit and SpyCatsuit in "[[Recap/Animaniacs2020Episode23 Reichenbrain Falls]]", a [[TheFifties 1950s]] housewife costume in "All's Fair in Love and Door"). The only one that includes shoes is the spacesuit.
* BlessedWithSuck: Her neural implant does greatly increase her intelligence, but also has a MindControlDevice function in case Brain wants to step in. The "obedience chip" is clearly defective and malfunctioning; it causes her terrible pain and causes her to go completely insane.
* BrainyBrunette: She's as intelligent as Brain and she has brown hair.
* BreakTheCutie: Poor Julia! Brain ruthlessly manipulates her mind, body and emotions, which ends up damaging her both physically and psychologically.
* CompositeCharacter:
** She seems to be a mix of Billie and Snowball from the original series; she's a genetically spliced lab mouse set up as a LoveInterest for Brain (Billie), but she's as smart as (if not smarter than) him, and becomes an EvilFormerFriend bent on revenge against him at the end (Snowball).
** She also becomes a composite of Pinky and the Brain, because she's both a genius and insane.
* CreateYourOwnVillain: Brain has no one but himself to blame for Julia turning against him, since it was his malfunctioning MindControlDevice that drove her crazy.
* EarNotch: She has one on her left ear.
* EveryoneHasStandards: Julia tells off Brain for how he mistreats Pinky. She says her "husband" ought to be nicer to his best friend. Brain responds by trying to brainwash her.
* HazyFeelTurn: It's unclear if she actually turns evil at the end of "Mousechurian Candidate". Julia has a hideout and webcam to monitor Brain and Pinky, but she just smugly watches as Pinky obliviously puts salt instead of sugar in Brain's coffee. Julia seems to be focusing solely on the Brain and mimicking his CatchPhrase to TakeOverTheWorld to mock him. However, "Reichenbrain Falls" confirms that she has indeed undergone a FaceHeelTurn. She's become Brain's vengeful ArchEnemy and plans to rule the world herself.
* InSpiteOfANail: In "All's Fair in Love and Door", Brain tries to create a simulation of what life would've been like if he hadn't been so terrible to Julia. Though this artificial version is as pleasant as her progenitor originally was, she immediately goes off the deep end when she finds out that she's just a computer program, implying that even without the neural implant, it wouldn't have taken much for her to become a megalomaniacal villain. However, this may or may not involve AI Julia gaining the original's memories.
* MasterOfDisguise: When she returns in "Reichenbrain Falls", she's disguised as Pinky for part of the episode. She ''almost'' pulls it off, but a few subtle OOCIsSeriousBusiness moments allow Brain to figure out that it's an impostor. She also becomes a MobileSuitHuman to kidnap Pinky in the first place.
* MistreatmentInducedBetrayal: After she realizes how much of a tyrant Brain is, he [[{{Brainwashed}} brainwashes]] her. However, she breaks free, escapes, and starts plotting against Brain.
* MoodSwinger: After her FaceHeelTurn, her continuing mental damage causes her to alternate between TranquilFury and just plain fury. Sometimes this happens mid-sentence, which leads to a SuddenlyShouting speech pattern.
* NiceMice: She's compassionate and idealistic... until Brain messes with her mind, which causes her FaceHeelTurn.
* PantslessMalesFullyDressedFemales: A zigzagged example. Julia initially makes her debut in "Mousechurian Candidate" wearing no clothes much like Pinky and Brain. But in later appearances she tends to wear full sets of clothes ([[BarefootCartoonAnimal except for shoes]]), in contrast to the pair's incomplete outfits or even lack of one, such as her green pantsuit in the same short she first appears in, or her catsuit in "Reichenbrain Falls". The only time Julia is shown clothesless more than once is when she pretends to be an ordinary mouse at the end of the former short, seemingly having lost her sapience as a result of her malfunctioning implant until she enters her hideout.
* PintSizedPowerhouse: During her FreakOut at the debate, Julia (who, we remind you, is a mouse) is somehow able to pick up the human-sized podium and throw it through a wall.
* TheResenter: One of the reasons she turns against Brain.
-->You think you're so smart, the Brain, which is barely a name, by the way, but I'm far more clever! More hard-working.
* TookALevelInBadass: By "Reichenbrain Falls", she's become quite a competent fighter.
* UpliftedAnimal: A rare example of such a character created by another uplifted animal.
* WalkingSpoiler: It's difficult to discuss her without revealing her surprise appearance and FaceHeelTurn in season two.
* WithGreatPowerComesGreatInsanity: Brain makes her as intelligent as himself for one of his schemes, but his failed attempt to control her has a negative impact on her mental state when she escapes. When they meet again, she has the mind of a MadScientist. Emphasis on ''mad''.
* WouldntHurtAChild: She follows along with Brain's plan up until she reads his script about having children build bombs. Upon which, she opts to do things her way.
[[/folder]]

[[folder:Brie]]
[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/brie.png]]
->'''Voiced by:''' Creator/GreyDeLisle

A Senate intern in "Pinko and the Brain" who becomes suspicious of Brain when he's impersonating Senator Garp.
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* AnimalMotifs: She was intentionally designed to resemble a mouse and have a "mousey" appearance with her nose, glasses, buck teeth and plain fashion. [[PunnyName Her name]] is also a type of [[StockAnimalDiet cheese]]. This comes to play later on when Brain accuses her of being a mouse.
* BadassPacifist: She defeats Brain and exposes him, not by scapegoating others or stooping to his level, but with simple logic to prove her point and keen observation.
* GoodIsNotSoft: She will browbeat a witness during a Senate trial against herself because she suspects that the latter is trying to lie under oath. Since the witness was Pinky, she was right to take this course of action.
* IncorruptiblePurePureness: Brie is the ''only'' member of the Senate whom Brain cannot blackmail or scapegoat; she has a clean record. Even when Brain tries to argue that she must be a mouse because she's from Wisconsin, the cheese capital of the U.S., she turns the tables on him by pointing out that cheese is an American staple and anyone who doesn't like it must lack patriotism.
* OnlySaneWoman: She's the only one who questions that Senator Garp is NotHimself -- owing to Brain impersonating him -- and starts keeping tabs on him. After all, she's worked with him for a year and knows that no human would want canned ham and mayonnaise in their coffee.
* PunnyName: Her name is also the name of a type of [[StockAnimalDiet cheese]], adding to her mouse AnimalMotifs.
* WorthyOpponent: Brain admits at the end of the episode that she's the only person who ever outsmarted him.
[[/folder]]

[[folder:The World Leaders]]

->'''Voiced by:''' Creator/EricBauza (UsefeulNotes/KimJongUn), Anthony Carrigan (UsefulNotes/VladimirPutin), Creator/CarlosAlazraqui (Nicolás Maduro)

Leaders of various nations.
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* EvenEvilHasStandards: Putin, Maduro and Kim Jong-un all consider Brain's attempts to talk about world domination during a banquet to be very rude.
* FunHatingVillain: Putin is portrayed as such in "Anima-Nyet". When the Warners perform a playful and upbeat song on the titular bootleg show, Putin sends an army to shut it down.
-->'''Putin:''' Happy-go-lucky tinkle-dee-doo-dah song? Nyet on my watch.
* TakeThat: None of their appearances paint them in a positive light. Brain even gives them a TheReasonYouSuckSpeech about how poorly they're running their countries.
* TerribleTrio: Putin, Maduro and Kim Jong-un form one. Putin is the ''de facto'' leader of the trio, clearly more powerful than the other two.
[[/folder]]
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